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List of works by Stefan Offermanns

(D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G.

scientific article published on June 2005

25 Identification of receptor-activated G proteins with photoreactive GTP analog, α-32PGTP azidoanilide

scientific article published on January 1, 1991

A differential role of the platelet ADP receptors P2Y1 and P2Y12 in Rac activation.

scientific article

A functional role for semaphorin 4D/plexin B1 interactions in epithelial branching morphogenesis during organogenesis

scientific article published on 17 September 2008

A high-affinity bradykinin receptor in membranes from rat myometrium is coupled to pertussis toxin-sensitive G-proteins of the G i family

scientific article published on 01 March 1990

A mouse model with tamoxifen-inducible thyrocyte-specific cre recombinase activity.

scientific article published on 15 January 2014

A new G(q)-initiated MAPK signaling pathway in the heart.

scientific article published in February 2009

A novel biological role for the phospholipid lysophosphatidylinositol in nociceptive sensitization via activation of diverse G-protein signalling pathways in sensory nerves in vivo

scientific article published on 22 August 2013

A novel luminescence-based method for the detection of functionally active antibodies to muscarinic acetylcholine receptors of the M3 type (mAchR3) in patients' sera

scientific article published in July 2014

A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib.

scientific article published on 22 December 2016

A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system

scientific article published on 15 May 2010

Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Gαq/Gα11 in cardiomyocytes

scientific article published on 01 November 2001

Activation of Calpain-2 by Mediators in Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension

scientific article published on 6 August 2015

Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets

scientific journal article

Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis

scientific article

Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice.

scientific article published on 31 January 2012

Activation of platelet function through G protein-coupled receptors

scientific article published on December 2006

Activity Modes in Thalamocortical Relay Neurons are Modulated by G(q)/G(11) Family G-proteins - Serotonergic and Glutamatergic Signaling

scientific article

Acylation of Galpha(13) is important for its interaction with thrombin receptor, transforming activity and actin stress fiber formation.

scientific article

Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice

scientific article published on 08 May 2020

Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages.

scientific article published on 16 October 2017

Age-dependent blood pressure elevation is due to increased vascular smooth muscle tone mediated by G-protein signalling

scientific article published on 3 November 2015

An X-linked Myh11-CreERT2 mouse line resulting from Y to X chromosome-translocation of the Cre allele.

scientific article published on 28 August 2017

An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81.

scientific article published in April 2010

Anaphylactic shock depends on endothelial Gq/G11.

scientific article published on 26 January 2009

Angiopoietin-2-integrin α5β1 signaling enhances vascular fatty acid transport and prevents ectopic lipid-induced insulin resistance

scientific article published on 12 June 2020

Antagonistic regulation of neurite morphology through Gq/G11 and G12/G13.

scientific article

Anti-glycoprotein VI treatment severely compromises hemostasis in mice with reduced alpha2beta1 levels or concomitant aspirin therapy

scientific article (publication date: 2 November 2004)

Arachidonic Acid Metabolite 19(S)-HETE Induces Vasorelaxation and Platelet Inhibition by Activating Prostacyclin (IP) Receptor

scientific article

ArhGEF18 regulates RhoA-Rock2 signaling to maintain neuro-epithelial apico-basal polarity and proliferation

scientific article published on 22 May 2013

Arterial Myogenic Activation through Smooth Muscle Filamin A.

scientific article published on 23 February 2016

Aspirin induces platelet receptor shedding via ADAM17 (TACE)

scientific article (publication date: 2 December 2005)

Association of axon guidance factor Semaphorin 3A with poor outcome in pancreatic cancer

scientific article published on 01 December 2007

Beta2 integrins mediate protein tyrosine phosphorylation in human neutrophils

scientific article published on 01 May 1996

Biological and pharmacological roles of HCA receptors

scientific article published on January 2011

Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases

scientific article published on 2 July 2010

Calcium-dependent persistent facilitation of spike backpropagation in the CA1 pyramidal neurons

scientific article published on 01 July 2000

Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors

scientific article

Characteristic defects in neural crest cell-specific Galphaq/Galpha11- and Galpha12/Galpha13-deficient mice

scientific article

Characterization of determinants of ligand binding to the nicotinic acid receptor GPR109A (HM74A/PUMA-G).

