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List of works by Tony Wyss-Coray

A cell surface ELISA for the screening of monoclonal antibodies to antigens on viable cells in suspension

scientific article published on 01 May 1994

A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk

scientific article

A positive allosteric modulator of mGluR5 promotes neuroprotective effects in mouse models of Alzheimer's disease

scientific article published on 18 September 2019

A revival of parabiosis in biomedical research

scientific article

A role for TGF-beta signaling in neurodegeneration: evidence from genetically engineered models

scientific article published on December 2006

ALK5-dependent TGF-β signaling is a major determinant of late-stage adult neurogenesis.

scientific article

APOE ε4 worsens hippocampal CA1 apical neuropil atrophy and episodic memory

scientific article published on 22 January 2014

APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia

scientific article published on 13 March 2024

Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation

scientific article published in December 2017

Adult hippocampal neural stem and progenitor cells regulate the neurogenic niche by secreting VEGF.

scientific article

Adult mouse astrocytes degrade amyloid-beta in vitro and in situ

scientific article published on 3 March 2003

Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1

scientific article published on 13 May 2019

Ageing hallmarks exhibit organ-specific temporal signatures

scientific article published on 15 July 2020

Ageing, neurodegeneration and brain rejuvenation

scientific article published on 10 November 2016

Aging. Aging-induced type I interferon response at the choroid plexus negatively affects brain function

scientific article published on 21 August 2014

All-you-can-eat: autophagy in neurodegeneration and neuroprotection.

scientific article published on 06 April 2009

Alzheimer's disease-like cerebrovascular pathology in transforming growth factor-beta 1 transgenic mice and functional metabolic correlates

scientific article published on April 2000

Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease

scientific article

An 80,000-Piece Puzzle of Alzheimer's Disease

scientific article published on 01 June 2019

An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging

scientific article published on 12 July 2021

Angiotensin II sustains brain inflammation in mice via TGF-beta

scientific article

Antigen-presenting T cells induce the development of cytotoxic CD4+ T cells. I. Involvement of the CD80-CD28 adhesion molecules.

scientific article

Antigen-presenting human T cells and antigen-presenting B cells induce a similar cytokine profile in specific T cell clones.

scientific article published in December 1993

Antiviral drug ganciclovir is a potent inhibitor of microglial proliferation and neuroinflammation.

scientific article published on 03 February 2014

Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons

scientific article published on 10 July 2001

Astrocyte-derived TGF-β1 accelerates disease progression in ALS mice by interfering with the neuroprotective functions of microglia and T cells

scientific article published on 16 April 2015

Astroglial overproduction of TGF-beta 1 enhances inflammatory central nervous system disease in transgenic mice .

scientific article

Astroglial regulation of apolipoprotein E expression in neuronal cells. Implications for Alzheimer's disease

scientific article published on 29 October 2003

Author Correction: Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

scientific article published on 01 February 2020

Author Correction: Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

scientific article published on 27 July 2020

Author Correction: Systemic factors as mediators of brain homeostasis, ageing and neurodegeneration

scientific article published on 13 March 2020

Autoimmunity contributes to nociceptive sensitization in a mouse model of complex regional pain syndrome

scientific article

Autophagy in dementias

scientific article published on January 2012

Beclin 1 complex in autophagy and Alzheimer disease

scientific article published on October 2010

Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases

scientific article

Beclin 1 regulates neuronal transforming growth factor-β signaling by mediating recycling of the type I receptor ALK5.

scientific article

Bioactive TGF-beta can associate with lipoproteins and is enriched in those containing apolipoprotein E3.

scientific article

Bioluminescence analysis of Smad-dependent TGF-beta signaling in live mice

scientific article published in January 2009

Bioluminescence imaging of Smad signaling in living mice shows correlation with excitotoxic neurodegeneration

scholarly article

Bioluminescence in vivo imaging of autoimmune encephalomyelitis predicts disease

scientific article published in February 2008

Blood protein signature for the early diagnosis of Alzheimer disease.

scientific article published on 08 December 2008

Blood-Borne Revitalization of the Aged Brain

scientific article (publication date: October 2015)

Brain Endothelial Cells Are Exquisite Sensors of Age-Related Circulatory Cues

scientific article published on 01 March 2020

Broad transcriptional dysregulation of brain and choroid plexus cell types with COVID-19 ⬇️

journal article from 'bioRxiv' published in 2020

CD22 blockade restores homeostatic microglial phagocytosis in ageing brains

scientific article published on 03 April 2019

CalFluors: A Universal Motif for Fluorogenic Azide Probes across the Visible Spectrum.

scientific article published on 2 June 2015

Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice

scientific article

Carrier-mediated uptake and presentation of a major histocompatibility complex class I-restricted peptide.

