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List of works by Christian Hertweck

A Binuclear Manganese Cluster That Catalyzes Radical-Mediated N-Oxygenation

scientific article published on 01 January 2007

A Branched Extender Unit Shared between Two Orthogonal Polyketide Pathways in an Endophyte

scientific article published on 19 April 2011

A Fivefold Parallelized Biosynthetic Process Secures Chlorination of Armillaria mellea (Honey Mushroom) Toxins.

scientific article published on 11 December 2015

A Non-canonical Melanin Biosynthesis Pathway Protects Aspergillus terreus Conidia from Environmental Stress ⬇️

scientific article published on 26 April 2016

A Pair of Bacterial Siderophores Releases and Traps an Intercellular Signal Molecule: An Unusual Case of Natural Nitrone Bioconjugation

article published in 2018

A Pair of Bacterial Siderophores Releases and Traps an Intercellular Signal Molecule: An Unusual Case of Natural Nitrone Bioconjugation

A Pair of Bacterial Siderophores Releases and Traps an Intercellular Signal Molecule: An Unusual Case of Natural Nitrone Bioconjugation

A Photochemical Macrocyclization Route to Asymmetric Strained [3.2] Paracyclophanes

scientific article published in 2022

A Plant-like Biosynthesis of Benzoyl-CoA in the Marine Bacterium ‘Streptomyces maritimus’

article

A Specialized Polythioamide‐Binding Protein Confers Antibiotic Self‐Resistance in Anaerobic Bacteria

scientific article published in 2022

A concise total synthesis of sespenine, a structurally unusual indole terpenoid from Streptomyces

article published in 2016

A cryptic PKS–NRPS gene locus in the plant commensal Pseudomonas fluorescens Pf-5 codes for the biosynthesis of an antimitotic rhizoxin complex

scientific article published on 18 June 2007

A dedicated glutathione S-transferase mediates carbon-sulfur bond formation in gliotoxin biosynthesis

scientific article published on 22 July 2011

A family of multicyclic indolosesquiterpenes from a bacterial endophyte

scientific article published on 28 April 2011

A functional link between hyphal maintenance and quorum sensing in Candida albicans

scientific article published on 14 September 2016

A gene cluster encoding resistomycin biosynthesis in Streptomyces resistomycificus; exploring polyketide cyclization beyond linear and angucyclic patterns

scientific article

A gene cluster encoding rhizoxin biosynthesis in "Burkholderia rhizoxina", the bacterial endosymbiont of the fungus Rhizopus microsporus

scientific article

A genomic approach to the cryptic secondary metabolome of the anaerobic world

scientific article published on 21 December 2012

A giant type I polyketide synthase participates in zygospore maturation in Chlamydomonas reinhardtii.

scientific article

A highly conserved basidiomycete peptide synthetase produces a trimeric hydroxamate siderophore ⬇️

scientific article

A highly conserved gene locus in endofungal bacteria codes for the biosynthesis of symbiosis-specific cyclopeptides

A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis

scientific article

A polyketide interferes with cellular differentiation in the symbiotic cyanobacterium Nostoc punctiforme

A polyyne toxin produced by an antagonistic bacterium blinds and lyses a Chlamydomonad alga

scientific article

A polyyne toxin produced by an antagonistic bacterium blinds and lyses a green microalga

scientific article published on 24 March 2021

A ribonucleotide reductase-like electron transfer system in the nitroaryl-forming N-oxygenase AurF.

scientific article

A widespread bacterial phenazine forms S-conjugates with biogenic thiols and crosslinks proteins

A „Magic Mushroom“ Multi‐Product Sesquiterpene Synthase

scientific article published in 2023

Activation of a silent fungal polyketide biosynthesis pathway through regulatory cross talk with a cryptic nonribosomal peptide synthetase gene cluster

scientific article published on 15 October 2010

Activation of fungal silent gene clusters: a new avenue to drug discovery.

scientific article published on January 2008

Active invasion of bacteria into living fungal cells

scientific article

Advances in cloning, functional analysis and heterologous expression of fungal polyketide synthase genes

scientific article

Alternative Benzoxazole Assembly Discovered in Anaerobic Bacteria Provides Access to Privileged Heterocyclic Scaffold

scientific article published in 2022

An Unexpected Split-Merge Pathway to the Symmetric Nonribosomal Peptide Antibiotic Closthioamide

scientific article published on 29 October 2020

An Unexpected Split‐Merge Pathway in the Assembly of the Symmetric Nonribosomal Peptide Antibiotic Closthioamide

scientific article published in 2020

An antifungal polyketide associated with horizontally acquired genes supports symbiont-mediated defense in Lagria villosa beetles. ⬇️

scientific article

An unusual galactofuranose lipopolysaccharide that ensures the intracellular survival of toxin-producing bacteria in their fungal host

scientific article published on October 2010

Anaerobic bacteria as producers of antibiotics

scientific article published on 02 August 2012

Analysis of Rhizonin Biosynthesis Reveals Origin of Pharmacophoric Furylalanine Moieties in Diverse Cyclopeptides

scientific article published in 2023

Analysis of the Aspergillus fumigatus proteome reveals metabolic changes and the activation of the pseurotin A biosynthesis gene cluster in response to hypoxia

scientific article

Antagonistic bacteria disrupt calcium homeostasis and immobilize algal cells.

scientific article published on 24 November 2017

Anti-bacterial activities and phytochemical screening of extracts of different parts of Thalictrum rhynchocarpum

scientific article published on 12 August 2013

Anti-inflammatory and anti-hyaluronate lyase activities of lanostanoids from Piptoporus betulinus ⬇️

scientific article

Antibiotic-producing symbionts dynamically transition between plant pathogenicity and insect-defensive mutualism

scientific article

Antibiotics from neglected bacterial sources

scientific article published on 04 September 2013

Antifungal potential of secondary metabolites involved in the interaction between citrus pathogens

scientific article published on 09 December 2019

Antimicrobial discovery inspired by ecological interactions.

