List of works - Charles Antzelevitch

A CACNA1C variant associated with reduced voltage-dependent inactivation, increased CaV1.2 channel window current, and arrhythmogenesis

scientific article

A common single nucleotide polymorphism can exacerbate long-QT type 2 syndrome leading to sudden infant death.

scientific article

A complete right bundle-branch block masking Brugada syndrome

scientific article published on 24 July 2012

A gain-of-function I(K-ATP) mutation and its role in sudden cardiac death associated with J-wave syndromes

scientific article

A molecular link between the sudden infant death syndrome and the long-QT syndrome

scientific article

A mutation in the beta 3 subunit of the cardiac sodium channel associated with Brugada ECG phenotype

scientific article

A novel mutation in KCNQ1 associated with a potent dominant negative effect as the basis for the LQT1 form of the long QT syndrome.

scientific article

A novel mutation in the HCN4 gene causes symptomatic sinus bradycardia in Moroccan Jews.

scientific article

A novel rare variant in SCN1Bb linked to Brugada syndrome and SIDS by combined modulation of Na(v)1.5 and K(v)4.3 channel currents

scientific article published on 7 December 2011

A temporal window of vulnerability for development of atrial fibrillation with advancing heart failure

article

A transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome.

scientific article published on 10 December 2008

ABCC9 is a novel Brugada and early repolarization syndrome susceptibility gene.

scientific article published on 04 January 2014

ABSTRACTS

scholarly article

AZD1305 exerts atrial predominant electrophysiological actions and is effective in suppressing atrial fibrillation and preventing its reinduction in the dog

scientific article

Abnormal repolarization as the basis for late potentials and fractionated electrograms recorded from epicardium in experimental models of Brugada syndrome

scientific article

Accelerated inactivation of the L-type calcium current due to a mutation in CACNB2b underlies Brugada syndrome

scientific article published in May 2009

Acute dronedarone is inferior to amiodarone in terminating and preventing atrial fibrillation in canine atria.

scientific article published on 15 May 2010

Acute myocardial ischemia: cellular mechanisms underlying ST segment elevation

scientific article published on 25 February 2014

Advances in the Pharmacologic Management of Atrial Fibrillation

scientific article published on March 2011

Advances in the Pharmacological Treatment of Atrial Fibrillation ⬇️

scientific article published on January 1, 2010

Ajmaline-Induced Slowing of Conduction in the Right Ventricular Outflow Tract Cannot Account for ST Elevation in Patients With Type I Brugada ECG.

scientific article published in October 2017

American Heart Association atrial fibrillation research summit: a conference report from the American Heart Association

scientific article

Amplified transmural dispersion of repolarization as the basis for arrhythmogenesis in a canine ventricular-wedge model of short-QT syndrome

scientific article published on 29 November 2004

An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing

scientific article

Andersen-Tawil syndrome: Clinical presentation and predictors of symptomatic arrhythmias - Possible role of polymorphisms K897T in KCNH2 and H558R in SCN5A gene

scientific article published on 20 March 2017

Androgens and male predominance of the Brugada syndrome phenotype

scientific article published in July 2003

Antiarrhythmic effects of losartan and enalapril in canine pulmonary vein sleeve preparations.

scientific article

Antiarrhythmic effects of ranolazine in a guinea pig in vitro model of long-QT syndrome

scientific article published on 18 March 2004

Antiarrhythmic effects of ranolazine in canine pulmonary vein sleeve preparations.

scientific article published on 21 March 2008

Antiarrhythmic effects of simvastatin in canine pulmonary vein sleeve preparations

scientific article

Antiarrhythmic effects of the highly selective late sodium channel current blocker GS-458967

scientific article published on 22 March 2013

Arrhythmogenic mechanisms of QT prolonging drugs: is QT prolongation really the problem?

scientific article

Assessing predictors of drug-induced torsade de pointes.

scientific article published on December 2003

Atria are More Sensitive Than Ventricles to GS-458967-Induced Inhibition of Late Sodium Current

scientific article published on 03 February 2015

Atrial fibrillation and Brugada syndrome

scientific article published on March 2008

Atrial fibrillation in inherited cardiac channelopathies: From mechanisms to management

scientific article

Atrial-selective effects of chronic amiodarone in the management of atrial fibrillation.

scientific article published on 16 September 2008

Atrial-selective inhibition of sodium-channel current by Wenxin Keli is effective in suppressing atrial fibrillation.

scientific article

Atrial-selective prolongation of refractory period with AVE0118 is due principally to inhibition of sodium channel activity

scientific article

Atrial-selective sodium channel block as a novel strategy for the management of atrial fibrillation

scientific article published on 20 August 2009

Atrial-selective sodium channel block as a novel strategy for the management of atrial fibrillation.

scientific article

Atrial-selective sodium channel block as a strategy for suppression of atrial fibrillation

scientific article

Atrial-selective sodium channel block for the treatment of atrial fibrillation.

scientific article published on June 2009

Atrial-selective sodium channel block strategy to suppress atrial fibrillation: ranolazine versus propafenone.

scientific article published on 17 October 2011

Atrial-selective sodium channel blockers: do they exist?

scientific article published on August 2008

Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation: differences in sodium channel inactivation between atria and ventricles and the role of ranolazine

scientific article published on 4 September 2007

Augmentation of J waves and electrical storms in patients with early repolarization

scientific article

Augmentation of late sodium current unmasks the proarrhythmic effects of amiodarone.

scientific article published on 13 November 2007

Author's response to letter to the editor from Perez and Froelicher.

