List of works by Matthias Gaestel

1 H NMR spectroscopy reveals that mouse Hsp25 has a flexible C-terminal extension of 18 amino acids

scientific article published on 01 August 1995

3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase, is targeted by three MAP kinase pathways

scientific article

A dominant mutation in MAPKAPK3, an actor of p38 signaling pathway, causes a new retinal dystrophy involving Bruch's membrane and retinal pigment epithelium

scientific article

A requirement of MAPKAPK2 in the uropod localization of PTEN during FMLP-induced neutrophil chemotaxis

scientific article published in April 2004

A theoretical approach to cluster formation in biological membranes.

scientific article published in January 1984

AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis

scientific article

Abnormal migration phenotype of mitogen-activated protein kinase-activated protein kinase 2-/- neutrophils in Zigmond chambers containing formyl-methionyl-leucyl-phenylalanine gradients

scientific article published in October 2001

Activation of mitogen-activated protein kinase kinase (MKK) 3 and MKK6 by type I interferons

scientific article published on 11 January 2005

Activation of p38 Mitogen-Activated Protein Kinase Contributes to the Early Cardiodepressant Action of Tumor Necrosis Factor

article

Adenosine increases calcium sensitivity via receptor-independent activation of the p38/MK2 pathway in mesenteric arteries

scientific article published on 14 November 2007

Affinity purification of ARE-binding proteins identifies poly(A)-binding protein 1 as a potential substrate in MK2-induced mRNA stabilization

scientific article published on 01 February 2003

Alpha A-crystallin confers cellular thermoresistance

scientific article published on November 1994

Alternative Translation Initiation Generates a Functionally Distinct Isoform of the Stress-Activated Protein Kinase MK2

scientific article published on 01 June 2019

Analysis of chaperone properties of small Hsp's

scientific article

Analysis of properties of small heat shock protein Hsp25 in MAPK-activated protein kinase 2 (MK2)-deficient cells: MK2-dependent insolubilization of Hsp25 oligomers correlates with susceptibility to stress

scientific article published on 13 July 2006

Analysis of small Hsp phosphorylation

scientific article

Analysis of the Interaction of Small Heat Shock Proteins with Unfolding Proteins

scientific article published in Journal of Biological Chemistry

Analysis of the role of Hsp25 phosphorylation reveals the importance of the oligomerization state of this small heat shock protein in its protective function against TNFalpha- and hydrogen peroxide-induced cell death

scientific article published on June 1998

Analysis of the role of Hsp25 phosphorylation reveals the importance of the oligomerization state of this small heat shock protein in its protective function against TNFα- and hydrogen peroxide-induced cell death

article

Anthrax lethal toxin disrupts the endothelial permeability barrier through blocking p38 signaling

scientific article

Binding of non-native protein to Hsp25 during heat shock creates a reservoir of folding intermediates for reactivation.

scientific article

Biological monitoring of non-thermal effects of mobile phone radiation: recent approaches and challenges

scientific article published on August 2010

Bispecific antibody-producing hybrid hybridomas selected by a fluorescence activated cell sorter

scientific article published on 01 February 1987

Blockade of MK2 is protective in inflammation-associated colorectal cancer development.

scientific article

CREB is activated by UVC through a p38/HOG-1-dependent protein kinase

scientific article published on March 1997

CXCL12 and C5a trigger cell migration via a PAK1/2-p38α MAPK-MAPKAP-K2-HSP27 pathway

scientific article published on 06 March 2006

Characterisation of cell-type-specific responses in the liver towards IL-1β by a mathematical model for the p38MAPK/MK2 pathway

article

Characterization of a novel MK3 splice variant from murine ventricular myocardium

scientific article published on 04 June 2010

Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5

scientific journal article

Characterization of the expression and regulation of MK5 in the murine ventricular myocardium

scientific article published on 7 March 2010

Characterization of the proline-rich region of mouse MAPKAP kinase 2: influence on catalytic properties and binding to the c-abl SH3 domain in vitro.

scientific article

Comparative Analysis of Two Gene-Targeting Approaches Challenges the Tumor-Suppressive Role of the Protein Kinase MK5/PRAK

scientific article

Comparison of the homologous carboxy-terminal domain and tail of alpha-crystallin and small heat shock protein.

