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List of works by Bruce D. Walker

A Cure for HIV Infection: "Not in My Lifetime" or "Just Around the Corner"?

scientific article

A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo

scientific article published on 30 October 2015

A Reproducibility-Based Computational Framework Identifies an Inducible, Enhanced Antiviral State in Dendritic Cells from HIV-1 Elite Controllers

scientific article published on 29 January 2018

A cell-intrinsic inhibitor of HIV-1 reverse transcription in CD4(+) T cells from elite controllers

scientific article

A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition

scholarly article

A high dimensional immune monitoring model of HIV-specific CD8 T cell responses accurately identifies subjects achieving spontaneous control of viral replication.

scientific article published on 25 May 2012

A method for identification of HIV gp140 binding memory B cells in human blood

scientific article

A microchip CD4 counting method for HIV monitoring in resource-poor settings

scientific article

A molecular assay for sensitive detection of pathogen-specific T-cells

scientific article

A novel immunodominant CD8+ T cell response restricted by a common HLA-C allele targets a conserved region of Gag HIV-1 clade CRF01_AE infected Thais

scientific article

A randomised, placebo-controlled, first-in-human study of a novel clade C therapeutic peptide vaccine administered ex vivo to autologous white blood cells in HIV infected individuals

scientific article

A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells

scientific article

Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes

scientific article

Absence of biologically important Kaposi sarcoma-associated herpesvirus gene products and virus-specific cellular immune responses in multiple myeloma

scientific article published on July 2002

Accelerating Next-Generation Vaccine Development for Global Disease Prevention ⬇️

scientific article published on May 31, 2013

Accelerating the development of a safe and effective HIV vaccine: HIV vaccine case study for the Decade of Vaccines

scientific article

Acute hepatitis C virus infection in incarcerated injection drug users

scientific article

Adaptation of HIV-1 to human leukocyte antigen class I

scientific article published on 25 February 2009

Additive contribution of HLA class I alleles in the immune control of HIV-1 infection

scientific article published on 21 July 2010

Alterations in natural killer cell receptor profiles during HIV type 1 disease progression among chronically infected South African adults

scientific article

Amino-acid co-variation in HIV-1 Gag subtype C: HLA-mediated selection pressure and compensatory dynamics

scientific article

Aminopeptidase substrate preference affects HIV epitope presentation and predicts immune escape patterns in HIV-infected individuals

scientific article published on 14 May 2012

Analysis of Major Histocompatibility Complex-Bound HIV Peptides Identified from Various Cell Types Reveals Common Nested Peptides and Novel T Cell Responses

scientific article published on 20 July 2016

Antagonism of HIV-specific CD4+ T cells by C-terminal truncation of a minimum epitope

scientific article published on 07 October 2005

Anti-APOBEC3G activity of HIV-1 Vif protein is attenuated in elite controllers

scientific article

Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells

scientific article (publication date: 6 May 2008)

Antigen recognition-triggered drug delivery mediated by nanocapsule-functionalized cytotoxic T-cells

scientific article published on 25 November 2016

Antiretroviral resistance associated with supervised treatment interruptions in treated acute HIV infection ⬇️

scientific article published on May 2, 2003

Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion

scientific article published on October 2016

Association between HIV Type 1-specific T cell responses and CD4+ T cell counts or CD4+:CD8+ T cell ratios in HIV Type 1 subtype B infection in China

scientific article published on August 2006

Association between injectable progestin-only contraceptives and HIV acquisition and HIV target cell frequency in the female genital tract in South African women: a prospective cohort study

scientific article published on 23 December 2015

Association of HLA-DRB1–restricted CD4+ T cell responses with HIV immune control ⬇️

scientific article published on June 23, 2013

Association of TRIM22 with the type 1 interferon response and viral control during primary HIV-1 infection

scientific article

Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls

scientific article

Attenuation of multiple Nef functions in HIV-1 elite controllers

scientific article published on 7 January 2013

Broad Specificity of Virus-Specific CD4+ T-Helper-Cell Responses in Resolved Hepatitis C Virus Infection

scientific article (publication date: December 2002)

Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads

scientific article

Broad and persistent Gag-specific CD8+ T-cell responses are associated with viral control but rarely drive viral escape during primary HIV-1 infection

scientific article published on January 2015

Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

scientific article

Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein

scientific article

Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes

scientific article

CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms

scientific article

CD161 expression on hepatitis C virus-specific CD8+ T cells suggests a distinct pathway of T cell differentiation

scientific article published in February 2008

CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21

scientific article

CD8 Epitope Escape and Reversion in Acute HCV Infection

scientific article

CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcription

scientific article

CD8(+) T Cells and cART: A Dynamic Duo?