scientific article published on 20 November 2017

Antimitotic rhizoxin derivatives from a cultured bacterial endosymbiont of the rice pathogenic fungus Rhizopus microsporus

scientific article

Antiproliferative effects of ester- and amide-functionalized rhizoxin derivatives

scientific article published on 25 August 2011

Antiterminator-Mediated Unveiling of Cryptic Polythioamides in an Anaerobic Bacterium

scientific article published on 27 January 2012

Artificial Reconstruction of Two Cryptic Angucycline Antibiotic Biosynthetic Pathways

scientific article published on 01 September 2007

Aspernidine A and B, prenylated isoindolinone alkaloids from the model fungus Aspergillus nidulans ⬇️

scientific article published on 26 May 2010

Assembly and absolute configuration of short-lived polyketides from Burkholderia thailandensis

scientific article published on 19 April 2012

Assessing Oxazole Bioisosteres as Mutasynthons on the Rhizoxin Assembly Line

scientific article published on 25 August 2011

Asymmetric α-Chloroallylboration of Amino Aldehydes: A Novel and Highly Versatile Route tod- andl-erythro-Sphingoid Bases†

scientific article published in June 1999

Bacaryolanes A-C, Rare Bacterial Caryolanes from a Mangrove Endophyte ⬇️

scientific article published on 27 November 2015

Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation

scientific article

Bacterial Synthesis of Diverse Indole Terpene Alkaloids by an Unparalleled Cyclization Sequence

scientific article published on 11 September 2012

Bacterial Synthesis of Unusual Sulfonamide and Sulfone Antibiotics by Flavoenzyme-Mediated Sulfur Dioxide Capture

scientific article published on 14 September 2015

Bacterial ectosymbionts in cuticular organs chemically protect a beetle during molting stages

scientific article published on 2 September 2022

Bacterial endosymbionts protect beneficial soil fungus from nematode attack

scientific article published on 14 September 2021

Bacterium Induces Cryptic Meroterpenoid Pathway in the Pathogenic FungusAspergillus fumigatus

scientific article published in 2013

Bacterium induces cryptic meroterpenoid pathway in the pathogenic fungus Aspergillus fumigatus

scientific article published in 2013

Benzopyrenomycin, a cytotoxic bacterial polyketide metabolite with a benzo[a]pyrene-type carbocyclic ring system

scientific article published in January 2008

Bezerramycins Aâ C, Antiproliferative Phenoxazinones fromStreptomyces griseusFeaturing Carboxy, Carboxamide or Nitrile Substituents

Bioinspired Total Synthesis of Sespenine

scientific article published on 24 June 2014

Biomimetic Thioesters as Probes for Enzymatic Assembly Lines: Synthesis, Applications, and Challenges

scientific article

Biosynthesis and Charging of Pyrrolysine, the 22nd Genetically Encoded Amino Acid ⬇️

scientific article published on July 27, 2011

Biosynthesis and attachment of novel bacterial polyketide synthase starter units

scientific article

Biosynthesis and function of gliotoxin in Aspergillus fumigatus

scientific article

Biosynthesis and mass spectrometric imaging of tolaasin, the virulence factor of brown blotch mushroom disease

scientific article

Biosynthesis and structure of aeruginoside 126A and 126B, cyanobacterial peptide glycosides bearing a 2-carboxy-6-hydroxyoctahydroindole moiety ⬇️

scientific article

Biosynthesis of Archetypal Plant Self-Defensive Oxylipins by an Endophytic Fungus Residing in Mangrove Embryos

article

Biosynthesis of Diverse Antimicrobial and Antiproliferative Acyloins in Anaerobic Bacteria

scientific article published on 21 June 2019

Biosynthesis of antifungal and antibacterial polyketides by Burkholderia gladioli in coculture with Rhizopus microsporus

scientific article published on 23 September 2014

Biosynthesis of cervimycin C, an aromatic polyketide antibiotic bearing an unusual dimethylmalonyl moiety

scientific article

Biosynthesis of nitro compounds

scientific article published on June 2007

Biosynthesis of pentangular polyphenols: deductions from the benastatin and griseorhodin pathways

scientific article

Biosynthesis of polyunsaturated fatty acids by polyketide synthases.

scientific article published in June 2002

Biosynthesis of the Antimetabolite 6-Thioguanine in<i>Erwinia amylovora</i>Plays a Key Role in Fire Blight Pathogenesis

scientific article published in 2013

Biosynthesis of the antimetabolite 6-thioguanine in Erwinia amylovora plays a key role in fire blight pathogenesis

scientific article published on 22 August 2013

Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide

scientific article published in May 2005

Biosynthesis of the halogenated mycotoxin aspirochlorine in koji mold involves a cryptic amino acid conversion

scientific article published on 10 October 2014

Biosynthesis of the mitochondrial adenine nucleotide translocase (ATPase) inhibitor bongkrekic acid in Burkholderia gladioli

scientific article published on 5 February 2010

Biosynthesis of the respiratory toxin bongkrekic acid in the pathogenic bacterium Burkholderia gladioli

scientific article published in September 2012

Biosynthetic code for divergolide assembly in a bacterial mangrove endophyte

scientific article published on 27 May 2014

Biosynthetic origin of the rare nitroaryl moiety of the polyketide antibiotic aureothin: involvement of an unprecedented N-oxygenase

scientific article published in March 2004

Bipiperidine conjugates as soluble sugar surrogates in DNA-intercalating antiproliferative polyketides

scientific article published on 14 March 2016

Botryorhodines A-D, antifungal and cytotoxic depsidones from Botryosphaeria rhodina, an endophyte of the medicinal plant Bidens pilosa

scientific article

Burkholderia rhizoxinica sp. nov. and Burkholderia endofungorum sp. nov., bacterial endosymbionts of the plant-pathogenic fungus Rhizopus microsporus

scientific article

Cell Chemical Biology: Home of Exciting Chemical Biology

scientific article published on 01 January 2016

Cervimycin A-D: a polyketide glycoside complex from a cave bacterium can defeat vancomycin resistance

scientific article

Cervimycin C resistance in Bacillus subtilis is due to a promoter up-mutation and increased mRNA stability of the constitutive ABC-transporter gene bmrA

article

Cervimycin-Resistant Staphylococcus aureus Strains Display Vancomycin-Intermediate Resistant Phenotypes

scientific article published in 2022

Characterization of Burkholderia rhizoxinica and B. endofungorum isolated from clinical specimens

scientific article

ChemInform Abstract: Bezerramycins A-C, Antiproliferative Phenoxazinones from Streptomyces griseus Featuring Carboxy, Carboxamide or Nitrile Substituents.