scientific article

Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif

scientific journal article

Cooperative and distinct functions of MK2 and MK3 in the regulation of the macrophage transcriptional response to lipopolysaccharide

scientific article published on 30 July 2019

Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling

scientific article published on 26 August 2013

Cross-regulation of cytokine signalling: pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation

scientific article

Crucial roles of the protein kinases MK2 and MK3 in a mouse model of glomerulonephritis

scientific article

Cytoskeletal changes in hypoxic pulmonary endothelial cells are dependent on MAPK-activated protein kinase MK2.

scientific article published on 28 August 2002

Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity

scientific article published on 30 September 2013

Deficiency of MAPK-activated protein kinase 2 (MK2) prevents adverse remodelling and promotes endothelial healing after arterial injury.

scientific article published on 14 August 2014

Deletion of MK2 signalling in vivo inhibits small Hsp phosphorylation but not diabetic nephropathy

scientific article published on 8 January 2008

Dephosphorylation of the small heat shock protein hsp25 by calcium/calmodulin-dependent (type 2B) protein phosphatase ⬇️

scientific article published on October 25, 1992

Development and tissue-specific distribution of mouse small heat shock protein hsp25.

scientific article published in January 1993

Differentiated macrophages acquire a pro-inflammatory and cell death-resistant phenotype due to increasing XIAP and p38-mediated inhibition of RipK1

scientific article published in Journal of Biological Chemistry

Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function

scientific article

Dimer structure as a minimum cooperative subunit of small heat-shock proteins

scientific article published on 01 December 1995

Distinct cellular functions of MK2.

scientific article published on July 2002

Distinct functions of the mitogen-activated protein kinase-activated protein (MAPKAP) kinases MK2 and MK3: MK2 mediates lipopolysaccharide-induced signal transducers and activators of transcription 3 (STAT3) activation by preventing negative regulat

scientific article published on 17 May 2011

Distinct role of MAPKAPK-2 in the regulation of TNF gene expression by Toll-like receptor 7 and 9 ligands

article

EMC10 (Endoplasmic Reticulum Membrane Protein Complex Subunit 10) Is a Bone Marrow-Derived Angiogenic Growth Factor Promoting Tissue Repair After Myocardial Infarction

scientific article

Editorial: Emerging Functions of Septins

scientific article published on 24 August 2017

Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination

scientific article published on November 2003

Endoplasmic reticulum-associated ubiquitin-conjugating enzyme Ube2j1 is a novel substrate of MK2 (MAPKAP kinase-2) involved in MK2-mediated TNFα production

scientific journal article

Erratum to: 'Normal endothelial but impaired arterial development in MAP-Kinase activated protein kinase 2 (MK2) deficient mice'.

scientific article published on 23 December 2016

Evidence for a hsp25-specific mechanism involved in transcriptional activation by heat shock

scientific article published on July 1998

Expression of fibulin-6 in failing hearts and its role for cardiac fibroblast migration

scientific article published on 20 June 2014

Expression of heat shock protein 25,000 in rat uterus during pregnancy and pseudopregnancy

scientific article published on 01 June 1996

Extracellular-signal regulated kinase (Erk1/2), mitogen-activated protein kinase-activated protein kinase 2 (MK2) and tristetraprolin (TTP) comprehensively regulate injury-induced immediate early gene (IEG) response in in vitro liver organ culture

scientific article

FRET-based detection of different conformations of MK2.

scientific article

Fluorescence-based quantitative scratch wound healing assay demonstrating the role of MAPKAPK-2/3 in fibroblast migration

GIGYF1/2-Driven Cooperation between ZNF598 and TTP in Posttranscriptional Regulation of Inflammatory Signaling

scientific article published on 01 March 2019

GTPase domain driven dimerization of SEPT7 is dispensable for the critical role of septins in fibroblast cytokinesis

scientific article published on 28 January 2016

Gene deletion of MK2 inhibits TNF-alpha and IL-6 and protects against cerulein-induced pancreatitis

scientific article published on 19 January 2006

Generation of antibodies against human hsp27 and murine hsp25 by immunization with a chimeric small heat shock protein

scientific article published on January 1, 1991

Genetic deletion of SEPT7 reveals a cell type-specific role of septins in microtubule destabilization for the completion of cytokinesis

scientific article (publication date: August 2014)

Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease

scientific article

Germ Line Deletion Reveals a Nonessential Role of Atypical Mitogen-Activated Protein Kinase 6/Extracellular Signal-Regulated Kinase 3

scientific article published on 01 March 2019

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HDM2 phosphorylation by MAPKAP kinase 2.

scientific article published on March 2005

Heat shock protein 27 is a substrate of cGMP-dependent protein kinase in intact human platelets: phosphorylation-induced actin polymerization caused by HSP27 mutants

scientific article

Hypo-osmotic cell swelling activates the p38 MAP kinase signalling cascade

scientific article published on October 1996

Hypoxia alters biophysical properties of endothelial cells via p38 MAPK- and Rho kinase-dependent pathways

scientific article

IFN-gamma regulation in anti-CD4 antibody-induced T cell unresponsiveness

scientific article published in March 2004

IL-1β-induced and p38MAPK-dependent activation of the mitogen-activated protein kinase-activated protein kinase 2 (MK2) in hepatocytes: Signal transduction with robust and concentration-independent signal amplification

scientific article published on 21 February 2017

IL-33 regulates cytokine production and neutrophil recruitment via the p38 MAPK-activated kinases MK2/3.

scientific article published on 19 October 2018

IL-33-activated murine mast cells control the dichotomy between RORγt+ and Helios+ Tregs via the MK2/3-mediated IL-6 production in vitro

scientific article published on 30 July 2019

Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins

scientific article

Identification of a phosphorylation site on skeletal muscle myosin light chain kinase that becomes phosphorylated during muscle contraction

scientific article published in January 2002

Identification of the phosphorylation sites of the murine small heat shock protein hsp25 ⬇️

scientific article published on August 5, 1991

In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance

scientific article

Inactivation of protein-tyrosine phosphatases as mechanism of UV-induced signal transduction

scientific article (publication date: 10 September 1999)

Increased expression of heat-shock protein 27 kDa in Alzheimer disease: a preliminary study

scientific article published on 01 October 1993

Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs

scientific article

Interleukin (IL)-6 signaling leads to phosphorylation of the small heat shock protein (Hsp)27 through activation of the MAP kinase and MAPKAP kinase 2 pathway in monocytes and monocytic leukemia cells.

scientific article published on February 1995

Interleukin-1-induced intracellular signaling pathways converge in the activation of mitogen-activated protein kinase and mitogen-activated protein kinase-activated protein kinase 2 and the subsequent phosphorylation of the 27-kilodalton heat shock

scientific article published on 01 December 1994

Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology.

scientific article

Interleukin-3 and granulocyte-macrophage colony-stimulating factor induce activation of the MAPKAP kinase 2 resulting in in vitro serine phosphorylation of the small heat shock protein (Hsp 27).

scientific article published on April 1994

Is MK2 (mitogen-activated protein kinase-activated protein kinase 2) the key for understanding post-transcriptional regulation of gene expression?

scientific article

LPS-induced production of TNF-α and IL-6 in mast cells is dependent on p38 but independent of TTP

scientific article published on 14 March 2013

Label-Free Protein-RNA Interactome Analysis Identifies Khsrp Signaling Downstream of the p38/Mk2 Kinase Complex as a Critical Modulator of Cell Cycle Progression

scientific article published on 20 May 2015

Lack of MK2 inhibits myofibroblast formation and exacerbates pulmonary fibrosis

scientific article published on 28 June 2007

Lateral lipid distribution and phase transition in phosphatidylethanolamine/phosphatidylserine vesicles. A cross-linking study.

scientific article published in July 1983

Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation

scientific article

MAP kinase-activated protein kinases 2 and 3 are required for influenza A virus propagation and act via inhibition of PKR.

scientific article

MAP-Kinase Activated Protein Kinase 2 Links Endothelial Activation and Monocyte/macrophage Recruitment in Arteriogenesis

scientific article (publication date: 2015)

MAP-kinase-activated protein kinase 2 expression and activity is induced after neuronal depolarization.