scientific article published on December 1993

Cellular signaling roles of TGF beta, TNF alpha and beta APP in brain injury responses and Alzheimer's disease

scientific article published on 01 February 1997

Cellular source of apolipoprotein E4 determines neuronal susceptibility to excitotoxic injury in transgenic mice

scientific article

Changes of the enteric nervous system in amyloid-β protein precursor transgenic mice correlate with disease progression

scientific article

Chronic over-expression of TGFβ1 alters hippocampal structure and causes learning deficits.

scientific article published on 5 August 2013

Chronic overproduction of transforming growth factor-beta1 by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice

scientific article published on January 2000

Chronically increased transforming growth factor-beta1 strongly inhibits hippocampal neurogenesis in aged mice

scientific article

Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins

scientific article

Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease

scientific article published on 08 January 2020

Collagen VI protects neurons against Abeta toxicity

scientific article

Collagenase-based Single Cell Isolation of Primary Murine Brain Endothelial Cells Using Flow Cytometry

scientific article published on 01 November 2018

Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival

scientific article published on 7 January 2013

Combined Plasma and Cerebrospinal Fluid Signature for the Prediction of Midterm Progression From Mild Cognitive Impairment to Alzheimer Disease

scientific article published on 14 December 2015

Common diseases alter the physiological age-related blood microRNA profile

scientific article published on 24 November 2020

Comparative analysis of surface antigens in cultured human outer root sheath cells and epidermal keratinocytes: persistence of low expression of class I MHC antigens in outer root sheath cells in vitro

scientific article published on 01 August 1994

Complement receptor 2 is expressed in neural progenitor cells and regulates adult hippocampal neurogenesis.

scientific article

CoolMPS for robust sequencing of single-nuclear RNAs captured by droplet-based method

scientific article published on 02 December 2020

Data mining of human plasma proteins generates a multitude of highly predictive aging clocks that reflect different aspects of aging

scientific article published on 08 October 2020

Deficiency in Neuronal TGF-β Signaling Leads to Nigrostriatal Degeneration and Activation of TGF-β Signaling Protects against MPTP Neurotoxicity in Mice

scientific article published on 31 March 2017

Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology

scientific article

Deficiency of a sulfotransferase for sialic acid-modified glycans mitigates Alzheimer's pathology

scientific article published on 20 March 2017

Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice

scientific article

Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing

scientific article published on 31 December 2018

Discrimination of human CD4 T cell clones based on their reactivity with antigen-presenting T cells

scientific article

Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease

scientific article published on January 2000

Dysregulation of brain and choroid plexus cell types in severe COVID-19

scientific article

Dysregulation of signal transduction pathways as a potential mechanism of nervous system alterations in HIV-1 gp120 transgenic mice and humans with HIV-1 encephalitis

scientific article published on February 1996

Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function

scientific article published in October 2014

Elimination of the class A scavenger receptor does not affect amyloid plaque formation or neurodegeneration in transgenic mice expressing human amyloid protein precursors

scientific article published on November 1999

Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age

scientific article published on 06 July 2020

Erratum to: Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain

scientific article published on 23 May 2016

Exercise rejuvenates quiescent skeletal muscle stem cells in old mice through restoration of Cyclin D1

scientific article published on 13 April 2020

Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration.

scientific article published on June 1999

Functional role of TGF beta in Alzheimer's disease microvascular injury: lessons from transgenic mice

scientific article

GeneTrail 3: advanced high-throughput enrichment analysis

scientific article published on 07 May 2020

Genes contributing to prion pathogenesis

scientific article

Geroscience: linking aging to chronic disease

scientific article

GhostKnockoff inference empowers identification of putative causal variants in genome-wide association studies

scientific article published in 2022

Glia-dependent TGF-beta signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis.

scientific article

Global analysis of Smad2/3-dependent TGF-beta signaling in living mice reveals prominent tissue-specific responses to injury

scientific article published in July 2005

Go with your gut: microbiota meet microglia

scientific article published on June 2015

Heparan sulfate subdomains that are degraded by Sulf accumulate in cerebral amyloid ß plaques of Alzheimer's disease: evidence from mouse models and patients

scientific article published on 17 March 2012

Highly sensitive and specific bioassay for measuring bioactive TGF-beta

scientific article published on 20 March 2006

Human umbilical cord plasma proteins revitalize hippocampal function in aged mice

scientific article

Ibuprofen, inflammation and Alzheimer disease

scientific article published in September 2000

Identification of Interleukin-27 (IL-27)/IL-27 Receptor Subunit Alpha as a Critical Immune Axis for In Vivo HIV Control

scientific article published on 07 June 2017

Identification of a central role for complement in osteoarthritis

scientific article

Immune activation in brain aging and neurodegeneration: too much or too little?

