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List of works by Denis Wirtz

A comparison of methods to assess cell mechanical properties

scientific article published on 18 June 2018

A direct interaction between actin and vimentin filaments mediated by the tail domain of vimentin

scientific article published on 9 August 2006

A distinctive role for focal adhesion proteins in three-dimensional cell motility.

scientific article published on 16 May 2010

A mechanism of coupling RCC1 mobility to RanGTP production on the chromatin in vivo

scientific article

A perinuclear actin cap regulates nuclear shape.

scientific article published on 22 October 2009

A physical sciences network characterization of non-tumorigenic and metastatic cells

scientific article published on January 2013

A robust nonlinear tissue-component discrimination method for computational pathology

scientific article published on 18 January 2016

A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei

scientific article published on 11 January 2021

Actin cap associated focal adhesions and their distinct role in cellular mechanosensing

scientific article

Adhesion and fusion efficiencies of human immunodeficiency virus type 1 (HIV-1) surface proteins

scientific article published on 22 October 2013

Affine and non-affine deformations quantified in cytoskeletal networks through three-dimensional form-finding model

scientific article

Age-dependent stochastic models for understanding population fluctuations in continuously cultured cells ⬇️

scientific article published on June 12, 2013

Alpha-actinin and filamin cooperatively enhance the stiffness of actin filament networks

scientific article

Altering mucus rheology to"solidify" human mucus at the nanoscale

scientific article

Asymmetric enrichment of PIE-1 in the Caenorhabditis elegans zygote mediated by binary counterdiffusion

scientific article published on 16 February 2009

Author Correction: Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology

scientific article published on 13 March 2018

Ballistic intracellular nanorheology reveals ROCK-hard cytoplasmic stiffening response to fluid flow.

scientific article published on May 2006

Biophysical and biomolecular determination of cellular age in humans

scientific article published on 11 July 2017

Biophysical changes reduce energetic demand in growth factor-deprived lymphocytes.

scientific article published on February 2016

Biophysical changes reduce energetic demand in growth factor–deprived lymphocytes.

scientific article published in March 2016

Biophysics of selectin–ligand interactions in inflammation and cancer ⬇️

scientific article published on February 7, 2011

COX-2 dependent regulation of mechanotransduction in human breast cancer cells

scientific article

Cancer Protrusions on a Tightrope: Nanofiber Curvature Contrast Quantitates Single Protrusion Dynamics.

scientific article published on 16 November 2017

Cdc42 mediates nucleus movement and MTOC polarization in Swiss 3T3 fibroblasts under mechanical shear stress

scientific article

Cell migration without a lamellipodium: translation of actin dynamics into cell movement mediated by tropomyosin

scientific article

Cell tension and mechanical regulation of cell volume

scientific article published on 16 August 2018

Chapter 15: Live-cell single-molecule force spectroscopy

scientific article

Chapter 18: Sensing cytoskeletal mechanics by ballistic intracellular nanorheology (BIN) coupled with cell transfection

scientific article published on January 2008

Collagen prolyl hydroxylases are essential for breast cancer metastasis

scientific article published on 28 March 2013

Collective cancer cell invasion induced by coordinated contractile stresses

scientific article published on 30 October 2015

Completing the Great Unfinished Symphony of Cancer Together: The Importance of Immigrants in Cancer Research

scientific article published on 01 September 2020

Condensation of FtsZ filaments can drive bacterial cell division

scientific article

Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways.

scientific article published on 4 May 2016

Correction

Cross‐linking FtsZ polymers into coherent Z rings ⬇️

scientific article published on September 20, 2010

Cytoskeletal tension induces the polarized architecture of the nucleus ⬇️

scientific article

Dendritic branching and homogenization of actin networks mediated by arp2/3 complex

scientific article published on 16 December 2004

Differences in the microrheology of human embryonic stem cells and human induced pluripotent stem cells

scientific article

Differential vesicular sorting of AMPA and GABAA receptors

scientific article

Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners.