scientific article

MAPK-Activated Protein Kinases (MKs): Novel Insights and Challenges

scientific article

MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease

scientific article published on 14 June 2006

MAPK-activated protein kinase 2 differentially regulates plasmodium falciparum glycosylphosphatidylinositol-induced production of tumor necrosis factor-{alpha} and interleukin-12 in macrophages

scientific article published on 09 April 2009

MAPKAP kinase 2 (MK2)-dependent and -independent models of blister formation in pemphigus vulgaris

scientific article published on 27 June 2013

MAPKAP kinase 2 is activated by heat shock and TNF-alpha: in vivo phosphorylation of small heat shock protein results from stimulation of the MAP kinase cascade

scientific article published on February 1995

MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis

scientific journal article

MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo

scientific journal article

MAPKAP kinase 2 regulates IL-10 expression and prevents formation of intrahepatic myeloid cell aggregates during cytomegalovirus infections

scientific article published on 20 August 2015

MAPKAP kinase 2-deficiency prevents neurons from cell death by reducing neuroinflammation – relevance in a mouse model of Parkinson’s disease

article

MAPKAP kinase 2-deficient mice are resistant to collagen-induced arthritis

scientific article published on 01 August 2006

MAPKAP kinase 3 suppresses Ifng gene expression and attenuates NK cell cytotoxicity and Th1 CD4 T-cell development upon influenza A virus infection

scientific article published on 16 June 2014

MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells

scientific article

MAPKAP kinases - MKs - two's company, three's a crowd

scientific article

MAPKAP kinases MK2 and MK3 in inflammation: complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin

scientific article published on 23 June 2010

MAPKAPK-2 Signaling Is Critical for Cutaneous Wound Healing

MAPKAPK-2 modulates p38-MAPK localization and small heat shock protein phosphorylation but does not mediate the injury associated with p38-MAPK activation during myocardial ischemia

scientific article

MAPKAPK2-mediated LSP1 phosphorylation and FMLP-induced neutrophil polarization

scientific article published in 2007

MK2 Deletion in Mice Prevents Diabetes-Induced Perturbations in Lipid Metabolism and Cardiac Dysfunction.

scientific article

MK2 and Fas receptor contribute to the severity of CNS demyelination

scientific article

MK2 and MK3--a pair of isoenzymes?

scientific article

MK2 controls the level of negative feedback in the NF-kappaB pathway and is essential for vascular permeability and airway inflammation

scientific article

MK2 regulates the early stages of skin tumor promotion.

scientific article published on December 2009

MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels

scientific journal article

MK2-TNF-Signaling Comes Full Circle

scientific article published on 21 December 2017

MK2/3 Are Pivotal for IL-33-Induced and Mast Cell-Dependent Leukocyte Recruitment and the Resulting Skin Inflammation

scientific article

MK5 haplodeficiency attenuates hypertrophy and preserves diastolic function during remodeling induced by chronic pressure overload in the mouse heart

scientific article published on 21 April 2017

MK5 haplodeficiency decreases collagen deposition and scar size during post-myocardial infarction wound repair

scientific article published on 22 March 2019

Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury

scientific article

Mitogen-Activated Protein Kinase 2 Signaling Shapes Macrophage Plasticity in Aggregatibacter actinomycetemcomitans-Induced Bone Loss

scientific article published on 17 October 2016

Mitogen-activated protein kinase 2 regulates physiological and pathological bone turnover

scientific article published in April 2013

Mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 deficiency protects brain from ischemic injury in mice

scientific article published on 4 September 2002

Mitogen-activated protein kinase-activated protein kinase 2 (MK2) contributes to secondary damage after spinal cord injury.

scientific article

Mitogen-activated protein kinase-activated protein kinase 2 deficiency reduces insulin sensitivity in high-fat diet-fed mice

scientific article

Mitogen-activated protein kinase-activated protein kinase 2 in angiotensin II-induced inflammation and hypertension: regulation of oxidative stress

scientific article published on 20 December 2010

Mitogen-activated protein kinase-activated protein kinase 2 mediates apoptosis during lung vascular permeability by regulating movement of cleaved caspase 3

scientific article

Mitogen-activated protein kinase-activated protein kinase 2 mediates resistance to hydrogen peroxide-induced oxidative stress in human hepatobiliary cancer cells.

scientific article

Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element

scientific article

Mitogen-activated protein kinase-activated protein kinase 2-deficient mice show increased susceptibility to Listeria monocytogenes infection

scientific article published in May 2002

Mitogen-activated protein kinase-activated protein kinases 2 and 3 regulate SERCA2a expression and fiber type composition to modulate skeletal muscle and cardiomyocyte function

scientific article published on 22 April 2013

Modulation of HSP27 alters hypoxia-induced endothelial permeability and related signaling pathways

scientific article published on September 2009

Molecular chaperones in signal transduction.