scientific article published on 22 April 2010

Chemical Mediators at the Bacterial-Fungal Interface

scientific article published on 13 July 2020

Chemical ecology of endophytic fungi: origins of secondary metabolites

scientific article published on July 2012

Chemical warfare between leafcutter ant symbionts and a co-evolved pathogen.

scientific article published on 7 June 2018

Chemoenzymatic Total Synthesis of the Antiproliferative Polyketide (+)-(R)-Aureothin

scientific article published on 01 September 2008

Chromatin mapping identifies BasR, a key regulator of bacteria-triggered production of fungal secondary metabolites

scientific article published on 12 October 2018

Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase. ⬇️

scientific article published on December 2000

Closthioamide: An Unprecedented Polythioamide Antibiotic from the Strictly Anaerobic Bacterium Clostridium cellulolyticum

scientific article published on 01 March 2010

Closthioamide: An Unprecedented Polythioamide Antibiotic from the Strictly Anaerobic Bacterium Clostridium cellulolyticum

scientific article published on 15 February 2010

Clostrindolin is an antimycobacterial pyrone alkaloid from Clostridium beijerinckii

scientific article published on 01 June 2019

Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi

scientific article

Comparison of proteomic responses as global approach to antibiotic mechanism of action elucidation

scientific article published on 12 October 2020

Complete genome sequence of Burkholderia rhizoxinica, an Endosymbiont of Rhizopus microsporus.

scientific article

Concise Total Synthesis of Hydrazidomycin A, a Rare Hydrazide Metabolite ofStreptomyces atratus

Context-dependent behavior of the enterocin iterative polyketide synthase; a new model for ketoreduction

scientific article

Control of plant defense mechanisms and fire blight pathogenesis through the regulation of 6-thioguanine biosynthesis in Erwinia amylovora

scientific article published on 21 January 2014

Convergent Asymmetric Synthesis of (+)-Aureothin Employing an Oxygenase-Mediated Resolution Step

scientific article published on 16 July 2012

Copper(II) Triflate in Organic Synthesis

Cover Picture: A Gene Cluster Encoding Rhizoxin Biosynthesis in “Burkholderia rhizoxina”, the Bacterial Endosymbiont of the FungusRhizopus microsporus (ChemBioChem 1/2007)

scientific article published in 2007

Cover Picture: Biosynthesis of the Antimetabolite 6-Thioguanine in<i>Erwinia amylovora</i>Plays a Key Role in Fire Blight Pathogenesis (Angew. Chem. Int. Ed. 40/2013)

scientific article published in 2013

Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification

scientific article published on 15 June 2017

Cryptic polyketide synthase genes in non-pathogenic Clostridium SPP

scientific article

Cyclopropanol Warhead in Malleicyprol Confers Virulence of Human- and Animal-Pathogenic Burkholderia Species ⬇️

scientific article published on 27 August 2019

Cyclopropanol Warhead in Malleicyprol Confers Virulence of Human‐ and Animal‐Pathogenic <i>Burkholderia</i> Species

scientific article published in 2019

Cytotoxic Alkaloids from Fusarium incarnatum Associated with the Mangrove Tree Aegiceras corniculatum

scientific article published on 22 March 2012

Cytotoxic pheofungins from an engineered fungus impaired in posttranslational protein modification

scientific article published on 12 September 2011

Daldionin, an Unprecedented Binaphthyl Derivative, and Diverse Polyketide Congeners from a Fungal Orchid Endophyte

scientific article published on 16 February 2016

Dandamycin and chandrananimycin E, benzoxazines from Streptomyces griseus ⬇️

scientific article published on 18 February 2015

Deciphering Chemical Mediators Regulating Specialized Metabolism in a Symbiotic Cyanobacterium

scientific article published on 11 April 2022

Decoding and reprogramming complex polyketide assembly lines: prospects for synthetic biology

scientific article

Detection of antibiotics synthetized in microfluidic picolitre-droplets by various actinobacteria

scientific article published on 30 August 2018

Die biosynthetische Grundlage der Polyketid-Vielfalt

scientific article published in 2009

Differential expression of silent polyketide biosynthesis gene clusters in chemostat cultures of Aspergillus nidulans

scientific article published on 26 January 2012

Discovery of Amidotemplated Natural Product Assembly

scientific article published on 11 November 2019

Discovery of Clostrubin, an Exceptional Polyphenolic Polyketide Antibiotic from a Strictly Anaerobic Bacterium

scientific article published on 14 May 2014

Discovery of an Extended Austinoid Biosynthetic Pathway in Aspergillus calidoustus

scientific article

Discovery of aspoquinolones A-D, prenylated quinoline-2-one alkaloids from Aspergillus nidulans, motivated by genome mining

scientific article published on 10 August 2006

Discovery of the Pseudomonas Polyyne Protegencin by a Phylogeny-Guided Study of Polyyne Biosynthetic Gene Cluster Diversity

scientific article published on 03 August 2021

Disruption of Membrane Integrity by the Bacterium-Derived Antifungal Jagaricin

scientific article published on 23 August 2019

Dissection of the late steps in aureothin biosynthesis

scientific article

Distinct amino acids of histone H3 control secondary metabolism in Aspergillus nidulans

scientific article

Divergolide congeners illuminate alternative reaction channels for ansamycin diversification

scientific article published on February 2015

Divergolides A-D from a Mangrove Endophyte Reveal an Unparalleled Plasticity in ansa-Macrolide Biosynthesis

scientific article published on 11 January 2011

Draft Genome Sequence and Gene Annotation of the Entomopathogenic Fungus Verticillium hemipterigenum

scientific article published on 22 January 2015

Draft Genome Sequences of Symbiotic and Nonsymbiotic Rhizopus microsporus Strains CBS 344.29 and ATCC 62417.

