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List of works by Nicholas Franks

A Neuronal Hub Binding Sleep Initiation and Body Cooling in Response to a Warm External Stimulus

scientific article published on 12 July 2018

A direct method for determination of membrane electron density profiles on an absolute scale

scientific article published in Nature

A propofol binding site on mammalian GABAA receptors identified by photolabeling

scientific article

A serious target for laughing gas.

scientific article published in April 1998

A simple method for recording single-channel activity from synaptic plasma membranes

scientific article published in August 1993

Actions of general anaesthetics and arachidonic pathway inhibitors on K+ currents activated by volatile anaesthetics and FMRFamide in molluscan neurones

scientific article published on September 1998

Actions of general anaesthetics on a neuronal nicotinic acetylcholine receptor in isolated identified neurones of Lymnaea stagnalis ⬇️

scientific article published on May 1, 1995

Activation and modulation of recombinant glycine and GABAA receptors by 4-halogenated analogues of propofol.

scientific article published on 26 July 2016

Altered activity in the central medial thalamus precedes changes in the neocortex during transitions into both sleep and propofol anesthesia.

scientific article

An X-ray diffraction analysis of oriented lipid multilayers containing basic proteins

scientific article published in August 1985

An anesthetic-sensitive superfamily of neurotransmitter-gated ion channels

scientific article published on May 1996

An unexpected role for TASK-3 potassium channels in network oscillations with implications for sleep mechanisms and anesthetic action

scientific article

Anesthetic inhibition of firefly luciferase, a protein model for general anesthesia, does not exhibit pressure reversal

scientific article

Are extrasynaptic GABAA receptors important targets for sedative/hypnotic drugs?

scientific article

Asynchronous administration of xenon and hypothermia significantly reduces brain infarction in the neonatal rat.

scientific article published on 8 January 2007

Background K+ channels: an important target for volatile anesthetics?

scientific article published in May 1999

Bench-to-bedside review: Molecular pharmacology and clinical use of inert gases in anesthesia and neuroprotection

scientific article

Bottom-Up versus Top-Down Induction of Sleep by Zolpidem Acting on Histaminergic and Neocortex Neurons.

scientific article

Can the stereoselective effects of the anesthetic isoflurane be accounted for by lipid solubility?

scientific article

Circadian factor BMAL1 in histaminergic neurons regulates sleep architecture

scientific article published on 13 November 2014

Combination of xenon and isoflurane produces a synergistic protective effect against oxygen-glucose deprivation injury in a neuronal-glial co-culture model

scientific article published in September 2003

Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor by the anesthetics xenon and isoflurane: evidence from molecular modeling and electrophysiology

scientific article

Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor mediates xenon neuroprotection against hypoxia-ischemia

scientific article

Contrasting synaptic actions of the inhalational general anesthetics isoflurane and xenon

scientific article published in April 2000

Corrigendum: Genetic lesioning of histamine neurons increases sleep-wake fragmentation and reveals their contribution to modafinil-induced wakefulness

scientific article published on 01 August 2019

Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes

scientific article

Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites

scientific article

Crystallization and preliminary diffraction studies of firefly luciferase from Photinus pyralis

scientific article published on 01 July 1996

Determinants of the anesthetic sensitivity of neuronal nicotinic acetylcholine receptors

scientific article published on 10 December 2001

Determinants of the anesthetic sensitivity of two-pore domain acid-sensitive potassium channels: molecular cloning of an anesthetic-activated potassium channel from Lymnaea stagnalis

scientific article published on 4 June 2007

Determinants of the sensitivity of AMPA receptors to xenon

scientific article

Dexmedetomidine produces its neuroprotective effect via the alpha 2A-adrenoceptor subtype

scientific article published in October 2004

Differential sensitivities of mammalian neuronal and muscle nicotinic acetylcholine receptors to general anesthetics

scientific article published in April 1997

Dysfunction of ventral tegmental area GABA neurons causes mania-like behavior

scientific article published on 17 June 2020

Effects of isoflurane and xenon on Ba2+-currents mediated by N-type calcium channels

scientific article

Effects of physiologically relevant pressures of helium on the structure of cholesterol-containing lipid bilayers. A neutron diffraction study

scientific article published on August 1991

Effects of temperature and volatile anesthetics on GABA(A) receptors

scientific article published on February 1999

Effects of temperature on the anaesthetic potency of halothane, enflurane and ethanol in Daphnia magna (Cladocera: Crustacea).