scientific article

Molecular cloning and characterization of the primary structure of the alkane hydroxylating cytochrome P-450 from the yeast Candida maltosa

scientific article

Molecular cloning, sequencing and expression in Escherichia coli of the 25-kDa growth-related protein of Ehrlich ascites tumor and its homology to mammalian stress proteins

scientific article published in January 1989

Molecular mechanisms of phosphorylation-regulated TTP (tristetraprolin) action and screening for further TTP-interacting proteins

scientific article

Monitoring protein-protein interactions in mammalian cells by trans-SUMOylation.

scientific article

Mouse Hsp25, a small heat shock protein

article

Mouse Hsp25, a small shock protein. The role of its C-terminal extension in oligomerization and chaperone action

scientific article (publication date: April 2000)

Mutually exclusive STAT1 modifications identified by Ubc9/substrate dimerization-dependent SUMOylation

scientific article

NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway

scientific article

Noradrenaline enhances angiotensin II responses via p38 MAPK activation after hypoxia/re-oxygenation in renal interlobar arteries.

scientific article published on 4 February 2015

Normal endothelial but impaired arterial development in MAP-Kinase activated protein kinase 2 (MK2) deficient mice

scientific article published on 21 October 2016

Oncostatin M regulates SOCS3 mRNA stability via the MEK-ERK1/2-pathway independent of p38(MAPK)/MK2.

scientific article published on 3 January 2015

Over-expression of the small heat-shock protein, hsp25, inhibits growth of Ehrlich ascites tumor cells

scientific article published in September 1992

P38 Mitogen Activated Protein Kinase Regulates Endothelial VCAM-1 Expression at the Post-transcriptional Level

article

P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity

scientific article

PMA-induced activation of the p42/44ERK- and p38RK-MAP kinase cascades in HL-60 cells is PKC dependent but not essential for differentiation to the macrophage-like phenotype

scientific article published on 01 December 1997

Peptides as signaling inhibitors for mammalian MAP kinase cascades

scientific article published on January 2009

Phosphorylation is not essential for protection of L929 cells by Hsp25 against H2O2-mediated disruption actin cytoskeleton, a protection which appears related to the redox change mediated by Hsp25.

scientific article

Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding

scientific article

Phosphorylation of steroid receptor coactivator-3 (SRC-3) at serine 857 is regulated by the p38MAPK-MK2 axis and affects NF-κB-mediated transcription

scientific article published on 09 July 2020

Preoperative Treatment of Rectal Cancer with Radiation, Chemotherapy and Hyperthermia: Analysis of Treatment Efficacy and Heat-Shock Response

article

Production and characterization of four monoclonal antibodies specific for human interferon-alpha-1 and -alpha-2.

scientific article

Proinflammatory Effect of Endothelial Microparticles Is Mitochondria Mediated and Modulated Through MAPKAPK2 (MAPK-Activated Protein Kinase 2) Leading to Attenuation of Cardiac Hypertrophy

scientific article published on 01 June 2019

Protein Kinases as Substrates for SAPKs

Protein kinases as small molecule inhibitor targets in inflammation.

scientific article published on January 2007

RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.

scientific article published on 18 February 2009

Reduced oxazolone-induced skin inflammation in MAPKAP kinase 2 knockout mice.

scientific article

Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation

scientific article (publication date: 2 July 1999)

Regulation of suppressor of cytokine signaling 3 (SOCS3) mRNA stability by TNF-alpha involves activation of the MKK6/p38MAPK/MK2 cascade

scientific article

Regulation of vimentin intermediate filaments in endothelial cells by hypoxia

scientific article

Role of heat shock protein 27 in cytoskeletal remodeling of the airway smooth muscle cell

scientific article

Role of p38alpha Map kinase in Type I interferon signaling

scientific article published on 24 October 2003

Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex

scientific article published on February 2008

SB202190-induced cell type-specific vacuole formation and defective autophagy do not depend on p38 MAP kinase inhibition

scientific article

SEPT7 Interacts with KIF20A and Regulates the Proliferative State of Neural Progenitor Cells During Cortical Development

scientific article published on 09 December 2019

Scaffolding by ERK3 regulates MK5 in development

scientific journal article

Selective NMR Experiments on Macromolecules: Implementation and Analysis of QUIET-NOESY.

scientific article published in June 1998

Sep(t)arate or not – how some cells take septin-independent routes through cytokinesis

scientific article

Septins: Active GTPases or just GTP-binding proteins?

