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List of works by Kang-Yell Choi

5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation

scientific article published on 21 October 2020

A Mixed Micellar Formulation for the Transdermal Delivery of an Indirubin Analog

scientific article published on 19 February 2020

A Ras destabilizer KYA1797K overcomes the resistance of EGFR tyrosine kinase inhibitor in KRAS-mutated non-small cell lung cancer

scientific article published in Scientific Reports

A Therapeutic Strategy for Chemotherapy-Resistant Gastric Cancer via Destabilization of Both β-Catenin and RAS

scientific article published on 08 April 2019

A mutant KRAS-induced factor REG4 promotes cancer stem cell properties via Wnt/β-catenin signaling

scientific article published on 23 November 2019

A small molecule approach to degrade RAS with EGFR repression is a potential therapy for KRAS mutation-driven colorectal cancer resistance to cetuximab

scholarly article by Sang-Kyu Lee published in November 2018

APC inhibits ERK pathway activation and cellular proliferation induced by RAS

scientific journal article

APC loss induces Warburg effect via increased PKM2 transcription in colorectal cancer

scientific article published on 19 October 2020

Activation of protein kinase C by 1-beta-D-arabinofuranosylcytosine conjugates of phospholipid.

scientific article

Akt is involved in the inhibition of cell proliferation by EGF.

scientific article

Axin inhibits extracellular signal-regulated kinase pathway by Ras degradation via beta-catenin.

scientific article published on 20 March 2007

Bone morphogenetic protein 4 stimulates neuronal differentiation of neuronal stem cells through the ERK pathway

scientific journal article

Both ERK and Wnt/beta-catenin pathways are involved in Wnt3a-induced proliferation

scientific article published on 22 December 2004

CXXC5 is a transcriptional activator of Flk-1 and mediates bone morphogenic protein-induced endothelial cell differentiation and vessel formation

scientific article published on 17 October 2013

CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth

scientific article published on 10 April 2019

CXXC5 plays a role as a transcription activator for myelin genes on oligodendrocyte differentiation

scientific article published on 14 October 2015

Caffeic acid phenethyl ester downregulates phospholipase D1 via direct binding and inhibition of NFκB transactivation

scientific article published on 5 October 2013

Chromosomal end fusion resulting from telomere erosion increases susceptibility to radiation via multinucleation: effect of p53.

scientific article published in October 2006

Co‐treatment with retinyl retinoate and a PPARα agonist reduces retinoid dermatitis ⬇️

scientific article published on 01 June 2012

Crystal structure of the PDZ domain of mouse Dishevelled 1 and its interaction with CXXC5.

scientific article published on 5 December 2016

Design, synthesis and biological evaluation of novel aliphatic amido/sulfonamido-quaternary ammonium salts as antitumor agents

scientific article

Destabilization of β-catenin and RAS by targeting the Wnt/β-catenin pathway as a potential treatment for triple-negative breast cancer

scientific article published on 26 May 2020

Differential modulation of zinc-stimulated p21(Cip/WAF1) and cyclin D1 induction by inhibition of PI3 kinase in HT-29 colorectal cancer cells

scientific article

Discovery of a small-molecule inhibitor of Dvl-CXXC5 interaction by computational approaches

scientific article published on 7 April 2018

Drosophila PI3 kinase and Akt involved in insulin-stimulated proliferation and ERK pathway activation in Schneider cells

scientific article published on November 2004

Drosophila extracellular signal-regulated kinase involves the insulin-mediated proliferation of Schneider cells

scientific article published on 7 February 2002

EGF receptor is involved in WNT3a-mediated proliferation and motility of NIH3T3 cells via ERK pathway activation

scientific article published on 20 February 2007

ERK activation is involved in tooth development via FGF10 signaling.

scientific article published in December 2009

Euodia sutchuenensis Dode extract stimulates osteoblast differentiation via Wnt/β-catenin pathway activation

scientific article

Feature genes of hepatitis B virus-positive hepatocellular carcinoma, established by its molecular discrimination approach using prediction analysis of microarray

scientific article published in December 2004

H-Ras is degraded by Wnt/beta-catenin signaling via beta-TrCP-mediated polyubiquitylation

scientific article

Hair growth-promoting effect of Aconiti Ciliare Tuber extract mediated by the activation of Wnt/β-catenin signaling

scientific article published on 21 September 2012

House dust mite allergen Der f 2 induces interleukin-13 expression by activating the PI3K/Akt pathway

scientific article published on May 2013

Hovenia dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/β-catenin pathway and increase bone mass in growing or ovariectomized mice

scientific article (publication date: 2014)

Identification of Ras-degrading small molecules that inhibit the transformation of colorectal cancer cells independent of β-catenin signaling.

