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List of works by Steven Rosenberg

'Final common pathway' of human cancer immunotherapy: targeting random somatic mutations.

scientific article published on February 2017

2D TCR-pMHC-CD8 kinetics determines T-cell responses in a self-antigen-specific TCR system.

scientific article published on 20 October 2013

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

scientific article (publication date: November 2016)

A High-avidity WT1-reactive T-Cell Receptor Mediates Recognition of Peptide and Processed Antigen but not Naturally Occurring WT1-positive Tumor Cells

scientific article published on March 2016

A Phase I study of an HLA-DPB1*0401-restricted T cell receptor targeting MAGE-A3 for patients with metastatic cancers

scientific article published on 4 November 2015

A Phase II Study of Tumor-infiltrating Lymphocyte Therapy for Human Papillomavirus-associated Epithelial Cancers

scientific article published on 05 December 2018

A Pilot Trial of the Combination of Vemurafenib with Adoptive Cell Therapy in Patients with Metastatic Melanoma

scientific article published on 7 October 2016

A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial Evaluating the Effect of Nystatin on the Development of Oral Irritation in Patients Receiving High-Dose Intravenous Interleukin-2

A Rapid Cell Expansion Process for Production of Engineered Autologous CAR-T Cell Therapies.

scientific article published on 29 November 2016

A TCR targeting the HLA-A*0201-restricted epitope of MAGE-A3 recognizes multiple epitopes of the MAGE-A antigen superfamily in several types of cancer.

scientific article published on 13 December 2010

A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity

scientific article published on November 2009

A high molecular weight melanoma-associated antigen-specific chimeric antigen receptor redirects lymphocytes to target human melanomas

scientific article published on April 2010

A highly recurrent RPS27 5'UTR mutation in melanoma

scientific article

A large scale method of separating multiple lymphokines secreted by the murine EL-4 thymoma

scientific article published on 01 January 1985

A mutated beta-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes

scientific article

A new approach to the therapy of cancer based on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2

scientific article published on 01 August 1986

A novel chimeric antigen receptor against prostate stem cell antigen mediates tumor destruction in a humanized mouse model of pancreatic cancer.

scientific article

A novel murine T-cell receptor targeting NY-ESO-1.

scientific article published on April 2014

A phase I study of nonmyeloablative chemotherapy and adoptive transfer of autologous tumor antigen-specific T lymphocytes in patients with metastatic melanoma

scientific article

A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer

scientific article

A pilot study of antiangiogenic therapy with bevacizumab and thalidomide in patients with metastatic renal cell carcinoma

scientific article published on July 2004

A pilot study of the combination of interleukin-2-based immunotherapy and radiation therapy

scientific article published on 01 November 1992

A pilot trial using lymphocytes genetically engineered with an NY-ESO-1-reactive T-cell receptor: long-term follow-up and correlates with response

scientific article

A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone

scientific article published on 01 April 1987

A prospective analysis of positron emission tomography and conventional imaging for detection of stage IV metastatic melanoma in patients undergoing metastasectomy

scientific article

A prospective randomized trial evaluating colloid versus crystalloid resuscitation in the treatment of the vascular leak syndrome associated with interleukin-2 therapy

scientific article published on 01 January 1994

A prospective, randomized, double-blind, placebo-controlled trial evaluating the effect of nystatin on the development of oral irritation in patients receiving high-dose intravenous interleukin-2

scientific article published on 01 March 2001

A randomized double-blinded comparison of the antiemetic efficacy of ondansetron and droperidol in patients receiving high-dose interleukin-2.

scientific article

A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer

scientific article published on July 2003

A simple and effective method to generate lentiviral vectors for ex vivo gene delivery to mature human peripheral blood lymphocytes

scientific article published on 19 April 2012

A simplified method for the clinical-scale generation of central memory-like CD8+ T cells after transduction with lentiviral vectors encoding antitumor antigen T-cell receptors

scientific article

A summary of the results of a review of 405 patients with non-Hodgkin's lymphoma at Stanford University ⬇️

scientific article published on March 1, 1975

A tumor-infiltrating lymphocyte from a melanoma metastasis with decreased expression of melanoma differentiation antigens recognizes MAGE-12.

scientific article

Acquired erythropoietin responsiveness of interleukin-2-dependent T lymphocytes retrovirally transduced with genes encoding chimeric erythropoietin/interleukin-2 receptors ⬇️

scientific article published on September 15, 1995

Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

scientific article

Acute and long-term effects on limb function of combined modality limb sparing therapy for extremity soft tissue sarcoma

scientific article

Administration of a CD25-directed immunotoxin, LMB-2, to patients with metastatic melanoma induces a selective partial reduction in regulatory T cells in vivo

scientific article

Adoptive Cell Therapy--Tumor-Infiltrating Lymphocytes, T-Cell Receptors, and Chimeric Antigen Receptors.

scientific article published on 12 June 2015

Adoptive Transfer of Autologous Natural Killer Cells Leads to High Levels of Circulating Natural Killer Cells but Does Not Mediate Tumor Regression ⬇️

scientific article published on August 15, 2011

Adoptive cell therapy for patients with melanoma, using tumor-infiltrating lymphocytes genetically engineered to secrete interleukin-2.

scientific article published on May 2008

Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens

scientific article

Adoptive cell therapy for the treatment of patients with metastatic melanoma

scientific article

Adoptive cell therapy: genetic modification to redirect effector cell specificity.

scientific article published on July 2010

Adoptive cell transfer as personalized immunotherapy for human cancer

scientific article published in April 2015

Adoptive cell transfer for patients with metastatic melanoma: the potential and promise of cancer immunotherapy.

scientific article published on October 2013

Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma

scientific article

Adoptive cell transfer: a clinical path to effective cancer immunotherapy

scientific article

Adoptive immunotherapy for cancer: building on success

scientific article

Adoptive immunotherapy for cancer: harnessing the T cell response

scientific article

Adoptive immunotherapy of a newly induced sarcoma: immunologic characteristics of effector cells

scientific article published on 01 October 1985

Adoptive immunotherapy of a syngeneic murine leukemia with a tumor-specific cytotoxic T cell clone and recombinant human interleukin 2: correlation with clonal IL 2 receptor expression

scientific article

Adoptive immunotherapy of established syngeneic solid tumors: role of T lymphoid subpopulations

scientific article published on 01 April 1984

Adoptive immunotherapy of murine hepatic metastases with lymphokine activated killer (LAK) cells and recombinant interleukin 2 (RIL 2) can mediate the regression of both immunogenic and nonimmunogenic sarcomas and an adenocarcinoma

scientific article published on 01 December 1985

Adoptive immunotherapy of renal cell carcinoma: studies from the Surgery Branch, National Cancer Institute

scientific article

Adoptive transfer of allogeneic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers.

scientific article published on 17 September 2008

Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells

scientific article

Adoptive transfer of tumor infiltrating lymphocytes for metastatic cervical cancer

scientific article published on 7 November 2013

Adoptive transfer of vaccine-induced peripheral blood mononuclear cells to patients with metastatic melanoma following lymphodepletion

scientific article

Adoptive-cell-transfer therapy for the treatment of patients with cancer

scientific article

Adoptively Transferred Tumor-Infiltrating Lymphocytes Can Cure Established Metastatic Tumor in Mice and Persist Long-Term In Vivo as Functional Memory T Lymphocytes ⬇️

scientific article published on December 1, 1991

Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity.

scientific article published on 24 September 2009

Adoptively transferred tumor-infiltrating T cells target somatic cancer mutations in a human papillomavirus+ cancer patient with complete tumor regression

scientific article published on 4 November 2015

Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics.

scientific article

Allogeneic T Cells That Express an Anti-CD19 Chimeric Antigen Receptor Induce Remissions of B-Cell Malignancies That Progress After Allogeneic Hematopoietic Stem-Cell Transplantation Without Causing Graft-Versus-Host Disease

scientific article published on 25 January 2016

Altered CD8(+) T-cell responses when immunizing with multiepitope peptide vaccines

scientific article

Alternating chemotherapy and irradiation in the treatment of advanced Hodgkin's disease ⬇️

scientific article published on February 1, 1979

An Efficient Single-Cell RNA-Seq Approach to Identify Neoantigen-Specific T Cell Receptors.

scientific article published on 28 October 2017

An antigenic peptide produced by reverse splicing and double asparagine deamidation ⬇️

scientific article published on June 13, 2011

An improved method for growing murine tumor-infiltrating lymphocytes with in vivo antitumor activity

scientific article published in April 1990

An ongoing prospective randomized comparison of interleukin-2 regimens for the treatment of metastatic renal cell cancer

scientific article published on December 1, 1997

Analysis of cytokine secretion by melanoma-specific CD4+ T lymphocytes

scientific article published on 01 August 1995

Analysis of expression of the melanoma-associated antigens MART-1 and gp100 in metastatic melanoma cell lines and in in situ lesions.

scientific article published on May 1996

Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade

scientific article

Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma

scientific article

Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma

scientific article published on 29 March 2009

Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4.

scientific article

Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer

scientific article

Antibody-dependent cellular cytotoxicity mediated by murine lymphocytes activated in recombinant interleukin 2

scientific article published on 01 March 1987

Antigen Experienced T Cells from Peripheral Blood Recognize p53 Neoantigens

scientific article published on 29 January 2020

Antigen-specific tumor vaccines. Development and characterization of recombinant adenoviruses encoding MART1 or gp100 for cancer therapy.