Sexual Dimorphism in MAPK-Activated Protein Kinase-2 (MK2) Regulation of RANKL-Induced Osteoclastogenesis in Osteoclast Progenitor Subpopulations

scientific article published on 6 May 2015

Signal integration, crosstalk mechanisms and networks in the function of inflammatory cytokines

scientific article published on 20 July 2011

Simple preparative two-step purification of interleukin-2 from culture medium of lectin stimulated normal human lymphocytes

article

Small heat shock proteins are molecular chaperones.

scientific article published on January 1993

Small heat-shock protein family: function in health and disease.

scientific article published in June 1998

Small-molecule protein and lipid kinase inhibitors in inflammation and specific models for their evaluation

scientific article

Smooth muscle alpha-actin expression and myofibroblast differentiation by TGFbeta are dependent upon MK2.

scientific article published on April 2007

Specificity of signaling from MAPKs to MAPKAPKs: kinases' tango nuevo

scientific article published on May 2008

Stress induced gene expression: a direct role for MAPKAP kinases in transcriptional activation of immediate early genes

scientific article published on 24 November 2010

Stress- and mitogen-induced phosphorylation of the small heat shock protein Hsp25 by MAPKAP kinase 2 is not essential for chaperone properties and cellular thermoresistance

scientific article

Stress-dependent phosphorylation of myocardin-related transcription factor A (MRTF-A) by the p38(MAPK)/MK2 axis

scientific article published on 05 August 2016

Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-gamma uses a different signaling pathway

scientific article published on November 1999

Stress-induced stimulation of early growth response gene-1 by p38/stress-activated protein kinase 2 is mediated by a cAMP-responsive promoter element in a MAPKAP kinase 2-independent manner

scientific journal article

Structural and functional homology between periplasmic bacterial molecular chaperones and small heat shock proteins

scientific article published on July 1995

Structure and organisation of a murine gene encoding small heat-shock protein Hsp25.

scientific article

Supramolecular structure of the recombinant murine small heat shock protein hsp25

scientific article published on 01 August 1991

Systemic Deficiency of the MAP Kinase–Activated Protein Kinase 2 Reduces Atherosclerosis in Hypercholesterolemic Mice

article by Kumaravelu Jagavelu et al published 26 November 2007 in Circulation Research

T cell LFA-1-induced proinflammatory mRNA stabilization is mediated by the p38 pathway kinase MK2 in a process regulated by hnRNPs C, H1 and K

scientific article published on 26 July 2018

TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation

scientific article published on 30 August 2019

TLR7 ligand prevents allergen-induced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathway.

scientific article published on 16 December 2005

TNF and Increased Intracellular Iron Alter Macrophage Polarization to a Detrimental M1 Phenotype in the Injured Spinal Cord

TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord

scientific article published on 14 August 2014

TPL2 meets p38MAPK: emergence of a novel positive feedback loop in inflammation

scientific article published in October 2016

TRIF Signaling Stimulates Translation of TNF- mRNA via Prolonged Activation of MK2

Targeting innate immunity protein kinase signalling in inflammation

scientific article published on June 2009

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics

scientific article published on 12 September 2016

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics.

scientific article published in February 2016

The 5'-untranslated region of p23 mRNA from the Ehrlich ascites tumor is involved in translation control of the growth related protein p23

scientific article published on January 1, 1991

The IL-33-induced p38-/JNK1/2-TNFα axis is antagonized by activation of β-adrenergic-receptors in dendritic cells

scientific article published on 18 May 2020

The MAP kinase-activated protein kinase 2 contains a proline-rich SH3-binding domain.

scientific article

The MAPK-Activated Kinase MK2 Attenuates Dendritic Cell-Mediated Th1 Differentiation and Autoimmune Encephalomyelitis

scientific article

The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways

scientific journal article

The MK2 cascade regulates mGluR-dependent synaptic plasticity and reversal learning

scientific article published on 23 May 2019

The MK2/3 cascade regulates AMPAR trafficking and cognitive flexibility

scientific article

The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis

scientific article

The RNA-binding protein TTP is a global post-transcriptional regulator of feedback control in inflammation

scientific article published on 24 May 2016

The Role of TTP Phosphorylation in the Regulation of Inflammatory Cytokine Production by MK2/3

scientific article published on 16 September 2019

The anti-cancer drug cisplatin induces H25 in Ehrlich ascites tumor cells by a mechanism different from transcriptional stimulation influencing predominantly H25 translation.