scientific article published on 11 August 2005

Characterization of the expression of PDZ-RhoGEF, LARG and G(alpha)12/G(alpha)13 proteins in the murine nervous system.

scientific article

Characterization of the extra-large G protein alpha-subunit XLalphas. II. Signal transduction properties.

scientific article

Climbing fiber synapse elimination during postnatal cerebellar development requires signal transduction involving G alpha q and phospholipase C beta 4.

scientific article published in January 2000

Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling

scientific article published on 26 February 2015

Complex information processing by the transmembrane signaling system involving G proteins

scientific article published on October 1994

Conditional gene deletion in primary nociceptive neurons of trigeminal ganglia and dorsal root ganglia

scientific article published in March 2004

Conditional mutagenesis of G-protein coupled receptors and G-proteins.

scientific article published on January 2007

Conditionally expressed G alpha 15 couples to endogenous receptors in GH3 cells.

scientific article

Connexin45 provides optimal atrioventricular nodal conduction in the adult mouse heart

scientific journal article

Consequences of postnatal vascular smooth muscle EGFR deletion on acute angiotensin II action

scientific article published on 5 October 2015

Conserved MIP receptor-ligand pair regulates Platynereis larval settlement

scientific article

Constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure

scientific article

Corticotropin releasing hormone receptor 2 exacerbates chronic cardiac dysfunction.

scientific article published on 26 May 2017

Costimulation of Gi- and G12/G13-mediated signaling pathways induces integrin alpha IIbbeta 3 activation in platelets

scientific article published on 14 August 2002

DVL as a scaffold protein capturing classical GPCRs

scientific article published on November 2010

Defective platelet activation in G alpha(q)-deficient mice.

scientific article published on September 1997

Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension

scientific article

Deletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels

scientific article published on 05 April 2013

Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis

scientific article

Der Gq/G11-vermittelte zelluläre Signalweg und seine Bedeutung für kardiale Erkrankungen

scientific article published on 01 September 2001

Developmental vascular remodeling defects and postnatal kidney failure in mice lacking Gpr116 (Adgrf5) and Eltd1 (Adgrl4).

scientific article published on 14 August 2017

Diabetes-related defects in sarcoplasmic Ca2+ release are prevented by inactivation of G(alpha)11 and G(alpha)q in murine cardiomyocytes

scientific article published on 7 April 2010

Dicer generates a regulatory microRNA network in smooth muscle cells that limits neointima formation during vascular repair

scientific article published on 12 September 2016

Differential activation of Gi and Gs proteins by E- and I-type prostaglandins in membranes from the human erythroleukaemia cell line, HEL

scientific journal article

Differential activation of dibutyryl cAMP-differentiated HL-60 human leukemia cells by chemoattractants

scientific article

Differential expression of protein kinase C isoforms in coronary arteries of diabetic mice lacking the G-protein Gα11.

scientific article published on 29 December 2010

Differential involvement of Galpha12 and Galpha13 in receptor-mediated stress fiber formation

scientific article published in June 1999

Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides.

scientific article

Disruption of TGF-β signaling in smooth muscle cell prevents elastase-induced abdominal aortic aneurysm

scientific article published on 18 October 2014

Distinct roles of Galpha(q) and Galpha11 for Purkinje cell signaling and motor behavior.

scientific article published in June 2004

Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis.

scientific article

Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice

scientific article

Endocannabinoid-mediated modulation of Gq/11 protein-coupled receptor signaling-induced vasoconstriction and hypertension

scientific article published on 13 January 2015

Endogenous metabolites as ligands for G protein-coupled receptors modulating risk factors for metabolic and cardiovascular disease

scientific article published on 15 December 2012

Endothelial Gαq/11 is required for VEGF-induced vascular permeability and angiogenesis

scientific article

Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release

scientific article published on 31 October 2016

Epidermal loss of Gαq confers a migratory and differentiation defect in keratinocytes

scientific article

Epithelial Gpr116 regulates pulmonary alveolar homeostasis via Gq/11 signaling

scientific article

ErbB-2 and met reciprocally regulate cellular signaling via plexin-B1.