scientific article published on October 2009

Immune cells may fend off Alzheimer disease

scientific article

Immunotherapy of cerebrovascular amyloidosis in a transgenic mouse model

scientific article

Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer's disease-like mice

scientific article

Improved sensitization of antigen-presenting cells with transferrin-bound peptides: advantages in competition for antigen presentation

scientific article published on October 1994

In vitro analysis of transforming growth factor-beta1 inhibition in novel transgenic SBE-luciferase mice

scientific article published on 01 August 2007

In vivo assessment of behavioral recovery and circulatory exchange in the peritoneal parabiosis model.

scientific article

Increased T cell recruitment to the CNS after amyloid beta 1-42 immunization in Alzheimer's mice overproducing transforming growth factor-beta 1

scientific article published in November 2006

Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor-beta 1

scientific article published on July 1995

Induction of matrix metalloproteinase-2 in human immunodeficiency virus-1 glycoprotein 120 transgenic mouse brains.

scientific article published on September 1998

Inflammation and Alzheimer's disease

scientific article (publication date: 2000)

Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature

scientific article published on January 2012

Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

scientific article published on September 2006

Inflammation in neurodegenerative disease--a double-edged sword

scientific article

Influences of circulatory factors on intervertebral disc aging phenotype

scientific article published on 11 June 2020

Insights into the pathogenesis of hydrocephalus from transgenic and experimental animal models

scientific article published in July 2004

KL1 Domain of Longevity Factor Klotho Mimics the Metabolome of Cognitive Stimulation and Enhances Cognition in Young and Aging Mice

scientific article published on 15 April 2022

Key signaling pathways regulate the biological activities and accumulation of amyloid-beta

scientific article

Killing pain, killing neurons?

scientific article published in May 2005

Limited proteolysis–mass spectrometry reveals aging-associated changes in cerebrospinal fluid protein abundances and structures

scientific article published in 2022

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

scientific article published on 20 January 2020

Live imaging of Smad2/3 signaling in mouse skin wound healing.

scientific article

Long-term cognitive impairments and pathological alterations in a mouse model of repetitive mild traumatic brain injury.

scientific article published on 04 February 2014

Loss of TGF-beta 1 leads to increased neuronal cell death and microgliosis in mouse brain

scientific article

Method of reducing the effects of aging-associated impairment of neurogenesis comprising modulating c-c chemokine receptor type 3 (CCR3)

US patent 11236340

Methods and compositions for treating aging-associated conditions

US patent 11141469

Methods to investigate intrathecal adaptive immunity in neurodegeneration

scientific article published on 22 January 2021

Microglia--a wrench in the running wheel?

scientific article published in August 2008

Microglial Barriers to Viral Gene Delivery

scientific article published on February 2017

Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease

scientific article

Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity.

scientific article published on 15 March 2017

Microglial dysfunction in brain aging and Alzheimer's disease

scientific article published on 18 January 2014

Modeling of pathological traits in Alzheimer's disease based on systemic extracellular signaling proteome.

scientific article

Modelling neuroinflammatory phenotypes in vivo

scientific article

Molecular and functional dissection of TGF-beta1-induced cerebrovascular abnormalities in transgenic mice

scientific article

Molecular hallmarks of heterochronic parabiosis at single-cell resolution

scientific article published in March 2022

Multiomics modeling of the immunome, transcriptome, microbiome, proteome and metabolome adaptations during human pregnancy

Multiple Click-Selective tRNA Synthetases Expand Mammalian Cell-Specific Proteomics

scientific article published on 30 May 2018

Myeloid cell replacement is neuroprotective in chronic experimental autoimmune encephalomyelitis

scientific article published on 21 March 2024

Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain

scientific article published on 26 April 2016

Neural progenitor cells regulate microglia functions and activity.

scientific article

Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases.

scientific article published in July 2006

Neuroinflammation in Alzheimer's disease

scientific article (publication date: April 2015)

Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.

scientific article published in March 2004

Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease.

scientific article

Nociceptive and Cognitive Changes in a Murine Model of Polytrauma

scientific article published on 30 June 2018

Noncytotoxic human CD4+ T-cell clones presenting and simultaneously responding to an antigen die of apoptosis

scientific article

Noninvasive in vivo monitoring of tissue-specific global gene expression in humans

scientific article

Novel role of human CD4 molecule identified in neurodegeneration

scientific article

Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions

scientific article

OH MYeloid! Immune cells wreaking havoc on brain homeostasis

scientific article published on 16 June 2017

Orally administered TGF-beta is biologically active in the intestinal mucosa and enhances oral tolerance

scientific article published on 02 July 2007

P1-203 Inhibition of the TGF-beta signaling pathway results in increased neurodegeneration and amyloid deposition in human APP transgenic mice