scientific article published on September 2016

CD8+ T Cell Breadth and Ex Vivo Virus Inhibition Capacity Distinguish between Viremic Controllers with and without Protective HLA Class I Alleles

scientific article

CD8+ T lymphocyte responses target functionally important regions of Protease and Integrase in HIV-1 infected subjects

scientific article

CD8+ T-cell responses to different HIV proteins have discordant associations with viral load

scientific article published on 17 December 2006

CD8+ TCR Bias and Immunodominance in HIV-1 Infection

scientific article published on 24 April 2015

CTL responses of high functional avidity and broad variant cross-reactivity are associated with HIV control

scientific article (publication date: 2012)

CXCL13 is a plasma biomarker of germinal center activity

scientific article published on 23 February 2016

Central role of reverting mutations in HLA associations with human immunodeficiency virus set point

scientific article published on 2 July 2008

Cervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tract

scientific article published on May 2015

Challenges to the success of HIV and tuberculosis care and treatment in the public health sector in South Africa

scientific article published on December 2007

Characteristics and Outcomes of Initial Virologic Suppressors during Analytic Treatment Interruption in a Therapeutic HIV-1 gag Vaccine Trial ⬇️

scientific article published on March 30, 2012

Chimeric immune receptor T cells bypass class I requirements and recognize multiple cell types relevant in HIV-1 infection

scientific article published on February 2003

Circulating CXCR5+CXCR3+PD-1lo Tfh-like cells in HIV-1 controllers with neutralizing antibody breadth

scientific article

Clonal expansion of genome-intact HIV-1 in functionally polarized Th1 CD4+ T cells

scientific article published on 19 June 2017

Co-operative additive effects between HLA alleles in control of HIV-1

scientific article published on 19 October 2012

Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller

scientific article

Comparison of overlapping peptide sets for detection of antiviral CD8 and CD4 T cell responses

scientific article published in April 2003

Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection

scientific article

Comprehensive Analysis of CD8+-T-Cell Responses against Hepatitis C Virus Reveals Multiple Unpredicted Specificities

scientific article (publication date: June 2002)

Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides

scientific article published on May 2004

Consistent patterns in the development and immunodominance of human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T-cell responses following acute HIV-1 infection

scientific article

Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus

scientific article

Continuous viral escape and selection by autologous neutralizing antibodies in drug-naive human immunodeficiency virus controllers

scientific article published on 5 November 2008

Control of HIV despite the Discontinuation of Antiretroviral Therapy

article

Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes

scientific article published on 20 December 2005

Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes

scientific article published on 24 January 2007

Coordinate linkage of HIV evolution reveals regions of immunological vulnerability

scientific article

Correction for Thobakgale et al., Impact of HLA in Mother and Child on Disease Progression of Pediatric Human Immunodeficiency Virus Type 1 Infection

scientific article published on 8 July 2015

Correction: Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination

scientific article published on 2 June 2016

Correction: Evidence of Differential HLA Class I-Mediated Viral Evolution in Functional and Accessory/Regulatory Genes of HIV-1

article

Corrigendum: Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117.

scientific article published on 23 March 2016

Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells

scientific article published on 14 June 2013

De novo generation of escape variant-specific CD8+ T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infection

scientific article

Decreased CXCR3+ CD8 T cells in advanced human immunodeficiency virus infection suggest that a homing defect contributes to cytotoxic T-lymphocyte dysfunction

scientific article

Defective immune function of primary effusion lymphoma cells is associated with distinct KSHV gene expression profiles

scientific article published in June 2004

Defining the directionality and quality of influenza virus-specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus

scientific article

Definition of the viral targets of protective HIV-1-specific T cell responses

scientific article published on 7 December 2011

Detection and treatment of Fiebig stage I HIV-1 infection in young at-risk women in South Africa: a prospective cohort study

scientific article published on 29 September 2017

Detection of HIV type 1 gag-specific CD4(+) T cell responses in acutely infected infants

scientific article published in February 2008

Detection of polyfunctional Mycobacterium tuberculosis-specific T cells and association with viral load in HIV-1-infected persons

scientific article published in April 2008

Determinant of HIV-1 mutational escape from cytotoxic T lymphocytes

scientific article

Differences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus

scientific article

Differences in the expressed HLA class I alleles effect the differential clustering of HIV type 1-specific T cell responses in infected Chinese and caucasians

scientific article published in May 2004

Differential Ability of Primary HIV-1 Nef Isolates To Downregulate HIV-1 Entry Receptors

scientific article

Differential HIV epitope processing in monocytes and CD4 T cells affects cytotoxic T lymphocyte recognition

scientific article published on July 2009

Differential Immunodominance Hierarchy of CD8+ T-Cell Responses in HLA-B*27:05- and -B*27:02-Mediated Control of HIV-1 Infection

scientific article published on 22 November 2017

Differential Immunogenicity of HIV‐1 Clade C Proteins in Eliciting CD8+and CD4+Cell Responses

article

Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single Gag epitope

scientific article published on 12 September 2012

Differential microRNA regulation of HLA-C expression and its association with HIV control ⬇️

scientific article published on April 17, 2011

Differential neutralization of human immunodeficiency virus (HIV) replication in autologous CD4 T cells by HIV-specific cytotoxic T lymphocytes

scientific article published on 21 January 2009

Differential regulation of toll-like receptor pathways in acute and chronic HIV-1 infection

scientific article published on March 2012

Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype

scientific article published in October 2006

Differential targeting and shifts in the immunodominance of Epstein-Barr virus--specific CD8 and CD4 T cell responses during acute and persistent infection

scientific article

Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection

scientific article published on 15 June 2015

Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.