scientific article published on 19 November 2007

ErbB-2 signals through Plexin-B1 to promote breast cancer metastasis

scientific article published in March 2012

Evidence for cross-talk between glycoprotein VI and Gi-coupled receptors during collagen-induced platelet aggregation.

scientific article published in June 2001

Evidence for opioid receptor-mediated activation of the G-proteins, Go and Gi2, in membranes of neuroblastoma x glioma (NG108-15) hybrid cells ⬇️

scientific article (publication date: 25 February 1991)

Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1

scientific article

Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia

scientific article published on 28 January 2015

FFA2 and FFA3 in Metabolic Regulation

scientific article published on 19 October 2016

Forebrain-specific inactivation of Gq/G11 family G proteins results in age-dependent epilepsy and impaired endocannabinoid formation

scientific article

Free fatty acid (FFA) and hydroxy carboxylic acid (HCA) receptors

scientific article published on 16 October 2013

Functional specificity of G alpha q and G alpha 11 in the cholinergic and glutamatergic modulation of potassium currents and excitability in hippocampal neurons.

scientific article published in February 2002

G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C

scientific article

G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells

scientific article

G alpha(q) signal in osteoblasts is inhibitory to the osteoanabolic action of parathyroid hormone

scientific article published on 23 February 2011

G protein-coupled receptor-mediated mitogen-activated protein kinase activation through cooperation of Galpha(q) and Galpha(i) signals

scientific article

G protein-coupled receptors for energy metabolites as new therapeutic targets

scientific article published on 13 July 2012

G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets

scientific article

G(12)/G(13)-mediated signalling in mammalian physiology and disease

scientific article published on 22 September 2008

G(13)-mediated signaling pathway is required for pressure overload-induced cardiac remodeling and heart failure

scientific article

G(alpha)q-deficient mice lack metabotropic glutamate receptor-dependent long-term depression but show normal long-term potentiation in the hippocampal CA1 region

scientific journal article

G(q/11)α and G(s)α mediate distinct physiological responses to central melanocortins

scientific article

G-protein stimulatory subunit alpha and Gq/11α G-proteins are both required to maintain quiescent stem-like chondrocytes

scientific article

G-protein-mediated signaling in vascular smooth muscle cells - implications for vascular disease

scientific article published on 14 June 2015

G-proteins as transducers in transmembrane signalling

scientific article

G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension

scientific article

G12/G13 family G proteins regulate marginal zone B cell maturation, migration, and polarization

scientific article

G13 controls angiogenesis through regulation of VEGFR-2 expression

scientific article published on 9 May 2013

G13 is an essential mediator of platelet activation in hemostasis and thrombosis

scientific journal article

G13-mediated signaling as a potential target for antiplatelet drugs

scientific article (publication date: October 2004)

GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo.

scientific article published on 17 March 2016

GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing

scientific article

GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathy

scientific article

GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors

scientific article

GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes

scientific article published on 24 July 2013

GPR54 regulates ERK1/2 activity and hypothalamic gene expression in a Gα(q/11) and β-arrestin-dependent manner

scientific article

Galpha12 and galpha13 are phosphorylated during platelet activation

scientific article

Galpha12/13 is essential for directed cell migration and localized Rho-Dia1 function

scientific article published on 25 October 2005

Galpha12/Galpha13 deficiency causes localized overmigration of neurons in the developing cerebral and cerebellar cortices

scientific article

Gene deletion mutants reveal a role for semaphorin receptors of the plexin-B family in mechanisms underlying corticogenesis

scientific article published on 30 November 2009

Genetic Evidence Supports a Major Role for Akt1 in VSMCs During Atherogenesis

scientific article

Genetic analysis of mammalian G-protein signalling

scientific article published in September 1998

Genetic dissection of plexin signaling in vivo

scientific article published on 27 January 2014

Genetic dissection of the vav2-rac1 signaling axis in vascular smooth muscle cells

scientific article

GnRH Neuron-Specific Ablation of Gαq/11 Results in Only Partial Inactivation of the Neuroendocrine-Reproductive Axis in Both Male and Female Mice: In Vivo Evidence for Kiss1r-Coupled Gαq/11-Independent GnRH Secretion

scientific article

Gonadotropin and gonadal steroid release in response to a gonadotropin-releasing hormone agonist in Gqalpha and G11alpha knockout mice

scientific article published in June 1998

Gpr177 regulates pulmonary vasculature development

scientific article

Gpr177 regulates pulmonary vasculature development.