scientific article

Antitumor effects in mice of the intravenous injection of attenuated Salmonella typhimurium

scientific article published on May 2002

Antitumor efficacy of lymphokine-activated killer cells and recombinant interleukin 2 in vivo: successful immunotherapy of established pulmonary metastases from weakly immunogenic and nonimmunogenic murine tumors of three district histological types

scientific article published on 01 October 1986

Antitumor efficacy of lymphokine-activated killer cells and recombinant interleukin-2 in vivo: survival benefit and mechanisms of tumor escape in mice undergoing immunotherapy.

scientific article published in February 1986

Assessment of Ovarian Function After Preparative Chemotherapy and Total Body Radiation for Adoptive Cell Therapy ⬇️

scientific article published on May 1, 2011

Audiovestibular Dysfunction Associated with Adoptive Cell Immunotherapy for Melanoma ⬇️

scientific article published on May 17, 2012

Augmentation of antitumor efficacy by the combination of recombinant tumor necrosis factor and chemotherapeutic agents in vivo

scientific article published on 01 July 1989

Augmented lymphocyte expansion from solid tumors with engineered cells for costimulatory enhancement ⬇️

scientific article

Author Correction: Combined inhibition of MEK and nuclear ERK translocation has synergistic antitumor activity in melanoma cells

scientific article published on 12 March 2019

Author Correction: RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells

scientific article published on 09 March 2019

Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4.

scientific article

B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor–transduced T cells ⬇️

scientific article (publication date: 22 March 2012)

BRAF Inhibition: Bridge or Boost to T-cell Therapy?

scientific article published on 01 March 2019

Bcl-2 overexpression enhances tumor-specific T-cell survival

scientific article

Bedside to bench and back again: how animal models are guiding the development of new immunotherapies for cancer

scientific article

Biological and antitumor effects of recombinant human macrophage colony-stimulating factor in mice

scientific article published on May 1991

Both CD4 and CD8 T cells mediate equally effective in vivo tumor treatment when engineered with a highly avid TCR targeting tyrosinase.

scientific article published on 28 April 2010

CARs on track in the clinic

scientific article

CD4+ T-cells from mice immunized to syngeneic sarcomas recognize distinct, non-shared tumor antigens

scientific article published on 01 February 1994

CD8+ Enriched “Young” Tumor Infiltrating Lymphocytes Can Mediate Regression of Metastatic Melanoma ⬇️

scientific article published on July 28, 2010

CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells.

scientific article

CEPP(B): an effective and well-tolerated regimen in poor-risk, aggressive non-Hodgkin's lymphoma

scientific article published on 01 October 1990

CTLA-4 Blockade with Ipilimumab: Long-term Follow-up of 177 Patients with Metastatic Melanoma ⬇️

scientific article published on January 23, 2012

CTLA-4 dysregulation of self/tumor-reactive CD8+ T-cell function is CD4+ T-cell dependent.

scientific article

Calcium ionophore-treated peripheral blood monocytes and dendritic cells rapidly display characteristics of activated dendritic cells ⬇️

scientific article published on October 15, 1997

Cancer immunotherapy

scientific article published on 01 September 2008

Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer

scientific article published in Science

Cancer immunotherapy using interleukin-2 and interleukin-2-activated lymphocytes

scientific article

Cancer immunotherapy: moving beyond current vaccines

scientific article

Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes

scientific article

Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

scientific article

Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy

scientific article published on February 2013

Cancer regression in patients after transfer of genetically engineered lymphocytes

scientific article

Cancer regression in patients with metastatic melanoma after the transfer of autologous antitumor lymphocytes

scholarly article

Cell transfer therapy for cancer: lessons from sequential treatments of a patient with metastatic melanoma

scientific article published on September 2003

Cellular immunotherapy of cancer

scientific article published on 01 February 1990

Cellular mechanisms of the antitumor activity of recombinant IL-6 in mice ⬇️

scientific article published on April 15, 1992

Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells

scientific article

Characterization of Lymphocytes Infiltrating Human Breast Cancer, Specific Immune Reactivity Detected by Measuring Cytokine Secretion ⬇️

scientific article published on July 1, 1992

Characterization of Postsplenectomy Bacteremia among Patients with and without Lymphoma ⬇️

scientific article published on July 13, 1972

Characterization of T-cell Receptors Directed Against HLA-A*01-restricted and C*07-restricted Epitopes of MAGE-A3 and MAGE-A12 ⬇️

scientific article published on November 1, 2012

Characterization of an Immunogenic Mutation in a Patient with Metastatic Triple-Negative Breast Cancer.

scientific article published on 4 April 2017

Characterization of genetically modified T-cell receptors that recognize the CEA:691-699 peptide in the context of HLA-A2.1 on human colorectal cancer cells

scientific article

Characterization of human tumor cell lines transduced with the cDNA encoding either tumor necrosis factor alpha (TNF-a) or interleukin-2 (IL-2).

scientific article published on May 1993

Characterization of the functional specificity of a cloned T-cell receptor heterodimer recognizing the MART-1 melanoma antigen.

scientific article published on February 1995

Characterization of the lysis of fresh human solid tumors by autologous lymphocytes activated in vitro with phytohemagglutinin

scientific article published on 01 February 1983

Chemotherapy of the non-Hodgkin's lymphomas: the Stanford experience

scientific article published on September 1, 1977

Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor

scientific article

Circulating IL-15 exists as heterodimeric complex with soluble IL-15Rα in human and mouse serum ⬇️

scientific article published on April 10, 2012

Circulating Tumor DNA as an Early Indicator of Response to T-cell Transfer Immunotherapy in Metastatic Melanoma

scientific article published on August 2016

Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma.

scientific article published on 5 May 2015

Clinical and surgical (laparotomy) evaluation of patients with non-Hodgkin's lymphomas

scientific article published on 01 September 1977

Clinical scale rapid expansion of lymphocytes for adoptive cell transfer therapy in the WAVE® bioreactor

scientific article

Clinical scale zinc finger nuclease (ZFN)-driven gene-editing of PD-1 in tumor infiltrating lymphocytes (TIL) for the potential treatment of metastatic melanoma.

scientific article published on 6 November 2014

Clinical trials in the non-Hodgkin's lymphomata at Stanford University experimental design and preliminary results ⬇️

scientific article published on March 1, 1975

Clinical trials with IL-2

scientific article published on 01 November 1986

Clinical-scale lentiviral vector transduction of PBL for TCR gene therapy and potential for expression in less-differentiated cells

scientific article

Collapse of the tumor stroma is triggered by IL-12 induction of Fas.

scientific article published on 09 April 2013

Combination chemotherapy and radiotherapy for Hodgkin's disease ⬇️

scientific article published on December 1, 1972

Combination cytokine immunotherapy with tumor necrosis factor alpha, interleukin 2, and alpha-interferon and its synergistic antitumor effects in mice

scientific article published on 01 March 1989

Combination therapy with interferon-gamma and interleukin-2 for the treatment of metastatic melanoma

scientific article published on 01 January 1996

Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma

article

Combined effects of chemotherapy and interleukin 2 in the therapy of mice with advanced pulmonary tumors

scientific article published on 01 January 1988

Combined inhibition of MEK and nuclear ERK translocation has synergistic antitumor activity in melanoma cells.

scientific article published on 27 November 2017

Combined modality therapy in malignant lymphomas

scientific article published on September 1, 1977

Combined modality therapy of Hodgkin's disease.A report on the stanford trials ⬇️

scientific article published on August 1, 1978

Common expression of melanoma tumor-associated antigens recognized by human tumor infiltrating lymphocytes: analysis by human lymphocyte antigen restriction

scientific article published on June 1991

Comparative exome sequencing of metastatic lesions provides insights into the mutational progression of melanoma ⬇️

scientific article published on September 24, 2012

Comparative studies of the long-term growth of lymphocytes from tumor infiltrates, tumor-draining lymph nodes, and peripheral blood by repeated in vitro stimulation with autologous tumor

scientific article published on 01 August 1990

Comparison between conventional salvage therapy and high-dose therapy with autografting for recurrent or refractory Hodgkin's disease

scientific article published on 01 February 1997

Comparison of common gamma-chain cytokines, interleukin-2, interleukin-7, and interleukin-15 for the in vitro generation of human tumor-reactive T lymphocytes for adoptive cell transfer therapy

scientific article published on May 2006

Complete regression of metastatic cervical cancer after treatment with human papillomavirus-targeted tumor-infiltrating T cells.

scientific article published on 30 March 2015

Computed tomography, lymphography, and staging laparotomy: correlations in initial staging of Hodgkin disease

scientific article published on 01 July 1984

Considerations for the Clinical Application of Chimeric Antigen Receptor T Cells: Observations from aRecombinant DNA Advisory Committee SymposiumHeld June 15, 2010 ⬇️

scientific article published on May 1, 2011

Construction and preclinical evaluation of an anti-CD19 chimeric antigen receptor

scientific article published on September 2009

Continuous intravenous administration of live genetically modified salmonella typhimurium in patients with metastatic melanoma

scientific article published in March 2003

Correlates of response to IL-2 therapy in patients treated for metastatic renal cancer and melanoma.

scientific article

Curative intravenous adoptive immunotherapy of Meth A murine sarcoma. A histologic and immunohistochemical assessment.