scientific article

The dynamics of Hsp25 quaternary structure. Structure and function of different oligomeric species

scientific article (publication date: 21 May 1999)

The effect of the intersubunit disulfide bond on the structural and functional properties of the small heat shock protein Hsp25.

scientific article published in May 1998

The electric potential across the erythrocyte membrane: a mathematical model

scientific article published on January 1, 1981

The electric potential profile across the erythrocyte membrane

scientific article published on 01 May 1982

The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology

scientific article

The growth-related protein P23 of the Ehrlich ascites tumor: translational control, cloning and primary structure

scientific article (publication date: August 1989)

The influence of Ca2+ on the lateral lipid distribution and phase transition in phosphatidylethanolamine/phosphatidylserine vesicles

scientific article published on 01 January 1984

The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK.

scientific article published on 9 October 2006

The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism.

scientific article published on September 1999

The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages

scientific article (publication date: 18 June 2009)

The p38 MAPK regulates IL-24 expression by stabilization of the 3' UTR of IL-24 mRNA.

scientific article

The p38-MK2/3 Module Is Critical for IL-33-Induced Signaling and Cytokine Production in Dendritic Cells.

scientific article

The p38/MK2-driven exchange between tristetraprolin and HuR regulates AU-rich element-dependent translation

scientific article

The problem of pyridinyl imidazole class inhibitors of MAPK14/p38α and MAPK11/p38β in autophagy research

scientific article published on 10 June 2015

The protein kinase inhibitor SB203580 uncouples PMA-induced differentiation of HL-60 cells from phosphorylation of Hsp27.

scientific article

The role of mammalian MAPK signaling in regulation of cytokine mRNA stability and translation

scientific article published on April 2014

The role of mitogen-activated protein kinase-activated protein kinase 2 in the p38/TNF-alpha pathway of systemic and cutaneous inflammation

scientific article published on 6 August 2009

The stress-activated protein kinases p38α/β and JNK1/2 cooperate with Chk1 to inhibit mitotic entry upon DNA replication arrest

scientific article published on 30 August 2012

The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation

scientific article

Thiol/disulfide exchange between small heat shock protein 25 and glutathione

scientific article published on 01 October 1998

To die or not to die: Regulatory feedback phosphorylation circuits determine receptor-interacting protein kinase-1 (RIPK1) function

scientific article published on 30 November 2017

Transcript levels for extracellular matrix proteins are altered in MK5-deficient cardiac ventricular fibroblasts

scientific article published on 16 May 2019

Treatment of Obese Insulin-Resistant Mice With an Allosteric MAPKAPK2/3 Inhibitor Lowers Blood Glucose and Improves Insulin Sensitivity

scientific article

Tristetraprolin regulates necroptosis during tonic Toll-like receptor 4 (TLR4) signaling in murine macrophages

scientific article published on 24 February 2020

Tumour necrosis factor-α plays a significant role in the Aldara-induced skin inflammation in mice.

scientific article

Ubc9 fusion-directed SUMOylation (UFDS): a method to analyze function of protein SUMOylation

scientific article published on 4 February 2007

Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation

scientific article published on 20 August 2007

Use of fluorescence-activated cell sorting to select hybrid hybridomas producing bispecific monoclonal antibodies

scientific article published on 01 January 1987

What goes up must come down: molecular basis of MAPKAP kinase 2/3-dependent regulation of the inflammatory response and its inhibition

scientific article published on October 2013

ZDHHC3 Tyrosine Phosphorylation Regulates Neural Cell Adhesion Molecule Palmitoylation

scientific article published on 31 May 2016

[28] Purification and characterization of small heat shock proteins

scientific article published on 01 January 1998

cDNA sequence coding for a translationally controlled human tumor protein

scientific article

p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins

scientific article

p38 MAPK signalling regulates cytokine production in IL-33 stimulated Type 2 Innate Lymphoid cells

scientific article published on 26 February 2020

p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication

scientific journal article

p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection

scientific article published on 18 September 2017

p38MAPK/MK2-mediated phosphorylation of RBM7 regulates the human nuclear exosome targeting complex

scientific article

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