List of works by Avram Hershko

"Covalent affinity" purification of ubiquitin-activating enzyme ⬇️

scientific article published on March 10, 1982

A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes. 1978.

scientific article

A multicomponent system that degrades proteins conjugated to ubiquitin. Resolution of factors and evidence for ATP-dependent complex formation.

scientific article

A ubiquitin-protein ligase specific for type III protein substrates

scientific article

ATP is required for the release of the anaphase-promoting complex/cyclosome from inhibition by the mitotic checkpoint

scientific article

ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation

scientific article

ATP-dependent degradation of ubiquitin-protein conjugates ⬇️

scientific article published on March 1, 1984

ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin

scientific article

Activation of the heat-stable polypeptide of the ATP-dependent proteolytic system ⬇️

scientific article published on February 1, 1981

Affinity purification of mitotic anaphase-promoting complex/cyclosome on p13Suc1.

scientific article published in January 2005

Affinity purification of ubiquitin-protein ligase on immobilized protein substrates. Evidence for the existence of separate NH2-terminal binding sites on a single enzyme

scientific article published on 01 March 1990

Alterations in components of the ubiquitin-protein ligase system following maturation of reticulocytes to erythrocytes

scientific article published on 01 June 1987

Assembly of the 26 S complex that degrades proteins ligated to ubiquitin is accompanied by the formation of ATPase activity.

scientific article

Basic Medical Research Award. The ubiquitin system

scientific article published in October 2000

Binding of activated cyclosome to p13(suc1). Use for affinity purification

scientific article

Binding sites of ubiquitin-protein ligase. Binding of ubiquitin-protein conjugates and of ubiquitin-carrier protein

scientific article published on 01 June 1989

Characterization of the heat-stable polypeptide of the ATP-dependent proteolytic system from reticulocytes.

scientific article published on August 1980

Components of a system that ligates cyclin to ubiquitin and their regulation by the protein kinase cdc2.

scientific article published in February 1994

Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown ⬇️

scientific article published on July 10, 1983

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage

scientific article (publication date: 6 November 2003)

Disassembly of mitotic checkpoint complexes by the joint action of the AAA-ATPase TRIP13 and p31(comet).

scientific article

Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase

scientific article

Dual mode of degradation of Cdc25 A phosphatase

scientific article

E2-C, a cyclin-selective ubiquitin carrier protein required for the destruction of mitotic cyclins

scientific article published on April 1996

Early effects of serum on phospholipid metabolism in untransformed and oncogenic virus-transformed cultured fibroblasts ⬇️

scientific article published on November 8, 1976

Early work on the ubiquitin proteasome system, an interview with Avram Hershko. Interview by CDD.

scientific article published in September 2005

From rabbit reticulocytes to clam oocytes: in search of the system that targets mitotic cyclins for degradation

scientific article

Hierarchical order of phosphorylation events commits Cdc25A to betaTrCP-dependent degradation

scientific article published in April 2004

Identification of the active amino acid residue of the polypeptide of ATP-dependent protein breakdown ⬇️

scientific article published on February 25, 1981

Immunochemical analysis of the turnover of ubiquitin-protein conjugates in intact cells. Relationship to the breakdown of abnormal proteins ⬇️

scientific article published on December 10, 1982

Inhibitory factors associated with anaphase-promoting complex/cylosome in mitotic checkpoint

scholarly article

Intermediates in the assembly of mitotic checkpoint complexes and their role in the regulation of the anaphase-promoting complex

scientific article published on 11 January 2016

Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas

scientific article published on 01 May 2001

Irwin Allan Rose (1926-2015).

