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List of works by Thomas A. Wynn

A Crucial Role for the Vitamin D Receptor in Experimental Inflammatory Bowel Diseases ⬇️

scientific article published on September 18, 2003

A Trypanosoma brucei kinesin heavy chain promotes parasite growth by triggering host arginase activity

scientific article

Accelerated and progressive and lethal liver fibrosis in mice that lack interleukin (IL)-10, IL-12p40, and IL-13Rα2.

scientific article

Acidic chitinase primes the protective immune response to gastrointestinal nematodes

scientific article published on 04 April 2016

An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection

scientific article published on 15 January 2012

Anti-IL-13Rα2 therapy promotes recovery in a murine model of inflammatory bowel disease

scientific article published on 15 July 2019

Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis

scientific article

Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent

scientific article

Blood fluke exploitation of non-cognate CD4+ T cell help to facilitate parasite development.

scientific article

CD4+ T Cell–mediated Granulomatous Pathology in Schistosomiasis Is Downregulated by a B Cell–dependent Mechanism Requiring Fc Receptor Signaling ⬇️

scientific article published on February 16, 1998

Cationic amino acid transporter-2 regulates immunity by modulating arginase activity

scientific article

Chitinase Dependent Control of Protozoan Cyst Burden in the Brain ⬇️

scientific article published on November 29, 2012

Colitis and intestinal inflammation in IL10-/- mice results from IL-13Rα2-mediated attenuation of IL-13 activity.

scientific article

Combinatorial targeting of TSLP, IL-25, and IL-33 in type 2 cytokine-driven inflammation and fibrosis

scientific article published on May 2016

Conventional NK cells can produce IL-22 and promote host defense in Klebsiella pneumoniae pneumonia

scientific article published on 17 January 2014

Critical role of IL-25 in nematode infection-induced alterations in intestinal function.

scientific article

Cutting Edge: Eosinophils Undergo Caspase-1-Mediated Pyroptosis in Response to Necrotic Liver Cells

scientific article published on 26 June 2017

Cytokines as determinants of disease and disease interactions ⬇️

scientific article published on January 1, 1998

Differences in expression, affinity, and function of soluble (s)IL-4Ralpha and sIL-13Ralpha2 suggest opposite effects on allergic responses

scientific article published on 01 November 2007

Failure of P strain mice to respond to vaccination against schistosomiasis correlates with impaired production of IL-12 and up-regulation of Th2 cytokines that inhibit macrophage activation ⬇️

scientific article published on June 1, 1998

Fibroblast-specific integrin-alpha V differentially regulates type 17 and type 2 driven inflammation and fibrosis

scientific article published on 24 January 2019

Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages

scientific article published on 3 February 2011

Fibrosis: from mechanisms to medicines

scientific article published on 25 November 2020

Functional importance of regional differences in localized gene expression of receptors for IL-13 in murine gut.

scientific article published on January 2006

Gene microarray analysis reveals interleukin-5-dependent transcriptional targets in mouse bone marrow.

scientific article published on 02 October 2003

Genetic deletion of IL-25 (IL-17E) confers resistance to dextran sulfate sodium-induced colitis in mice

scientific article published on 26 November 2014

Global gene expression profiles during acute pathogen-induced pulmonary inflammation reveal divergent roles for Th1 and Th2 responses in tissue repair

scientific article published on 01 October 2003

Heat shock protein 70 is a positive regulator of airway inflammation and goblet cell hyperplasia in a mouse model of allergic airway inflammation

scientific article published on 20 August 2019

Host responses in tissue repair and fibrosis ⬇️

scientific article published on October 22, 2012

IL-10 and TGF-beta control the establishment of persistent and transmissible infections produced by Leishmania tropica in C57BL/6 mice

scientific article published in March 2008

IL-10 blocks the development of resistance to re-infection with Schistosoma mansoni

scientific article

IL-10 is critical for host resistance and survival during gastrointestinal helminth infection.

scientific article published on March 2002

IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent

scientific article published in September 2004

IL-13 receptor alpha 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasis

scientific article

IL-13 receptor alpha2 regulates the immune and functional response to Nippostrongylus brasiliensis infection

scientific article

IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice

scientific article

IL-25 or IL-17E Protects against High-Fat Diet-Induced Hepatic Steatosis in Mice Dependent upon IL-13 Activation of STAT6.