scientific article published on 30 January 2013

Autonomic aspects of arrhythmogenesis: the enduring and the new.

scientific article

Basic mechanisms of reentrant arrhythmias

scientific article

Biophysical and molecular characterization of a novel de novo KCNJ2 mutation associated with Andersen-Tawil syndrome and catecholaminergic polymorphic ventricular tachycardia mimicry

scientific article

Blinded validation of the isolated arterially perfused rabbit ventricular wedge in preclinical assessment of drug-induced proarrhythmias.

scientific article

Brugada Syndrome: Cellular Mechanisms and Approaches to Therapy

scientific article

Brugada Syndrome: Clinical, Genetic, Molecular, Cellular, and Ionic Aspects

scientific article published on 11 June 2015

Brugada Syndrome: Overview

Brugada syndrome

scientific article published on 01 October 2006

Brugada syndrome and ischemia-induced ST-segment elevation. Similarities and differences.

scientific article

Brugada syndrome.

scientific article published in May 2005

Brugada syndrome: 12 years of progression

scientific article

Brugada syndrome: 1992-2002: a historical perspective

scientific article published in May 2003

Brugada syndrome: a decade of progress

scientific article published in December 2002

Brugada syndrome: clinical, genetic, molecular, cellular and ionic aspects

scientific article published on July 2003

Brugada syndrome: from cell to bedside

scientific article

Brugada syndrome: recent advances and controversies.

scientific article published on September 2008

Brugada syndrome: report of the second consensus conference.

scientific article

Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association.

scientific article

Brugada-like electrocardiographic pattern.

scientific article published on July 2003

Brugada-like syndrome in infancy presenting with rapid ventricular tachycardia and intraventricular conduction delay.

scientific article

Call “the Cleaners”

scientific article published on 11 July 2015

Can inhibition of IKur promote atrial fibrillation?

scientific article published on 6 August 2008

Cardiac repolarization. The long and short of it.

scientific article

Cardiomyocyte calcium cycling in a naturally occurring German shepherd dog model of inherited ventricular arrhythmia and sudden cardiac death

article

Case scenario: anesthesia-related cardiac arrest in a child with Timothy syndrome

scientific article

Cellular and Ionic Mechanisms Underlying Erythromycin-Induced Long QT Intervals and Torsade de Pointes

scientific article published on 01 December 1996

Cellular and ionic basis for the sex-related difference in the manifestation of the Brugada syndrome and progressive conduction disease phenotypes

scientific article

Cellular and ionic mechanisms responsible for the Brugada syndrome

scientific article

Cellular and ionic mechanisms underlying the effects of cilostazol, milrinone, and isoproterenol to suppress arrhythmogenesis in an experimental model of early repolarization syndrome.

scientific article published on 25 January 2016

Cellular and subcellular alternans in the canine left ventricle

scientific article published on 28 September 2007

Cellular basis and mechanism underlying normal and abnormal myocardial repolarization and arrhythmogenesis.

scientific article published on January 2004

Cellular basis for QT dispersion.

scientific article published on January 1998

Cellular basis for arrhythmogenesis in an experimental model of the SQT1 form of the short QT syndrome

scientific article

Cellular basis for atrial fibrillation in an experimental model of short QT1: implications for a pharmacological approach to therapy.

scientific article published on 17 October 2009

Cellular basis for electrocardiographic and arrhythmic manifestations of Andersen-Tawil syndrome (LQT7).

scientific article

Cellular basis for long QT, transmural dispersion of repolarization, and torsade de pointes in the long QT syndrome

scientific article

Cellular basis for the electrocardiographic and arrhythmic manifestations of Timothy syndrome: effects of ranolazine

scientific article

Cellular basis for the monophasic action potential. Which electrode is the recording electrode?

scientific article published in September 2004

Cellular basis for the normal T wave and the ECG manifestations of the long QT syndrome

Cellular basis for the repolarization waves of the ECG.

scientific article published on October 2006

Cellular mechanism and arrhythmogenic potential of T-wave alternans in the Brugada syndrome

scientific article published on 21 November 2007

Cellular mechanism underlying hypothermia-induced ventricular tachycardia/ventricular fibrillation in the setting of early repolarization and the protective effect of quinidine, cilostazol, and milrinone

scientific article

Cellular mechanisms underlying the development of catecholaminergic ventricular tachycardia.

scientific article

Cellular mechanisms underlying the effects of milrinone and cilostazol to suppress arrhythmogenesis associated with Brugada syndrome

scientific article published on August 2013

Cellular mechanisms underlying the long QT syndrome.

scientific article

Cellular, Molecular, and Pharmacologic Mechanisms Underlying Drug-Induced Cardiac Arrhythmogenesis

scholarly article

Chromanol 293B inhibits slowly activating delayed rectifier and transient outward currents in canine left ventricular myocytes

scientific article

Cisapride-induced transmural dispersion of repolarization and torsade de pointes in the canine left ventricular wedge preparation during epicardial stimulation

scientific article published on 11 August 2003

Clinical approaches to tachyarrhythmias, volume 10: The brugada syndrome

Clinical relevance of cardiac arrhythmias generated by afterdepolarizations. Role of M cells in the generation of U waves, triggered activity and torsade de pointes.

scientific article

Coexistence of atrioventricular accessory pathways and drug-induced type 1 Brugada pattern

scientific article published on 16 July 2018

Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

scientific article

Comparison of electrophysiological and antiarrhythmic effects of vernakalant, ranolazine, and sotalol in canine pulmonary vein sleeve preparations.