scientific article published in December 2004

Dynamic range of Nef functions in chronic HIV-1 infection

scientific article published on 13 March 2013

Early proliferation of CCR5(+) CD38(+++) antigen-specific CD4(+) Th1 effector cells during primary HIV-1 infection

scientific article published on 19 May 2005

Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection

scientific article

Early virological suppression despite high frequency NNRTI resistance following perinatal prophylaxis in HIV-infected African infants

article

Early virological suppression with three-class antiretroviral therapy in HIV-infected African infants

scientific article published in July 2008

Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection

scientific article

Elite Controllers with Low to Absent Effector CD8 + T Cell Responses Maintain Highly Functional, Broadly Directed Central Memory Responses ⬇️

scientific article published on April 18, 2012

Elite controller CD8+ T cells exhibit comparable viral inhibition capacity, but better sustained effector properties compared to chronic progressors

scientific article published on 12 July 2016

Enhanced binding of antibodies generated during chronic HIV infection to mucus component MUC16

scientific article published on 09 March 2016

Enhanced detection of human immunodeficiency virus type 1-specific T-cell responses to highly variable regions by using peptides based on autologous virus sequences

scientific article

Epidemiologically linked transmission of HIV-1 illustrates the impact of host genetics on virological outcome

scientific article published on January 2009

Epigenetic regulation of telomerase expression in HIV-1-specific CD8+ T cells

scientific article

Epithelial adhesion molecules can inhibit HIV-1-specific CD8⁺ T-cell functions

scientific article

Erratum: addendum: HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus

scientific article published in Nature

Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A.

scientific article

Escape from the immune system

scientific article published in Nature

Evaluating the impact of functional genetic variation on HIV-1 control

scientific article published on 9 September 2017

Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1

scientific article

Evolution of HLA-B*5703 HIV-1 escape mutations in HLA-B*5703-positive individuals and their transmission recipients

scientific article published on 23 March 2009

Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers

scientific article

Expansion of HIV-specific CD4+ and CD8+ T cells by dendritic cells transfected with mRNA encoding cytoplasm- or lysosome-targeted Nef

scientific article published on 25 October 2005

Expansion of pre-existing, lymph node-localized CD8+ T cells during supervised treatment interruptions in chronic HIV-1 infection

scientific article

Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10

scientific article

Extended high viremics: a substantial fraction of individuals maintain high plasma viral RNA levels after acute HIV-1 subtype C infection

scientific article published on July 2011

Extensive HLA class I allele promiscuity among viral CTL epitopes

scientific article published on September 2007

Extensive intrasubtype recombination in South African human immunodeficiency virus type 1 subtype C infections

scientific article published on 21 February 2007

Factors Associated With Viral Rebound in HIV-1-Infected Individuals Enrolled in a Therapeutic HIV-1 gag Vaccine Trial ⬇️

scientific article published on April 1, 2011

Factors predicting discordant virological and immunological responses to antiretroviral therapy in HIV-1 clade C infected Zulu/Xhosa in South Africa

scientific article

Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site

scientific article published on 8 March 2018

Fine specificity and cross-clade reactivity of HIV type 1 Gag-specific CD4+ T cells

scientific article published on March 2004

Fine-mapping classical HLA variation associated with durable host control of HIV-1 infection in African Americans

scientific article

Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1

scientific article

Fluctuations of functionally distinct CD8+ T-cell clonotypes demonstrate flexibility of the HIV-specific TCR repertoire

scientific article published on December 2005

Follicular Dendritic Cells Retain Infectious HIV in Cycling Endosomes

scientific article published in December 2015

Frequencies of Circulating Th1-Biased T Follicular Helper Cells in Acute HIV-1 Infection Correlate with the Development of HIV-Specific Antibody Responses and Lower Set Point Viral Load

article

Frequencies of circulating Th1-biased T follicular helper cells in acute HIV-1 infection correlate with the development of HIV-specific antibody responses and lower set point viral load

article

Frequent and strong antibody-mediated natural killer cell activation in response to HIV-1 Env in individuals with chronic HIV-1 infection

scientific article

Full-breadth analysis of CD8+ T-cell responses in acute hepatitis C virus infection and early therapy

scientific article

Fully differentiated HIV-1 specific CD8+ T effector cells are more frequently detectable in controlled than in progressive HIV-1 infection

scientific article

Functional and genetic analysis of coreceptor usage by dualtropic HIV-1 subtype C isolates

scientific article

Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters

scientific article

Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy.

