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List of works by Thomas Klingebiel

A Two-Phase Expansion Protocol Combining Interleukin (IL)-15 and IL-21 Improves Natural Killer Cell Proliferation and Cytotoxicity against Rhabdomyosarcoma

scientific article

A common ancestral DNMT3A-mutated preleukemic clone giving rise to AML and MDS in an adolescent girl

scientific article published on 28 November 2016

A novel five-colour flow cytometric assay to determine NK cell cytotoxicity against neuroblastoma and other adherent tumour cells

scientific article

A novel four-colour flow cytometric assay to determine natural killer cell or T-cell-mediated cellular cytotoxicity against leukaemic cells in peripheral or bone marrow specimens containing greater than 20% of normal cells

scientific article

A novel homozygous mutation in UNC13D presenting as Epstein-Barr-virus-associated lymphoproliferative disease at 9 years of age.

scientific article

Adult stem cells as an alternative source of multipotential (pluripotential) cells in regenerative medicine

scientific article published on May 2009

Advanced flowcytometric analysis of regulatory T cells: CD127 downregulation early post stem cell transplantation and altered Treg/CD3(+)CD4(+)-ratio in severe GvHD or relapse

scientific article published on 3 August 2011

Age-matched lymphocyte subpopulation reference values in childhood and adolescence: application of exponential regression analysis

scientific article published on 12 February 2008

Allogeneic peripheral blood stem cell transplantation following fludarabine-based conditioning in six children with advanced Hodgkin's disease

scientific article published on 19 November 2003

Allogeneic transplantation for pediatric acute lymphoblastic leukemia: the emerging role of peritransplantation minimal residual disease/chimerism monitoring and novel chemotherapeutic, molecular, and immune approaches aimed at preventing relapse

scientific article published on January 2009

Antibody levels against tetanus and diphtheria after polychemotherapy for childhood sarcoma: A report from the Late Effects Surveillance System

scientific article published in 2011

Array-based DNA-methylation profiling in sarcomas with small blue round cell histology provides valuable diagnostic information

scientific article published on 23 March 2018

Arsenic trioxide induces Noxa-dependent apoptosis in rhabdomyosarcoma cells and synergizes with antimicrotubule drugs

scientific article published on 10 August 2016

Association of ABO(H) and I blood group system development with von Willebrand factor and Factor VIII plasma levels in children and adolescents

scientific article published on 26 February 2010

Author Correction: The landscape of genomic alterations across childhood cancers

scientific article published in Nature

Bone marrow involvement identifies a subgroup of advanced Ewing sarcoma patients with fatal outcome irrespective of therapy in contrast to curable patients with multiple bone metastases but unaffected marrow

scientific article published on 29 July 2016

Brentuximab vedotin for paediatric relapsed or refractory Hodgkin's lymphoma and anaplastic large-cell lymphoma: a multicentre, open-label, phase 1/2 study

scientific article published on 01 October 2018

Busulfan induces activin A expression in vitro and in vivo: a possible link to venous occlusive disease

scientific article published on September 2003

C1-inhibitor concentrate for individual replacement therapy in patients with severe hereditary angioedema refractory to danazol prophylaxis.

scientific article published on 20 May 2009

CD271 antigen defines a subset of multipotent stromal cells with immunosuppressive and lymphohematopoietic engraftment-promoting properties

scientific article

Changes in host defence induced by malignancies and antineoplastic treatment: implication for immunotherapeutic strategies

scientific article published on March 2008

Characterization of acute hereditary angioedema attacks during pregnancy and breast-feeding and their treatment with C1 inhibitor concentrate

scientific article published on 14 May 2010

Chemotherapy versus allogeneic transplantation for very-high-risk childhood acute lymphoblastic leukaemia in first complete remission: comparison by genetic randomisation in an international prospective study

scientific article published in August 2005

Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology

scientific article published on 7 February 2017

Chimaerism analyses and subsequent immunological intervention after stem cell transplantation in patients with juvenile myelomonocytic leukaemia

scientific article

Circulating levels and promoter polymorphisms of interleukins-6 and 8 in pediatric cancer patients with fever and neutropenia.