scientific article published in October 2013

Group I metabotropic glutamate receptor signaling via Galpha q/Galpha 11 secures the induction of long-term potentiation in the hippocampal area CA1.

scientific article published in October 2002

Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility.

scientific article published on 30 April 2009

Gα(q/11) signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization

scientific article

Heating Up the Cutaneous Flushing Response

scientific article published on 01 June 2014

Heterologously expressed formyl peptide receptor 2 (FPR2/ALX) does not respond to lipoxin A₄.

scientific article published in May 2013

Heterotrimeric G proteins of the Gq/11 family are crucial for the induction of maternal behavior in mice

scientific article

Histamine increases cytosolic Ca2+ in dibutyryl-cAMP-differentiated HL-60 cells via H1 receptors and is an incomplete secretagogue

scientific article published in August 1992

Hydroxy-Carboxylic Acid Receptor Actions in Metabolism

scientific article published on 10 January 2017

Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate's protective effect in EAE.

scientific article

Hyperhomocysteinemia is detrimental to pregnancy in mice and is associated with preterm birth

scientific article published on 8 April 2013

IGF-1 receptor deficiency in thyrocytes impairs thyroid hormone secretion and completely inhibits TSH-stimulated goiter

scientific article

Identification of Hic-5 as a novel scaffold for the MKK4/p54 JNK pathway in the development of abdominal aortic aneurysms

scientific article

Identification of receptor-activated G proteins: selective immunoprecipitation of photolabeled G-protein alpha subunits

scientific article published in January 1994

Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking Galphaq

scientific journal article

In vivo functions of heterotrimeric G-proteins: studies in Galpha-deficient mice.

scientific article

In vivo modulation of endothelial polarization by Apelin receptor signalling

scientific article

Increased apoptosis and browning of TAK1-deficient adipocytes protects against obesity

scientific article published on 19 May 2016

Inducible human endothelin-1 overexpression in endothelium raises blood pressure via endothelin type A receptors

scientific article

Inducible knockout mutagenesis reveals compensatory mechanisms elicited by constitutive BK channel deficiency in overactive murine bladder

scientific article

Inhibition of voltage-dependent Ca2+ currents and activation of pertussis toxin-sensitive G-proteins via muscarinic receptors in GH3 cells.

scientific article published on July 1991

Interaction of G alpha(12) with G alpha(13) and G alpha(q) signaling pathways

scientific journal article

International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B).

scientific article

Intravascular Survival and Extravasation of Tumor Cells

scientific article published in September 2017

It Ain’t Over ‘Til the Fat Lady Sings ⬇️

scientific article published on August 22, 2012

LPA1 receptor-mediated thromboxane A2 release is responsible for lysophosphatidic acid-induced vascular smooth muscle contraction

scientific article published on 9 January 2017

Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner

scientific article

Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling

scientific article published on 15 July 2020

Leukemia-associated Rho guanine-nucleotide exchange factor is not critical for RhoA regulation, yet is important for platelet activation and thrombosis in mice.

scientific article published on 03 September 2015

Lineage tracing of cells involved in atherosclerosis.

scientific article published on 11 June 2016

Lipopeptides activate Gi-proteins in dibutyryl cyclic AMP-differentiated HL-60 cells.

scientific article published on November 1993

Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells ⬇️

scientific article published on March 1, 1992

Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function

scientific article published on 26 May 2020

Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes

scientific article published on 12 January 2015

Loss of Gq/11 family G proteins in the nervous system causes pituitary somatotroph hypoplasia and dwarfism in mice

scientific article

Loss of epithelial Gq and G11 signaling inhibits TGFβ production but promotes IL-33-mediated macrophage polarization and emphysema

scientific article published on 25 October 2016

Lysophospholipids Control Integrin-dependent Adhesion in Splenic B Cells through Giand G12/G13Family G-proteins but Not through Gq/G11

scientific article published in Journal of Biological Chemistry

Mammalian G proteins and their cell type specific functions

scientific article

Maternal extracellular vesicles and platelets promote preeclampsia via inflammasome activation in trophoblasts

scientific article

Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis.