scientific article

Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes

scientific article published on 18 June 2008

Genetic interplay between HLA-C and MIR148A in HIV control and Crohn disease

scientific article

Genotypic and functional impact of HIV-1 adaptation to its host population during the North American epidemic

scientific article

Gradual adaptation of HIV to human host populations: good or bad news?

article

Greater viral rebound and reduced time to resume antiretroviral therapy after therapeutic immunization with the ALVAC-HIV vaccine (vCP1452)

article

HIV Controllers Exhibit Enhanced Frequencies of Major Histocompatibility Complex Class II Tetramer+ Gag-Specific CD4+ T Cells in Chronic Clade C HIV-1 Infection

scientific article published on 11 January 2017

HIV and HLA Class I: An Evolving Relationship ⬇️

scientific article published on September 21, 2012

HIV control is mediated in part by CD8+ T-cell targeting of specific epitopes

scientific article

HIV control through a single nucleotide on the HLA-B locus

scientific article published on 15 August 2012

HIV patients developing primary CNS lymphoma lack EBV-specific CD4+ T cell function irrespective of absolute CD4+ T cell counts

scientific article published in March 2007

HIV subtype influences HLA-B*07:02-associated HIV disease outcome

scientific article

HIV-1 Antibody Neutralization Breadth Is Associated with Enhanced HIV-Specific CD4+ T Cell Responses

scientific article published on 9 December 2015

HIV-1 Nef is preferentially recognized by CD8 T cells in primary HIV-1 infection despite a relatively high degree of genetic diversity

scientific article

HIV-1 Vpu Mediates HLA-C Downregulation

scientific article published on May 2016

HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption

scientific article

HIV-1 antiviral activity of recombinant natural killer cell enhancing factors, NKEF-A and NKEF-B, members of the peroxiredoxin family

scientific article (publication date: 17 January 2003)

HIV-1 integration landscape during latent and active infection

scientific article

HIV-1 persistence in CD4+ T cells with stem cell-like properties

scientific article published on 12 January 2014

HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus

scientific article published in November 2002

HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response

scientific article published in June 2005

HIV-1-specific cytotoxicity is preferentially mediated by a subset of CD8(+) T cells producing both interferon-gamma and tumor necrosis factor-alpha

scientific article published in April 2004

HIV-1-specific interleukin-21+ CD4+ T cell responses contribute to durable viral control through the modulation of HIV-specific CD8+ T cell function

scientific article

HIV-Specific CD4 T Cell Responses to Different Viral Proteins Have Discordant Associations with Viral Load and Clinical Outcome ⬇️

scientific article published on October 26, 2011

HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory

scientific article published on 24 July 2006

HIV-specific CD8⁺ T cells and HIV eradication

scientific article published on 5 January 2016

HIV-specific cytolytic CD4 T cell responses during acute HIV infection predict disease outcome

scientific article published on February 2012

HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8(+) T Cell Response against HIV-1.

scientific article published in October 2006

HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load

scientific article published on 23 April 2008

HLA footprints on human immunodeficiency virus type 1 are associated with interclade polymorphisms and intraclade phylogenetic clustering

scientific article published on 25 February 2009

HLA-A*68:02-restricted Gag-specific cytotoxic T lymphocyte responses can drive selection pressure on HIV but are subdominant and ineffective

scientific article published on July 2013

HLA-B*14:02-Restricted Env-Specific CD8+ T-Cell Activity Has Highly Potent Antiviral Efficacy Associated with Immune Control of HIV Infection

scientific article published on 6 September 2017

HLA-B*57 Micropolymorphism shapes HLA allele-specific epitope immunogenicity, selection pressure, and HIV immune control

scientific article published on 16 November 2011

HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognition

scientific article published on 30 December 2008

HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load

scientific article

HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C.

scientific article

HLA-Cw*03-restricted CD8+ T-cell responses targeting the HIV-1 gag major homology region drive virus immune escape and fitness constraints compensated for by intracodon variation

scientific article published on 25 August 2010

HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1.

scientific article published on 29 October 2008

HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins

scientific article

HLA-associated viral mutations are common in human immunodeficiency virus type 1 elite controllers

scientific article published on 19 January 2009

HLA-specific intracellular epitope processing shapes an immunodominance pattern for HLA-B*57 that is distinct from HLA-B*58:01

scientific article published on 17 July 2013

Heat shock protein-mediated cross-presentation of exogenous HIV antigen on HLA class I and class II.

scientific article published on August 2004

High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8+ and CD4+ T Cells during Acute HCV Infection, Irrespective of Clinical Outcome

scientific article

High avidity CD8+ T cells efficiently eliminate motile HIV-infected targets and execute a locally focused program of anti-viral function

scientific article (publication date: 2014)