scientific article published in January 1992

Effects of thiopental and its optical isomers on nicotinic acetylcholine receptors

scientific article published in September 2000

Effects of xenon on in vitro and in vivo models of neuronal injury

scientific article published in June 2002

Excitatory Pathways from the Lateral Habenula Enable Propofol-Induced Sedation

scientific article published on 29 January 2018

Expansion of gas bubbles by nitrous oxide and xenon

scientific article published in February 2006

Fast and Slow Inhibition in the Visual Thalamus Is Influenced by Allocating GABAA Receptors with Different γ Subunits

scientific article published on 04 April 2017

Fatty acid binding to human serum albumin: new insights from crystallographic studies

scientific article

Feasibility and safety of delivering xenon to patients undergoing coronary artery bypass graft surgery while on cardiopulmonary bypass: phase I study

scientific article published in March 2006

GABA Receptors and the Pharmacology of Sleep.

scientific article

GABA and glutamate neurons in the VTA regulate sleep and wakefulness

scientific article published on 17 December 2018

GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousness

scientific article

Galanin Neurons Unite Sleep Homeostasis and α2-Adrenergic Sedation

scientific article published on 19 September 2019

General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal

scientific article published on May 2008

General anesthesia and ascending arousal pathways

scientific article published in October 2009

Genetic lesioning of histamine neurons increases sleep-wake fragmentation and reveals their contribution to modafinil-induced wakefulness

scientific article published on 01 May 2019

Histamine: neural circuits and new medications

scientific article published on 01 January 2019

How does xenon produce anaesthesia?

scientific article published in November 1998

Identification of anesthetic binding sites on human serum albumin using a novel etomidate photolabel

scientific article published on 20 February 2007

Identification of two mutations (F758W and F758Y) in the N-methyl-D-aspartate receptor glycine-binding site that selectively prevent competitive inhibition by xenon without affecting glycine binding

scientific article

Inhibitory synapses. Anaesthetics set their sites on ion channels

scientific article published in September 1997

Insensitivity of P-type calcium channels to inhalational and intravenous general anesthetics.

scientific article published in July 1994

Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial.

scientific article

Modulation of the general anesthetic sensitivity of a protein: a transition between two forms of firefly luciferase.

scientific article published on January 1991

Molecular Organization of Liquid n-Octanol: An X-ray Diffraction Analysis

scientific article published on 01 May 1993

Molecular modeling of a tandem two pore domain potassium channel reveals a putative binding site for general anesthetics

scientific article

Molecular targets underlying general anaesthesia

scientific article

Mutational Analysis of the Putative High-Affinity Propofol Binding Site in Human β3 Homomeric GABAA Receptors.

scientific article

Neuronal ensembles sufficient for recovery sleep and the sedative actions of α2 adrenergic agonists.

scientific article published on 23 February 2015

Neuroprotection against traumatic brain injury by xenon, but not argon, is mediated by inhibition at the N-methyl-D-aspartate receptor glycine site

scientific article

Neuroprotection by nitrous oxide and xenon and its relation to minimum alveolar concentration

scientific article

Neuroprotective interaction produced by xenon and dexmedetomidine on in vitro and in vivo neuronal injury models

scientific article published on 18 October 2006

Noble gas neuroprotection: xenon and argon protect against hypoxic-ischaemic injury in rat hippocampus in vitro via distinct mechanisms

scientific article published on 27 August 2019

Preparation of barbiturate optical isomers and their effects on GABA(A) receptors

scientific article published in June 1999

Rapid movement of molecules across membranes. Measurement of the permeability coefficient of water using neutron diffraction.

scientific article

Relevant concentrations of inhaled anesthetics for in vitro studies of anesthetic mechanisms

scientific article

Rested and refreshed after anesthesia? Overlapping neurobiologic mechanisms of sleep and anesthesia

scientific article published in June 2004

Role of endogenous sleep-wake and analgesic systems in anesthesia

scientific article published on June 2008

Role of hydrogen bonding in general anesthesia

scientific article published in August 1991

Seeing the light: protein theories of general anesthesia. 1984.

scientific article

Selective actions of volatile general anaesthetics at molecular and cellular levels ⬇️

scientific article published on July 1, 1993

Selective synaptic actions of thiopental and its enantiomers

scientific article published in April 2002

Selectivity of general anesthetics: a new dimension

scientific article published in April 1997

Sleep and Sedative States Induced by Targeting the Histamine and Noradrenergic Systems.

