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List of works by David Tuveson

5th International Symposium on Focused Ultrasound: North Bethesda, MD, USA. 28 August- 1 September 2016.

scientific article published on 21 November 2016

A FATal Combination: Fibroblast-Derived Lipids and Cancer-Derived Autotaxin Promote Pancreatic Cancer Growth

scientific article published on 01 May 2019

A framework for advancing our understanding of cancer-associated fibroblasts

scientific article published on 24 January 2020

A minimally invasive, lentiviral based method for the rapid and sustained genetic manipulation of renal tubules

scientific article published on 5 June 2015

A novel method for quantification of gemcitabine and its metabolites 2',2'-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC-MS/MS: comparison with (19)F NMR spectroscopy

scientific article published on 23 March 2011

A phase I trial of the oral, multikinase inhibitor sorafenib in combination with carboplatin and paclitaxel

scientific article

A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma ⬇️

scientific article published on 13 February 2018

ADAM8 as a drug target in pancreatic cancer.

scientific article

ATP citrate lyase inhibition can suppress tumor cell growth

scientific article

Accumulation of extracellular hyaluronan by hyaluronan synthase 3 promotes tumor growth and modulates the pancreatic cancer microenvironment.

scientific article published on 24 July 2014

Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

scientific article

Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening

An shRNA silencing a non-toxic transgene reduces nutrient consumption and increases production of adenoviral vectors in a novel packaging cell

scientific article

Anti-tumour efficacy of capecitabine in a genetically engineered mouse model of pancreatic cancer

scientific article (publication date: 2013)

Augmenting NF-κB in poor-risk CLL: A general paradigm for other cancers?

scientific article published on June 2015

Author Correction: Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution

scientific article published on 01 April 2020

BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages.

scientific article

BRAF as a potential therapeutic target in melanoma and other malignancies

scientific article

BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model

scientific article

Bioactivation of Napabucasin Triggers Reactive Oxygen Species-Mediated Cancer Cell Death

scientific article published on 16 September 2019

C-Raf inhibits MAPK activation and transformation by B-Raf(V600E).

scientific article

C-Raf is required for the initiation of lung cancer by K-Ras(G12D).

scientific article published on 11 May 2011

CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer ⬇️

scientific article published on 08 July 2013

Cancer Cell-Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma

scientific article published on 06 February 2020

Cancer modeling meets human organoid technology

scientific article published on 06 June 2019

Cancer: Double trouble for tumours.

scientific article published on 18 January 2017

Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice

scientific article published on 09 December 2011

Challenges and Opportunities in Modeling Pancreatic Cancer

scientific article published on 13 March 2017

Claudin-4-targeted optical imaging detects pancreatic cancer and its precursor lesions

scientific article

Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease

scientific article

Conjugation to the sigma-2 ligand SV119 overcomes uptake blockade and converts dm-Erastin into a potent pancreatic cancer therapeutic

scientific article published on 22 May 2016

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

scientific article published on 13 June 2019

Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice

scientific article published on 7 November 2011

Deciphering cancer fibroblasts

scientific article published on 23 November 2018

Decreased Serum Thrombospondin-1 Levels in Pancreatic Cancer Patients Up to 24 Months Prior to Clinical Diagnosis: Association with Diabetes Mellitus

scientific article published on 16 November 2015

Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885

scientific article

Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia.

scientific article

Deploying mouse models of pancreatic cancer for chemoprevention studies

scientific article published on 2 November 2010

Detecting and diagnosing ampullary neoplasms

scientific article published on 20 July 2004

Direct histological processing of EUS biopsies enables rapid molecular biomarker analysis for interventional pancreatic cancer trials

scientific article

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer.

scientific article published on 23 February 2017

Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer

scientific article published on 23 January 2020

Dynamic changes during the treatment of pancreatic cancer

scientific article published on 13 February 2018

Dynamics of the immune reaction to pancreatic cancer from inception to invasion

scientific article published on 01 October 2007

Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors

scientific article (publication date: 15 August 2002)

Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma

scientific article

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

scientific article

Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis

scientific article

Erratum: Corrigendum: Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis

scientific article published on 01 June 2016

Erratum: Corrigendum: The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

scientific article published in Nature

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

scientific article

Expression of oncogenic K-ras from its endogenous promoter leads to a partial block of erythroid differentiation and hyperactivation of cytokine-dependent signaling pathways

scientific article published on 22 February 2007

Famotidine use and quantitative symptom tracking for COVID-19 in non-hospitalised patients: a case series

scientific article published on 04 June 2020

Fibroblast heterogeneity in the cancer wound

scientific article

Finding and killing the CRABs of pancreatic cancer.