scientific article published on 20 October 2011

Comparison of the effects of a transient outward potassium channel activator on currents recorded from atrial and ventricular cardiomyocytes

scientific article

Compound heterozygous mutations P336L and I1660V in the human cardiac sodium channel associated with the Brugada syndrome

scientific article

Coordinated down-regulation of KCNQ1 and KCNE1 expression contributes to reduction of I(Ks) in canine hypertrophied hearts.

scientific article

Correspondence

scientific article published on 01 October 1997

Descripción de la utilización de cuñas ventriculares aisladas de corazón canino en el laboratorio de electrofisiología experimental

Development of a coronary-perfused interventricular septal preparation as a model for studying the role of the septum in arrhythmogenesis

scientific article published on November 2007

Developmental changes in expression and biophysics of ion channels in the canine ventricle

scientific article published on 10 September 2013

Diagnostic and genetic aspects of the Brugada and other inherited arrhythmias syndromes.

scientific article

Differences in the electrophysiologic response of four canine ventricular cell types to α1-adrenergic agonists

scientific article published on 01 September 1999

Differential effects of beta-adrenergic agonists and antagonists in LQT1, LQT2 and LQT3 models of the long QT syndrome.

scientific article

Differential effects of the transient outward K(+) current activator NS5806 in the canine left ventricle

scientific article

Dimethyl lithospermate B, an extract of Danshen, suppresses arrhythmogenesis associated with the Brugada syndrome.

scientific article

Divergent expression of delayed rectifier K+ channel subunits during mouse heart development

article

Does Tpeak-Tend provide an index of transmural dispersion of repolarization?

scientific article

Drug-induced Brugada syndrome

Drug-induced Channelopathies

Drug-induced QT-interval shortening following antiepileptic treatment with oral rufinamide.

scientific article

Drug-induced spatial dispersion of repolarization

scientific article published on January 2008

Drug-induced torsades de pointes and implications for drug development.

scientific article

Dual variation in SCN5A and CACNB2b underlies the development of cardiac conduction disease without Brugada syndrome.

scientific article

ECG phenomenon of idiopathic and paradoxical short QT intervals

scientific article

Early repolarization syndrome: a decade of progress

scientific article published on March 2013

Early repolarization syndrome: clinical characteristics and possible cellular and ionic mechanisms.

scientific article

Effect of Wenxin Keli and quinidine to suppress arrhythmogenesis in an experimental model of Brugada syndrome ⬇️

scientific article

Effect of epicardial or biventricular pacing to prolong QT interval and increase transmural dispersion of repolarization: does resynchronization therapy pose a risk for patients predisposed to long QT or torsade de pointes?

scientific article

Electrical Diseases of the Heart

Electrocardiographic changes predicting sudden death in propofol-related infusion syndrome.

scientific article

Electromechanical coupling in patients with the short QT syndrome: further insights into the mechanoelectrical hypothesis of the U wave.

scientific article published on 9 October 2007

Electrophysiologic and antiarrhythmic effects of AZD1305 in canine pulmonary vein sleeves

scientific article

Electrophysiologic basis for the antiarrhythmic actions of ranolazine ⬇️

scientific article published on March 21, 2011

Electrophysiologic characteristics and pharmacologic response of human cardiomyocytes isolated from a patient with hypertrophic cardiomyopathy

scientific article published on October 2013

Electrophysiologic characteristics of M cells in the canine left ventricular free wall

scientific article published in August 1995

Electrophysiological characteristics of canine superior vena cava sleeve preparations: effect of ranolazine

scientific article published on 9 March 2012

Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties

scientific article

Empiric quinidine therapy for asymptomatic Brugada syndrome: time for a prospective registry

scientific article

Enhancing rare variant interpretation in inherited arrhythmias through quantitative analysis of consortium disease cohorts and population controls

scientific article published on 7 September 2020

Epicardial Substrate as a Target for Radiofrequency Ablation in an Experimental Model of Early Repolarization Syndrome

scientific article published on 01 September 2018

Epicardial activation of left ventricular wall prolongs QT interval and transmural dispersion of repolarization: implications for biventricular pacing

scientific article published on 12 April 2004

Erratum: Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

scholarly article published in Nature Genetics

Evidence for the presence of M cells in the guinea pig ventricle

scientific article published in June 1996

Expert's opinion

Extending the conditions of application of an inversion of the Hodgkin-Huxley gating model

scientific article published on 18 April 2013

Extracellular proton depression of peak and late Na⁺ current in the canine left ventricle

scientific article

Fever accentuates transmural dispersion of repolarization and facilitates development of early afterdepolarizations and torsade de pointes under long-QT Conditions

scientific article published on August 2008

Fever-induced Brugada pattern: how common is it and what does it mean?

scientific article published on 19 July 2013

Foreword: Brugada syndrome

Functional effects of KCNE3 mutation and its role in the development of Brugada syndrome

scientific article

Functional expression of "cardiac-type" Nav1.5 sodium channel in canine intracardiac ganglia.

scientific article

Functionally distinct sodium channels in ventricular epicardial and endocardial cells contribute to a greater sensitivity of the epicardium to electrical depression.