scientific article published on February 2004

Clinical grade purification and expansion of NK cell products for an optimized manufacturing protocol

scientific article published on 17 May 2013

Clinical-scale generation of multi-specific anti-fungal T cells targeting Candida, Aspergillus and mucormycetes

scientific article

Clofarabine, high-dose cytarabine and liposomal daunorubicin in pediatric relapsed/refractory acute myeloid leukemia: a phase IB study

scientific article published on 17 May 2018

Clonal analysis of multipotent stromal cells derived from CD271+ bone marrow mononuclear cells: functional heterogeneity and different mechanisms of allosuppression

scientific article published on 23 August 2013

Combination therapy with caspofungin and liposomal amphotericin B for invasive aspergillosis

scientific article published in July 2003

Computed tomography-guided biopsies in children: accuracy, efficiency and dose usage

scientific article published on 06 January 2017

Cooperative trial CWS-91 for localized soft tissue sarcoma in children, adolescents, and young adults

scientific article published on 17 February 2009

Costs and cost-effectiveness of allogeneic stem cell transplantation in children are predictable

scientific article published on 5 April 2012

Crizotinib in ALK+ inflammatory myofibroblastic tumors-Current experience and future perspectives

scientific article published on 29 December 2017

Cytomegalovirus-specific cytokine-induced killer cells: concurrent targeting of leukemia and cytomegalovirus

scientific article published on 10 June 2015

Cytotoxic Capacity of IL-15-Stimulated Cytokine-Induced Killer Cells Against Human Acute Myeloid Leukemia and Rhabdomyosarcoma in Humanized Preclinical Mouse Models

scientific article published on 9 April 2012

Cytotoxic effects of treosulfan and busulfan against leukemic cells of pediatric patients

scientific article published on 2 February 2008

Cytotoxic potential of IL-15-activated cytokine-induced killer cells against human neuroblastoma cells

scientific article published on 19 July 2016

Cytotoxicity of dimethylacetamide and pharmacokinetics in children receiving intravenous busulfan

scientific article published on May 2007

Development of Three Different NK Cell Subpopulations during Immune Reconstitution after Pediatric Allogeneic Hematopoietic Stem Cell Transplantation: Prognostic Markers in GvHD and Viral Infections

scientific article published on 10 February 2017

Development of resistance to vincristine and doxorubicin in neuroblastoma alters malignant properties and induces additional karyotype changes: a preclinical model

scientific article published in March 2003

Diagnostic tool for the identification of MLL rearrangements including unknown partner genes

scientific article

Differential loss of humoral immunity against measles, mumps, rubella and varicella-zoster virus in children treated for cancer

scientific article published on 29 April 2014

Distinct contributions of CD4(+) and CD8(+) naive and memory T-cell subsets to overall T-cell-receptor repertoire complexity following transplantation of T-cell-depleted CD34-selected hematopoietic progenitor cells from unrelated donors

scientific article published in September 2002

Effective treatment of steroid and therapy-refractory acute graft-versus-host disease with a novel mesenchymal stromal cell product (MSC-FFM).

scientific article published on 29 January 2018

Efficient lysis of rhabdomyosarcoma cells by cytokine-induced killer cells: implications for adoptive immunotherapy after allogeneic stem cell transplantation

scientific article published on 7 April 2010

Epidemiology of inhibitors and current treatment strategies

scientific article

Epidemiology, risk factors, and prognosis of capillary leak syndrome in pediatric recipients of stem cell transplants: a retrospective single-center cohort study

scientific article

Epstein-Barr virus-specific cytokine-induced killer cells for treatment of Epstein-Barr virus-related malignant lymphoma

scientific article

Feasibility of VECOPA, a dose-intensive chemotherapy regimen for children and adolescents with intermediate and advanced stage Hodgkin lymphoma: results of the GPOH-HD-2002/VECOPA pilot trial

scientific article published on 9 October 2014

Fertility Preservation in Prepubertal und Pubertal Children and Adolescents

scientific article published on 8 February 2018

Gastrointestinal stromal tumours in children and young adults: a clinicopathologic series with long-term follow-up from the database of the Cooperative Weichteilsarkom Studiengruppe (CWS).