High degree of inter-clade cross-reactivity of HIV-1-specific T cell responses at the single peptide level

scientific article published in September 2005

High frequency of rapid immunological progression in African infants infected in the era of perinatal HIV prophylaxis

scientific article published in June 2007

High frequency of transmitted HIV-1 Gag HLA class I-driven immune escape variants but minimal immune selection over the first year of clade C infection

scientific article published on 17 March 2015

High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection

scientific article published on September 2004

High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control

scientific article published on 11 December 2012

High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control

scientific article published on 13 July 2011

High-resolution definition of humoral immune response correlates of effective immunity against HIV.

scientific article

Histone deacetylase inhibitors impair the elimination of HIV-infected cells by cytotoxic T-lymphocytes

scientific article

Human Immunodeficiency Virus Type 1-Hepatitis C Virus Coinfection: Intraindividual Comparison of Cellular Immune Responses against Two Persistent Viruses

scientific article (publication date: March 2002)

Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy

scientific article published on September 2007

Human immunodeficiency virus type 1 specific cytotoxic T lymphocyte responses in Chinese infected with HIV-1 B'/C Recombinant (CRF07_BC)

scientific article

Human immunodeficiency virus type 1-specific CD8+ T-cell responses during primary infection are major determinants of the viral set point and loss of CD4+ T cells

scientific article published on 20 May 2009

Human immunodeficiency virus-specific CD8+ T-cell activity is detectable from birth in the majority of in utero-infected infants

scientific article

Human leukocyte antigen-specific polymorphisms in HIV-1 Gag and their association with viral load in chronic untreated infection

article

IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells

scientific article published on 13 April 2009

IL-8 responsiveness defines a subset of CD8 T cells poised to kill

scientific article published on 3 August 2004

Identification of HIV-1-specific regulatory T-cells using HLA class II tetramers

scientific article published on October 2012

Identification of HLA-A11-restricted HIV-1-specific cytotoxic T-lymphocyte epitopes in China

scientific article published on January 2007

Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells

scientific article published on August 2008

IgG subclass profiles in infected HIV type 1 controllers and chronic progressors and in uninfected recipients of Env vaccines

scientific article

Immune control of HIV-1 after early treatment of acute infection

scientific article published in Nature

Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection

scientific article

Immunodominant HIV-1 Cd4+ T cell epitopes in chronic untreated clade C HIV-1 infection

scientific article

Immunodominant HIV-1-specific HLA-B- and HLA-C-restricted CD8+ T cells do not differ in polyfunctionality

scientific article

Immunogenetics of Spontaneous Control of HIV ⬇️

scientific article published on January 1, 2012

Immunologic control of HIV-1.

scientific article

Immunologic evidence for lack of heterologous protection following resolution of HCV in patients with non genotype 1 infection

scientific article (publication date: September 2007)

Immunological and virological impact of highly active antiretroviral therapy initiated during acute HIV-1 infection

scientific article published on 15 August 2006

Immunology and the elusive AIDS vaccine

scientific article published in Nature

Immunopathogenesis and immunotherapy in AIDS virus infections

scientific article (publication date: July 2003)

Immunotherapy for AIDS virus infections: cautious optimism for cell-based vaccine

scientific article published in January 2003

Impact of HLA Allele-KIR Pairs on HIV Clinical Outcome in South Africa

scientific article published in 2019

Impact of HLA in mother and child on disease progression of pediatric human immunodeficiency virus type 1 infection

scientific article published on 15 July 2009

Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responses

scientific article published in April 2006

Impact of HLA-driven HIV adaptation on virulence in populations of high HIV seroprevalence

scientific article published in December 2014

Impact of Kaposi Sarcoma–Associated Herpesvirus (KSHV) Burden and HIV Coinfection on the Detection of T Cell Responses to KSHV ORF73 and ORF65 Proteins

article

Impact of intrapeptide epitope location on CD8 T cell recognition

Impact of select immunologic and virologic biomarkers on CD4 cell count decrease in patients with chronic HIV-1 subtype C infection: results from Sinikithemba Cohort, Durban, South Africa

scientific article published on September 2009

Impacts of Avidity and Specificity on the Antiviral Efficiency of HIV-1-Specific CTL ⬇️

scientific article published on October 1, 2003

Impaired Hepatitis C Virus-Specific T Cell Responses and Recurrent Hepatitis C Virus in HIV Coinfection

scientific article

Impaired Nef function is associated with early control of HIV-1 viremia

scientific article published on 25 June 2014

Impaired replication capacity of acute/early viruses in persons who become HIV controllers

scientific article

Impairment of CD1d-restricted natural killer T cells in chronic HIV type 1 clade C infection

scientific article

Impairment of viral replication capacity by nef alleles from HIV elite controllers.