scientific article published on 2 May 2008

Further Insights in the Most Common SCN5A Mutation Causing Overlapping Phenotype of Long QT Syndrome, Brugada Syndrome, and Conduction Defect

scientific article published on 05 July 2016

Further insights into the effect of quinidine in short QT syndrome caused by a mutation in HERG

scientific article

Gain of function in IKs secondary to a mutation in KCNE5 associated with atrial fibrillation

scientific article

Genetic and biophysical basis for bupivacaine-induced ST segment elevation and VT/VF. Anesthesia unmasked Brugada syndrome

scientific article published on 7 July 2006

Genetic and biophysical basis of sudden unexplained nocturnal death syndrome (SUNDS), a disease allelic to Brugada syndrome

scientific article

Genetic basis and molecular mechanism for idiopathic ventricular fibrillation

scientific article

Genetic basis of Brugada syndrome

scientific article

Genetic predisposition and cellular basis for ischemia-induced ST-segment changes and arrhythmias

scientific article

Genetic, molecular and cellular mechanisms underlying the J wave syndromes

scientific article published on 11 April 2012

Genetics and Cellular Mechanisms of the J Wave Syndromes

Genetics and Sinus Node Dysfunction

scientific article

HMR 1556, a potent and selective blocker of slowly activating delayed rectifier potassium current

scientific article

Heterogeneity and cardiac arrhythmias: an overview.

scientific article published on 6 April 2007

Heterogeneity of cellular repolarization in LQTS: the role of M cells

article published in 2001

High prevalence of concealed Brugada syndrome in patients with atrioventricular nodal reentrant tachycardia

scientific article published on 18 May 2015

How Do Atrial-Selective Drugs Differ From Antiarrhythmic Drugs Currently Used in the Treatment of Atrial Fibrillation?

scientific article published on 16 July 2008

How Do Atrial-Selective Drugs Differ From Antiarrhythmic Drugs Currently Used in the Treatment of Atrial Fibrillation?

scientific article published on January 2008

Identification and characterization of a transient outward K+ current in human induced pluripotent stem cell-derived cardiomyocytes.

scientific article published on 28 March 2013

Identification of a novel de novo mutation associated with PRKAG2 cardiac syndrome and early onset of heart failure

scientific article

Identification of a novel loss-of-function calcium channel gene mutation in short QT syndrome (SQTS6)

scientific journal article

Identification of specific pluripotent stem cell death--inducing small molecules by chemical screening.

scientific article

Impact of Ancestral Differences and Reassessment of the Classification of Previously Reported Pathogenic Variants in Patients With Brugada Syndrome in the Genomic Era: A SADS-TW BrS Registry

scholarly article by Ching-Yu Julius Chen et al published 2018 in Frontiers in Genetics

In vivo human demonstration of phase 2 reentry

scientific article published on August 2005

Induced pluripotent stem cells as a model for accelerated patient- and disease-specific drug discovery.

scientific article

Inferolateral J-wave syndromes: A reflection of abnormal repolarization, depolarization, or both?

scientific article published on 20 November 2018

Inherited Arrhythmogenic Diseases

Inhibition of IKr potentiates development of atrial-selective INa block leading to effective suppression of atrial fibrillation

scientific article published on 26 December 2014

Inter-Regulation of Kv4.3 and Voltage-Gated Sodium Channels Underlies Predisposition to Cardiac and Neuronal Channelopathies

scientific article published on 17 July 2020

Intravenous drug challenge using flecainide and ajmaline in patients with Brugada syndrome

scientific article

Ion channels and ventricular arrhythmias: cellular and ionic mechanisms underlying the Brugada syndrome

scientific article

Ionic and cellular basis for the predominance of the Brugada syndrome phenotype in males

scientific article published in October 2002

Ionic and cellular mechanisms underlying the development of acquired Brugada syndrome in patients treated with antidepressants.

scientific article

Ionic, molecular, and cellular bases of QT-interval prolongation and torsade de pointes.

scientific article published on September 2007

Is a narrow and tall QRS complex an ECG marker for sudden death?

scientific article published on 29 July 2008

Is extensive atrial fibrosis in the setting of heart failure associated with a reduced atrial fibrillation burden?

scientific article published on 09 September 2018

Is there a significant transmural gradient in repolarization time in the intact heart? Cellular basis of the T wave: a century of controversy.

scientific article published on February 2009

Ischemic ventricular arrhythmias: experimental models and their clinical relevance

scientific article published on 06 July 2011

J wave syndromes as a cause of malignant cardiac arrhythmias

J wave syndromes.

scientific article

J wave syndromes: molecular and cellular mechanisms

scientific article published on 06 September 2013

J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge

scientific article

J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge.

scientific article

J-wave syndromes. from cell to bedside

scientific article published on 9 September 2011

J-wave syndromes: Brugada and early repolarization syndromes

scientific article

KCNE2 modulation of Kv4.3 current and its potential role in fatal rhythm disorders

scientific article

LQT5 masquerading as LQT2: a dominant negative effect of KCNE1-D85N rare polymorphism on KCNH2 current.

scientific article

Larger late sodium conductance in M cells contributes to electrical heterogeneity in canine ventricle

scientific article published in August 2001

Late potentials and the Brugada syndrome**Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology

scientific article published on 01 June 2002

Late-phase 3 EAD. A unique mechanism contributing to initiation of atrial fibrillation

scientific article

Lidocaine-induced Brugada syndrome phenotype linked to a novel double mutation in the cardiac sodium channel.

scientific article published on 03 July 2008

Link between hypothermia and the Brugada syndrome.

scientific article published on August 2004

Long QT, syndactyly, joint contractures, stroke and novel CACNA1C mutation: expanding the spectrum of Timothy syndrome

scientific article published on 21 November 2011

Long-term follow-up of individuals with the electrocardiographic pattern of right bundle-branch block and ST-segment elevation in precordial leads V1 to V3.

scientific article

Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death

scientific article

M cells in the human heart

scientific article published on March 2010

Malignant early repolarization: It's the T-wave, stupid….