scientific article

Generation and characterization of ErbB2-CAR-engineered cytokine-induced killer cells for the treatment of high-risk soft tissue sarcoma in children

scientific article published on 2 August 2017

Generation and characterization of anti-Candida T cells as potential immunotherapy in patients with Candida infection after allogeneic hematopoietic stem-cell transplant

scientific article published on 18 June 2007

Generation and flow cytometric quality control of clinical-scale TCRαβ/CD19-depleted grafts

scientific article published on 28 September 2015

Haploidentical allogeneic hematopoietic stem cell transplantation in patients with high-risk soft tissue sarcomas: results of a single-center prospective trial

scientific article published on 24 January 2018

Haploidentical transplantation for acute lymphoblastic leukemia in childhood

scientific article published on September 2004

Hedgehog signaling negatively co-regulates BH3-only protein Noxa and TAp73 in TP53-mutated cells

scientific article published on 24 April 2018

Hematopoietic stem cell transplantation for complete IFN-γ receptor 1 deficiency: A multi-institutional survey

article by Joachim Roesler et al published December 2004 in The Journal of Pediatrics

High-Dose Chemotherapy and Blood Autologous Stem-Cell Rescue Compared With Standard Chemotherapy in Localized High-Risk Ewing Sarcoma: Results of Euro-E.W.I.N.G.99 and Ewing-2008

article by Jeremy Whelan et al published 6 September 2018 in Journal of Clinical Oncology

High-dose compared with intermediate-dose methotrexate in children with a first relapse of acute lymphoblastic leukemia

scientific article published on 18 December 2007

Highlights of the third International Conference on Immunotherapy in Pediatric Oncology

scientific article published on 12 June 2013

Home therapy with intravenous human C1-inhibitor in children and adolescents with hereditary angioedema

scientific article

Humoral immune responsiveness to a defined epitope on factor VIII before and after B cell ablation with rituximab

scientific article

IL-2 activated NK cell immunotherapy of three children after haploidentical stem cell transplantation

scientific article published in November 2004

IL-2 stimulated but not unstimulated NK cells induce selective disappearance of peripheral blood cells: concomitant results to a phase I/II study

scientific article

Immune cell subsets at birth may help to predict risk of late-onset sepsis and necrotizing enterocolitis in preterm infants

scientific article published on 15 December 2015

Immunomagnetic selection or irradiation eliminates alloreactive cells but also reduces anti-tumor potential of cytokine-induced killer cells: implications for unmanipulated cytokine-induced killer cell infusion

scientific article published on 28 February 2014

Immunosuppressive compounds exhibit particular effects on functional properties of human anti-Aspergillus Th1 cells

scientific article published on 7 April 2014

Immunosuppressive therapy with anti-thymocyte globulin and cyclosporine A in selected children with hypoplastic refractory cytopenia

scientific article published in March 2007

Immunotherapy against invasive fungal diseases in stem cell transplant recipients

scientific article published on 31 May 2011

Immunotherapy in Invasive Fungal Infection - Focus on Invasive Aspergillosis ⬇️

scientific article published on January 1, 2013

Immunotherapy of invasive fungal infection in hematopoietic stem cell transplant recipients ⬇️

scientific article published on 07 February 2013

Impaired T-cell activation and cytokine productivity after transplantation of positively selected CD34+ allogeneic hematopoietic stem cells

scientific article published in January 2004

Importance of whole-body imaging with complete coverage of hands and feet in alveolar rhabdomyosarcoma staging

scientific article

Improvements in the Treatment of Patients Suffering from Bladder-Prostate Rhabdomyosarcoma: A Report from the CWS-2002P Trial

scientific article published on 7 July 2016

In vitro migration and proliferation ("wound healing") potential of mesenchymal stromal cells generated from human CD271(+) bone marrow mononuclear cells

scientific article

In-vitro influence of mycophenolate mofetil (MMF) and Ciclosporin A (CsA) on cytokine induced killer (CIK) cell immunotherapy

scientific article published on 13 September 2016

Incidence and time trends of soft tissue sarcomas in German children 1985-2004 - a report from the population-based German Childhood Cancer Registry

scientific article published in February 2008

Increasing mixed chimerism is an important prognostic factor for unfavorable outcome in children with acute lymphoblastic leukemia after allogeneic stem-cell transplantation: possible role for pre-emptive immunotherapy?