scientific article

Cutting edge: persistence of transferred lymphocyte clonotypes correlates with cancer regression in patients receiving cell transfer therapy

scientific article

Cytokine regulation of tumor necrosis factor-alpha and -beta (lymphotoxin)-messenger RNA expression in human peripheral blood mononuclear cells

scientific article published on 01 August 1990

Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene

scientific article published on 12 March 2007

Cytokines alter target cell susceptibility to lysis. II. Evaluation of tumor infiltrating lymphocytes

scientific article published on 01 March 1989

Cytokines alter target cell susceptibility to lysis: I. Evaluation of non-major histocompatibility complex-restricted effectors reveals differential effects on natural and lymphokine-activated killing

scientific article published in April 1990

Cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma: a new cause of uveitis

article

Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer

scientific article

Decrease in interleukin 2-induced vascular leakage in the lungs of mice by administration of recombinant interleukin 1 alpha in vivo

scientific article published on 01 February 1989

Defining best practices for tissue procurement in immuno-oncology clinical trials: consensus statement from the Society for Immunotherapy of Cancer Surgery Committee

scientific article published on 01 November 2020

Delata-9-tetrahydrocannabinol as an antiemetic in cancer patients receiving high-dose methotrexate. A prospective, randomized evaluation

scientific article published on December 1979

Delayed reactions to contrast media after interleukin-2 immunotherapy

scientific article published on April 1, 1992

Dendritic Cells Retrovirally Transduced with a Model Antigen Gene Are Therapeutically Effective against Established Pulmonary Metastases ⬇️

scientific article published on October 20, 1997

Determinants of successful CD8+ T-cell adoptive immunotherapy for large established tumors in mice

scientific article

Development of Human Anti-Murine T-Cell Receptor Antibodies in Both Responding and Nonresponding Patients Enrolled in TCR Gene Therapy Trials ⬇️

scientific article published on December 1, 2010

Development of a T cell receptor targeting an HLA-A*0201 restricted epitope from the cancer-testis antigen SSX2 for adoptive immunotherapy of cancer

scientific article

Development of an automated closed system for generation of human lymphokine-activated killer (LAK) cells for use in adoptive immunotherapy

scientific article published in August 1987

Development of long-term cell lines and lymphoid clones reactive against murine and human tumors: a new approach to the adoptive immunotherapy of cancer

scientific article published on 01 August 1982

Differences in the effects of host suppression on the adoptive immunotherapy of subcutaneous and visceral tumors

scientific article published on 01 July 1986

Different adjuvanticity of incomplete freund's adjuvant derived from beef or vegetable components in melanoma patients immunized with a peptide vaccine.

scientific article published on July 2010

Differential Anti-MART-1/MelanA CTL Activity in Peripheral Blood of HLA-A2 Melanoma Patients in Comparison to Healthy Donors

Differential anti-MART-1/MelanA CTL activity in peripheral blood of HLA-A2 melanoma patients in comparison to healthy donors: evidence of in vivo priming by tumor cells

scientific article published on 01 July 1996

Discovery and characterization of an immunogenic neoantigen in a patient with metastatic triple negative breast cancer.

scientific article published on 4 November 2015

Disseminated human malignant melanoma in congenitally immune-deficient (bg/nu/xid) mice

scientific article published in March 1991

Diversity of mutated antigen recognition by tumor infiltrating lymphocytes from patients with metastatic melanoma

scientific article published on 4 November 2015

Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation

scientific article published on 20 September 2013

Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting.

scientific article published on 13 December 2016

Durable Complete Response from Metastatic Melanoma after Transfer of Autologous T Cells Recognizing 10 Mutated Tumor Antigens

scientific article published on 16 June 2016

Durable complete response in a patient with metastatic melanoma following adoptive transfer of autologous T cells recognizing 10 mutated tumor antigens.

scientific article published on 4 November 2015

Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy

scientific article

EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss.

scientific article published on 18 December 2013

Effect of anti-B16 melanoma monoclonal antibody on established murine B16 melanoma liver metastases

scientific article published on 01 June 1987

Effect of combined therapy with lymphokine-activated killer cells, interleukin 2 and specific monoclonal antibody on established B16 melanoma lung metastases.

scientific article published in December 1988

Effect of corticosteroid on the antitumor activity of lymphokine-activated killer cells and interleukin 2 in mice

scientific article published on 01 November 1986

Effect of hydration on plasma-methotrexate levels

scientific article published on October 1, 1977

Effect of immunotherapy with allogeneic lymphokine-activated killer cells and recombinant interleukin 2 on established pulmonary and hepatic metastases in mice

scientific article published on 01 November 1986

Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity

scholarly article

Effects of high-dose methotrexate and vincristine on ovarian and testicular functions in patients undergoing postoperative adjuvant treatment of osteosarcoma

scientific article published on 01 September 1981

Effects of murine tumor class I major histocompatibility complex expression on antitumor activity of tumor-infiltrating lymphocytes

scientific article published on May 1990

Effects of postoperative adjuvant chemotherapy and radiotherapy on ovarian function in women undergoing treatment for soft tissue sarcoma

scientific article published on 01 December 1981

Efficacy of adjuvant radiation therapy in the treatment of soft tissue sarcoma of the extremity: 20-year follow-up of a randomized prospective trial

scientific article published on 23 April 2014

Efficient identification of mutated cancer antigens recognized by T cells associated with durable tumor regressions.

scientific article

Efficient transfer of a tumor antigen-reactive TCR to human peripheral blood lymphocytes confers anti-tumor reactivity

scientific article published on 01 July 1999

Endothelial activation during interleukin 2 immunotherapy. A possible mechanism for the vascular leak syndrome

scientific article published on 01 March 1988

Engineered T cells targeting E7 mediate regression of human papillomavirus cancers in a murine model.

scientific article published on 19 April 2018

Engineering improved T cell receptors using an alanine-scan guided T cell display selection system ⬇️

scientific article published on March 13, 2013

Engineering the immune response to "self" for effective cancer immunotherapy

scientific article published on 6 November 2014

Enhanced antitumor activity of T cells engineered to express T-cell receptors with a second disulfide bond.

scientific article

Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability

scientific article

Enhanced detection of neoantigen-reactive T cells targeting unique and shared oncogenes for personalized cancer immunotherapy

scientific article published on 04 October 2018

Enhanced efficacy and limited systemic cytokine exposure with membrane-anchored interleukin-12 T-cell therapy in murine tumor models

scientific article published on 01 January 2020

Enhanced receptor expression and in vitro effector function of a murine-human hybrid MART-1-reactive T cell receptor following a rapid expansion

scientific article

Enrichment of CD8+ cells from melanoma tumor-infiltrating lymphocyte cultures reveals tumor reactivity for use in adoptive cell therapy.

scientific article

Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4

scientific article

Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19 ⬇️

scientific article published on July 28, 2010

Eradication of a disseminated syngeneic mouse lymphoma by systemic adoptive transfer of immune lymphocytes and its dependence upon a host component(s).

scientific article published in February 1985

Evaluation of computed tomography in the detection of pulmonary metastases.A prospective study ⬇️

scientific article published on March 1, 1979

Evaluation of prime/boost regimens using recombinant poxvirus/tyrosinase vaccines for the treatment of patients with metastatic melanoma

scientific article

Evaluation of γ-Retroviral Vectors That Mediate the Inducible Expression of IL-12 for Clinical Application ⬇️

scientific article published on June 1, 2012

Evidence for an orderly progression in the spread of Hodgkin's disease

scientific article published on 01 June 1966

Evidence that lymphokine-activated killer cells and natural killer cells are distinct based on an analysis of congenitally immunodeficient mice

scientific article published on 01 November 1985

Exome Sequencing of ABCB5 Identifies Recurrent Melanoma Mutations that Result in Increased Proliferative and Invasive Capacities

scientific article published on 21 March 2019

Exome sequencing identifies GRIN2A as frequently mutated in melanoma

scientific article

Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma.

scientific article

Expansion and characterization of T cells transduced with a chimeric receptor against ovarian cancer

scientific article published on 01 November 2000

Expansion of human tumor infiltrating lymphocytes for use in immunotherapy trials

scientific article published in August 1987

Experimental and clinical studies with intraoperative radiotherapy

scientific article published on 01 September 1983

Expression of MAGE-A and NY-ESO-1 in Primary and Metastatic Cancers

scientific article published in January 2016

Expression of New York esophageal squamous cell carcinoma-1 in primary and metastatic melanoma.

scientific article

Expression of a "self-"antigen by human tumor cells enhances tumor antigen-specific CD4(+) T-cell function.

scientific article

Expression profiling of TCR-engineered T cells demonstrates overexpression of multiple inhibitory receptors in persisting lymphocytes

scientific article published on 16 July 2013

Extended-field radiation therapy in Hodgkin's disease. A progress report.

scientific article

Extended-field radical radiotherapy in advanced Hodgkin's disease: short-term results of 2 randomized clinical trials

scientific article published on 01 June 1966

Extralymphatic Hodgkin's disease. Prognosis and response to therapy.

scientific article

Extrathymic generation of tumor-specific T cells from genetically engineered human hematopoietic stem cells via Notch signaling

scientific article

Extravasation of intravascular fluid mediated by the systemic administration of recombinant interleukin 2

scientific article published on 01 September 1986

Extremity soft tissue sarcomas: analysis of prognostic variables in 300 cases and evaluation of tumor necrosis as a factor in stratifying higher-grade sarcomas

scientific article published on August 1989

FOXP3 expression accurately defines the population of intratumoral regulatory T cells that selectively accumulate in metastatic melanoma lesions

scientific article

Factors predicting survival in adults with stage I and II large-cell lymphoma treated with primary radiation therapy

scientific article published in June 1986

Female Reproductive Potential after Treatment for Hodgkin's Disease ⬇️

scientific article published on 01 June 1981

Frequency of MART-1/MelanA and gp100/PMel17-specific T cells in tumor metastases and cultured tumor-infiltrating lymphocytes

scientific article published on May 2002

Frequent mutations in the MITF pathway in melanoma

scientific article published on 29 April 2009

Functional analysis of antigen-specific T lymphocytes by serial measurement of gene expression in peripheral blood mononuclear cells and tumor specimens

scientific article published in December 1999

Functional dissociation between local and systemic immune response during anti-melanoma peptide vaccination

scientific article published on 01 October 1998

Functional heterogeneity of vaccine-induced CD8(+) T cells

scientific article published on June 2002

Gene expression profiling using nanostring digital RNA counting to identify potential target antigens for melanoma immunotherapy

scientific article published on 10 September 2013

Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice ⬇️

scientific article published on October 11, 2010

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

scientific article

Gene transfer into humans--immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction

scientific article

Gene transfer of tumor-reactive TCR confers both high avidity and tumor reactivity to nonreactive peripheral blood mononuclear cells and tumor-infiltrating lymphocytes

scientific article

Generation from tumor-bearing mice of lymphocytes with in vivo therapeutic efficacy

scientific article published on 01 July 1987

Generation of NY-ESO-1-specific CD4+ and CD8+ T cells by a single peptide with dual MHC class I and class II specificities: a new strategy for vaccine design.