scientific article published on 9 December 2015

Management of ventricular arrhythmias in suspected channelopathies

scientific article

Maximum diastolic potential of human induced pluripotent stem cell-derived cardiomyocytes depends critically on I(Kr).

scientific article

Mechanisms Underlying Arrhythmogenesis in Long QT Syndrome

Mechanisms Underlying Epicardial Radiofrequency Ablation to Suppress Arrhythmogenesis in Experimental Models of Brugada Syndrome

scientific article published on 21 December 2016

Mechanisms Underlying the Actions of Antidepressant and Antipsychotic Drugs That Cause Sudden Cardiac Arrest

Mechanisms of Action of Antiarrhythmic Drugs in Atrial Fibrillation

Mechanisms of Cardiac Arrhythmia

Mechanisms of atrial-selective block of Na⁺ channels by ranolazine: I. Experimental analysis of the use-dependent block

scientific article

Mechanisms of atrial-selective block of Na⁺ channels by ranolazine: II. Insights from a mathematical model

scientific article

Mechanisms underlying atrial-selective block of sodium channels by Wenxin Keli: Experimental and theoretical analysis.

scientific article published on 07 January 2016

Mechanisms underlying the development of the electrocardiographic and arrhythmic manifestations of early repolarization syndrome

scientific article published on 28 December 2013

Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing.

scientific article

Mode of onset of ventricular fibrillation in patients with early repolarization pattern vs. Brugada syndrome

scientific article published on 29 October 2009

Modulation of canine cardiac sodium current by Apelin

scientific article

Modulation of transmural repolarization

scientific article

Molecular Genetics of Arrhythmias and Cardiovascular Conditions Associated with Arrhythmias

article

Molecular and Functional Characterization of Rare CACNA1C Variants in Sudden Unexplained Death in the Young

scientific article published on 24 May 2016

Molecular genetic and functional association of Brugada and early repolarization syndromes with S422L missense mutation in KCNJ8

scientific article published on 3 November 2011

Molecular genetics of arrhythmias and cardiovascular conditions associated with arrhythmias

scientific article published on November 2003

Molecular mechanisms underlying the long QT syndrome

scientific article

Multiple arrhythmic syndromes in a newborn, owing to a novel mutation in SCN5A

scientific article

Multiple serial ECGs aid with the diagnosis and prognosis of Brugada syndrome

Mutation in Nav1.5 Associated with Brugada Syndrome - a Mutational Hotspot?

Mutations in SCN10A are responsible for a large fraction of cases of Brugada syndrome

scientific article

Mutations in the cardiac L-type calcium channel associated with inherited J-wave syndromes and sudden cardiac death.

scientific article

New approaches to antiarrhythmic therapy: emerging therapeutic applications of the cell biology of cardiac arrhythmias(1).

scientific article

New developments in atrial antiarrhythmic drug therapy

scientific article published on March 2010

New pharmacological strategies for the treatment of atrial fibrillation

scientific article published on July 2009

Novel Pharmacological Targets for the Management of Atrial Fibrillation

scholarly article

Novel Therapeutic Strategies for the Management of Ventricular Arrhythmias Associated with the Brugada Syndrome

scientific article published on 13 May 2015

Novel Timothy syndrome mutation leading to increase in CACNA1C window current

scientific article published on 28 September 2014

Novel mutation in the SCN5A gene associated with arrhythmic storm development during acute myocardial infarction

scientific article

Novel mutations in domain I of SCN5A cause Brugada syndrome

scientific article published in April 2002

Novel mutations in the KCND3-encoded Kv4.3 K+ channel associated with autopsy-negative sudden unexplained death ⬇️

scientific article published on March 27, 2012

Novel pharmacological targets for the rhythm control management of atrial fibrillation.

scientific article

Occurrence of "J waves" in 12-lead ECG as a marker of acute ischemia and their cellular basis

scientific article published on June 2007

Optical and electrical recordings from isolated coronary-perfused ventricular wedge preparations.

scientific article

Overlapping LQT1 and LQT2 phenotype in a patient with long QT syndrome associated with loss-of-function variations in KCNQ1 and KCNH2

scientific article published in December 2010

Overview of Basic Mechanisms of Cardiac Arrhythmia ⬇️

scientific article published on March 1, 2011

PQ segment depression in patients with short QT syndrome: a novel marker for diagnosing short QT syndrome?

scientific article

Pathophysiology of atrial fibrillation

Pharmacological approach to the treatment of long and short QT syndromes

scientific article published on April 2008

Phase 2 reentry as a mechanism of initiation of circus movement reentry in canine epicardium exposed to simulated ischemia

scientific article published on September 1996

Phenotypic characterization of a large European family with Brugada syndrome displaying a sudden unexpected death syndrome mutation in SCN5A:.

scientific article

Phenotypical manifestations of mutations in the genes encoding subunits of the cardiac voltage-dependent L-type calcium channel

scientific article published on March 2011

Physiological consequences of transient outward K+ current activation during heart failure in the canine left ventricle.

scientific article

Pooled Analysis of Risk Stratification of Spontaneous Type 1 Brugada ECG: Focus on the Influence of Gender and EPS

Postpacing abnormal repolarization in catecholaminergic polymorphic ventricular tachycardia associated with a mutation in the cardiac ryanodine receptor gene.