scientific article published in July 2015

Mechanisms and regulation of the degradation of cyclin B

scientific article

Mechanisms of Intracellular Protein Breakdown ⬇️

scientific article published on January 1, 1982

Methylated ubiquitin inhibits cyclin degradation in clam embryo extracts ⬇️

scientific article published on September 5, 1991

Mode of interaction of TRIP13 AAA-ATPase with the Mad2-binding protein p31comet and with mitotic checkpoint complexes

scientific article

Occurrence of a polyubiquitin structure in ubiquitin-protein conjugates

scientific article published on 01 May 1985

Phosphorylation of Cdc20/fizzy negatively regulates the mammalian cyclosome/APC in the mitotic checkpoint

scientific article published on 01 May 2000

Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit

scientific article published on November 2008

Probing CpG methylation at CACGTG with BbrPI restriction enzyme

scientific article

Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis

scientific article

Purification and characterization of arginyl-tRNA-protein transferase from rabbit reticulocytes. Its involvement in post-translational modification and degradation of acidic NH2 termini substrates of the ubiquitin pathway

scientific article

Regulation of APC/C (Cdh1) ubiquitin ligase in differentiation of human embryonic stem cells.

scientific article published on 15 May 2010

Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate

scholarly article

Regulation of the action of early mitotic inhibitor 1 on the anaphase-promoting complex/cyclosome by cyclin-dependent kinases

scientific article published on 16 March 2011

Relevance of protease “inhibitor” to the ATP-ubiquitin proteolytic system ⬇️

scientific article published on July 18, 1984

Resolution of the ATP-dependent proteolytic system from reticulocytes: a component that interacts with ATP ⬇️

scientific article published on July 1, 1979

Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase

scientific article

Role of CCT chaperonin in the disassembly of mitotic checkpoint complexes

scientific article published on 17 January 2017

Role of Polo-like kinase 1 in the regulation of the action of p31comet in the disassembly of mitotic checkpoint complexes

scientific article published on 22 May 2019

Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome

scientific article

Role of Suc1 in the activation of the cyclosome by protein kinase Cdk1/cyclin B

scientific article published on 01 April 1999

Role of phosphorylation of Cdc20 in p31(comet)-stimulated disassembly of the mitotic checkpoint complex

scientific article

Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase

scientific article (publication date: 11 July 2003)

Role of the alpha-amino group of protein in ubiquitin-mediated protein breakdown ⬇️

scientific article published on November 1, 1984

Role of ubiquitylation of components of mitotic checkpoint complex in their dissociation from anaphase-promoting complex/cyclosome

scientific article published on 5 February 2018

Roles of different pools of the mitotic checkpoint complex and the mechanisms of their disassembly

scientific article published on 10 June 2013

Roles of the anaphase-promoting complex/cyclosome and of its activator Cdc20 in functional substrate binding

scholarly article

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

scientific article (publication date: August 1999)

Science as an adventure - lessons for the young scientist

scientific article published on 2 July 2010

Some lessons from my work on the biochemistry of the ubiquitin system

scientific article published on 15 December 2008

Specificity of binding of NH2-terminal residue of proteins to ubiquitin-protein ligase. Use of amino acid derivatives to characterize specific binding sites

scientific article published on 01 February 1988

The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

scientific article (publication date: March 2001)

The cyclin-ubiquitin ligase activity of cyclosome/APC is jointly activated by protein kinases Cdk1-cyclin B and Plk.

scientific article

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis

scientific article

The mouse and human genes encoding the recognition component of the N-end rule pathway

scientific article

The protein substrate binding site of the ubiquitin-protein ligase system.

scientific article

The ubiquitin pathway for the degradation of intracellular proteins

scientific article published on January 1986

The ubiquitin system

scientific article (publication date: 1998)

The ubiquitin system for protein degradation

scientific article published on January 1, 1992

The ubiquitin system for protein degradation and some of its roles in the control of the cell-division cycle (Nobel lecture).

scientific article

Three different binding sites of Cks1 are required for p27-ubiquitin ligation

scientific article (publication date: November 2002)

Two different mitotic checkpoint inhibitors of the anaphase-promoting complex/cyclosome antagonize the action of the activator Cdc20

scientific article

Ubiquitin C-terminal hydrolase activity associated with the 26 S protease complex

scientific article published on 01 March 1993

Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation ⬇️

scientific article published on March 10, 1982

Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processes

scientific article

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

scientific journal article

p31comet Promotes disassembly of the mitotic checkpoint complex in an ATP-dependent process

scientific article

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