scientific article

Members of Bitter Taste Receptor Cluster Tas2r143/Tas2r135/Tas2r126 Are Expressed in the Epithelium of Murine Airways and Other Non-gustatory Tissues

scientific article published on 30 October 2017

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome.

scientific article published on April 2015

Mice lacking Plexin-B3 display normal CNS morphology and behaviour

scientific article published on 21 August 2009

MicroRNAs are necessary for vascular smooth muscle growth, differentiation, and function

scientific article

Mouse models to study G-protein-mediated signaling

scientific article published on January 2004

Muscarinic ACh receptor-mediated control of thalamic activity via G(q)/G (11)-family G-proteins

scientific article

Muscarinic inhibition of calcium current and M current in Galpha q-deficient mice

scientific journal article

Mutations in Myosin Light Chain Kinase Cause Familial Aortic Dissections.

scientific article published in April 2011

Mutations in myosin light chain kinase cause familial aortic dissections

scientific article

Myogenic vasoconstriction requires G/G and LARG to maintain local and systemic vascular resistance

scientific article published on 24 September 2019

NK2 receptor-mediated detrusor muscle contraction involves Gq/11-dependent activation of voltage-dependent Ca2+ channels and the RhoA-Rho kinase pathway

scientific article published on 28 August 2019

Neurotensin Is Coexpressed, Coreleased, and Acts Together With GLP-1 and PYY in Enteroendocrine Control of Metabolism

scientific article published on 15 October 2015

New insights into the in vivo function of heterotrimeric G-proteins through gene deletion studies.

scientific article

Niacin activates the PI3K/Akt cascade via PKC- and EGFR-transactivation-dependent pathways through hydroxyl-carboxylic acid receptor 2.

scientific article

Niacin stimulates adiponectin secretion through the GPR109A receptor

scientific journal article

Nicotinic acid (niacin): new lipid-independent mechanisms of action and therapeutic potentials

scientific article published on 22 September 2011

Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells

scientific article

Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice

scientific article

Nicotinic acid-induced flushing is mediated by activation of epidermal langerhans cells

scientific article

Nicotinic acid: an old drug with a promising future

scientific article

Nicotinic acid: pharmacological effects and mechanisms of action

scientific article (publication date: 2008)

Nikotinsäure bei Fettstoffwechselstörungen: Molekularer Mechanismus und klinischer Stellenwert

scientific article published on 01 January 2007

Nutritional or pharmacological activation of HCA(2) ameliorates neuroinflammation

scientific article

Obesogenic and Diabetogenic Effects of High-Calorie Nutrition Require Adipocyte BK Channels

scientific article

Organization of transmembrane signalling by heterotrimeric G proteins.

scientific article published on January 1996

P2Y₂ and Gq/G₁₁ control blood pressure by mediating endothelial mechanotransduction.

scientific article

PAR1 Scaffolds TGFβRII to Downregulate TGF-β Signaling and Activate ESC Differentiation to Endothelial Cells

scientific article published on 14 November 2016

PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12

scientific article

PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect

scientific article (publication date: March 2003)

Parathyroid-specific double knockout of Gq and G11 alpha-subunits leads to a phenotype resembling germline knockout of the extracellular Ca2+ -sensing receptor

scientific article published on 20 September 2006

Pertussis toxin reverses prostaglandin E2- and somatostatin-induced inhibition of rat parietal cell H+-production

scientific article published on 01 May 1992

Pharmacology of platelet adhesion and aggregation

scientific article published on January 2004

Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation.

scientific article published on 7 September 2018

Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling

scientific article published on 29 October 2015

Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor.

scientific article published on 27 June 2013

Pleiotropic effects of Pasteurella multocida toxin are mediated by Gq-dependent and -independent mechanisms. involvement of Gq but not G11.

scientific article published on 2 November 2000

Plexin-B family members demonstrate non-redundant expression patterns in the developing mouse nervous system: an anatomical basis for morphogenetic effects of Sema4D during development

scientific article published on May 2004

Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology

scientific article (publication date: 3 July 2002)

Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2

scientific article

Plexin-B2, but not Plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system in vivo

scientific journal article

Previously differentiated medial vascular smooth muscle cells contribute to neointima formation following vascular injury

scientific article published on October 2014

Procontractile G protein-mediated signaling pathways antagonistically regulate smooth muscle differentiation in vascular remodeling.

scientific article

Promiscuous Coupling of Receptors to Gq Class α Subunits and Effector Proteins in Pancreatic and Submandibular Gland Cells

scientific article published in Journal of Biological Chemistry

Protease-activated receptor-1 (PAR1) acts via a novel Galpha13-dishevelled axis to stabilize beta-catenin levels.

scientific article published on 11 March 2010

Protective role of vascular smooth muscle cell PPARγ in angiotensin II-induced vascular disease

scientific article published on 17 December 2012

Quantitative analysis of the TNF-α-induced phosphoproteome reveals AEG-1/MTDH/LYRIC as an IKKβ substrate

scientific article

RGS Proteins Determine Signaling Specificity of Gq-coupled Receptors

scientific article published in Journal of Biological Chemistry

Radial construction of an arterial wall

scientific article

Real-time visualization of heterotrimeric G protein Gq activation in living cells

scientific article

Receptor-dependent RhoA activation in G12/G13-deficient cells: genetic evidence for an involvement of Gq/G11.

scientific article published on 27 May 2003

Receptor-mediated activation of G-proteins by kappa opioid agonists in frog (Rana esculenta) brain membranes

scientific article published in March 1998

Recombinase-mediated cassette exchange reveals the selective use of Gq/G11-dependent and -independent endothelin 1/endothelin type A receptor signaling in pharyngeal arch development

scientific article published on 16 January 2008

Regeneration of fat cells from myofibroblasts during wound healing.

scientific article published on 5 January 2017

Response to Harper et al

scientific article published on 01 September 2013

Response to letter regarding article, "Vitamin D promotes vascular regeneration".

scientific article published in June 2015

Rho/Rho-kinase mediated signaling in physiology and pathophysiology

scientific article

RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock.

scientific article

RhoGEF12 controls cardiac remodeling by integrating G protein- and integrin-dependent signaling cascades.

scientific article published on 25 March 2013

Role for G(12)/G(13) in agonist-induced vascular smooth muscle cell contraction

scientific article published in August 2000

Role of HCA₂ (GPR109A) in nicotinic acid and fumaric acid ester-induced effects on the skin

scientific article published on 26 June 2012

Role of vascular extracellular superoxide dismutase in hypertension.

scientific article published on 5 July 2011

SCAI promotes DNA double-strand break repair in distinct chromosomal contexts

scientific article

SDF-1α induction in mature smooth muscle cells by inactivation of PTEN is a critical mediator of exacerbated injury-induced neointima formation

scientific article published on 17 March 2011

Saturated phosphatidic acids mediate saturated fatty acid-induced vascular calcification and lipotoxicity

scientific article published on 26 October 2015

Secretion-stimulating and secretion-inhibiting hormones stimulate high-affinity pertussis-toxin-sensitive GTPases in membranes of a pituitary cell line

scientific article

Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain

scientific article published on 2 August 2017

Semaphorin 4D signaling requires the recruitment of phospholipase C gamma into the plexin-B1 receptor complex

scientific article

Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair

scientific article published on 16 April 2015

Semaphorins and plexins as therapeutic targets

scientific article published on August 2014

Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells

scientific article published on 04 September 2013

Single-cell profiling reveals GPCR heterogeneity and functional patterning during neuroinflammation

scientific article

Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system

scientific article

Smooth muscle filamin A is a major determinant of conduit artery structure and function at the adult stage

scientific article

Smooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular function

scientific article

Smooth muscle specific Rac1 deficiency induces hypertension by preventing p116RIP3-dependent RhoA inhibition

scientific article

Smooth muscle-specific deletion of nitric oxide-sensitive guanylyl cyclase is sufficient to induce hypertension in mice

scientific article published on 11 January 2010

Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin

scientific article published on 2 April 2015

Stimulation of mitogen-activated protein kinase activity by different secretory stimuli in rat basophilic leukemia cells.