scientific article

Potent antiarrhythmic effects of chronic amiodarone in canine pulmonary vein sleeve preparations

scientific article published on 27 February 2009

Potential proarrhythmic effects of biventricular pacing

scientific article

Preface

Prominent I(Ks) in epicardium and endocardium contributes to development of transmural dispersion of repolarization but protects against development of early afterdepolarizations

scientific article published in February 2002

Proposed Diagnostic Criteria for the Brugada Syndrome

article published in 2002

Proposed diagnostic criteria for the Brugada syndrome

scientific article

Proposed diagnostic criteria for the Brugada syndrome: consensus report

scientific article published in November 2002

Provocation of sudden heart rate oscillation with adenosine exposes abnormal QT responses in patients with long QT syndrome: a bedside test for diagnosing long QT syndrome.

scientific article

Pulmonary Vein Sleeves as a Pharmacologic Model for the Study of Atrial Fibrillation

scientific article published on October 2010

Quinidine: a valuable medication joins the list of 'endangered species'.

scientific article published on 30 August 2007

Ranolazine effectively suppresses atrial fibrillation in the setting of heart failure.

scientific article

Ranolazine for Congenital Long-QT Syndrome Type III: Experimental and Long-Term Clinical Data

scientific article

Ranolazine versus amiodarone for prevention of postoperative atrial fibrillation.

scientific article published on November 2011

Ranolazine: a new antiarrhythmic agent for patients with non-ST-segment elevation acute coronary syndromes?

scientific article published on 11 March 2008

Rare syndromes, commotio cordis, sudden death in athletes

Rate dependence of action potential duration and refractoriness in canine ventricular endocardium differs from that of epicardium: role of the transient outward current.

scientific article published on October 1989

Rate-dependent effects of vernakalant in the isolated non-remodeled canine left atria are primarily due to block of the sodium channel: comparison with ranolazine and dl-sotalol

scientific article published on 9 February 2012

Rationale for the use of the terms J-wave syndromes and early repolarization.

scientific article

Recognition and Clinical Implications of High Prevalence of Migraine in Patients with Brugada Syndrome and Drug-Induced Type 1 Brugada Pattern

scientific article published on 15 October 2020

Reinduction of atrial fibrillation immediately after termination of the arrhythmia is mediated by late phase 3 early afterdepolarization-induced triggered activity

scientific article published on 14 April 2003

Reply to the Editor- Tpeak-Tend is alive and well

scientific article published on 23 January 2019

Reply to the Editor--PQ-segment depression in short QT syndrome patients: a novel marker for diagnosing short QT syndrome?

scientific article

Reply to the Editor–Mechanoelectrical factors in M-cell debate

Resolving the M-cell debate: why and how.

scientific article

Risk stratification [corrected] of Brugada syndrome revisited.

scientific article published in June 2008

Risk stratification in Brugada syndrome: Clinical characteristics, electrocardiographic parameters, and auxiliary testing

scientific article

Role of Late Sodium Channel Current Block in the Management of Atrial Fibrillation ⬇️

scientific article published on February 1, 2013

Role of M cells in acquired long QT syndrome, U waves, and torsade de pointes

scientific article published on January 1995

Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of quinidine

scientific article published on 06 September 2008

Role of repolarization restitution in the development of coarse and fine atrial fibrillation in the isolated canine right atria

scientific article

Role of sodium and calcium channel block in unmasking the Brugada syndrome

scientific article published on July 2004

Role of spatial dispersion of repolarization in inherited and acquired sudden cardiac death syndromes.

scientific article published on 22 June 2007

Role of transmural dispersion of repolarization in the genesis of drug-induced torsades de pointes

scientific article

Short QT syndrome. Genotype-phenotype correlations

scientific article published in October 2005

Short QT syndrome: from bench to bedside.

scientific article

Short QT syndrome: pharmacological treatment

scientific article

Should theophylline be added to the J wave syndrome therapeutic armamentarium?

scientific article published on 16 November 2017

Sodium channel blockers identify risk for sudden death in patients with ST-segment elevation and right bundle branch block but structurally normal hearts

scientific article

Sodium pentobarbital reduces transmural dispersion of repolarization and prevents torsades de Pointes in models of acquired and congenital long QT syndrome

scientific article published in February 1999

Specific therapy based on the genotype and cellular mechanism in inherited cardiac arrhythmias. Long QT syndrome and Brugada syndrome

scientific article

Study of the extent of the information of cardiologists from São Paulo city, Brazil, regarding a low-prevalence entity: Brugada syndrome.

scientific article published on October 2008

Sudden cardiac death secondary to antidepressant and antipsychotic drugs

article by Serge Sicouri & Charles Antzelevitch published 1 March 2008 in Expert Opinion on Drug Safety

Sudden death associated with short-QT syndrome linked to mutations in HERG.

scientific article

Sympathetic modulation of the long QT syndrome

scientific article published on 01 August 2002

Synergistic effect of the combination of ranolazine and dronedarone to suppress atrial fibrillation.

scientific article

Synergistic electrophysiologic and antiarrhythmic effects of the combination of ranolazine and chronic amiodarone in canine atria

scientific article

The Brugada Syndrome

The Brugada Syndrome: From Bench to Bedside

The Brugada syndrome

scientific article published on 01 January 2002

The Brugada syndrome: clinical, electrophysiologic and genetic aspects.

scientific article

The Brugada syndrome: diagnostic criteria and cellular mechanisms

scientific article published on 01 March 2001

The Brugada syndrome: is an implantable cardioverter defibrillator the only therapeutic option?

scientific article

The Cardiac Electrophysiology Society abstracts that have published in the November issue of HeartRhythm Journal (2013;10:1741-1754) were inadvertently posted on PubMed. These abstracts were not peer-reviewed and they were posted without approval or