scientific article published on July 2002

Generation of long-term T-lymphoid cell lines with specific cytotoxic reactivity for a syngeneic murine lymphoma

scientific article published on 01 July 1982

Generation of lytic and proliferative lymphoid clones to syngeneic tumor: in vitro and in vivo studies

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Generation of tumor-infiltrating lymphocyte cultures for use in adoptive transfer therapy for melanoma patients

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Generation of tumor-specific CTLs from melanoma patients by using peripheral blood stimulated with allogeneic melanoma tumor cell lines. Fine specificity and MART-1 melanoma antigen recognition.

scientific article published on January 1995

Genetic engineering of murine CD8+ and CD4+ T cells for preclinical adoptive immunotherapy studies.

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Genetic inference of immune responsiveness of melanoma cancer patients to TIL therapy

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Glucocorticoids do not inhibit antitumor activity of activated CD8+ T cells

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HLA association with response and toxicity in melanoma patients treated with interleukin 2-based immunotherapy

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Helper T cells infiltrating human renal cell carcinomas have the phenotype of activated memory-like T lymphocytes

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Hematologic effects of immunotherapy with lymphokine-activated killer cells and recombinant interleukin-2 in cancer patients.

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Hematologic neoplasia in patients treated for Hodgkin's disease

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Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8 T cells

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Hemodynamic effects of the administration of tumor-infiltrating lymphocytes to cancer patients.

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Heterogeneity of lymphokine-activated killer cells induced by IL-2. Separate lymphoid subpopulations lyse tumor, allogeneic blasts, and modified syngeneic blasts

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High avidity CTLs for two self-antigens demonstrate superior in vitro and in vivo antitumor efficacy.

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High efficiency TCR gene transfer into primary human lymphocytes affords avid recognition of melanoma tumor antigen glycoprotein 100 and does not alter the recognition of autologous melanoma antigens

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High frequency CD8+PD-1+ TCR clonotypes isolated from fresh melanomas display anti-tumor activity

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High-affinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines.

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High-affinity oligoclonal TCRs define effective adoptive T cell therapy targeting mutant KRAS-G12D

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High-dose interleukin-2 for the treatment of metastatic renal cell carcinoma : a retrospective analysis of response and survival in patients treated in the surgery branch at the National Cancer Institute between 1986 and 2006.

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High-dose therapy and autologous bone marrow transplantation for follicular lymphoma in first complete or partial remission: results of a phase II clinical trial

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High-efficiency transfection of primary human and mouse T lymphocytes using RNA electroporation

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Highlights of the society for immunotherapy of cancer (SITC) 27th annual meeting

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Hodgkin's disease, stages I and II occurring below the diaphragm ⬇️

scientific article published on May 1, 1979

Human CD4+ T cells specifically recognize a shared melanoma-associated antigen encoded by the tyrosinase gene

scientific article published on September 1994

Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy.

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Human lymphokine-activated killer cells: further isolation and characterization of the precursor and effector cell

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Human melanoma antigens recognized by T lymphocytes

scientific article published on June 1996

Human melanoma metastases demonstrate nonstochastic site-specific antigen heterogeneity that correlates with T-cell infiltration

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Human tumor infiltrating lymphocytes. Analysis of lymphokine mRNA expression and relevance to cancer immunotherapy

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Hybrids of dendritic cells and tumor cells generated by electrofusion simultaneously present immunodominant epitopes from multiple human tumor-associated antigens in the context of MHC class I and class II molecules

scientific article published on May 2003

IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain

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IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors.

scientific article published on 7 November 2011

IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells

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IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients

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IL-2 and IL-15 each mediate de novo induction of FOXP3 expression in human tumor antigen-specific CD8 T cells

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IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy

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IL-2-based immunotherapy alters circulating neutrophil Fc receptor expression and chemotaxis

scientific article published on 01 May 1990

IL-4 regulates IL-2 induction of lymphokine-activated killer activity from human lymphocytes

scientific article published on May 1989

IL-4 regulation of murine lymphokine-activated killer activity in vitro. Effects on the IL-2-induced expansion, cytotoxicity, and phenotype of lymphokine-activated killer effectors

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IL-6/IFN-beta-2 as a circulating hormone. Induction by cytokine administration in humans

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IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells

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Identification and characterization of a tumor infiltrating CD56(+)/CD16 (-) NK cell subset with specificity for pancreatic and prostate cancer cell lines.

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Identification of BING-4 cancer antigen translated from an alternative open reading frame of a gene in the extended MHC class II region using lymphocytes from a patient with a durable complete regression following immunotherapy

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Identification of MART-1-specific T-cell receptors: T cells utilizing distinct T-cell receptor variable and joining regions recognize the same tumor epitope ⬇️

scientific article published on October 15, 1994

Identification of Neoantigen-Reactive Tumor-Infiltrating Lymphocytes in Primary Bladder Cancer

scientific article published on 29 April 2019

Identification of a colorectal tumor-associated antigen (COA-1) recognized by CD4(+) T lymphocytes ⬇️

scientific article published on October 15, 2003

Identification of a gene encoding a melanoma tumor antigen recognized by HLA-A31-restricted tumor-infiltrating lymphocytes

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Identification of a new shared HLA-A2.1 restricted epitope from the melanoma antigen tyrosinase

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Identification of a shared HLA-A*0201-restricted T-cell epitope from the melanoma antigen tyrosinase-related protein 2 (TRP2)

scientific article published on 01 November 1998

Identification of a tyrosinase epitope recognized by HLA-A24-restricted, tumor-infiltrating lymphocytes.

scientific article published on August 1995

Identification of cellular mechanisms operational in vivo during the regression of established pulmonary metastases by the systemic administration of high-dose recombinant interleukin 2

scientific article published on 01 July 1987

Identification of endogenous HLA-A2-restricted reactivity against shared melanoma antigens in patients using the quantitative real-time polymerase chain reaction

scientific article published on January 2002

Identification of multiple antigens recognized by tumor-infiltrating lymphocytes from a single patient: tumor escape by antigen loss and loss of MHC expression

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Identification of mutation-specific tumor infiltrating lymphocytes from metastatic ovarian cancer

scientific article published on 4 November 2015

Identification of specific cytolytic immune responses against autologous tumor in humans bearing malignant melanoma.

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Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes

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Identification of tumor-regression antigens in melanoma.

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Identification of tyrosinase-related protein 2 as a tumor rejection antigen for the B16 melanoma

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Identification of unique murine tumor associated antigens by tumor infiltrating lymphocytes using tumor specific secretion of interferon-gamma and tumor necrosis factor

scientific article published on July 1991

Identifying and Targeting Human Tumor Antigens for T Cell-Based Immunotherapy of Solid Tumors

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Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer

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Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia

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Immunization against epitopes in the human melanoma antigen gp100 following patient immunization with synthetic peptides

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Immunization of HLA-A*0201 and/or HLA-DPbeta1*04 patients with metastatic melanoma using epitopes from the NY-ESO-1 antigen

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Immunization of patients with melanoma peptide vaccines: immunologic assessment using the ELISPOT assay

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Immunization of patients with metastatic melanoma using both class I- and class II-restricted peptides from melanoma-associated antigens

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Immunization of patients with the hTERT:540-548 peptide induces peptide-reactive T lymphocytes that do not recognize tumors endogenously expressing telomerase

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Immunogenicity of somatic mutations in human gastrointestinal cancers.

scientific article published on 29 October 2015

Immunohistochemical correlates of response to recombinant interleukin-2-based immunotherapy in humans

scientific article published on 01 December 1989

Immunohistologic responses within dermal metastatic melanoma lesions of patients treated with a synthetic peptide vaccine

scientific article published on 01 September 2000

Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer

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Immunoproteasome expression is associated with better prognosis and response to checkpoint therapies in melanoma

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Immunoselection of a human melanoma resistant to specific lysis by autologous tumor-infiltrating lymphocytes. Possible mechanisms for immunotherapeutic failures

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Immunotherapy for Metastatic Solid Cancers ⬇️

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Immunotherapy of cancer with lymphokine-activated killer cells and recombinant interleukin-2

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Immunotherapy of murine sarcomas using lymphokine activated killer cells: optimization of the schedule and route of administration of recombinant interleukin-2

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Immunotherapy: The path to win the war on cancer?