scientific article published on 3 October 2011

Important contribution of p15 Gag-specific responses to the total Gag-specific CTL responses

scientific article published on February 2002

In vitro priming recapitulates in vivo HIV-1 specific T cell responses, revealing rapid loss of virus reactive CD4 T cells in acute HIV-1 infection

scientific article published on 23 January 2009

Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression

scientific article

Increased detection of HIV-specific T cell responses by combination of central sequences with comparable immunogenicity

article

Increased frequencies of CD8+CD57+ T cells are associated with antibody neutralization breadth against HIV in viraemic controllers

scientific article published on 9 December 2016

Increased sequence diversity coverage improves detection of HIV-specific T cell responses

scientific article published in November 2007

Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice

scientific article published on 06 May 2009

Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection

scientific article

Influence of Gag-protease-mediated replication capacity on disease progression in individuals recently infected with HIV-1 subtype C.

scientific article

Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection

scientific article published in December 2003

Influence of HLA-C expression level on HIV control

scientific article published on April 2013

Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1.

scientific article

Inter-clade cross-reactivity of HIV-1-specific T cell responses in human immunodeficiency virus type 1 infection in China

scientific article published on March 2007

Intersubtype differences in the effect of a rare p24 gag mutation on HIV-1 replicative fitness

scientific article

Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1.

scientific article published on 20 February 2018

LILRB2 interaction with HLA class I correlates with control of HIV-1 infection

scientific article

Lack of Duffy antigen receptor for chemokines: no influence on HIV disease progression in an African treatment-naive population

scientific article

Lack of association between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals

scientific article published on 16 November 2011

Lack of detectable HIV-1-specific CD8(+) T cell responses in Zambian HIV-1-exposed seronegative partners of HIV-1-positive individuals ⬇️

scientific article

Lactobacillus-Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women

scientific article published on 9 January 2017

Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes

scientific article published on 15 May 2006

Lentiviral vectors encoding human immunodeficiency virus type 1 (HIV-1)-specific T-cell receptor genes efficiently convert peripheral blood CD8 T lymphocytes into cytotoxic T lymphocytes with potent in vitro and in vivo HIV-1-specific inhibitory act

scientific article

Leukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllers

scientific article

Ligand-independent exhaustion of killer immunoglobulin-like receptor-positive CD8+ T cells in human immunodeficiency virus type 1 infection

scientific article published on 25 June 2008

Limited durability of viral control following treated acute HIV infection

scientific article

Limited immunogenicity of HIV CD8+ T-cell epitopes in acute Clade C virus infection

scientific article

Limited sequence evolution within persistently targeted CD8 epitopes in chronic human immunodeficiency virus type 1 infection

scientific article

Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells

scientific article

Loss of HIV-1-specific T-cell responses associated with very rapid HIV-1 disease progression

scientific article published in April 2007

Low Replication Capacity Virus Is Preferentially Transmitted In Mother-To-Child-Transmission But Not In Adult-To-Adult-Transmission Of HIV-1

article

Low levels of peripheral CD161++CD8+ mucosal associated invariant T (MAIT) cells are found in HIV and HIV/TB co-infection

scientific article

Lower Viral Loads and Slower CD4+ T-Cell Count Decline in MRKAd5 HIV-1 Vaccinees Expressing Disease-Susceptible HLA-B*58:02

scientific article published on 06 March 2016

Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point

scientific article published on 5 September 2015

Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection

scientific article published on 9 July 2008

Matrix metalloprotease inhibitors restore impaired NK cell-mediated antibody-dependent cellular cytotoxicity in human immunodeficiency virus type 1 infection

scientific article published on 24 June 2009

Metabolic pathway activation distinguish transcriptional signatures of CD8+ T cells from HIV-1 elite controllers

article

Migration of antigen-specific T cells away from CXCR4-binding human immunodeficiency virus type 1 gp120.

scientific article published on May 2004

Modest attenuation of HIV-1 Vpu alleles derived from elite controller plasma

scientific article published on 20 March 2015

Monocyte chemoattractant protein-2 (CC chemokine ligand 8) inhibits replication of human immunodeficiency virus type 1 via CC chemokine receptor 5.

scientific article published on April 2002

Mosaic HIV-1 Gag antigens can be processed and presented to human HIV-specific CD8+ T cells

scientific article published on 16 May 2011

Motif inference reveals optimal CTL epitopes presented by HLA class I alleles highly prevalent in southern Africa

scientific article

Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes

scientific article published on 22 November 2006

Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients

scientific article (publication date: December 2008)

Naturally-arising amino acid polymorphisms of HIV-1 Nef that differentially modulate downregulation of HLA-A and HLA-B molecules

article

Nef Proteins from HIV-1 Elite Controllers Are Inefficient at Preventing Antibody-Dependent Cellular Cytotoxicity

scientific article published on 30 December 2015

Nef-mediated down-regulation of CD4 and HLA class I in HIV-1 subtype C infection: association with disease progression and influence of immune pressure

scientific article published on 3 September 2014

Nef-mediated resistance of human immunodeficiency virus type 1 to antiviral cytotoxic T lymphocytes

scientific article published on February 2002

Nef-specific CD8+ T cell responses contribute to HIV-1 immune control

scientific article

Neutralizing antibodies to adenovirus serotype 5 vaccine vectors are directed primarily against the adenovirus hexon protein

scientific article published in June 2005

Non-immunogenicity of overlapping gag peptides pulsed on autologous cells after vaccination of HIV infected individuals ⬇️

scientific article published on 04 October 2013

Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection

scientific article published in September 2016

PD-1 and CTLA-4 inhibitory cosignaling pathways in HIV infection and the potential for therapeutic intervention

scientific article published on May 2009

Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control

scientific article

Persistent low-level viremia in HIV-1 elite controllers and relationship to immunologic parameters

scientific article published in September 2009

Pervasive influence of hepatitis C virus on the phenotype of antiviral CD8+ T cells

scientific article published on February 2004

Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag.