The Contribution of HCN4 to normal sinus node function in humans and animal models

scientific article

The Early Repolarization Pattern: A Consensus Paper

scientific article (publication date: 28 July 2015)

The Effects of Peg-Interleukin-2 and Interleukin-2 on Essential Hypertension and Cellular Immune Function in the Spontaneously Hypertensive Rat

scientific article published on 01 March 1993

The J Wave Syndromes and their Role in Sudden Cardiac Death.

scientific article

The M cell: its contribution to the ECG and to normal and abnormal electrical function of the heart

scientific article

The Role of Spatial Dispersion of Repolarization and Intramural Reentry in Inherited and Acquired Sudden Cardiac Death Syndromes

The acquired Brugada syndrome and the paradox of choice.

scientific article published on 21 July 2009

The arrhythmogenic consequences of increasing late INa in the cardiomyocyte

scientific article published on 10 June 2013

The cardiologists' worst nightmare sudden death from "benign" ventricular arrhythmias

scientific article published on October 2005

The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient

scientific journal article

The pathophysiological mechanism underlying Brugada syndrome: depolarization versus repolarization

scientific article published on 24 July 2010

The phenomenon of "QT stunning": the abnormal QT prolongation provoked by standing persists even as the heart rate returns to normal in patients with long QT syndrome

scientific article

The potential for QT prolongation and pro-arrhythmia by non-anti-arrhythmic drugs: clinical and regulatory implications. Report on a Policy Conference of the European Society of Cardiology.

scientific article published in August 2000

The response of the QT interval to the brief tachycardia provoked by standing: a bedside test for diagnosing long QT syndrome

scientific article

The role of late I Na in development of cardiac arrhythmias

scientific article

The role of local voltage potentials in outflow tract ectopy

scientific article

The role of sodium channel current in modulating transmural dispersion of repolarization and arrhythmogenesis.

scientific article

Theophylline: The forgotten antiarrhythmic drug… now for malignant early repolarization

scientific article published on 16 November 2017

Tissue-specific effects of acetylcholine in the canine heart.

scientific article published on 03 May 2013

To the Editor Response

Torsades de pointes following acute myocardial infarction: evidence for a deadly link with a common genetic variant

scientific article published on 13 February 2012

Tpeak-Tend and Tpeak-Tend dispersion as risk factors for ventricular tachycardia/ventricular fibrillation in patients with the Brugada syndrome.

scientific article published on 17 April 2006

Tpeak-Tend as a predictor of ventricular arrhythmogenesis

scientific article published in December 2017

Tpeak-Tend interval as a marker of arrhythmic risk

scientific article published on 17 January 2019

Tpeak-tend interval as a marker of arrhythmic risk in early repolarization syndrome

scientific article published on 26 August 2019

Traditional Chinese Medicine and Vascular Disease

scientific article published on 21 October 2015

Transcriptional changes associated with advancing stages of heart failure underlie atrial and ventricular arrhythmogenesis.

scientific article

Transient outward current (I(to)) gain-of-function mutations in the KCND3-encoded Kv4.3 potassium channel and Brugada syndrome

scientific journal article

Transmembrane action potential heterogeneity in the canine isolated arterially perfused right atrium: effect of IKr and IKur/Ito block

scientific article

Transmural dispersion of repolarization and arrhythmogenicity: the Brugada syndrome versus the long QT syndrome

scientific article

Transmural dispersion of repolarization and the T wave

scientific article published on 01 June 2001

Transmural heterogeneity of calcium activity and mechanical function in the canine left ventricle

scientific article published on 11 December 2003

Transseptal dispersion of repolarization and its role in the development of Torsade de Pointes arrhythmias

scientific article published on 10 November 2009

Unique topographical distribution of M cells underlies reentrant mechanism of torsade de pointes in the long-QT syndrome

scientific article published in March 2002

Unraveling the Enigma of Bangungut: Is Sudden Unexplained Nocturnal Death Syndrome (SUNDS) in the Philippines a Disease Allelic to the Brugada Syndrome? ⬇️

scientific article published on July 1, 2011

Usefulness of exercise test in the diagnosis of short QT syndrome

scientific article published on 01 April 2015

Value of electrocardiographic parameters and ajmaline test in the diagnosis of Brugada syndrome caused by SCN5A mutations

scientific article

Ventricular fibrillation associated with complete right bundle branch block

scientific article published on 14 March 2013

When u say "U Waves," what do u mean?

scientific article published on February 2004

[Genetic and molecular basis for sodium channel-mediated Brugada syndrome].

scientific article

List of works by Charles Antzelevitch

A CACNA1C variant associated with reduced voltage-dependent inactivation, increased CaV1.2 channel window current, and arrhythmogenesis

A common single nucleotide polymorphism can exacerbate long-QT type 2 syndrome leading to sudden infant death.

A complete right bundle-branch block masking Brugada syndrome

A gain-of-function I(K-ATP) mutation and its role in sudden cardiac death associated with J-wave syndromes

A molecular link between the sudden infant death syndrome and the long-QT syndrome

A mutation in the beta 3 subunit of the cardiac sodium channel associated with Brugada ECG phenotype

A novel mutation in KCNQ1 associated with a potent dominant negative effect as the basis for the LQT1 form of the long QT syndrome.

A novel mutation in the HCN4 gene causes symptomatic sinus bradycardia in Moroccan Jews.

A novel rare variant in SCN1Bb linked to Brugada syndrome and SIDS by combined modulation of Na(v)1.5 and K(v)4.3 channel currents

A temporal window of vulnerability for development of atrial fibrillation with advancing heart failure

A transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome.