scientific article published on 28 July 2009

Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma

scientific article published on 20 February 2012

Generation and Characterisation of a Pax8-CreERT2 Transgenic Line and a Slc22a6-CreERT2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells

scientific article published on 11 February 2016

Generation and Culture of Human Pancreatic Ductal Adenocarcinoma Organoids from Resected Tumor Specimens

Generation and Culture of Human Pancreatic Ductal Adenocarcinoma Organoids from Resected Tumor Specimens

Generation and Culture of Tumor and Metastatic Organoids from Murine Models of Pancreatic Ductal Adenocarcinoma

article

Germline Brca2 Heterozygosity Promotes KrasG12D -Driven Carcinogenesis in a Murine Model of Familial Pancreatic Cancer ⬇️

scientific article published on November 4, 2010

Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism

scientific article published on 01 October 2019

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

scientific article published on 30 March 2012

IL-1-induced JAK/STAT signaling is antagonized by TGF-beta to shape CAF heterogeneity in pancreatic ductal adenocarcinoma

scientific article published on 26 October 2018

ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity

scientific article published on 19 February 2020

Identification of Resistance Pathways Specific to Malignancy Using Organoid Models of Pancreatic Cancer

scientific article published on 06 September 2019

Identification of novel vascular projections with cellular trafficking abilities on the microvasculature of pancreatic ductal adenocarcinoma.

scientific article published on 17 February 2015

Immigration in science

scientific article published on 01 November 2020

Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma.

scientific article

In search of an early warning system for pancreatic cancer

scientific article published on 01 January 2003

In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma

scientific article

Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D.

scientific article published on 2 April 2014

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

scientific article (publication date: 12 June 2009)

Kras in Organoids

scientific article published on 8 January 2018

Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas

scientific article

K‐Ras‐Driven Pancreatic Cancer Mouse Model for Anticancer Inhibitor Analyses

scientific article published on 01 January 2008

MARK2/MARK3 Kinases Are Catalytic Codependencies of YAP/TAZ in Human Cancer

scientific article published on 25 July 2024

MAX-ing out MYC: a novel small molecule inhibitor against MYC-dependent tumors

scientific article published on 27 November 2014

MRI with hyperpolarised [1-13C]pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse model

scientific article

Macrophage-Derived Granulin Drives Resistance to Immune Checkpoint Inhibition in Metastatic Pancreatic Cancer

scientific article published on 22 May 2018

Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis.

scientific article published on 18 April 2016

Maximizing mouse cancer models

scientific article

Mice expressing a mammary gland-specific R270H mutation in the p53 tumor suppressor gene mimic human breast cancer development.

scientific article published in September 2005

Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma

scientific article published on 01 January 2006

Model organoids provide new research opportunities for ductal pancreatic cancer

scientific article published on 23 February 2015

Modeling pancreatic cancer with organoids

scientific article published on April 2016

Modelling oncogenic Ras/Raf signalling in the mouse.

scientific article

Mouse Models of Pancreatic Ductal Adenocarcinoma

scientific article published on 11 June 2015

Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors

scientific article

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

scientific article published on 01 December 2004

NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer

scientific article published on 27 July 2016

Neratinib inhibits Hippo/YAP signaling, reduces mutant K-RAS expression, and kills pancreatic and blood cancer cells

scientific article published on 28 June 2019

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

scientific article (publication date: 6 July 2011)

Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer

scientific article published on 01 July 2019

Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy

scientific article published on 03 May 2019

Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer

article

Organoid models for translational pancreatic cancer research

scientific article published on 01 February 2019

PanIN Neuroendocrine Cells Promote Tumorigenesis via Neuronal Cross-talk.

scientific article published on 6 April 2017

Pancreatic cancer

article

Pancreatic cancer foiled by a switch of tumour subtype

journal article; published in Nature on 2018-05-14

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

scientific article

Pancreatic cancer in mice and man: the Penn Workshop 2004

scientific article published on 01 January 2006

Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations.