scientific article published on 22 January 2015

Ecological Niche-Inspired Genome Mining Leads to the Discovery of Crop-Protecting Nonribosomal Lipopeptides Featuring a Transient Amino Acid Building Block

scientific article published on 20 January 2023

Efficient Synthesis of 9- and 13-Oxo Leucomycin Derivatives Using Hypervalent Iodine Reagents in Solution and on Solid Support

scientific article published on 01 January 2005

Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.

scientific article

Electrochemical monitoring of ROS generation by anticancer agents: the case of chartreusin

scholarly article in RSC Advances, vol. 7 no. 71, 2017

Emulating evolutionary processes to morph aureothin-type modular polyketide synthases and associated oxygenases

scientific article published on 02 September 2019

Endofungal bacteria as producers of mycotoxins

scientific article published on October 2009

Endofungal bacteria boost anthelminthic host protection with the biosurfactant symbiosin

scientific article published in 2023

Endofungal bacterium controls its host by an hrp type III secretion system

scientific article

Endosymbiont-Dependent Host Reproduction Maintains Bacterial-Fungal Mutualism

scientific article (publication date: May 2007)

Enzymatic Amide Tailoring Promotes Retro-Aldol Amino Acid Conversion To Form the Antifungal Agent Aspirochlorine

Enzymatic Amide Tailoring Promotes Retro-Aldol Amino Acid Conversion To Form the Antifungal Agent Aspirochlorine

Enzymatic Carbon-Sulfur Bond Formation in Natural Product Biosynthesis.

scientific article

Enzymatic Thioamide Formation in a Bacterial Antimetabolite Pathway

scientific article published on 02 August 2018

Enzymatic Thioamide Formation in a Bacterial Antimetabolite Pathway

Enzymatic polyketide chain branching to give substituted lactone, lactam, and glutarimide heterocycles

scientific article published on 11 September 2014

Enzyme‐Primed Native Chemical Ligation Produces Autoinducing Cyclopeptides in Clostridia ⬇️

scientific article published on 24 February 2021

Enzyme‐Primed Native Chemical Ligation Produces Autoinducing Cyclopeptides in Clostridia

scientific article published in 2021

Epicoccalone, a Coumarin-Type Chymotrypsin Inhibitor, and Isobenzofuran Congeners from anEpicoccumsp. Associated with a Tree Fungus

Epicoccamides B–D, Glycosylated Tetramic Acid Derivatives from anEpicoccumsp. Associated with the Tree FungusPholiota squarrosa

scientific article published on 30 October 2007

Epicoccarines A, B and epipyridone: tetramic acids and pyridone alkaloids from an Epicoccum sp. associated with the tree fungus Pholiota squarrosa

scientific article published on 24 April 2007

Epidithiodiketopiperazine biosynthesis: a four-enzyme cascade converts glutathione conjugates into transannular disulfide bridges

scientific article published on 26 August 2013

Epidithiol formation by an unprecedented twin carbon-sulfur lyase in the gliotoxin pathway

scientific article

Evolution of an endofungal lifestyle: Deductions from the Burkholderia rhizoxinica genome ⬇️

scientific article

Evolution of host resistance in a toxin-producing bacterial-fungal alliance

scientific article

Evolution of metabolic diversity in polyketide-derived pyrones: using the non-colinear aureothin assembly line as a model system

scientific article published on 03 August 2009

Evolution of siderophore pathways in human pathogenic bacteria

scientific article published on 7 April 2014

Evolutionary imprint of catalytic domains in fungal PKS-NRPS hybrids

scientific article published on 28 September 2012

Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues

scientific article

Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

scientific article published on 27 January 2008

Exploiting the natural diversity of microviridin gene clusters for discovery of novel tricyclic depsipeptides ⬇️

scientific article

Exploration of polyyne biosynthetic gene cluster diversity in bacteria leads to the discovery of the Pseudomonas polyyne protegencin

scientific article published on 6 March 2021

Exploring the chemical space of microbial natural products

scientific article published on 10 April 2009

Factors supporting cysteine tolerance and sulfite production in Candida albicans

scientific article

Farinamycin, a quinazoline from Streptomyces griseus

scientific article

Flavoenzyme-catalyzed formation of disulfide bonds in natural products

scientific article

Food preparation with mucoralean fungi: A potential biosafety issue?

scientific article published on 19 December 2015

Food-Poisoning Bacteria Employ a Citrate Synthase and a Type II NRPS to Synthesize Bolaamphiphilic Lipopeptide Antibiotics

scientific article published on 11 August 2020

Formation of a dinuclear copper(I) complex from the Clostridium-derived antibiotic closthioamide

scientific article published on 23 August 2013

Formation of the aureothin tetrahydrofuran ring by a bifunctional cytochrome p450 monooxygenase

scientific article published in December 2004

Freedom and constraint in engineered noncolinear polyketide assembly lines

scientific article published on 5 February 2015

From Powerful Review Articles to Research Breakthroughs

article

Frontispiece: Metal-Free Synthesis of Pharmaceutically Important Biaryls by Photosplicing

Frontispiz: Metal-Free Synthesis of Pharmaceutically Important Biaryls by Photosplicing

Functional Analysis of the Aureothin Iterative Type I Polyketide Synthase

scientific article published on 01 May 2005

Functional analysis of environmental DNA-derived microviridins provides new insights into the diversity of the tricyclic peptide family ⬇️

scientific article published on 13 December 2013

Functional genomic profiling of Aspergillus fumigatus biofilm reveals enhanced production of the mycotoxin gliotoxin

scientific article published on September 2010

Functionally distinct modules operate two consecutive alpha,beta-->beta,gamma double-bond shifts in the rhizoxin polyketide assembly line

scientific article published in February 2010

Fungal phytotoxins as mediators of virulence

scientific article published on 14 July 2009

Fusaric acid detoxification: a strategy of Gliocladium roseum involved in its antagonism against Fusarium verticillioides

scientific article published in 2022

Geminal Bismethylation Prevents Polyketide Oxidation and Dimerization in the Benastatin Pathway

scholarly article by Angéla Schenk et al published 17 September 2007 in Angewandte Chemie International Edition

Geminal tandem C-methylation in the discoid resistomycin pathway

scientific article

Genome Editing Reveals Novel Thiotemplated Assembly of Polythioamide Antibiotics in Anaerobic Bacteria

article by Kyle L. Dunbar et al published 3 October 2018 in Angewandte Chemie International Edition