ABCC9 is a novel Brugada and early repolarization syndrome susceptibility gene.

ABSTRACTS

AZD1305 exerts atrial predominant electrophysiological actions and is effective in suppressing atrial fibrillation and preventing its reinduction in the dog

Abnormal repolarization as the basis for late potentials and fractionated electrograms recorded from epicardium in experimental models of Brugada syndrome

Accelerated inactivation of the L-type calcium current due to a mutation in CACNB2b underlies Brugada syndrome

Acute dronedarone is inferior to amiodarone in terminating and preventing atrial fibrillation in canine atria.

Acute myocardial ischemia: cellular mechanisms underlying ST segment elevation

Advances in the Pharmacologic Management of Atrial Fibrillation

Advances in the Pharmacological Treatment of Atrial Fibrillation ⬇️

Ajmaline-Induced Slowing of Conduction in the Right Ventricular Outflow Tract Cannot Account for ST Elevation in Patients With Type I Brugada ECG.

American Heart Association atrial fibrillation research summit: a conference report from the American Heart Association

Amplified transmural dispersion of repolarization as the basis for arrhythmogenesis in a canine ventricular-wedge model of short-QT syndrome

An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing

Andersen-Tawil syndrome: Clinical presentation and predictors of symptomatic arrhythmias - Possible role of polymorphisms K897T in KCNH2 and H558R in SCN5A gene

Androgens and male predominance of the Brugada syndrome phenotype

Antiarrhythmic effects of losartan and enalapril in canine pulmonary vein sleeve preparations.

Antiarrhythmic effects of ranolazine in a guinea pig in vitro model of long-QT syndrome

Antiarrhythmic effects of ranolazine in canine pulmonary vein sleeve preparations.

Antiarrhythmic effects of simvastatin in canine pulmonary vein sleeve preparations

Antiarrhythmic effects of the highly selective late sodium channel current blocker GS-458967

Arrhythmogenic mechanisms of QT prolonging drugs: is QT prolongation really the problem?

Assessing predictors of drug-induced torsade de pointes.

Atria are More Sensitive Than Ventricles to GS-458967-Induced Inhibition of Late Sodium Current

Atrial fibrillation and Brugada syndrome

Atrial fibrillation in inherited cardiac channelopathies: From mechanisms to management

Atrial-selective effects of chronic amiodarone in the management of atrial fibrillation.

Atrial-selective inhibition of sodium-channel current by Wenxin Keli is effective in suppressing atrial fibrillation.

Atrial-selective prolongation of refractory period with AVE0118 is due principally to inhibition of sodium channel activity

Atrial-selective sodium channel block as a novel strategy for the management of atrial fibrillation

Atrial-selective sodium channel block as a novel strategy for the management of atrial fibrillation.

Atrial-selective sodium channel block as a strategy for suppression of atrial fibrillation

Atrial-selective sodium channel block for the treatment of atrial fibrillation.

Atrial-selective sodium channel block strategy to suppress atrial fibrillation: ranolazine versus propafenone.

Atrial-selective sodium channel blockers: do they exist?

Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation: differences in sodium channel inactivation between atria and ventricles and the role of ranolazine

Augmentation of J waves and electrical storms in patients with early repolarization

Augmentation of late sodium current unmasks the proarrhythmic effects of amiodarone.

Author's response to letter to the editor from Perez and Froelicher.

Autonomic aspects of arrhythmogenesis: the enduring and the new.

Basic mechanisms of reentrant arrhythmias

Biophysical and molecular characterization of a novel de novo KCNJ2 mutation associated with Andersen-Tawil syndrome and catecholaminergic polymorphic ventricular tachycardia mimicry

Blinded validation of the isolated arterially perfused rabbit ventricular wedge in preclinical assessment of drug-induced proarrhythmias.

Brugada Syndrome: Cellular Mechanisms and Approaches to Therapy

Brugada Syndrome: Cellular Mechanisms and Approaches to Therapy

Brugada Syndrome: Clinical, Genetic, Molecular, Cellular, and Ionic Aspects

Brugada Syndrome: Overview

Brugada syndrome

Brugada syndrome and ischemia-induced ST-segment elevation. Similarities and differences.

Brugada syndrome.

Brugada syndrome: 12 years of progression

Brugada syndrome: 1992-2002: a historical perspective

Brugada syndrome: a decade of progress

Brugada syndrome: clinical, genetic, molecular, cellular and ionic aspects

Brugada syndrome: from cell to bedside

Brugada syndrome: recent advances and controversies.

Brugada syndrome: report of the second consensus conference.

Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association.

Brugada-like electrocardiographic pattern.

Brugada-like syndrome in infancy presenting with rapid ventricular tachycardia and intraventricular conduction delay.

Call “the Cleaners”

Can inhibition of IKur promote atrial fibrillation?

Cardiac repolarization. The long and short of it.

Cardiomyocyte calcium cycling in a naturally occurring German shepherd dog model of inherited ventricular arrhythmia and sudden cardiac death

Case scenario: anesthesia-related cardiac arrest in a child with Timothy syndrome

Cellular and Ionic Mechanisms Underlying Erythromycin-Induced Long QT Intervals and Torsade de Pointes

Cellular and ionic basis for the sex-related difference in the manifestation of the Brugada syndrome and progressive conduction disease phenotypes

Cellular and ionic mechanisms responsible for the Brugada syndrome

Cellular and ionic mechanisms underlying the effects of cilostazol, milrinone, and isoproterenol to suppress arrhythmogenesis in an experimental model of early repolarization syndrome.