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Impact of Cysteine Residues on MHC Binding Predictions and Recognition by Tumor-Reactive T Cells

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Impact of a recombinant fowlpox vaccine on the efficacy of adoptive cell therapy with tumor infiltrating lymphocytes in a patient with metastatic melanoma

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Impact of salvage treatment on initial relapses in patients with Hodgkin disease, stages I-III ⬇️

scientific article published on 01 May 1978

Improved gene transfer into human lymphocytes using retroviruses with the gibbon ape leukemia virus envelope

scientific article published in August 1996

Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding residues

scientific article published on 01 September 1996

Improving Adoptive T Cell Therapy by Targeting and Controlling IL-12 Expression to the Tumor Environment ⬇️

scientific article published on February 1, 2011

In search of an effective antiemetic: a nusring staff participates in marijuana research

scientific article published on 01 August 1980

In vitro and in vivo antitumor properties of a T-cell clone generated from murine tumor-infiltrating lymphocytes

scientific article published on October 1990

In vitro differentiation of T-cells capable of mediating the regression of established syngeneic tumors in mice

scientific article published on 01 March 1987

In vitro growth of cytotoxic human lymphocytes. II. Use of T cell growth factor (TCGF) to clone human T cells

scientific article published on 01 June 1980

In vitro growth of cytotoxic human lymphocytes. III. The preparation of lectin-free T cell growth factor (TCGF) and an analysis of its activity

scientific article published on 01 June 1981

In vitro growth of murine T cells. V. The isolation and growth of lymphoid cells infiltrating syngeneic solid tumors.

scientific article published in July 1980

In vitro growth of murine T cells. VI. Accelerated skin graft rejection caused by adoptively transferred cells expanded in T cell growth factor

scientific article published on 01 August 1981

In vitro sensitization and expansion with viable tumor cells and interleukin 2 in the generation of specific therapeutic effector cells

scientific article published in May 1986

In vivo administration of interferon alpha and interleukin 2 induces proliferation of lymphoid cells in the organs of mice

scientific article published on 01 September 1990

In vivo administration of purified Jurkat-derived interleukin 2 in mice

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In vivo administration of purified human interleukin 2. I. Half-life and immunologic effects of the Jurkat cell line-derived interleukin 2.

scientific article published on January 1985

In vivo administration of purified human interleukin 2. II. Half life, immunologic effects, and expansion of peripheral lymphoid cells in vivo with recombinant IL 2.

scientific article published on October 1985

In vivo administration of purified human interleukin-2 to patients with cancer: development of interleukin-2 receptor positive cells and circulating soluble interleukin-2 receptors following interleukin-2 administration

scientific article published on 01 April 1987

In vivo administration of recombinant macrophage colony-stimulating factor induces macrophage-mediated antibody-dependent cytotoxicity of tumor cells

scientific article published on 01 August 1992

In vivo antitumor activity of T cells redirected with chimeric antibody/T-cell receptor genes

scientific article published on 01 August 1995

In vivo antitumor activity of tumor-infiltrating lymphocytes expanded in recombinant interleukin-2.

scientific article published in November 1987

In vivo induction of IL-6 by administration of exogenous cytokines and detection of de novo serum levels of IL-6 in tumor-bearing mice

scientific article published on 01 July 1989

In vivo proliferation of adoptively transferred tumor-infiltrating lymphocytes in mice

scientific article published on 01 April 1991

Inability of a fusion protein of IL-2 and diphtheria toxin (Denileukin Diftitox, DAB389IL-2, ONTAK) to eliminate regulatory T lymphocytes in patients with melanoma

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Inability to immunize patients with metastatic melanoma using plasmid DNA encoding the gp100 melanoma-melanocyte antigen.

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Inability to mediate prolonged reduction of regulatory T Cells after transfer of autologous CD25-depleted PBMC and interleukin-2 after lymphodepleting chemotherapy

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Increased intensity lymphodepletion and adoptive immunotherapy--how far can we go?

scientific article published on December 2006

Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells

scientific article published on January 2010

Increased vaccine-specific T cell frequency after peptide-based vaccination correlates with increased susceptibility to in vitro stimulation but does not lead to tumor regression

scientific article published on 01 December 1999

Individual cultures of melanoma tumor infiltrating lymphocytes possess distinct patterns of reactivity with mutated antigens identified by whole exome sequencing of autologous tumors

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Induction of CD4+ Th1 lymphocytes that recognize known and novel class II MHC restricted epitopes from the melanoma antigen gp100 by stimulation with recombinant protein

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Induction of antibody-dependent cellular cytotoxicity in vivo by IFN-alpha and its antitumor efficacy against established B16 melanoma liver metastases when combined with specific anti-B16 monoclonal antibody

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Induction of endogenous cytokine-mRNA in circulating peripheral blood mononuclear cells by IL-2 administration to cancer patients.

scientific article published in July 1989

Induction of melanoma reactive T cells by stimulator cells expressing melanoma epitope-major histocompatibility complex class I fusion proteins

scientific article published on 01 January 1997

Initial relapse in previously treated Hodgkin's disease—II retrograde transdiaphragmatic extension ⬇️

scientific article published on September 1, 1977

Initial relapses in previously treated Hodgkin's disease. I. Results of second treatment

scientific article published on June 1, 1976

Intercurrent death after Hodgkin disease therapy in radiotherapy and adjuvant MOPP trials

scientific article published on August 1988

Interleukin 2 and psoriasis

scientific article published on 01 December 1988

Interleukin 2 expanded tumor-infiltrating lymphocytes in human renal cell cancer: isolation, characterization, and antitumor activity

scientific article published on 01 January 1988

Interleukin 4 promotes the growth of tumor-infiltrating lymphocytes cytotoxic for human autologous melanoma

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Interleukin-2 based immunotherapy for metastatic renal cell carcinoma with the kidney in place

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Interleukin-2-transduced lymphocytes grow in an autocrine fashion and remain responsive to antigen.

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Intralymphatic dendritic cell vaccination induces tumor antigen-specific, skin-homing T lymphocytes

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Intrapatient dose escalation of anti-CTLA-4 antibody in patients with metastatic melanoma

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Intraperitoneal administration of interleukin-2 in patients with cancer

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Intratumoral LAK cell and interleukin-2 therapy of human gliomas.

scientific article published in February 1989

In vitro generated anti-tumor T lymphocytes exhibit distinct subsets mimicking in vivo antigen-experienced cells.

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Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis

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Irradiation Enhances Human T-cell Function by Upregulating CD70 Expression on Antigen-presenting Cells In Vitro ⬇️

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Isolation and Characterization of an HLA-DPB1*04: 01-restricted MAGE-A3 T-Cell Receptor for Cancer Immunotherapy

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Isolation of T cell receptors specifically reactive with mutated tumor associated antigens

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Isolation of T-Cell Receptors Specifically Reactive with Mutated Tumor-Associated Antigens from Tumor-Infiltrating Lymphocytes Based on CD137 Expression.

scientific article published on 8 November 2016

Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes

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LIGHT Elevation Enhances Immune Eradication of Colon Cancer Metastases

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Lack of retroperitoneal lymphadenopathy predicts survival of patients with metastatic renal cell carcinoma

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Lack of specific gamma-retroviral vector long terminal repeat promoter silencing in patients receiving genetically engineered lymphocytes and activation upon lymphocyte restimulation

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Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer

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Large scale production of human lymphokine activated killer cells for use in adoptive immunotherapy

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Large-scale depletion of CD25+ regulatory T cells from patient leukapheresis samples

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Lentiviral vector design for optimal T cell receptor gene expression in the transduction of peripheral blood lymphocytes and tumor-infiltrating lymphocytes

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Levels of peripheral CD4(+)FoxP3(+) regulatory T cells are negatively associated with clinical response to adoptive immunotherapy of human cancer ⬇️

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Limb-sparing surgery for soft tissue sarcomas: wound related morbidity in patients undergoing wide local excision.

scientific article published in September 1987

Liver resection for metastatic melanoma with postoperative tumor-infiltrating lymphocyte therapy.

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Local delivery of interleukin-12 using T cells targeting VEGF receptor-2 eradicates multiple vascularized tumors in mice.

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Long-Duration Complete Remissions of Diffuse Large B Cell Lymphoma after Anti-CD19 Chimeric Antigen Receptor T Cell Therapy

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Long-Term Follow-Up of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy

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Long-term outcome in 87 patients with low-grade soft-tissue sarcoma

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Long-term survival of adoptively transferred tumor-infiltrating lymphocytes in mice.

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Loss of S100 antigenicity in metastatic melanoma

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Lymphoblastic lymphoma in adults: results of a pilot protocol

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Lymphokine-activated killer (LAK) cell phenomenon. IV. Lysis by LAK cell clones of fresh human tumor cells from autologous and multiple allogeneic tumors

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Lymphokine-activated killer (LAK) cells. Analysis of factors relevant to the immunotherapy of human cancer

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Lymphokine-activated killer cells: lysis of fresh syngeneic natural killer-resistant murine tumor cells by lymphocytes cultured in interleukin 2.

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Lymphoma Remissions Caused by Anti-CD19 Chimeric Antigen Receptor T Cells Are Associated With High Serum Interleukin-15 Levels.

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Lysis of fresh and cultured autologous tumor by human lymphocytes cultured in T-cell growth factor

scientific article published on 01 November 1981

Lysis of fresh human solid tumors by autologous lymphocytes activated in vitro with lectins

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Lysis of fresh natural killer-resistant tumor cells by lectin-activated syngeneic and allogeneic murine splenocytes.

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Lysis of human solid tumors by autologous cells sensitized in vitro to alloantigens

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Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor gamma chain

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MAGE-A is More Highly Expressed Than NY-ESO-1 in a Systematic Immunohistochemical Analysis of 3668 Cases

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MHC class I-restricted recognition of a melanoma antigen by a human CD4+ tumor infiltrating lymphocyte

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MHC-I-restricted melanoma antigen specific TCR-engineered human CD4+ T cells exhibit multifunctional effector and helper responses, in vitro

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MOPP chemotherapy for advanced Hodgkin's disease. Prognostic factors in 81 patients.