scientific article

Dimensional control of cancer cell migration

scientific article published on January 2013

Dissecting cellular mechanics: Implications for aging, cancer, and immunity

article

Distinct Kinetic and Molecular Requirements Govern CD44 Binding to Hyaluronan versus Fibrin(ogen) ⬇️

scientific article published on August 8, 2012

Distinct kinetic and mechanical properties govern mucin 16- and podocalyxin-mediated tumor cell adhesion to E- and L-selectin in shear flow

scientific article

Distinct kinetic and mechanical properties govern selectin-leukocyte interactions

scientific article

Divergent roles of CD44 and carcinoembryonic antigen in colon cancer metastasis ⬇️

scientific article published on March 13, 2012

Dorsoventral polarity directs cell responses to migration track geometries

scientific article published on 31 July 2020

Dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes

scientific article published on 14 January 2020

Dynamics of the bacterial intermediate filament crescentin in vitro and in vivo

scientific article

Dysfunctional connections between the nucleus and the actin and microtubule networks in laminopathic models.

scientific article published on 12 September 2008

EB1 and cytoplasmic dynein mediate protrusion dynamics for efficient 3-dimensional cell migration

scientific article published on 2 November 2017

Effect of length, topology, and concentration on the microviscosity and microheterogeneity of DNA solutions

scientific article published on October 2002

Effect of modifying quantum dot surface charge on airway epithelial cell uptake in vitro

journal article published in 2013

Efficient active transport of gene nanocarriers to the cell nucleus

scientific article

Emergency seed funding for COVID-19 research: lessons from Johns Hopkins University

scientific article published on 10 November 2020

Enabling migration by moderation: YAP/TAZ are essential for persistent migration

scientific article published on 14 March 2019

Engineered Models of Confined Cell Migration

scientific article published on July 2016

Enhanced viscoelasticity of human cystic fibrotic sputum correlates with increasing microheterogeneity in particle transport

scientific article published on 17 September 2003

Evolution of cellular morpho-phenotypes in cancer metastasis.

scientific article

Fibronectin fibrillogenesis regulates three-dimensional neovessel formation

scientific article published on May 2008

Focal adhesion size uniquely predicts cell migration ⬇️

scientific article published on December 19, 2012

Form-finding model shows how cytoskeleton network stiffness is realized

scientific article

Functional interplay between the cell cycle and cell phenotypes ⬇️

scientific article published on March 1, 2013

Functional synergy of actin filament cross-linking proteins

scientific article

GTPase activity, structure, and mechanical properties of filaments assembled from bacterial cytoskeleton protein MreB.

scientific article

Going with the Flow: Water Flux and Cell Shape during Cytokinesis

scientific article published in December 2017

High-Throughput Secretomic Analysis of Single Cells to Assess Functional Cellular Heterogeneity ⬇️

scientific article published on February 19, 2013

High-throughput ballistic injection nanorheology to measure cell mechanics

scientific article

How actin crosslinking and bundling proteins cooperate to generate an enhanced cell mechanical response.

scientific article published on August 2005

Hypoxia Selectively Enhances Integrin α5β1 Receptor Expression in Breast Cancer to Promote Metastasis

scientific article published on 17 February 2017

Hypoxia and the extracellular matrix: drivers of tumour metastasis

scientific article

Hypoxia-inducible Factor 1 (HIF-1) Promotes Extracellular Matrix Remodeling under Hypoxic Conditions by Inducing P4HA1, P4HA2, and PLOD2 Expression in Fibroblasts ⬇️

scientific article published on February 19, 2013

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation ⬇️

scientific article published on September 12, 2011

Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells

retracted scientific article

Immunolabeling of Cleared Human Pancreata Provides Insights into Three-Dimensional Pancreatic Anatomy and Pathology

scientific article published on 22 April 2018

Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming

scientific article published on 01 June 2020

Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules.