scientific article

Perspectives on the role of Wnt biology in cancer

scientific article published on 09 July 2019

Pharmacokinetics and pharmacodynamics of new drugs for pancreatic cancer

scientific article published on 05 July 2019

Physiological analysis of oncogenic K-ras

scientific article

Preclinical models of pancreatic ductal adenocarcinoma

scientific article

Predictive in vivo animal models and translation to clinical trials

scientific article published on March 2012

Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells

scientific article published on 04 September 2019

Quid pro Quo: A Tumor is Not Alone

scientific article published on 10 April 2017

RAS in cellular transformation and senescence

scientific article published on September 2009

ROS in Cancer: The Burning Question

scientific article

ROS in translation: Chink in the armor

scientific article published on 16 September 2016

Rapid and tunable method to temporally control gene editing based on conditional Cas9 stabilization

scientific article published on 22 February 2017

Ras redux: rethinking how and where Ras acts.

scientific article

Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine

scientific article published on 14 June 2018

Recapitulating human cancer in a mouse.

scientific article published in May 2013

Recurrent noncoding regulatory mutations in pancreatic ductal adenocarcinoma

scientific article published on 8 May 2017

Requirement for Rac1 in a K-ras induced lung cancer in the mouse

scientific article published in September 2007

Restoration of p53 function leads to tumour regression in vivo

scientific article (publication date: 8 February 2007)

Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression

scientific article published on 24 June 2011

RhoC interacts with integrin α5β1 and enhances its trafficking in migrating pancreatic carcinoma cells

scientific article

Roadmap for the Emerging Field of Cancer Neuroscience

scientific article published on 01 April 2020

SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia

scientific article published on 3 October 2011

SPARC independent drug delivery and antitumour effects ofnab-paclitaxel in genetically engineered mice ⬇️

scientific article published on September 25, 2013

Single-Pass vs 2-Pass Endoscopic Ultrasound-Guided Fine-Needle Biopsy Sample Collection for Creation of Pancreatic Adenocarcinoma Organoids

scientific article published on 29 February 2020

Soils and Seeds That Initiate Pancreatic Cancer Metastasis

scientific article published in October 2017

Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo

scientific article published on 23 May 2006

Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder

scholarly article

Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis

scientific article published on March 2007

Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation

scientific article published on 24 April 2020

Stromal biology and therapy in pancreatic cancer.

scientific article published on 21 October 2010

Stromal biology and therapy in pancreatic cancer: a changing paradigm

scientific article published on 20 May 2015

Stromal biology and therapy in pancreatic cancer: ready for clinical translation?

scientific article published on 03 September 2018

Successful creation of pancreatic cancer organoids by means of EUS-guided fine-needle biopsy for personalized cancer treatment

scientific article published on 8 January 2018

Suppression of BRAF(V599E) in human melanoma abrogates transformation ⬇️

scientific article published on 01 September 2003

Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha

scientific article

TLR9 ligation in pancreatic stellate cells promotes tumorigenesis

scientific article

TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

scientific article

Targeting oncogene dependence and resistance

scientific article

Technologically advanced cancer modeling in mice ⬇️

scientific article published on February 1, 2002

The RAS and YAP1 dance, who is leading?

scientific article published on 25 September 2014

The RON receptor tyrosine kinase mediates oncogenic phenotypes in pancreatic cancer cells and is increasingly expressed during pancreatic cancer progression.

scientific article

The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1.

scientific article published on 2 July 2015

The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

scientific article

The differential effects of mutant p53 alleles on advanced murine lung cancer

scientific article published on 01 November 2005

The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice

scientific article

The promise and perils of antioxidants for cancer patients

scientific article published in July 2014

The use of GEM models for experimental cancer therapeutics

scientific article published in September 2008

The use of targeted mouse models for preclinical testing of novel cancer therapeutics.

scientific article published on September 2006

Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution

scientific article published on 13 January 2020

Transcriptional Regulation by Nrf2.

scientific article

Translational medicine: Cancer lessons from mice to humans

scientific article published in Nature

Twist induces an epithelial-mesenchymal transition to facilitate tumor metastasis

scientific article

Understanding metastasis in pancreatic cancer: a call for new clinical approaches

scientific article published on 01 January 2012

Untangling the genetics from the epigenetics in pancreatic cancer metastasis

scientific article published in February 2017

VAV1: a new target in pancreatic cancer?

scientific article

Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy

scientific article

Waging war against pancreatic cancer: an interview with David Tuveson

scientific article

What we have learned about pancreatic cancer from mouse models.

scientific article published on 08 March 2012

nab-Paclitaxel potentiates gemcitabine activity by reducing cytidine deaminase levels in a mouse model of pancreatic cancer

scientific article published on 28 February 2012

p53 mutations change phosphatidylinositol acyl chain composition

scientific article

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