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Manipulation of oxygen radical-scavenging capacity in mice alters host sensitivity to tumor necrosis factor toxicity but does not interfere with its antitumor efficacy

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Measuring tissue-based biomarkers by immunochromatography coupled with reverse-phase lysate microarray

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Mechanism of action of Cyclosporin A: inhibition of lymphokine secretion studied with antigen-stimulated T cell hybridomas

scientific article published on 01 December 1984

Mechanisms of immunologic antitumor therapy: lessons from the laboratory and clinical applications

scientific article published on June 1990

Mechanistic aspects of successful immunotherapy of established pulmonary metastases by the systemic administration of high-dose recombinant interleukin-2.

scientific article published on January 1987

Melanocyte lineage-specific antigen gp100 is recognized by melanoma-derived tumor-infiltrating lymphocytes

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Melanoma-associated B cells are distinct from peripheral blood-derived B cells, and may serve as a source of tumor-targeting antibodies

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Melanoma-specific CD4+ T cells recognize nonmutated HLA-DR-restricted tyrosinase epitopes

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Melanoma: Why is sentinel lymph node biopsy 'standard of care' for melanoma?

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Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy

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Memory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients

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Metabolic and renal effects of interleukin-2 immunotherapy for metastatic cancer.

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Metastasectomy Following Immunotherapy with Adoptive Cell Transfer for Patients with Advanced Melanoma.

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Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8 T cells via TLR4 signaling

Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling.

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Minimally cultured tumor-infiltrating lymphocytes display optimal characteristics for adoptive cell therapy

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Minimally invasive liver resection to obtain tumor-infiltrating lymphocytes for adoptive cell therapy in patients with metastatic melanoma

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Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells

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Mobilization of dendritic cell precursors in patients with cancer by flt3 ligand allows the generation of higher yields of cultured dendritic cells

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Modulating the differentiation status of ex vivo-cultured anti-tumor T cells using cytokine cocktails.

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Modulation by IL-2 of CD70 and CD27 expression on CD8+ T cells: importance for the therapeutic effectiveness of cell transfer immunotherapy

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Modulation of murine tumor major histocompatibility antigens by cytokines in vivo and in vitro

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Multiple HLA class II-restricted melanocyte differentiation antigens are recognized by tumor-infiltrating lymphocytes from a patient with melanoma

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Multiple chimeric antigen receptors successfully target chondroitin sulfate proteoglycan 4 in several different cancer histologies and cancer stem cells.

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Murine Autoantibodies to a Cryptic Membrane Antigen: Possible Explanation for Neuraminidase-Induced Increase in Cell Immunogenicity2 ⬇️

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Murine lymphokine-activated killer (LAK) cells: phenotypic characterization of the precursor and effector cells

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Mutated PPP1R3B is recognized by T cells used to treat a melanoma patient who experienced a durable complete tumor regression.

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Mutational and functional analysis of the tumor-suppressor PTPRD in human melanoma

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Mutational and functional analysis reveals ADAMTS18 metalloproteinase as a novel driver in melanoma

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Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma

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Mutational inactivation of STAG2 causes aneuploidy in human cancer

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Mutational signatures of de-differentiation in functional non-coding regions of melanoma genomes

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Myeloid cells obtained from the blood but not from the tumor can suppress T-cell proliferation in patients with melanoma.

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NIH conference. New approaches to the immunotherapy of cancer using interleukin-2.

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NY-ESO-1 expression in synovial sarcoma and other mesenchymal tumors: significance for NY-ESO-1-based targeted therapy and differential diagnosis.

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NY-ESO-1 may be a potential target for lung cancer immunotherapy.

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Neoantigen screening identifies broad TP53 mutant immunogenicity in patients with epithelial cancers

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No Initial Therapy for Stage III and IV Non-Hodgkin's Lymphomas of Favorable Histologic Types

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No correlation between clinical response to CTLA-4 blockade and presence of NY-ESO-1 antibody in patients with metastatic melanoma

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Non-Hodgkin's lymphomas. IV. Clinicopathologic correlation in 405 cases.

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Non-Hodgkin's lymphomas.V. Results of radiotherapy ⬇️

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Normal tissue depresses while tumor tissue enhances human T cell responses in vivo to a novel self/tumor melanoma antigen, OA1

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Novel CD4-Based Bispecific Chimeric Antigen Receptor Designed for Enhanced Anti-HIV Potency and Absence of HIV Entry Receptor Activity

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Novel somatic mutations in heterotrimeric G proteins in melanoma

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Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer

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Occurrence of Non-Hodgkin's Lymphoma after Therapy for Hodgkin's Disease ⬇️

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Ocular and systemic autoimmunity after successful tumor-infiltrating lymphocyte immunotherapy for recurrent, metastatic melanoma

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Outcomes of Adoptive Cell Transfer With Tumor-infiltrating Lymphocytes for Metastatic Melanoma Patients With and Without Brain Metastases

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Overview of interleukin-2 as an immunotherapeutic agent

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PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumors

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Paraneoplastic granulocytosis in metastatic melanoma

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Partial reduction of human FOXP3+ CD4 T cells in vivo after CD25-directed recombinant immunotoxin administration

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Pathologic findings associated with interleukin-2-based immunotherapy for cancer: a postmortem study of 19 patients

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Patterns of relapse and response to retreatment in patients with metastatic melanoma or renal cell carcinoma who responded to interleukin-2-based immunotherapy

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Penetration of recombinant interleukin-2 across the blood-cerebrospinal fluid barrier

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Persistence of CTL clones targeting melanocyte differentiation antigens was insufficient to mediate significant melanoma regression in humans

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Personalized Cell Transfer Immunotherapy for B-Cell Malignancies and Solid Cancers ⬇️

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Personalized immunotherapy for non-small cell lung cancer through identification of tumor-specific mutations by next generation sequencing and adoptive transfer of tumor infiltrating lymphocytes that recognize neoantigens

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Phase 1 study in patients with metastatic melanoma of immunization with dendritic cells presenting epitopes derived from the melanoma-associated antigens MART-1 and gp100.

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Phase 2 Trial of Single Agent Ipilimumab (Anti-CTLA-4) for Locally Advanced or Metastatic Pancreatic Adenocarcinoma ⬇️

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Phase I study of human leukocyte interferon in patients with advanced cancer

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Phase I study of the intravenous administration of attenuated Salmonella typhimurium to patients with metastatic melanoma

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Phenotypic and functional maturation of tumor antigen-reactive CD8+ T lymphocytes in patients undergoing multiple course peptide vaccination

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Phenotypic characterization of murine tumor-infiltrating T lymphocytes ⬇️

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Pilot Trial of Adoptive Transfer of Chimeric Antigen Receptor-transduced T Cells Targeting EGFRvIII in Patients With Glioblastoma

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Prednisone in MOPP chemotherapy for Hodgkin's disease ⬇️

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Preinfusion polyfunctional anti-CD19 chimeric antigen receptor T cells are associated with clinical outcomes in NHL

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Primary human T lymphocytes engineered with a codon-optimized IL-15 gene resist cytokine withdrawal-induced apoptosis and persist long-term in the absence of exogenous cytokine

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Primary human lymphocytes transduced with NY-ESO-1 antigen-specific TCR genes recognize and kill diverse human tumor cell lines

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Production of recombinant MART-1 proteins and specific antiMART-1 polyclonal and monoclonal antibodies: use in the characterization of the human melanoma antigen MART-1.

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Prognostic factors in pathologic stage III Hodgkin's disease

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Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade

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Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients

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Prospective molecular profiling of melanoma metastases suggests classifiers of immune responsiveness.

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Prospective study of cardiomyopathy induced by adjuvant doxorubicin therapy in patients with soft-tissue sarcomas

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RANTES secretion by gene-modified tumor cells results in loss of tumorigenicity in vivo: role of immune cell subpopulations

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RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells

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Randomized selection design trial evaluating CD8+-enriched versus unselected tumor-infiltrating lymphocytes for adoptive cell therapy for patients with melanoma.

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Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer

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Randomized, Prospective Evaluation Comparing Intensity of Lymphodepletion Before Adoptive Transfer of Tumor-Infiltrating Lymphocytes for Patients With Metastatic Melanoma

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Rapid Identification and Evaluation of Neoantigen-reactive T-Cell Receptors From Single Cells

scientific article published on 20 October 2020

Rapid production of clinical-grade gammaretroviral vectors in expanded surface roller bottles using a "modified" step-filtration process for clearance of packaging cells

scientific article

Recognition of Glioma Stem Cells by Genetically Modified T Cells Targeting EGFRvIII and Development of Adoptive Cell Therapy for Glioma ⬇️

scientific article published on September 24, 2012

Recognition of NY-ESO-1+ tumor cells by engineered lymphocytes is enhanced by improved vector design and epigenetic modulation of tumor antigen expression

scientific article published on 02 August 2008

Recognition of an antigenic peptide derived from tyrosinase-related protein-2 by CTL in the context of HLA-A31 and -A33 ⬇️

scientific article published on January 15, 1998

Recognition of fresh human tumor by human peripheral blood lymphocytes transduced with a bicistronic retroviral vector encoding a murine anti-p53 TCR.