scientific article

Inhibition of ovarian tumor cell invasiveness by targeting SYK in the tyrosine kinase signaling pathway.

scientific article published on 11 April 2018

Interplay of RhoA and motility in the programmed spreading of daughter cells postmitosis

scientific article

Interstitial Friction Greatly Impacts Membrane Mechanics ⬇️

scientific article published on March 19, 2013

Intracellular mechanics of migrating fibroblasts

scientific article

Intracellular microrheology as a tool for the measurement of the local mechanical properties of live cells

scientific article published on January 2004

Isomeric control of the mechanical properties of supramolecular filament hydrogels

scientific article published on 7 December 2017

Local 3D matrix confinement determines division axis through cell shape

scientific article published on 15 October 2015

Local mechanical response of cells to the controlled rotation of magnetic nanorods

scientific article published on 3 April 2014

Loss of alpha-catenin decreases the strength of single E-cadherin bonds between human cancer cells

scientific article published on 19 May 2009

Loss of giant obscurins alters breast epithelial cell mechanosensing of matrix stiffness

scientific article published on August 2016

MEX-5 enrichment in the C. elegans early embryo mediated by differential diffusion

scientific article

Magnetic manipulation of nanorods in the nucleus of living cells

scientific article

Magnetic tweezers for DNA micromanipulation

Magnetic tweezers measurement of single molecule torque.

scientific article published on April 2009

Mammalian Cell Division in 3D Matrices via Quantitative Confocal Reflection Microscopy.

scientific article published on 29 November 2017

Mapping local matrix remodeling induced by a migrating tumor cell using three-dimensional multiple-particle tracking

scientific article

Mechanical shear can accelerate the gelation of actin filament networks

scientific article published on 21 July 2005

Mechanical tension mobilizes Lgr6<sup>+</sup> epidermal stem cells to drive skin growth

scientific article published on 27 April 2022

Mechanics and dynamics of actin-driven thin membrane protrusions

scientific article published on 7 October 2005

Mechanics of enveloped virus entry into host cells

scientific article published on 11 November 2005

Mechanics of the Cell Nucleus

scientific article published on 01 January 2018

Metabolic and Mechanical Cues Regulating Pluripotent Stem Cell Fate

scientific article published on 22 October 2018

Micro- and macrorheology of mucus

scientific article

Micro-organization and visco-elasticity of the interphase nucleus revealed by particle nanotracking.

scientific article published on April 2004

Microheterogeneity and microrheology of wheat gliadin suspensions studied by multiple-particle tracking

scientific article published in January 2002

Microheterogeneity controls the rate of gelation of actin filament networks

scientific article published on 11 March 2002

Micromechanical coupling between cell surface receptors and RGD peptides

scientific article published in August 2002

Micromechanical mapping of live cells by multiple-particle-tracking microrheology

scientific article

Microrheology and ROCK signaling of human endothelial cells embedded in a 3D matrix

scientific article

MinC spatially controls bacterial cytokinesis by antagonizing the scaffolding function of FtsZ.

scientific article published in February 2008

Mismatch in mechanical and adhesive properties induces pulsating cancer cell migration in epithelial monolayer.

scientific article

Modeling the two-way feedback between contractility and matrix realignment reveals a nonlinear mode of cancer cell invasion

scientific article

Modulation of keratocyte phenotype by collagen fibril nanoarchitecture in membranes for corneal repair

scientific article published on 13 September 2013

Monitoring early fusion dynamics of human immunodeficiency virus type 1 at single-molecule resolution

scientific article published on 14 May 2008

Morphological effects on expression of growth differentiation factor 15 (GDF15), a marker of metastasis.