scientific article

Plasma CXCL13 but Not B Cell Frequencies in Acute HIV Infection Predicts Emergence of Cross-Neutralizing Antibodies

scientific article published on 8 September 2017

Polyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV Control

scientific article published on 8 January 2016

Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load

scientific article

Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation

scientific article published on September 2010

Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants

scientific article published on 24 December 2006

Population-Level Immune-Mediated Adaptation in HIV-1 Polymerase during the North American Epidemic

scientific article

Portable flanking sequences modulate CTL epitope processing

scientific article

Possession of HLA class II DRB1*1303 associates with reduced viral loads in chronic HIV-1 clade C and B infection

scientific article

Potent Cell-Intrinsic Immune Responses in Dendritic Cells Facilitate HIV-1-Specific T Cell Immunity in HIV-1 Elite Controllers

scientific article published on 11 June 2015

Preferential CTL targeting of Gag is associated with relative viral control in long-term surviving HIV-1 infected former plasma donors from China

scientific article

Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue

scientific article

Prevalence of HIV-1 drug resistance after failure of a first highly active antiretroviral therapy regimen in KwaZulu Natal, South Africa

scientific article published on May 2008

Programmed death-1 as a factor in immune exhaustion and activation in HIV infection

scientific article published on May 2008

Progress in defining CD4 helper cell responses in chronic viral infections

scientific article published on December 2003

Progression to AIDS in South Africa is associated with both reverting and compensatory viral mutations

scientific article

Progressive reversion of human immunodeficiency virus type 1 resistance mutations in vivo after transmission of a multiply drug-resistant virus

scientific article published on 17 November 2003

Proliferative capacity of epitope-specific CD8 T-cell responses is inversely related to viral load in chronic human immunodeficiency virus type 1 infection

scientific article published on 18 October 2006

Prolonged Antiretroviral Therapy Preserves HIV-1-Specific CD8 T Cells with Stem Cell-Like Properties

scientific article published on 20 May 2015

Promises and pitfalls in the reconstitution of immunity in patients who have HIV-1 infection

scientific article

Prospective monitoring reveals dynamic levels of T cell immunity to Mycobacterium tuberculosis in HIV infected individuals

scientific article

Protective HLA class I alleles that restrict acute-phase CD8+ T-cell responses are associated with viral escape mutations located in highly conserved regions of human immunodeficiency virus type 1.

scientific article

Purification of a modified form of bovine antithrombin III as an HIV-1 CD8+ T-cell antiviral factor

scientific article published on 20 August 2002

Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control

scientific article

Random T-cell receptor recruitment in human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells from genetically identical twins infected with the same HIV-1 strain

scientific article published on 5 September 2007

Rare HLA drive additional HIV evolution compared to more frequent alleles

scientific article published on March 2009

Reactivation of latent HIV-1 by inhibition of BRD4.

scientific article

Recognition of HIV-1 peptides by host CTL is related to HIV-1 similarity to human proteins

scientific article

Recognition of a defined region within p24 gag by CD8+ T cells during primary human immunodeficiency virus type 1 infection in individuals expressing protective HLA class I alleles

scientific article published on 9 May 2007

Reconstitution of virus-specific CD4 proliferative responses in pediatric HIV-1 infection

scientific article published in December 2003

Reduced replication capacity of NL4-3 recombinant viruses encoding reverse transcriptase-integrase sequences from HIV-1 elite controllers

scientific article published on February 2011

Regulatory T cell frequencies do not correlate with breadth or magnitude of HIV-1-specific T cell responses

scientific article published on 5 April 2012

Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences

scientific article

Relative dominance of Env-gp41-specific cytotoxic T lymphocytes responses in HIV-1 advanced infection

scientific article published in May 2008

Relative dominance of Gag p24-specific cytotoxic T lymphocytes is associated with human immunodeficiency virus control

scientific article

Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable

scientific article published on 23 May 2016

Replicative capacity of human immunodeficiency virus type 1 transmitted from mother to child is associated with pediatric disease progression rate

scientific article

Rev activity determines sensitivity of HIV-1-infected primary T cells to CTL killing

scientific article

Role of functional avidity in HIV-specific memory CD8 T cell effector functions.