PET imaging of translocator protein (18 kDa) in a mouse model of Alzheimer's disease using N-(2,5-dimethoxybenzyl)-2-18F-fluoro-N-(2-phenoxyphenyl)acetamide

scientific article published on 22 January 2015

Papain-based Single Cell Isolation of Primary Murine Brain Endothelial Cells Using Flow Cytometry

scientific article published on 01 November 2018

Peptide-induced T cell clones: specificity, MHC restriction, proliferation and cytokine pattern as a function of different stimulations

Physiological blood-brain transport is impaired with age by a shift in transcytosis

scientific article published on 01 July 2020

Postmortem Human Dura Mater Cells Exhibit Phenotypic, Transcriptomic and Genetic Abnormalities that Impact their Use for Disease Modeling

scientific article published in 2022

Preclinical Assessment of Young Blood Plasma for Alzheimer Disease.

scientific article

Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice

scientific article

Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration

Reduced brain tissue perfusion in TGF-beta 1 transgenic mice showing Alzheimer's disease-like cerebrovascular abnormalities

scientific article

Regulation of amyloid precursor protein processing by the Beclin 1 complex

scientific article

Safety, Tolerability, and Feasibility of Young Plasma Infusion in the Plasma for Alzheimer Symptom Amelioration Study: A Randomized Clinical Trial

scientific article published on 01 January 2019

Selective expansion of foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells

scientific article published in August 2007

Selective restimulation of antigen or allergen preactivated T cells using OKT3 F(ab)2 results in the secretion of TH-1 or TH-2-like cytokine patterns

scientific article published on 01 November 1995

Single-cell analysis reveals T cell infiltration in old neurogenic niches

scientific article published on 03 July 2019

Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model.

scientific article published on 29 March 2013

Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AβPP(L/S) transgenic mice

scientific article

Small molecule tgf-beta mimetics as potential neuroprotective factors

scientific article published in April 2005

Sorting through the roles of beclin 1 in microglia and neurodegeneration

scientific article

Stem cells as vehicles for youthful regeneration of aged tissues.

scientific article

Systematic review and analysis of human proteomics aging studies unveils a novel proteomic aging clock and identifies key processes that change with age

scientific article published on 18 April 2020

Systemic and acquired immune responses in Alzheimer's disease

scientific article published on January 2007

Systemic factors as mediators of brain homeostasis, ageing and neurodegeneration

scientific article published on 08 January 2020

T cells as antigen-presenting cells ⬇️

scientific article published on July 1, 1994

TDP-43 frontotemporal lobar degeneration and autoimmune disease

scientific article published on 30 March 2013

TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.

scientific article

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

scientific article

Targeting autophagy for disease therapy

scientific article published in April 2013

Tgf-Beta pathway as a potential target in neurodegeneration and Alzheimer's

scientific article published on July 2006

The 1st International standard for transforming growth factor-β3 (TGF-β3).

scientific article published on 20 March 2012

The B7 adhesion molecule is expressed on activated human T cells: functional involvement in T-T cell interactions

scientific article published on September 1993

The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C

scientific article published on 01 December 2021

The Role of the Microenvironmental Niche in Declining Stem-Cell Functions Associated with Biological Aging

scientific article

The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans

article

The ageing systemic milieu negatively regulates neurogenesis and cognitive function.

scientific article

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice

scientific article

The circulatory systemic environment as a modulator of neurogenesis and brain aging

scientific article

The future of blood-based biomarkers for Alzheimer's disease

scientific article

The immunology of neurodegeneration

scientific article published on 2 April 2012

The inherent challenges of classifying senescence-Response

scientific article

The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo

scientific article published on August 2009

The role of inflammation in age-related disease

scientific article published on January 2013

Thy1-hAPP(Lond/Swe+) mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function

scientific article

To help aging populations, classify organismal senescence

scientific article

Tony Wyss-Coray: How young blood might help reverse aging. Yes, really

TEDGlobalLondon

Transforming growth factor-beta signaling pathway as a therapeutic target in neurodegeneration

scientific article published in January 2004

Traumatic Brain Injury Imaging in the Second Near-Infrared Window with a Molecular Fluorophore

scientific article published on 2 June 2016

Undulating changes in human plasma proteome profiles across the lifespan

scientific article published on 05 December 2019

Use of antibody/peptide constructs to direct antigenic peptides to T cells: Evidence for T cell processing and presentation ⬇️

scientific article published on January 1, 1992

Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis

scientific article

Workshop summary: roles of the TNF family in neuronal development, function and pathology

scientific article published in January 2011

Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17

scientific article published on 11 May 2022

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice.

scientific article

[18F]FSPG-PET reveals increased cystine/glutamate antiporter (xc-) activity in a mouse model of multiple sclerosis.

scientific article published on 22 February 2018

miRNATissueAtlas2: an update to the human miRNA tissue atlas

scientific article published on 01 January 2022

β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis

scientific article

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