scientific article

Recognition of human gastrointestinal cancer neoantigens by circulating PD-1+ lymphocytes

scientific article published on 01 November 2019

Recognition of multiple epitopes in the human melanoma antigen gp100 by peripheral blood lymphocytes stimulated in vitro with synthetic peptides ⬇️

scientific article published on 01 November 1995

Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating T lymphocytes associated with in vivo tumor regression

scientific article published on 01 April 1995

Recognition of shared melanoma antigens by human tumor-infiltrating lymphocytes

scientific article published on October 1, 1992

Recognition of shared melanoma antigens in association with major HLA-A alleles by tumor infiltrating T lymphocytes from 123 patients with melanoma

scientific article published on 01 January 2000

Recognition of tyrosinase by tumor-infiltrating lymphocytes from a patient responding to immunotherapy

scientific article published on June 1994

Recombinant fowlpox viruses encoding the anchor-modified gp100 melanoma antigen can generate antitumor immune responses in patients with metastatic melanoma

scientific article

Recombinant interleukin 2 stimulates in vivo proliferation of adoptively transferred lymphokine-activated killer (LAK) cells

scientific article published on 01 November 1985

Recurrent inactivating RASA2 mutations in melanoma

scientific article published on 26 October 2015

Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer

scientific article

Relapse after response to interleukin-2-based immunotherapy: patterns of progression and response to retreatment

scientific article published on 01 October 1991

Relationship of p53 overexpression on cancers and recognition by anti-p53 T cell receptor-transduced T cells

scientific article

Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells

scientific article

Replication-competent retroviruses in gene-modified T cells used in clinical trials: is it time to revise the testing requirements?

scientific article published on February 2012

Results of clinical trials with the administration of interleukin 2 and adoptive immunotherapy with activated cells in patients with cancer

scientific article

Retroviral transduction of human dendritic cells with a tumor-associated antigen gene.

scientific article published in December 1996

Risk of bowel perforation in patients receiving interleukin-2 after therapy with anti-CTLA 4 monoclonal antibody

scientific article

Risk of second cancers after treatment for Hodgkin's disease

scientific article published on 01 January 1988

Routine Computer Tomography Imaging for the Detection of Recurrences in High-Risk Melanoma Patients

scientific article published on 31 January 2017

Safety and efficacy of high-dose interleukin-2 therapy in patients with brain metastases

scientific article

Selection of CD8+PD-1+ lymphocytes in fresh human melanomas enriches for tumor-reactive T cells

scientific article

Selection of circulating PD-1+ lymphocytes from cancer patients enriches for tumor-reactive and mutation-specific lymphocytes.

scientific article

Selective elimination of human regulatory T lymphocytes in vitro with the recombinant immunotoxin LMB-2.

scientific article

Selective growth, in vitro and in vivo, of individual T cell clones from tumor-infiltrating lymphocytes obtained from patients with melanoma

scientific article

Separation and functional studies of the human lymphokine-activated killer cell.

scientific article

Separation and growth of human CD4+ and CD8+ tumor-infiltrating lymphocytes and peripheral blood mononuclear cells by direct positive panning on covalently attached monoclonal antibody-coated flasks

scientific article published on 01 October 1990

Serum interleukin-6 levels in metastatic renal cell carcinoma before treatment with interleukin-2 correlates with paraneoplastic syndromes but not patient survival ⬇️

scientific article published on March 1, 1998

Shared human melanoma antigens. Recognition by tumor-infiltrating lymphocytes in HLA-A2.1-transfected melanomas.

scientific article

Simplified Method of the Growth of Human Tumor Infiltrating Lymphocytes in Gas-permeable Flasks to Numbers Needed for Patient Treatment ⬇️

scientific article published on April 1, 2012

Simultaneous targeting of tumor antigens and the tumor vasculature using T lymphocyte transfer synergize to induce regression of established tumors in mice.

scientific article published on 30 April 2013

Single and dual amino acid substitutions in TCR CDRs can enhance antigen-specific T cell functions

scientific article published on May 2008

Single-Cell Transcriptome Analysis Reveals Gene Signatures Associated with T-cell Persistence Following Adoptive Cell Therapy

scientific article published on 04 September 2019

Single-pass, closed-system rapid expansion of lymphocyte cultures for adoptive cell therapy

scientific article published on 21 April 2009

Skin reactions in a subset of patients with stage IV melanoma treated with anti-cytotoxic T-lymphocyte antigen 4 monoclonal antibody as a single agent

article by Samer H Jaber et al published February 2006 in Archives of Dermatology

Soft tissue sarcoma: functional outcome after wide local excision and radiation therapy

scientific article published on 01 August 1984

Somatic mutation of GRIN2A in malignant melanoma results in loss of tumor suppressor activity via aberrant NMDAR complex formation

scientific article

Somatic mutations in MAP3K5 attenuate its proapoptotic function in melanoma through increased binding to thioredoxin

scientific article

Specific increase in T cell potency via structure-based design of a T cell receptor for adoptive immunotherapy.

scientific article published on 6 November 2014

Specific increase in potency via structure-based design of a TCR.

scientific article

Specific release of cytokines by lymphocytes infiltrating human melanomas in response to shared melanoma antigens.

scientific article published on January 1993

Specific release of granulocyte-macrophage colony-stimulating factor, tumor necrosis factor-alpha, and IFN-gamma by human tumor-infiltrating lymphocytes after autologous tumor stimulation

scientific article published on 01 May 1991

Stable, Nonviral Expression of Mutated Tumor Neoantigen-specific T-cell Receptors Using the Sleeping Beauty Transposon/Transposase System.

scientific article published on 05 March 2016

Staging laparotomies in unselected previously untreated patients with non-Hodgkin's lymphomas ⬇️

scientific article published on September 1, 1973

Staging laparotomy and splenectomy in Hodgkin's disease: analysis of indications and patterns of involvement in 285 consecutive, unselected patients

scientific article published on 01 May 1973

Status of activation of circulating vaccine-elicited CD8+ T cells

scientific article published on August 2000

Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer

scientific article

Stimulation of tumor-reactive T lymphocytes using mixtures of synthetic peptides derived from tumor-associated antigens with diverse MHC binding affinities ⬇️

scientific article published on May 1, 2003

Structure-based design of altered MHC class II-restricted peptide ligands with heterogeneous immunogenicity

scientific article

Studies of effects of recombinant human tumor necrosis factor on autochthonous tumor and transplanted normal tissue in mice.

scientific article published in April 1990

Studies on the anti-tumor efficacy of systemically administered recombinant tumor necrosis factor against several murine tumors in vivo

scientific article published on 01 February 1987

Study and characterization of mutated antigen specific T cells isolated from fresh tumor and peripheral lymphocytes in cancer patients

scientific article published on 4 November 2015

Successful treatment of melanoma brain metastases with adoptive cell therapy.

scientific article published on 18 August 2010

Surgical Staging of Abdominal Involvement in Unselected Patients with Hodgkin's Disease ⬇️

scientific article published on 01 November 1970

Surgical management of melanoma brain metastases in patients treated with immunotherapy.

scientific article

Survival, persistence, and progressive differentiation of adoptively transferred tumor-reactive T cells associated with tumor regression

scientific article

Synergistic antitumor effects of combination immunotherapy with recombinant interleukin-2 and a recombinant hybrid alpha-interferon in the treatment of established murine hepatic metastases.

scientific article

Synergistic antitumor effects of immunotherapy with recombinant interleukin-2 and recombinant tumor necrosis factor-alpha

scientific article published on 01 July 1988

Systemic administration of interleukin-2 in humans

scientific article published on October 1, 1984

Systemic administration of recombinant human interleukin-2 in mice

scientific article published on 01 October 1984

Systemic administration of recombinant interleukin 2 stimulates in vivo lymphoid cell proliferation in tissues

scientific article published in August 1985

Systemic induction of cells mediating antibody-dependent cellular cytotoxicity following administration of interleukin 2

scientific article published on 01 December 1989

T cell receptor affinity and avidity defines antitumor response and autoimmunity in T cell immunotherapy

scientific article published on 7 November 2013

T cell responses to Mls determinants are restricted by cross-reactive MHC determinants

scientific article published on 01 April 1985

T cells associated with tumor regression recognize frameshifted products of the CDKN2A tumor suppressor gene locus and a mutated HLA class I gene product

scientific article published in May 2004

T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

scientific article published on 13 October 2014

T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis.

scientific article

T-Cell Receptor Gene Therapy for Human Papillomavirus-Associated Epithelial Cancers: A First-in-Human, Phase I/II Study

scientific article published on 13 August 2019

T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer.

scientific article

T-cell Responses to TP53 "Hotspot" Mutations and Unique Neoantigens Expressed by Human Ovarian Cancers

scientific article published on 31 May 2018

T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy

scientific article published on April 2013

T-cell receptor gene therapy of established tumors in a murine melanoma model

scientific article

T-cell receptor repertoire in tumor-infiltrating lymphocytes. Analysis of melanoma-specific long-term lines

scientific article published on August 1994

T-cell therapy against cancer mutations

scientific article published on July 2014

TGF-beta 1 attenuates the acquisition and expression of effector function by tumor antigen-specific human memory CD8 T cells

scientific article published on May 2005

TIL therapy broadens the tumor-reactive CD8(+) T cell compartment in melanoma patients.