scientific article published on 25 May 2012

STI and beyond: the prospects of boosting anti-HIV immune responses

scientific article

Saporin-conjugated tetramers identify efficacious anti-HIV CD8+ T-cell specificities

scientific article published on 11 October 2017

Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South Africa

scientific article

Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection

scientific article

Selective depletion of high-avidity human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells after early HIV-1 infection

scientific article published on 7 February 2007

Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution

scientific article

Sensitive population profiling and genome assembly of HIV and Flaviviruses using ultra-deep sequencing technologies.

scientific article published on 11 October 2010

Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

scientific article

Sex Differences in Antiretroviral Therapy Initiation in Pediatric HIV Infection

scientific article published on 7 July 2015

Short communication: CD8(+) T cell polyfunctionality profiles in progressive and nonprogressive pediatric HIV type 1 infection

scientific article published on 21 March 2011

Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes

scientific article

Spontaneous resolution of chronic hepatitis C virus disease after withdrawal of immunosuppression

scientific article published in June 2003

Statistical resolution of ambiguous HLA typing data

scientific article

Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid

scientific article published on 2 April 2008

Structural basis for degenerate recognition of natural HIV peptide variants by cytotoxic lymphocytes

scientific article published on 15 May 2006

T cell failure in hepatitis C virus infection

scientific article

T cell receptor cross-recognition of an HIV-1 CD8+ T cell epitope presented by closely related alleles from the HLA-A3 superfamily

article

T cell receptors for the HIV KK10 epitope from patients with differential immunologic control are functionally indistinguishable

scientific article published on 7 February 2018

TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection

scientific article published on 10 June 2012

Telomerase activity of HIV-1-specific CD8+ T cells: constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressors

scientific article published on 26 August 2008

Temporal effect of HLA-B*57 on viral control during primary HIV-1 infection

scientific article

The ?1030/?862-linked TNF promoter single-nucleotide polymorphisms are associated with the inability to control HIV-1 viremia

article

The Breadth of Expandable Memory CD8+ T Cells Inversely Correlates with Residual Viral Loads in HIV Elite Controllers

scientific article

The Duffy antigen receptor for chemokines null promoter variant does not influence HIV-1 acquisition or disease progression

scientific article

The challenges of host and viral diversity in HIV vaccine design

scientific article published on 13 June 2006

The complex and specific pMHC interactions with diverse HIV-1 TCR clonotypes reveal a structural basis for alterations in CTL function

scientific article published on 13 February 2014

The fitness landscape of HIV-1 gag: advanced modeling approaches and validation of model predictions by in vitro testing

scientific article

The immune response to AIDS virus infection: good, bad, or both?

scientific article published on March 2004

The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1.

scientific article published on 30 September 2004

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation

scientific article

The majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: implications for vaccine design

scientific article

The paradox of incomplete CD4+ cell count restoration despite successful antiretroviral treatment and the need to start highly active antiretroviral therapy early

scientific article published in March 2009

The role of IFN-gamma Elispot assay in HIV vaccine research

scientific article published on January 2009

Therapeutic vaccines against HIV need international partnerships

scientific article

Tolerability and efficacy of PI versus NNRTI-based regimens in subjects receiving HAART during acute or early HIV infection

scientific article

Toward an AIDS vaccine

scientific article

Tracking the culprit: HIV-1 evolution and immune selection revealed by single-genome amplification

scientific article published on June 2009

Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF

scientific article published on 3 October 2010

Translating HIV sequences into quantitative fitness landscapes predicts viral vulnerabilities for rational immunogen design

scientific article

Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA.

scientific article

Transmission and long-term stability of compensated CD8 escape mutations

scientific article published on 17 December 2008

Tuberculosis distorts the inhibitory impact of interleukin-10 in HIV infection

scientific article

Type 2 Bias of T cells expanded from the blood of melanoma patients switched to type 1 by IL-12p70 mRNA-transfected dendritic cells

scientific article published in November 2008

Uncommon pathways of immune escape attenuate HIV-1 integrase replication capacity

scientific article

Unravelling the mechanisms of durable control of HIV-1.

scientific article published on July 2013

Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction

scientific article

Use of a novel GFP reporter cell line to examine replication capacity of CXCR4- and CCR5-tropic HIV-1 by flow cytometry

scientific article

Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117.

scientific article published on 08 April 2015

Viral control in chronic HIV-1 subtype C infection is associated with enrichment of p24 IgG1 with Fc effector activity

scientific article published on 3 April 2018

Viral immunology. Comprehensive serological profiling of human populations using a synthetic human virome

scientific article

Virus-driven Inflammation Is Associated With the Development of bNAbs in Spontaneous Controllers of HIV.

scientific article published on 3 February 2017

Whole genome deep sequencing of HIV-1 reveals the impact of early minor variants upon immune recognition during acute infection

scientific article published on 8 March 2012

Widespread impact of HLA restriction on immune control and escape pathways of HIV-1

scientific article published on 29 February 2012

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