scientific article published on 6 June 2018

Identification of small-molecule compounds targeting the dishevelled PDZ domain by virtual screening and binding studies.

scientific article

Indirubin-3'-oxime reverses bone loss in ovariectomized and hindlimb-unloaded mice via activation of the Wnt/β-catenin signaling

scientific article published on 01 January 2014

Indirubin-3'-oxime stimulates chondrocyte maturation and longitudinal bone growth via activation of the Wnt/β-catenin pathway

scientific article published on 12 September 2019

Indirubin-3'-oxime, an activator of Wnt/β-catenin signaling, enhances osteogenic commitment of ST2 cells and restores bone loss in high-fat diet-induced obese male mice

scientific article published on 9 May 2014

Inhibition of phospholipase D2 induces autophagy in colorectal cancer cells

scientific article

Interaction between Wnt/β-catenin and RAS-ERK pathways and an anti-cancer strategy via degradations of β-catenin and RAS by targeting the Wnt/β-catenin pathway.

scientific article

Interaction of hepatitis C virus core protein with Hsp60 triggers the production of reactive oxygen species and enhances TNF-alpha-mediated apoptosis

scientific article

Interaction of the Wnt/β-catenin and RAS-ERK pathways involving co-stabilization of both β-catenin and RAS plays important roles in the colorectal tumorigenesis

scientific article published on 10 January 2018

Isolation and characterization of a Drosophila homologue of mitogen-activated protein kinase phosphatase-3 which has a high substrate specificity towards extracellular-signal-regulated kinase

scientific article

Isolation and maintenance of cortical neural progenitor cells in vitro

scientific article published on January 2013

K-Ras stabilization by estrogen via PKCδ is involved in endometrial tumorigenesis

scientific article

KR-POK interacts with p53 and represses its ability to activate transcription of p21WAF1/CDKN1A.

scientific article published on 17 January 2012

KY1022, a small molecule destabilizing Ras via targeting the Wnt/β-catenin pathway, inhibits development of metastatic colorectal cancer

scientific article

MEK1/2 Inhibitors AS703026 and AZD6244 May Be Potential Therapies for KRAS Mutated Colorectal Cancer That Is Resistant to EGFR Monoclonal Antibody Therapy ⬇️

scientific article published on November 30, 2010

Metabolic improvement and liver regeneration by inhibiting CXXC5 function for non-alcoholic steatohepatitis treatment

scientific article published in 2022

MicroRNA-320a and microRNA-4496 attenuate Helicobacter pylori cytotoxin-associated gene A (CagA)-induced cancer-initiating potential and chemoresistance by targeting β-catenin and ATP-binding cassette, subfamily G, member 2.

scientific article published on 23 December 2016

N-Formyl-Methionyl-Leucyl-Phenylalanine (fMLP) Promotes Osteoblast Differentiation via the N-Formyl Peptide Receptor 1-mediated Signaling Pathway in Human Mesenchymal Stem Cells from Bone Marrow ⬇️

scientific article published on March 3, 2011

N-Nicotinoyl dopamine, a novel niacinamide derivative, retains high antioxidant activity and inhibits skin pigmentation ⬇️

scientific article published on August 15, 2011

NM23H2 inhibits EGF- and Ras-induced proliferation of NIH3T3 cells by blocking the ERK pathway

scientific article

PLD1 and PLD2 differentially regulate the balance of macrophage polarization in inflammation and tissue injury

scientific article published on 23 December 2020

Persicaria hydropiper (L.) Spach and its Flavonoid Components, Isoquercitrin and Isorhamnetin, Activate the Wnt/β‐catenin Pathway and Inhibit Adipocyte Differentiation of 3T3‐L1 Cells ⬇️

scientific article published on March 17, 2011

Phospholipase D Meets Wnt Signaling: A New Target for Cancer Therapy ⬇️

scientific article published on January 11, 2011

Phospholipase D inhibitor enhances radiosensitivity of breast cancer cells

scientific article published on 30 August 2013

Phospholipase D1 Acts through Akt/TopBP1 and RB1 to Regulate the E2F1-Dependent Apoptotic Program in Cancer Cells

scientific article

Phospholipase D1 Inhibition Linked to Upregulation of ICAT Blocks Colorectal Cancer Growth Hyperactivated by Wnt/β-Catenin and PI3K/Akt Signaling

scientific article

Phospholipase D1 drives a positive feedback loop to reinforce the Wnt/beta-catenin/TCF signaling axis

scientific article

Phospholipase D1 has a pivotal role in interleukin-1β-driven chronic autoimmune arthritis through regulation of NF-κB, hypoxia-inducible factor 1α, and FoxO3a

scientific article published on 20 May 2013

Phospholipase D1 protein coordinates dynamic assembly of HIF-1α-PHD-VHL to regulate HIF-1α stability

scientific article

Phospholipase D2 promotes degradation of hypoxia-inducible factor-1α independent of lipase activity

scientific article

Polygonum aviculare L. and its active compounds, quercitrin hydrate, caffeic acid, and rutin, activate the Wnt/β-catenin pathway and induce cutaneous wound healing

scientific article published on 01 March 2016

Proto-oncogene FBI-1 represses transcription of p21CIP1 by inhibition of transcription activation by p53 and Sp1.