scientific article published on 26 January 2018

Sleep and general anesthesia

scientific article published on 18 December 2010

Sleep deprivation and stress: a reciprocal relationship

scientific article published on 17 April 2020

Staying awake--a genetic region that hinders α2 adrenergic receptor agonist-induced sleep.

scientific article

Stereoselective effects of etomidate optical isomers on gamma-aminobutyric acid type A receptors and animals

scientific article

Stereoselective loss of righting reflex in rats by isoflurane

scientific article published in September 2000

Structural analysis of hydrated egg lecithin and cholesterol bilayers. I. X-ray diffraction

scientific article published on January 25, 1976

Structural analysis of hydrated egg lecithin and cholesterol bilayers. II. Neutrol diffraction

scientific article published in January 1976

Structural basis for the inhibition of firefly luciferase by a general anesthetic

scientific article

Structural comparisons of ligand-gated ion channels in open, closed, and desensitized states identify a novel propofol-binding site on mammalian γ-aminobutyric acid type A receptors

scientific article published on April 2015

Structure of myelin lipid bilayers

scientific article published on 01 February 1982

Temperature dependence of the potency of volatile general anesthetics: implications for in vitro experiments

scientific article published in March 1996

The Mechanistic Relationship between NREM Sleep and Anesthesia

The TREK K2P channels and their role in general anaesthesia and neuroprotection

scientific article published in November 2004

The Temperature Dependence of Sleep

article

The Unfolding Story of How General Anesthetics Act

The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects

scientific article (publication date: February 2003)

The common chemical motifs within anesthetic binding sites

scientific article

The differential effects of nitrous oxide and xenon on extracellular dopamine levels in the rat nucleus accumbens: a microdialysis study

scientific article

The effects of general anaesthetics on carbachol-evoked gamma oscillations in the rat hippocampus in vitro.

scientific article published in June 2003

The effects of hypoxia on the modulation of human TREK-1 potassium channels

scientific article

The involvement of hypothalamic sleep pathways in general anesthesia: testing the hypothesis using the GABAA receptor beta3N265M knock-in mouse

scientific article published in February 2009

The neuroprotective effect of xenon administration during transient middle cerebral artery occlusion in mice

scientific article published in October 2003

The neuroprotective effects of xenon and helium in an in vitro model of traumatic brain injury

scientific article published in February 2008

The role of K₂p channels in anaesthesia and sleep.

scientific article

The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathway

scientific article published in October 2002

The stillness of sleep

scientific article

The structure of lipid bilayers and the effects of general anaesthetics. An x-ray and neutron diffraction study

scientific article published in October 1979

Thermodynamics of anesthetic/protein interactions. Temperature studies on firefly luciferase

scientific article

Two-pore domain potassium channels enable action potential generation in the absence of voltage-gated potassium channels

scientific article

Two-pore-domain K+ channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropane

scientific article

Wakefulness Is Governed by GABA and Histamine Cotransmission

scientific article published on 18 June 2015

What is the molecular nature of general anaesthetic target sites?

Where do general anaesthetics act?

scientific article published on July 27, 1978

Which molecular targets are most relevant to general anaesthesia?

scientific article

Xenon Protects against Blast-Induced Traumatic Brain Injury in an In Vitro Model.

scientific article published on 29 December 2017

Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia.

scientific article published in August 2005

Xenon attenuates cardiopulmonary bypass-induced neurologic and neurocognitive dysfunction in the rat.

scientific article published in March 2003

Xenon exerts age-independent antinociception in Fischer rats

scientific article published in May 2004

Xenon improves long-term cognitive function, reduces neuronal loss and chronic neuroinflammation, and improves survival after traumatic brain injury in mice

scientific article published on 21 May 2019

Xenon improves neurologic outcome and reduces secondary injury following trauma in an in vivo model of traumatic brain injury

scientific article

Xenon mitigates isoflurane-induced neuronal apoptosis in the developing rodent brain

scientific article

Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage

scientific article

Xenon preconditioning reduces brain damage from neonatal asphyxia in rats

scientific article published in February 2006

nNOS-Expressing Neurons in the Ventral Tegmental Area and Substantia Nigra Pars Compacta

scientific article published on 01 September 2018

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