scientific article published in March 2014

Morphology of the lamellipodium and organization of actin filaments at the leading edge of crawling cells

scientific article

Multi-nucleated cells use ROS to induce breast cancer chemo-resistance in vitro and in vivo

scientific article published on 10 May 2018

Multiple scale model for cell migration in monolayers: Elastic mismatch between cells enhances motility

scientific article

NAC1 is an actin-binding protein that is essential for effective cytokinesis in cancer cells.

scientific article

Normal mammary epithelial cells promote carcinoma basement membrane invasion by inducing microtubule-rich protrusions

scientific article published on 3 August 2015

Nuclear envelope breakdown requires overcoming the mechanical integrity of the nuclear lamina

scientific article

Nuclear envelope in nuclear positioning and cell migration

scientific article

Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration

scientific journal article

Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology

scientific article published on 14 December 2017

Nucleation and Decay Initiation Are the Stiffness-Sensitive Phases of Focal Adhesion Maturation ⬇️

scientific article published on December 20, 2011

Organization of cellular receptors into a nanoscale junction during HIV-1 adhesion

scientific article

PEG-based hydrogels with collagen mimetic peptide-mediated and tunable physical cross-links

scientific article

Pairwise assembly determines the intrinsic potential for self-organization and mechanical properties of keratin filaments

scientific article

Particle-tracking microrheology of living cells: principles and applications

scientific article published on January 2009

Physical oncology. Preface

scientific article published on 07 February 2011

Pluri-IQ: Quantification of Embryonic Stem Cell Pluripotency through an Image-Based Analysis Software

scientific article published on 01 August 2018

Pluri-IQ: Quantification of Embryonic Stem Cell Pluripotency through an Image-Based Analysis Software

scientific article published on 3 July 2017

Polymerization and bundling kinetics of FtsZ filaments

scientific article published on 11 July 2008

Predicting how cells spread and migrate: focal adhesion size does matter

scientific article published on 29 April 2013

Probing cellular mechanical responses to stimuli using ballistic intracellular nanorheology.

scientific article published in January 2007

Probing intercellular interactions between vascular endothelial cadherin pairs at single-molecule resolution and in living cells

scientific article published on 28 February 2006

Probing single-cell micromechanics in vivo: the microrheology of C. elegans developing embryos

scientific article

Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis

scientific article published on February 2013

Programmed subcellular release for studying the dynamics of cell detachment

scientific article

Protein filaments: Bundles from boundaries

scientific article published on 01 October 2010

Real-time intracellular transport of gene nanocarriers studied by multiple particle tracking

scientific article published in March 2004

Recapitulating cancer cell invasion in vitro

scientific article

Recapitulation of molecular regulators of nuclear motion during cell migration

scientific article published on 27 September 2018

Receptor-ligand binding: 'catch' bonds finally caught

scientific article

Reply: reducing background fluorescence reveals adhesions in 3D matrices

Resolving the role of actoymyosin contractility in cell microrheology

scientific article

Rho kinase regulates the intracellular micromechanical response of adherent cells to rho activation

scientific article

Role of membrane-tension gated Ca flux in cell mechanosensation

scientific article published on 22 January 2018

SMRT analysis of MTOC and nuclear positioning reveals the role of EB1 and LIC1 in single-cell polarization.

scientific article published on 22 December 2011

Senescent stromal cells induce cancer cell migration via inhibition of RhoA/ROCK/myosin-based cell contractility

scientific article

Simultaneously defining cell phenotypes, cell cycle, and chromatin modifications at single‐cell resolution ⬇️

scientific article published on March 28, 2013

Single molecule characterization of P-selectin/ligand binding

scientific article published on 08 January 2003

Single-cell morphology encodes metastatic potential

scientific article published on 22 January 2020

Single-molecule analysis of cadherin-mediated cell-cell adhesion

scientific article published in January 2006

Single-molecule analysis of human immunodeficiency virus type 1 gp120-receptor interactions in living cells

scientific article

Single-molecule binding of CD44 to fibrin versus P-selectin predicts their distinct shear-dependent interactions in cancer ⬇️

