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List of works by Jay Bradner

A novel β-catenin/BCL9 complex inhibitor blocks oncogenic Wnt signaling and disrupts cholesterol homeostasis in colorectal cancer

scientific article published on 29 April 2022

Assessment of Bromodomain Target Engagement by a Series of BI2536 Analogues with Miniaturized BET-BRET.

scientific article

BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure

scientific article

Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands.

scientific article published on 18 April 2017

Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma.

scientific article published on 29 January 2018

Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation

scientific article published on 07 May 2020

Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands

scientific article published on 5 March 2018

HIF activation causes synthetic lethality between the VHL tumor suppressor and the EZH1 histone methyltransferase.

scientific article published in July 2017

High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program

scientific article published on 25 September 2019

Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma.

scientific article

Inhibition of Polo-like kinase 1 (PLK1) facilitates the elimination of HIV-1 viral reservoirs in CD4+ T cells ex vivo

scientific article published on 15 July 2020

Jay Bradner: Open-source cancer research

TEDxBoston 2011

MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation

scientific article published on 27 May 2019

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

scientific article published on 03 June 2019

PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma

scientific article published on 20 August 2019

Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.

scientific article

Plasticity in binding confers selectivity in ligand-induced protein degradation

scientific article published on 11 June 2018

Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules

scientific article published on 18 September 2020

Selective Mediator dependence of cell-type-specifying transcription

scientific article published on 01 June 2020

Selective targeting of MYC mRNA by stabilized antisense oligonucleotides

scientific article published on 14 October 2021

Small-molecule targeting of brachyury transcription factor addiction in chordoma

scientific article published on 21 January 2019

Structure-Guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitors

scientific article published on 30 August 2018

Synthetic transcription elongation factors license transcription across repressive chromatin

scientific article

Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors

scientific article published on 4 January 2018

The dTAG system for immediate and target-specific protein degradation.

scientific article published on 26 March 2018

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