scientific article

Targeting of HPV-16+ Epithelial Cancer Cells by TCR Gene Engineered T Cells Directed against E6

scientific article

Technical aspects of lymphokine-activated killer cell production ⬇️

scientific article published on 01 January 1988

Tetramer based approach for efficient identification and isolation of neo-antigen specific CD8 T cells from peripheral blood (PBL) of patients with metastatic cancers

scientific article published on 4 November 2015

The GYMSSA trial: a prospective randomized trial comparing gastrectomy, metastasectomy plus systemic therapy versus systemic therapy alone

scientific article

The Persistence of Human Peripheral Lymphocytes, Tumor Infiltrating Lymphocytes, and Colon Adenocarcinomas in Immunodeficient Mice ⬇️

scientific article published on January 1, 1992

The Shedding of CD62L (L-Selectin) Regulates the Acquisition of Lytic Activity in Human Tumor Reactive T Lymphocytes ⬇️

scientific article published on July 28, 2011

The Use of Melanosomal Proteins in the Immunotherapy of Melanoma ⬇️

scientific article published on July 1, 1998

The Waardenburg syndrome type 4 gene, SOX10, is a novel tumor-associated antigen identified in a patient with a dramatic response to immunotherapy

scientific article published on June 2002

The anti-tumor efficacy of lymphokine-activated killer cells and recombinant interleukin 2 in vivo

scientific article published on 01 July 1985

The anti-tumor efficacy of lymphokine-activated killer cells and recombinant interleukin 2 in vivo: direct correlation between reduction of established metastases and cytolytic activity of lymphokine-activated killer cells

scientific article published on 01 May 1986

The concept, evolution and preliminary results of the current Stanford clinical trials for Hodgkin's disease

scientific article published on 01 January 1985

The current status and future applications of interleukin 2- and adoptive immunotherapy in cancer treatment

scientific article published on May 1988

The development of gene therapy for the treatment of cancer

scientific article published in October 1993

The effect of various cytokines on the in vitro induction of antibody-dependent cellular cytotoxicity in murine cells. Enhancement of IL-2-induced antibody-dependent cellular cytotoxicity activity by IL-1 and tumor necrosis factor-alpha

scientific article published on 01 April 1989

The evolution and summary results of the Stanford randomized clinical trials of the management of Hodgkin's disease: 1962-1984.

scientific article

The fate of interleukin-2 after in vivo administration

scientific article published on 01 May 1983

The hematologic toxicity of interleukin-2 in patients with metastatic melanoma and renal cell carcinoma

scientific article

The in vivo distribution of autologous human and murine lymphoid cells grown in T cell growth factor (TCGF): implications for the adoptive immunotherapy of tumors

scientific article published on 01 October 1980

The intronic region of an incompletely spliced gp100 gene transcript encodes an epitope recognized by melanoma-reactive tumor-infiltrating lymphocytes

scientific article published on July 1997

The management of stage I--II Hodgkin's disease with irradiation alone or combined modality therapy: the Stanford experience

scientific article published on 01 March 1982

The natural history of initially untreated low-grade non-Hodgkin's lymphomas

scientific article published on 01 December 1984

The potential benefits of therapeutic splenectomy for patients with Hodgkin's disease and non-Hodgkin's lymphomas

scientific article published in January 1985

The stoichiometric production of IL-2 and IFN-γ mRNA defines memory T cells that can self-renew after adoptive transfer in humans.

scientific article published in August 2012

The systemic administration of purified interleukin 2 enhances the ability of sensitized murine lymphocytes to cure a disseminated syngeneic lymphoma

scientific article published on 01 April 1984

The treatment of advanced stage favorable histology non-Hodgkin's lymphoma: a preliminary report of a randomized trial comparing single agent chemotherapy, combination chemotherapy, and whole body irradiation.

scientific article

The treatment of malignant histiocytosis

scientific article published on 01 July 1984

The use of interleukin-6 to generate tumor-infiltrating lymphocytes with enhanced in vivo antitumor activity

scientific article published on 01 February 1994

The value of sequential bone marrow biopsy and laparotomy and splenectomy in a series of 127 consecutive untreated patients with non-Hodgkin's lymphoma ⬇️

scientific article published on March 1, 1975

Third-line chemotherapy for resistant Hodgkin's disease with lomustine, etoposide, and methotrexate.

scientific article published in May 1987

Thoracic metastasectomy for adoptive immunotherapy of melanoma: a single-institution experience

scientific article published on 02 July 2010

Thrombotic microangiopathy in metastatic melanoma patients treated with adoptive cell therapy and total body irradiation

scientific article

Thyroid dysfunction in 281 patients with metastatic melanoma or renal carcinoma treated with interleukin-2 alone

scientific article published on 01 November 1995

Toll-like receptors in tumor immunotherapy

scientific article

Toward cell transfer immunotherapy against patient-specific mutations in gastrointestinal cancers

scientific article published on 6 November 2014

Toxicity of recombinant human interleukin-2 in rats following intravenous infusion

scientific article published on 01 August 1985

Transduction of an HLA-DP4-restricted NY-ESO-1-specific TCR into primary human CD4+ lymphocytes

scientific article

Transfer of a TCR gene derived from a patient with a marked antitumor response conveys highly active T-cell effector functions

scientific article

Transition of late-stage effector T cells to CD27+ CD28+ tumor-reactive effector memory T cells in humans after adoptive cell transfer therapy

scientific article published on 2 September 2004

Treating cancer with genetically engineered T cells ⬇️

scientific article published on June 12, 2011

Treatment of Patients With Metastatic Cancer Using a Major Histocompatibility Complex Class II-Restricted T-Cell Receptor Targeting the Cancer Germline Antigen MAGE-A3.

scientific article published on 15 August 2017

Treatment of advanced Hodgkin's disease with B-CAVE following MOPP failure

scientific article

Treatment of advanced Hodgkin's disease with adriamycin, bleomycin, vinblastine, and imidazole carboxamide (ABVD) after failure of MOPP therapy

scientific article

Treatment of advanced non-Hodgkin's lymphomas with favorable histologies: preliminary results of a prospective trial

scientific article published on 01 May 1976

Treatment of metastatic melanoma using interleukin-2 alone or in conjunction with vaccines

scientific article published on September 2008

Treatment of metastatic uveal melanoma with adoptive transfer of tumour-infiltrating lymphocytes: a single-centre, two-stage, single-arm, phase 2 study

scientific article

Treatment of refractory non-Hodgkin's lymphomas of unfavorable histology with teniposide, cytarabine, and cisplatin

scientific article published on 01 June 1987

Trends in the safety of high dose bolus interleukin-2 administration in patients with metastatic cancer ⬇️

scientific article published on August 15, 1998

Tumor Infiltrating Lymphocyte Therapy for Metastatic Melanoma: Analysis of Tumors Resected for TIL ⬇️

scientific article published on October 1, 2010

Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired

scientific article

Tumor progression can occur despite the induction of very high levels of self/tumor antigen-specific CD8+ T cells in patients with melanoma

scientific article published in November 2005

Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells.

scientific article

Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study

scientific article

Tumor- and Neoantigen-Reactive T-cell Receptors Can Be Identified Based on Their Frequency in Fresh Tumor

scientific article published on 28 June 2016

Tumor-infiltrating human CD4+ regulatory T cells display a distinct TCR repertoire and exhibit tumor and neoantigen reactivity

scientific article published on 01 January 2019

Tumor-infiltrating lymphocytes derived from select B-cell lymphomas secrete granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-alpha in response to autologous tumor stimulation

scientific article published on 01 August 1993

Tumor-infiltrating lymphocytes from human ovarian cancer patients recognize autologous tumor in an MHC class II-restricted fashion

scientific article published on 01 September 1996

Tumor-infiltrating lymphocytes genetically engineered with an inducible gene encoding interleukin-12 for the immunotherapy of metastatic melanoma

scientific article published on 18 February 2015

Tumor-reactive CD8+ T cells in metastatic gastrointestinal cancer refractory to chemotherapy.

scientific article

Tumor-specific CD4+ melanoma tumor-infiltrating lymphocytes

scientific article published on 01 June 2012

Tumor-specific CD8+ T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts

scientific article

Tumor-specific cytolysis by lymphocytes infiltrating human melanomas

scientific article published on 01 May 1989

Tumorigenicity and immunogenicity of murine tumor cells expressing an MHC class II molecule with a covalently bound antigenic peptide

scientific article

Unique Neoantigens Arise from Somatic Mutations in Patients with Gastrointestinal Cancers

scientific article published on 04 June 2019

Unique murine tumor-associated antigens identified by tumor infiltrating lymphocytes

scientific article published in February 1990

Unique neoantigens expressed by melanomas and common epithelial cancers presented by multiple HLA alleles can be efficiently identified utilizing peptide prediction algorithms

scientific article published on 4 November 2015

Upregulation of tumor necrosis factor-alpha production by retrovirally transduced human tumor-infiltrating lymphocytes using trans-retinoic acid

scientific article published in July 1994

Use of CD137 up-regulation to identify T cell receptors specifically reactive with mutated tumor associated antigens from tumor infiltrating lymphocytes

scientific article published on 4 November 2015

Use of HLA peptidomics and whole exome sequencing to identify human immunogenic neo-antigens.

scientific article published on 20 January 2016

Use of interleukin-7, interleukin-2, and interferon-gamma to propagate CD4+ T cells in culture with maintained antigen specificity

scientific article published on 01 October 1993

Use of recombinant poxviruses to stimulate anti-melanoma T cell reactivity ⬇️

scientific article published on January 1, 1998

Use of soluble recombinant TNF receptor to improve detection of TNF secretion in cultures of tumor infiltrating lymphocytes ⬇️

scientific article published on July 6, 1992

Use of standard criteria for assessment of cancer vaccines.

scientific article

Use of the piggyBac transposon to create stable packaging cell lines for the production of clinical-grade self-inactivating γ-retroviral vectors

scientific article

Use of tumor-infiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma. A preliminary report

scientific article published on 01 December 1988

Utilization of an alternative open reading frame of a normal gene in generating a novel human cancer antigen

scientific article

Vitiligo in patients with melanoma: normal tissue antigens can be targets for cancer immunotherapy

scientific article published on 01 January 1996

Whole-genome sequencing identifies a recurrent functional synonymous mutation in melanoma

scientific article published on 30 July 2013

gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma

scientific article

mRNA vaccine-induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer

scientific article published on 05 October 2020

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