Genome Editing Reveals Novel Thiotemplated Assembly of Polythioamide Antibiotics in Anaerobic Bacteria

Genome Mining Reveals Endopyrroles from a Nonribosomal Peptide Assembly Line Triggered in Fungal-Bacterial Symbiosis

scientific article published on 22 July 2019

Genome Mining and Heterologous Expression Reveal Two Distinct Families of Lasso Peptides Highly Conserved in Endofungal Bacteria

scientific article published on 18 December 2019

Genome Sequence of Mushroom Soft-Rot Pathogen Janthinobacterium agaricidamnosum

scientific article published on 16 April 2015

Genome mining for ribosomally synthesized and post-translationally modified peptides (RiPPs) in anaerobic bacteria

scientific article

Genomics-Driven Discovery of NO-Donating Diazeniumdiolate Siderophores in Diverse Plant-Associated Bacteria ⬇️

scientific article published on 05 August 2019

Genomics-Driven Discovery of a Symbiont-Specific Cyclopeptide from Bacteria Residing in the Rice Seedling Blight Fungus

scientific article published on 02 October 2018

Genomics-Guided Discovery of Endophenazines from Kitasatospora sp. HKI 714

scientific article published on 11 March 2014

Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans

scientific article published on 18 March 2007

Genomics-driven discovery of a linear lipopeptide promoting host colonization by endofungal bacteria

scientific article published on 01 September 2018

Genomics-driven discovery of burkholderic acid, a noncanonical, cryptic polyketide from human pathogenic Burkholderia species

scientific article published on 10 October 2012

Genomics-inspired discovery of natural products

scientific article

Genomics‐Driven Discovery of NO‐Donating Diazeniumdiolate Siderophores in Diverse Plant‐Associated Bacteria

scientific article published in 2019

Gliotoxin Biosynthesis: Structure, Mechanism, and Metal Promiscuity of Carboxypeptidase GliJ.

scientific article published on 19 May 2017

Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B4 Formation through Inhibition of Leukotriene A4 Hydrolase

scientific article published on 07 February 2019

Global distribution and evolution of a toxinogenic Burkholderia-Rhizopus symbiosis

scientific article

Gramibactin is a bacterial siderophore with a diazeniumdiolate ligand system

scholarly article by Ron Hermenau published in July 2018

Harnessing the evolvability of tricyclic microviridins to dissect protease-inhibitor interactions

scientific article

Helper bacteria halt and disarm mushroom pathogens by linearizing structurally diverse cyclolipopeptides ⬇️

scientific article published on 31 August 2020

Hidden biosynthetic treasures brought to light

scientific article published on 01 July 2009

High-density cultivation of terrestrial Nostoc strains leads to reprogramming of secondary metabolome ⬇️

scientific article

Highly Efficient Total Synthesis of the Clostridium-Derived anti-MRSA Antibiotic Closthioamide

article by Florian Kloss et al published 3 February 2011 in European Journal of Organic Chemistry

Highly efficient synthesis of (±)-lamoxirene, the gamete-releasing and gamete-attracting pheromone of the Laminariales (Phaeophyta)

Horizontal Gene Transfer to a Defensive Symbiont with a Reduced Genome in a Multipartite Beetle Microbiome

scientific article published on 25 February 2020

Hydrazidomycins, cytotoxic alkylhydrazides from Streptomycesatratus

scientific article

Hygrobafilomycin, a cytotoxic and antifungal macrolide bearing a unique monoalkylmaleic anhydride moiety, from Streptomyces varsoviensis ⬇️

scientific article published on 16 June 2010

Identification and Mobilization of a Cryptic Antibiotic Biosynthesis Gene Locus from a Human-Pathogenic Nocardia Isolate

scientific article published on 14 November 2019

Imaging mass spectrometry and genome mining reveal highly antifungal virulence factor of mushroom soft rot pathogen

scientific article

Impact of Endofungal Bacteria on Infection Biology, Food Safety, and Drug Development ⬇️

scientific article published on June 30, 2011

Induced Biosynthesis of Cryptic Polyketide Metabolites in a Burkholderia thailandensis Quorum Sensing Mutant

scientific article published on 01 October 2010

Induced Chemical Defense of a Mushroom by a Double-Bond-Shifting Polyene Synthase

scientific article published on 25 April 2017

Induced Production, Synthesis, and Immunomodulatory Action of Clostrisulfone, a Diarylsulfone from Clostridium acetobutylicum

scientific article published on 30 September 2020

Injury-Triggered Blueing Reactions of Psilocybe "Magic" Mushrooms

scientific article published on 04 December 2019

Injury‐Triggered Blueing Reactions of <i>Psilocybe</i> “Magic” Mushrooms

scientific article published in 2019

Inotilone and related phenylpropanoid polyketides from Inonotus sp. and their identification as potent COX and XO inhibitors

scientific article published on 24 May 2006

Insect-Associated Bacteria Assemble the Antifungal Butenolide Gladiofungin by Non-Canonical Polyketide Chain Termination ⬇️

scientific article published on 26 June 2020

Insect‐Associated Bacteria Assemble the Antifungal Butenolide Gladiofungin by Non‐Canonical Polyketide Chain Termination

scientific article published in 2020

Interchenar Retrotransfer of Aureothin Intermediates in an Iterative Polyketide Synthase Module

scientific article published on 23 July 2012

Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans ⬇️

scholarly article

Iron coordination properties of gramibactin as model for the new class of diazeniumdiolate based siderophores

scientific article published on 02 October 2020

Isoflavones with unusually modified B-rings and their evaluation as antiproliferative agents

scientific article published on 28 August 2009

Iteration as programmed event during polyketide assembly; molecular analysis of the aureothin biosynthesis gene cluster

scientific article

Kandenols A–E, Eudesmenes from an Endophytic Streptomyces sp. of the Mangrove Tree Kandelia candel

scientific article published on 12 December 2012

Keratin degradation by dermatophytes relies on cysteine dioxygenase and a sulfite efflux pump

scientific article published on 25 January 2013

Ketosynthase III as a gateway to engineering the biosynthesis of antitumoral benastatin derivatives.