scientific article

IL-33-induced alterations in murine intestinal function and cytokine responses are MyD88, STAT6, and IL-13 dependent

scientific article published on 20 December 2012

Immunopathogenesis of schistosomiasis

scientific article published in October 2004

Immunopathology of schistosomiasis

scientific article

Inflammation and metabolism in tissue repair and regeneration.

scientific article

Integrating mechanisms of pulmonary fibrosis ⬇️

scientific article published on July 4, 2011

Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interferon gamma-induced activation ⬇️

scientific article published on September 15, 1992

Interleukin-13 Receptor α1-Dependent Responses in the Intestine Are Critical to Parasite Clearance

scientific article published on 25 January 2016

Interleukin-5 does not influence differential transcription of transmembrane and soluble isoforms of IL-5R alpha in vivo.

scientific article

Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): A tale of two waters ⬇️

scientific article published on April 13, 2012

Macrophage activation governs schistosomiasis-induced inflammation and fibrosis

scientific article

Macrophages as IL-25/IL-33-responsive cells play an important role in the induction of type 2 immunity

scientific article

Macrophages: master regulators of inflammation and fibrosis

scientific article

Mapping mouse IL-13 binding regions using structure modeling, molecular docking, and high-density peptide microarray analysis

scientific article

Matrix metalloproteinase 12-deficiency augments extracellular matrix degrading metalloproteinases and attenuates IL-13-dependent fibrosis

scientific article

Molecular mimicry between cockroach and helminth glutathione S-transferases promotes cross-reactivity and cross-sensitization ⬇️

scientific article published on April 25, 2012

Muc5ac: a critical component mediating the rejection of enteric nematodes ⬇️

scientific article

Obstacles and opportunities for understanding macrophage polarization

scientific article

Opposing roles for IL-13 and IL-13 receptor alpha 2 in health and disease

scientific article

P-selectin suppresses hepatic inflammation and fibrosis in mice by regulating interferon gamma and the IL-13 decoy receptor

scientific article published in March 2004

Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils ⬇️

scientific article published on October 19, 2011

Plasminogen activator inhibitor-2 (PAI-2) in eosinophilic leukocytes

scientific article published on 26 July 2004

Protective and pathogenic functions of macrophage subsets ⬇️

scientific article (publication date: 14 October 2011)

Quantitative assessment of macrophage functions in repair and fibrosis

scientific article

RGS16 attenuates pulmonary Th2/Th17 inflammatory responses

scientific article

Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids

scientific article

Regional differences in human biliary tissues and corresponding in vitro derived organoids

scientific article published on 29 March 2020

Regulation of helminth-induced Th2 responses by thymic stromal lymphopoietin ⬇️

scientific article published on May 2009

Regulation of pathogenesis and immunity in helminth infections

scientific article published on 21 September 2009

Repetitive Intradermal Bleomycin Injections Evokes T Helper Cell 2 Cytokine-driven Pulmonary Fibrosis

scientific article

Retnla (relmalpha/fizz1) suppresses helminth-induced Th2-type immunity

scientific article

Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity.

scientific article published on 06 August 2008

Schistosoma mansoni infection in eosinophil lineage-ablated mice

scientific article published on 13 June 2006

Shedding LIGHT on severe asthma

scientific article published on May 2011

Strain-dependent genomic factors affect allergen-induced airway hyperresponsiveness in mice

scientific article published on 4 March 2011

Suppression of murine allergic airway disease by IL-2:anti-IL-2 monoclonal antibody-induced regulatory T cells

scientific article

TNF-alpha differentially regulates Ia antigen expression and macrophage tumoricidal activity in two murine macrophage cell lines

scientific article published on March 1, 1992

Th2 cytokine-induced alterations in intestinal smooth muscle function depend on alternatively activated macrophages

scientific article

The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation

scientific article published on February 2009

The debate over the effector function of eosinophils in helminth infection: new evidence from studies on the regulation of vaccine immunity by IL-12 ⬇️

scientific article published on January 1, 1997

The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells

scientific article published in March 2004

Type 2 immunity is protective in metabolic disease but exacerbates NAFLD collaboratively with TGF-β.

scientific article published on June 2017

Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain

scientific article published on 09 December 2007

miR-182 and miR-10a are key regulators of Treg specialisation and stability during Schistosome and Leishmania-associated inflammation

scientific article

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