scientific article published on May 10, 2011

Solid Stress in Brain Tumors

scientific article published on 08 April 2019

Statistical analysis of cell migration in 3D using the anisotropic persistent random walk model

scientific article

Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness

scientific article

Structure of the actin crosslinking core of fimbrin

scientific article

Structure-function relationship of biological gels revealed by multiple-particle tracking and differential interference contrast microscopy: the case of human lamin networks

scientific article published on 27 October 2004

Supramolecular Design of Unsymmetric Reverse Bolaamphiphiles for Cell-Sensitive Hydrogel Degradation and Drug Release

scientific article published on 30 January 2020

Switching from protease-independent to protease-dependent cancer cell invasion

scientific article

Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration.

scientific article

The Arp2/3 complex mediates multigeneration dendritic protrusions for efficient 3-dimensional cancer cell migration.

scientific article

The LINC-anchored actin cap connects the extracellular milieu to the nucleus for ultrafast mechanotransduction.

scientific article published on 18 January 2013

The Mechanobiology of Aging

scientific article published on December 2015

The assembly of MreB, a prokaryotic homolog of actin

scientific article published on 16 November 2004

The bimodal role of filamin in controlling the architecture and mechanics of F-actin networks

scientific article published in November 2003

The differential formation of the LINC-mediated perinuclear actin cap in pluripotent and somatic cells

scientific article

The distinct roles of the nucleus and nucleus-cytoskeleton connections in three-dimensional cell migration

scientific article published on 3 July 2012

The filamentous actin cross-linking/bundling activity of mammalian formins.

scientific article published on 26 September 2008

The mechanical properties of simple epithelial keratins 8 and 18: discriminating between interfacial and bulk elasticities

scientific article published in July 2003

The multi-faceted role of the actin cap in cellular mechanosensation and mechanotransduction

scientific article published on June 2013

The perinuclear actin cap in health and disease.

scientific article published on 23 April 2010

The physics of cancer: the role of physical interactions and mechanical forces in metastasis ⬇️

scientific article published on June 24, 2011

The rapid onset of elasticity during the assembly of the bacterial cell-division protein FtsZ.

scientific article

Three-dimensional analysis of extrahepatic cholangiocarcinoma and tumor budding

scientific article published on 01 June 2020

Three-dimensional cell migration does not follow a random walk

scientific article published on 04 March 2014

Three-dimensional matrix fiber alignment modulates cell migration and MT1-MMP utility by spatially and temporally directing protrusions

scientific article published on October 2015

Three-dimensional visualization of cleared human pancreas cancer reveals that sustained epithelial-to-mesenchymal transition is not required for venous invasion

scientific article published on 07 November 2019

Tight coupling between nucleus and cell migration through the perinuclear actin cap

scientific article

Torsional Mechanics of DNA Are Regulated by Small-Molecule Intercalation ⬇️

scientific article published on November 24, 2010

Towards a regional approach to cell mechanics

scientific article published on April 2004

Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes.

scientific article published on 25 January 2017

Transport of polymeric nanoparticle gene carriers in gastric mucus

scientific article

Triggering cell detachment from patterned electrode arrays by programmed subcellular release.

scientific article published on 17 June 2010

Tumor cell density regulates matrix metalloproteinases for enhanced migration

scientific article published on 24 August 2018

Volume regulation and shape bifurcation in the cell nucleus

scientific article

Volume regulation and shape bifurcation in the cell nucleus

scientific article published on 01 January 2016

Water permeation drives tumor cell migration in confined microenvironments

scientific article

YAP and TAZ regulate cell volume

scientific article published on 03 September 2019

{alpha}-Catenin mediates initial E-cadherin-dependent cell-cell recognition and subsequent bond strengthening

scholarly article

β-Catenin serves as a clutch between low and high intercellular E-cadherin bond strengths.

scientific article

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