scientific article

Lack of evidence of endosymbiotic toxin-producing bacteria in clinical Rhizopus isolates

article

Leader peptide and a membrane protein scaffold guide the biosynthesis of the tricyclic peptide microviridin

scientific article published in November 2011

Lichen-like association of Chlamydomonas reinhardtii and Aspergillus nidulans protects algal cells from bacteria

scientific article published on 04 August 2020

Loss of Single-Domain Function in a Modular Assembly Line Alters the Size and Shape of a Complex Polyketide

scientific article published on 30 October 2019

Loss of Single‐Domain Function in a Modular Assembly Line Alters the Size and Shape of a Complex Polyketide

scientific article published in 2019

Mapping Natural Dyes in Archeological Textiles by Imaging Mass Spectrometry

article by Annemarie Elisabeth Kramell et al published 20 February 2019 in Scientific Reports

Mapping of the modular closthioamide architecture reveals crucial motifs of polythioamide antibiotics

scientific article

Matrix-free single-cell LDI-MS investigations of the diatoms Coscinodiscus granii and Thalassiosira pseudonana.

scientific article

Mediators of mutualistic microbe-microbe interactions

scientific article published on 8 September 2017

Melleolides impact fungal translation via elongation factor 2

scientific article published on 01 May 2019

Metabolic Pathway Rerouting in Paraburkholderia rhizoxinica Evolved Long-Overlooked Derivatives of Coenzyme F420

scientific article published on 11 September 2019

Metal-Free Aryl Cross-Coupling Directed by Traceless Linkers

scientific article published on 17 October 2019

Metal-Free Aryl Cross-Coupling Directed by Traceless Linkers

Metal-Free Synthesis of Pharmaceutically Important Biaryls by Photosplicing

Metal-Free Synthesis of Pharmaceutically Important Biaryls by Photosplicing

Metal-Free Synthesis of Pharmaceutically Important Biaryls by Photosplicing

Microalgae in the postgenomic era: a blooming reservoir for new natural products

scientific article published on 27 September 2011

Microalgae in the postgenomic era: a blooming reservoir for new natural products

scientific article published in 2013

Microcyclamide biosynthesis in two strains of Microcystis aeruginosa: from structure to genes and vice versa ⬇️

scientific article

Minimum Information about a Biosynthetic Gene cluster.

scientific article published on August 2015

Mining Symbionts of a Spider-Transmitted Fungus Illuminates Uncharted Biosynthetic Pathways to Cytotoxic Benzolactones ⬇️

scientific article published on 10 February 2020

Mining Symbionts of a Spider‐Transmitted Fungus Illuminates Uncharted Biosynthetic Pathways to Cytotoxic Benzolactones

scientific article published in 2020

Mining and unearthing hidden biosynthetic potential

scientific article published in 2021

Mode of action of closthioamide: the first member of the polythioamide class of bacterial DNA gyrase inhibitors

scientific article published on 14 July 2015

Molecular Basis of Cytochalasan Biosynthesis in Fungi: Gene Cluster Analysis and Evidence for the Involvement of a PKS-NRPS Hybrid Synthase by RNA Silencing

article

Molecular analysis of the benastatin biosynthetic pathway and genetic engineering of altered fatty acid-polyketide hybrids

scientific article published on 17 April 2007

Molecular bacteria-fungi interactions: effects on environment, food, and medicine

scientific article published on 26 June 2013

Molecular basis for mycophenolic acid biosynthesis in Penicillium brevicompactum ⬇️

scientific article

Molecular diversity sculpted by fungal PKS-NRPS hybrids

scientific article published on 07 December 2012

Moonlighting Arabidopsis molybdate transporter 2 family and GSH-complex formation facilitate molybdenum homeostasis

scientific article published in 2023

Multifactorial control of iteration events in a modular polyketide assembly line

scientific article published on 18 April 2013

Multifactorial induction of an orphan PKS-NRPS gene cluster in Aspergillus terreus

scientific article published on 13 January 2011

Mutasynthesis of Aureonitrile: An Aureothin Derivative with Significantly Improved Cytostatic Effect

scientific article published on 01 February 2005

Mutasynthesis of enterocin and wailupemycin analogues

scientific article published in August 2003

N-Heterocyclization in Gliotoxin Biosynthesis is Catalyzed by a Distinct Cytochrome P450 Monooxygenase

scientific article published on 24 August 2020

Natural 1,3-Dipolar Cycloadditions

scientific article published on 7 September 2015

Natural Products as Source of Therapeutics against Parasitic Diseases

scientific article published on 6 November 2015

Natural products from reconstructed bacterial genomes of the Middle and Upper Paleolithic

scientific article published on 04 May 2023

Nebularic Acids and Nebularilactones, Novel Drimane Sesquiterpenoids from the FungusLepista nebularis

Nitro versus hydroxamate in siderophores of pathogenic bacteria: effect of missing hydroxylamine protection in malleobactin biosynthesis

scientific article published on 2 July 2013

Non-canonical two-step biosynthesis of anti-oomycete indole alkaloids in Kickxellales

scientific article published in 2023

Non-colinear polyketide biosynthesis in the aureothin and neoaureothin pathways: an evolutionary perspective

scientific article

Nostopeptolide plays a governing role during cellular differentiation of the symbiotic cyanobacterium Nostoc punctiforme

scientific article

Oak-Associated Negativicute Equipped with Ancestral Aromatic Polyketide Synthase Produces Antimycobacterial Dendrubins

scientific article published on 29 June 2020

On-Line Polyketide Cyclization into Diverse Medium-Sized Lactones by a Specialized Ketosynthase Domain

scientific article published on 24 July 2018

On-Line Polyketide Cyclization into Diverse Medium-Sized Lactones by a Specialized Ketosynthase Domain

