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List of works by Siddharthan Chandran

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Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study

scientific article published on 10 January 2012
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability

scientific article published on 26 March 2012
Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.

scientific article
Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

scientific article published on 25 July 2016
Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability

scientific article
Modeling ALS with motor neurons derived from human induced pluripotent stem cells

scientific article
Improving the translational hit of experimental treatments in multiple sclerosis

scientific article published on 04 August 2010
Prevalence and natural history of pain in adults with multiple sclerosis: systematic review and meta-analysis

scientific article
Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.

scientific article
Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

scientific article
The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments

scientific article
Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity

scientific article
Validation of the Edinburgh Cognitive and Behavioural Amyotrophic Lateral Sclerosis Screen (ECAS): A cognitive tool for motor disorders.

scientific article published on 12 May 2015
C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity

scientific article
Drug repurposing: a systematic approach to evaluate candidate oral neuroprotective interventions for secondary progressive multiple sclerosis

scientific article
Multidimensional apathy in ALS: validation of the Dimensional Apathy Scale.

scientific article published on 22 July 2015
Adaptive preconditioning in neurological diseases – therapeutic insights from proteostatic perturbations

scientific article
Maturation of AMPAR composition and the GABAAR reversal potential in hPSC-derived cortical neurons

scientific article published on March 2014
Human stem cell-derived astrocytes replicate human prions in a PRNP genotype-dependent manner

scientific article published on 15 November 2017
Maturation and electrophysiological properties of human pluripotent stem cell-derived oligodendrocytes

scientific article published on 13 January 2016
Evidence for abnormal tau phosphorylation in early aggressive multiple sclerosis

scientific article published on 14 March 2009
Human stem cell-derived neurons: a system to study human tau function and dysfunction

scientific article
Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis

scientific article published on 22 December 2017
Functional properties of in vitro excitatory cortical neurons derived from human pluripotent stem cells.

scientific article
Hypothermic Preconditioning of Human Cortical Neurons Requires Proteostatic Priming

scientific article
ALS-specific cognitive and behavior changes associated with advancing disease stage in ALS

scientific article published on 12 September 2018
Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons

scientific article published on October 2016
Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial (MS-SMART): a multiarm phase IIb randomised, double-blind, placebo-controlled clinical trial comparing the efficacy of three neuroprotective drugs in secondary progressive multipl

article by Peter Connick et al published 30 August 2018 in BMJ Open
Ionotropic GABA and glycine receptor subunit composition in human pluripotent stem cell-derived excitatory cortical neurones

scientific article
Genetic epidemiology of motor neuron disease-associated variants in the Scottish population

scientific article published on 21 December 2016
Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism

scientific article published on 13 July 2018
Multidimensional apathy and executive dysfunction in amyotrophic lateral sclerosis.

scientific article
Abnormal tau phosphorylation in primary progressive multiple sclerosis

scientific article published on 21 March 2010
Real-time quantitative monitoring of hiPSC-based model of macular degeneration on Electric Cell-substrate Impedance Sensing microelectrodes.

scientific article published on 25 April 2015
Chorioretinal thinning in chronic kidney disease links to inflammation and endothelial dysfunction.

scientific article published on 08 December 2016
The clinico-radiological paradox of cognitive function and MRI burden of white matter lesions in people with multiple sclerosis: A systematic review and meta-analysis

scientific article
Management of sialorrhoea in motor neuron disease: a survey of current UK practice.

scientific article published on 07 May 2013
Reversal of proliferation deficits caused by chromosome 16p13.11 microduplication through targeting NFκB signaling: an integrated study of patient-derived neuronal precursor cells, cerebral organoids and in vivo brain imaging

July 2017 ENCALS statement on edaravone

scientific article
Lateral thinking - Interocular symmetry and asymmetry in neurovascular patterning, in health and disease.

scientific article published on 27 April 2017
Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells".

scientific article published on June 2013
Modeling the C9ORF72 repeat expansion mutation using human induced pluripotent stem cells

scientific article published on July 2017
Siddharthan Chandran: Can the damaged brain repair itself?

TEDGlobal 2013
A multicentre evaluation of oropharyngeal secretion management practices in amyotrophic lateral sclerosis

scientific article published on 31 August 2016
Characterisation of tissue-type metabolic content in secondary progressive multiple sclerosis: a magnetic resonance spectroscopic imaging study

scientific article published on 30 May 2018
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

scholarly article
Hypothermic Preconditioning Reverses Tau Ontogenesis in Human Cortical Neurons and is Mimicked by Protein Phosphatase 2A Inhibition

scientific article published on 12 December 2015
DISC1 regulates N-methyl-D-aspartate receptor dynamics: abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness

scientific article published on 06 September 2018
Mesenchymal stromal cell transplantation modulates neuroinflammatory milieu in amyotrophic lateral sclerosis

scientific article published on August 1, 2014
Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72 -ALS iPSC-derived microglia contributes to neurodegeneration

scientific article published on 21 April 2023

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