scientific article published on 25 February 2009

Ras Stabilization Through Aberrant Activation of Wnt/β-Catenin Signaling Promotes Intestinal Tumorigenesis ⬇️

scientific article published on April 10, 2012

Rebamipide attenuates Helicobacter pylori CagA-induced self-renewal capacity via modulation of β-catenin signaling axis in gastric cancer-initiating cells

scientific article published on 2 June 2016

Regulation of Drosophila MKP-3 by Drosophila ERK.

scientific article published on December 2003

Response

scientific article published on 18 August 2014

Retinoic-acid-mediated HRas stabilization induces neuronal differentiation of neural stem cells during brain development

scientific article

Retinyl retinoate induces hyaluronan production and less irritation than other retinoids

scientific article published in May 2010

Role of oncogenic K-Ras in cancer stem cell activation by aberrant Wnt/β-catenin signaling.

scientific article published on February 2014

Simultaneous destabilization of β-catenin and Ras via targeting of the axin-RGS domain as a potential therapeutic strategy for colorectal cancer

scientific article published on 29 July 2016

Small molecule inhibitors of the Dishevelled-CXXC5 interaction are new drug candidates for bone anabolic osteoporosis therapy

scientific article published on 2 March 2016

Small molecule-induced simultaneous destabilization of β-catenin and RAS is an effective molecular strategy to suppress stemness of colorectal cancer cells

scientific article published on 06 March 2020

Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation

scientific article

Stabilization of Sur8 via PKCα/δ degradation promotes transformation and migration of colorectal cancer cells

scientific article published on 14 December 2017

Strategies to overcome resistance to epidermal growth factor receptor monoclonal antibody therapy in metastatic colorectal cancer

scientific article

Sur8 mediates tumorigenesis and metastasis in colorectal cancer

scientific article published on 29 July 2016

Sur8/Shoc2 involves both inhibition of differentiation and maintenance of self-renewal of neural progenitor cells via modulation of extracellular signal-regulated kinase signaling.

scientific article published on February 2011

Sur8/Shoc2 promotes cell motility and metastasis through activation of Ras-PI3K signaling

scientific article published on 5 September 2015

Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis

scientific article published on 5 June 2017

Targeting phospholipase D1 attenuates intestinal tumorigenesis by controlling β-catenin signaling in cancer-initiating cells

scientific article published on 29 June 2015

Tautomycetin inhibits growth of colorectal cancer cells through p21cip/WAF1 induction via the extracellular signal-regulated kinase pathway

scientific article published on December 2006

Temporal cDNA microarray analysis of gene expression in human hepatocellular carcinoma upon radiation exposure.

scientific article

The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing

scientific article published on 8 June 2015

The ERK pathway involves positive and negative regulations of HT-29 colorectal cancer cell growth by extracellular zinc.

scientific article published on 19 June 2003

The pleckstrin homology domain of phospholipase D1 accelerates EGFR endocytosis by increasing the expression of the Rab5 effector, rabaptin-5.

scientific article

Transcriptional activity of Sp1 is regulated by molecular interactions between the zinc finger DNA binding domain and the inhibitory domain with corepressors, and this interaction is modulated by MEK

scientific article

Troglitazone activates p21Cip/WAF1 through the ERK pathway in HCT15 human colorectal cancer cells

scientific article published in May 2002

Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells ⬇️

scientific article published on April 10, 2012

Valproic acid induces cutaneous wound healing in vivo and enhances keratinocyte motility

scientific article

Valproic acid induces differentiation and inhibition of proliferation in neural progenitor cells via the beta-catenin-Ras-ERK-p21Cip/WAF1 pathway

scientific article

WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer

scientific article published on 30 July 2019

WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation

scientific article published in Nature Communications

Wnt5a is required for endothelial differentiation of embryonic stem cells and vascularization via pathways involving both Wnt/beta-catenin and protein kinase Calpha.

scientific article published on 18 December 2008

beta-Catenin-mediated signaling: a novel molecular target for chemoprevention with anti-inflammatory substances

scientific article

β-Catenin-RAS interaction serves as a molecular switch for RAS degradation via GSK3β

scientific article published on 09 November 2018

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