On-line enzymatic tailoring of polyketides and peptides in thiotemplate systems

scientific article published on 06 February 2016

Opposed effects of enzymatic gliotoxin N- and S-methylations

scientific article published on 7 August 2014

Optimisation of a 2-D gel electrophoresis protocol for the human-pathogenic fungus Aspergillus fumigatus

scientific article published on 17 December 2005

Orchestration of discoid polyketide cyclization in the resistomycin pathway

scientific article

Our Advisors, Our Ambassadors, Our Editorial Board Members

scientific article published on 01 March 2016

Oxygenated Geosmins and Plant-like Eudesmanes from a Bacterial Mangrove Endophyte ⬇️

scientific article published on 19 June 2020

Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead

scientific article published in 2022

Pathogenic fungus harbours endosymbiotic bacteria for toxin production

scientific article

Phenalenone-type phytoalexins mediate resistance of banana plants (Musa spp.) to the burrowing nematode Radopholus similis.

scientific article

Photochemical Origin of the Immunosuppressive SNF4435C/D and Formation of Orinocin through “Polyene Splicing”

scientific article published on 01 November 2006

Photochemical oxazole-nitrile conversion downstream of rhizoxin biosynthesis and its impact on antimitotic activity

scientific article

Phytotoxin production in Aspergillus terreus is regulated by independent environmental signals

scientific article published on 14 July 2015

Pitucamycin: structural merger of a phenoxazinone with an epoxyquinone antibiotic

scientific article published on September 2010

Plant pathogenic anaerobic bacteria use aromatic polyketides to access aerobic territory

scientific article

Plant-like Cadinane Sesquiterpenes from an Actinobacterial Mangrove Endophyte

scientific article published on 29 June 2020

Plant-like biosynthetic pathways in bacteria: from benzoic acid to chalcone

scientific article

Plasticity and evolution of aeruginosin biosynthesis in cyanobacteria

scientific article published on 05 February 2009

Plasticity in gilvocarcin-type C-glycoside pathways: discovery and antitumoral evaluation of polycarcin V from Streptomyces polyformus

scientific article

Plasticity of the malleobactin pathway and its impact on siderophore action in human pathogenic bacteria

scientific article

Polyketide proofreading by an acyltransferase-like enzyme

scientific article

Polyketide synthase chimeras reveal key role of ketosynthase domain in chain branching

scientific article published on 19 October 2015

Polyketide-chain branching by an enzymatic Michael addition

scientific article published in January 2009

Proof-Reading Thioesterase Boosts Activity of Engineered Nonribosomal Peptide Synthetase

scientific article published in 2022

Pseudoxylallemycins A-F, Cyclic Tetrapeptides with Rare Allenyl Modifications Isolated from Pseudoxylaria sp. X802: A Competitor of Fungus-Growing Termite Cultivars

scientific article published on 24 June 2016

Publisher Correction: Detection of antibiotics synthetized in microfluidic picolitre-droplets by various actinobacteria

scientific article published in Scientific Reports

Pyran formation by an atypical CYP-mediated four-electron oxygenation-cyclization cascade in an engineered aureothin pathway

scientific article published on 7 September 2012

Quercinol, an anti-inflammatory chromene from the wood-rotting fungus Daedalea quercina (Oak Mazegill).

scientific article

Rapid Screening of Polyol Polyketides from Marine Dinoflagellates

scientific article published in 2022

Rational Design of an Apoptosis-Inducing Photoreactive DNA Intercalator

scientific article published on 06 May 2013

Rational design of modular polyketide synthases: morphing the aureothin pathway into a luteoreticulin assembly line

scientific article published on 8 January 2014

Reconstitution of Enzymatic Carbon–Sulfur Bond Formation Reveals Detoxification-Like Strategy in Fungal Toxin Biosynthesis

scientific article published on 17 August 2018

Reconstitution of Iterative Thioamidation in Closthioamide Biosynthesis Reveals Tailoring Strategy for Nonribosomal Peptide Backbones

scientific article published on 07 August 2019

Reconstitution of Iterative Thioamidation in Closthioamide Biosynthesis Reveals Tailoring Strategy for Nonribosomal Peptide Backbones

scientific article published in 2019

Reconstitution of polythioamide antibiotic backbone formation reveals unusual thiotemplated assembly strategy

scientific article published in 2020

Reflecting on the past and looking forward to the future of bridging chemistry and biology

scientific article published in September 2014

Regio- and Chemoselective Enzymatic N-Oxygenation In Vivo, In Vitro, and in Flow

scientific article published on 01 December 2006

Regiodivergent N-C and N-N aryl coupling reactions of indoloterpenes and cycloether formation mediated by a single bacterial flavoenzyme

scientific article

Regioselective Dichlorination of a Non-Activated Aliphatic Carbon Atom and Phenolic Bismethylation by a Multifunctional Fungal Flavoenzyme

scientific article published on 25 August 2016

Rhizonin, the first mycotoxin isolated from the zygomycota, is not a fungal metabolite but is produced by bacterial endosymbionts

scientific article published on 22 November 2006

Ribosomal synthesis of tricyclic depsipeptides in bloom-forming cyanobacteria

scientific article

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

scientific article

Ribosome-independent peptide biosynthesis: the challenge of a unifying nomenclature

scientific article published in 2022

ScbA from Streptomyces coelicolor A3(2) has homology to fatty acid synthases and is able to synthesize -butyrolactones

scientific article published on 01 May 2007

Semisynthetic preparation of leucomycin derivatives: introduction of aromatic side chains by reductive amination

scientific article

Sequential Allylic Alcohol Formation by a Multifunctional Cytochrome P450 Monooxygenase with Rare Redox Partners

scientific article published in 2022

Sequential asymmetric polyketide heterocyclization catalyzed by a single cytochrome P450 monooxygenase (AurH).

scientific article

Sequential enzymatic oxidation of aminoarenes to nitroarenes via hydroxylamines

scientific article published in June 2005

Serinal-derived vinyl oxiranes as novel and versatile building blocks for the stereoselective synthesis of D- and L-erythro-sphingosines

article published in 1998

Simultaneous Production of Psilocybin and a Cocktail of β-Carboline Monoamine Oxidase Inhibitors in "Magic" Mushrooms

scientific article published on 13 December 2019

Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function

scientific article published on 24 June 2022

Specialized Flavoprotein Promotes Sulfur Migration and Spiroaminal Formation in Aspirochlorine Biosynthesis

scientific article published on 22 December 2020

Squarrosidine and Pinillidine: 3,3′-Fused Bis(styrylpyrones) fromPholiota squarrosa andPhellinus pini