scientific article published in January 1994

Stimulation of rat parietal cell function by histamine and GLP-1-(7-36) amide is mediated by Gs alpha

scientific article published on 01 May 1994

Stimulation of tyrosine phosphorylation and mitogen-activated-protein (MAP) kinase activity in human SH-SY5Y neuroblastoma cells by carbachol ⬇️

scientific article published on September 1, 1993

Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle

scientific article published on 24 May 2017

Synthetic lipopeptide Pam3CysSer(Lys)4 is an effective activator of human platelets

scientific article published on 01 June 1994

Tamoxifen-inducible Cre-mediated recombination in adipocytes

scientific article published on October 2010

Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis

scientific article published on 7 September 2017

Targeted Ablation of Periostin-Expressing Activated Fibroblasts Prevents Adverse Cardiac Remodeling in Mice

scientific article published on 2 May 2016

Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis

scientific article published on 09 January 2014

The Concise Guide to PHARMACOLOGY 2013/14: overview

scientific article

The G2A receptor (GPR132) contributes to oxaliplatin-induced mechanical pain hypersensitivity

scientific article

The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice

scientific article

The H1 receptor agonist 2-(3-chlorophenyl)histamine activates Gi proteins in HL-60 cells through a mechanism that is independent of known histamine receptor subtypes.

scientific article published on April 1994

The IκB kinase complex is required for plexin-B-mediated activation of RhoA

scientific article

The Max Planck Institute for Heart and Lung Research Curiosity-Driven Basic Research to Fight Cardio-Pulmonary Diseases

scientific article published in April 2017

The Microbial Metabolite Butyrate Induces Expression of Th1-Associated Factors in CD4+ T Cells

scientific article published on 28 August 2017

The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure.

scientific article published on 24 January 2010

The human thyrotropin receptor activates G-proteins Gs and Gq/11

scientific article

The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families

scientific article

The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons.

scientific article

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

scientific article published on 03 January 2014

The nicotinic acid receptor GPR109A (HM74A or PUMA-G) as a new therapeutic target

scientific article published on July 2006

The role of HCA2 (GPR109A) in regulating macrophage function

scientific article published on 23 July 2013

The semaphorin 4D-plexin-B signalling complex regulates dendritic and axonal complexity in developing neurons via diverse pathways

scientific article

The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function.

scientific article

The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages

scientific article published in Nature Communications

Therapeutically Targeting Tumor Necrosis Factor-α/Sphingosine-1-Phosphate Signaling Corrects Myogenic Reactivity in Subarachnoid Hemorrhage

scientific article

Three-Month Endothelial Human Endothelin-1 Overexpression Causes Blood Pressure Elevation and Vascular and Kidney Injury

scientific article published on 13 November 2017

Thrombin Ca2+-dependently stimulates protein tyrosine phosphorylation in BC3H1 muscle cells ⬇️

scientific article published on February 15, 1993

Thrombin protease-activated receptor-1 signals through Gq- and G13-initiated MAPK cascades regulating c-Jun expression to induce cell transformation.

scientific article published on 3 September 2003

Thyrocyte-specific Gq/G11 deficiency impairs thyroid function and prevents goiter development

scientific article published in September 2007

Tumor Necrosis Factor/Sphingosine-1-Phosphate Signaling Augments Resistance Artery Myogenic Tone in Diabetes

scientific article

Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis.

scientific article published on 3 August 2016

Tyrosine phosphorylation is an early and requisite signal induced by interferon-gamma in HL-60 cells

scientific article published in October 1992

Unresponsiveness of platelets lacking both Galpha(q) and Galpha(13). Implications for collagen-induced platelet activation

scientific article

Vascular smooth muscle cell peroxisome proliferator-activated receptor γ protects against endothelin-1-induced oxidative stress and inflammation.

scientific article published on 22 February 2017

Vascular system defects and impaired cell chemokinesis as a result of Galpha13 deficiency

scientific article

Vitamin D promotes vascular regeneration

scientific article published on 11 July 2014

YAP and TAZ protect against white adipocyte cell death during obesity

scientific article published on 28 October 2020

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