Stereochemical specificity of lamoxirene, the sperm-releasing pheromone in kelp (Laminariales, Phaeophyceae).

scientific article published in October 2001

Structural and Conformational Study of the O-Antigenic Portion of the Lipopolysaccharide Isolated fromBurkholderia gladiolipv.cocovenenans

Structural and biochemical basis for the firm chemo- and regioselectivity of the nitro-forming N-oxygenase AurF.

scientific article published on 8 September 2010

Structural basis of head to head polyketide fusion by CorB.

scientific article

Structural characterization of two lipopolysaccharide O-antigens produced by the endofungal bacterium Burkholderia sp. HKI-402 (B4)

Structural fine-tuning of a multifunctional cytochrome P450 monooxygenase

scientific article

Structural investigation of the lipopolysaccharide O-chain isolated from Burkholderia fungorum strain DSM 17061.

scientific article published on 9 July 2016

Structure and action of the N-oxygenase AurF from Streptomyces thioluteus

scientific article

Structure and alignment of the membrane-associated peptaibols ampullosporin A and alamethicin by oriented 15N and 31P solid-state NMR spectroscopy

scientific article published on January 2009

Structure, genetics and function of an exopolysaccharide produced by a bacterium living within fungal hyphae

scientific article published on 21 December 2014

Sulfonium Acids Loaded onto an Unusual Thiotemplate Assembly Line Construct the Cyclopropanol Warhead of a <i>Burkholderia</i> Virulence Factor

scientific article published in 2020

Sulfonium Acids Loaded onto an Unusual Thiotemplate Assembly Line Construct the Cyclopropanol Warhead of a Burkholderia Virulence Factor

scientific article published on 21 April 2020

Sustainable and highly controlled aryl couplings revealed by systematic assessment of photoactivatable linkers

scientific article published in 2022

Symbiont-Derived Antimicrobials Contribute to the Control of the Lepidopteran Gut Microbiota

scientific article published on January 2017

Symbiotic Cooperation in the Biosynthesis of a Phytotoxin

scientific article published on 22 August 2012

Symbiotic Streptomycetes provide antibiotic combination prophylaxis for wasp offspring

scientific article published on 28 February 2010

Synthesis and biological evaluation of hydrazidomycin analogues

scientific article published on 19 September 2013

Synthetic remodeling of the chartreusin pathway to tune antiproliferative and antibacterial activities

scientific article

Tandem reduction-chloroallylboration of esters: asymmetric synthesis of lamoxirene, the spermatozoid releasing and attracting pheromone of the laminariales (Phaeophyceae)

scientific article

Targeted induction of a silent fungal gene cluster encoding the bacteria-specific germination inhibitor fumigermin

scientific article published on 21 February 2020

Terpenoid biosynthesis off the beaten track: unconventional cyclases and their impact on biomimetic synthesis

scientific article published on 08 December 2014

Terrein biosynthesis in Aspergillus terreus and its impact on phytotoxicity

scientific article published on 8 May 2014

The Boat-Shaped Polyketide Resistoflavin Results fromRe-Facial Central Hydroxylation of the Discoid Metabolite Resistomycin

scientific article published on 01 November 2006

The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus

scientific article published on 30 August 2011

The biosynthetic logic of polyketide diversity

scientific article published on January 2009

The chemistry and biology of cytochalasans

scientific article published on 22 April 2010

The fungal quorum-sensing molecule farnesol activates innate immune cells but suppresses cellular adaptive immunity

scientific article published on 17 March 2015

The molecular basis of conjugated polyyne biosynthesis in phytopathogenic bacteria

scientific article published on 4 June 2014

Three Redundant Synthetases Secure Redox-Active Pigment Production in the Basidiomycete Paxillus involutus.

scientific article published on October 2015

Titelbild: Biosynthesis of the Antimetabolite 6-Thioguanine in<i>Erwinia amylovora</i>Plays a Key Role in Fire Blight Pathogenesis (Angew. Chem. 40/2013)

scientific article published in 2013

Total synthesis of the antitumor natural product polycarcin V and evaluation of its DNA binding profile

scientific article

Toxin production by bacterial endosymbionts of a Rhizopus microsporus strain used for tempe/sufu processing

scientific article published on 19 October 2009

Transannular disulfide formation in gliotoxin biosynthesis and its role in self-resistance of the human pathogen Aspergillus fumigatus

scientific article published in July 2010

Transcriptome analysis of cyclic AMP-dependent protein kinase A-regulated genes reveals the production of the novel natural compound fumipyrrole by Aspergillus fumigatus

scientific article published on 11 March 2015

Triggering cryptic natural product biosynthesis in microorganisms

scientific article published on 06 March 2009

Tuf of Streptococcus pneumoniae is a surface displayed human complement regulator binding protein

scientific article published on 01 November 2014

Two Types of Threonine-Tagged Lipopeptides Synergize in Host Colonization by Pathogenic Burkholderia Species

scientific article published on 18 April 2018

Two induced fungal polyketide pathways converge into antiproliferative spiroanthrones

scientific article

Twofold polyketide branching by a stereoselective enzymatic Michael addition

scientific article

Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork

scientific article published on 22 November 2006

Unexpected Bacterial Origin of the Antibiotic Icosalide: Two-Tailed Depsipeptide Assembly in Multifarious Burkholderia Symbionts

scientific article published on 04 September 2018

Unique Biosynthetic Pathway in Bloom-Forming Cyanobacterial Genus Microcystis Jointly Assembles Cytotoxic Aeruginoguanidines and Microguanidines ⬇️

scientific article published on 28 December 2018

Vegetation-derived abscisic acid and four terpenes enforce dormancy in seeds of the post-fire annual, Nicotiana attenuata

Vinylogous chain branching catalysed by a dedicated polyketide synthase module

scientific article

Voices of Chemical Biology: Charting the Next Decade

scholarly article by Milka Kostic et al published February 2016 in Cell chemical biology

Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte

scientific article

Zincophorin - biosynthesis in Streptomyces griseus and antibiotic properties

scientific article published on 28 November 2016

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