scientific article

Infectious complications after allogeneic stem cell transplantation: epidemiology and interventional therapy strategies--guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO).

scientific article published on 10 September 2003

Inhibitor development in previously untreated patients with hemophilia A: a prospective long-term follow-up comparing plasma-derived and recombinant products

scientific article published in June 2002

Interleukin-15-activated cytokine-induced killer cells may sustain remission in leukemia patients after allogeneic stem cell transplantation: feasibility, safety and first insights on efficacy

scientific article published on 14 January 2016

Joint Modeling of Immune Reconstitution Post Haploidentical Stem Cell Transplantation in Pediatric Patients With Acute Leukemia Comparing CD34-Selected to CD3/CD19-Depleted Grafts in a Retrospective Multicenter Study

Lack of Effectiveness of Neutropenic Diet and Social Restrictions as Anti-Infective Measures in Children With Acute Myeloid Leukemia: An Analysis of the AML-BFM 2004 Trial

scientific article

Late MRD response determines relapse risk overall and in subsets of childhood T-cell ALL: results of the AIEOP-BFM-ALL 2000 study

scientific article

Long term outcome of high-risk neuroblastoma patients after immunotherapy with antibody ch14.18 or oral metronomic chemotherapy

scientific article

Long-term IL-2 therapy after transplantation of T cell depleted stem cells from alternative donors in children

scientific article published on 25 June 2011

Long-term outcome after haploidentical stem cell transplantation in children

scientific article published in November 2004

Long-term outcome in children with relapsed ALL by risk-stratified salvage therapy: results of trial acute lymphoblastic leukemia-relapse study of the Berlin-Frankfurt-Münster Group 87.

scientific article published on November 2005

Long-term outcome in children with relapsed acute lymphoblastic leukemia after time-point and site-of-relapse stratification and intensified short-course multidrug chemotherapy: results of trial ALL-REZ BFM 90.

scientific article published on 12 April 2010

Malignant ectomesenchymoma in children and adolescents: report from the Cooperative Weichteilsarkom Studiengruppe (CWS).

scientific article

Megadose transplantation of highly purified haploidentical stem cells: current results and future prospects

scientific article

Mesenchymal stromal cells from pooled mononuclear cells of multiple bone marrow donors as rescue therapy in pediatric severe steroid-refractory graft-versus-host disease: a multicenter survey

scientific article published on 12 May 2016

Minimal residual disease after induction is the strongest predictor of prognosis in intermediate risk relapsed acute lymphoblastic leukaemia - long-term results of trial ALL-REZ BFM P95/96.

scientific article published on 19 December 2012

Molecular signature of human bone marrow-derived mesenchymal stromal cell subsets

scientific article published in Scientific Reports

Monitoring of hematopoietic chimerism after transplantation for pediatric myelodysplastic syndrome: real-time or conventional short tandem repeat PCR in peripheral blood or bone marrow?

scientific article published on 31 July 2014

More than mere games: a review of card and board games for medical education

scientific article

Multimerization of peptide mimotopes for blocking of factor VIII neutralizing antibodies

scientific article published in August 2009

Myeloablative megatherapy with autologous stem-cell rescue versus oral maintenance chemotherapy as consolidation treatment in patients with high-risk neuroblastoma: a randomised controlled trial

scientific article

Natural killer cell activity influences outcome after T cell depleted stem cell transplantation from matched unrelated and haploidentical donors

scientific article published on 25 June 2011

Neurotoxic side effects in children with refractory or relapsed T-cell malignancies treated with nelarabine based therapy

scientific article

Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study

scientific article published on 28 July 2016

Odontoid infiltration and spinal compression in Farber Disease: reversal by haematopoietic stem cell transplantation

scientific article published on 24 July 2013

On demand treatment and home therapy of hereditary angioedema in Germany - the Frankfurt experience ⬇️

scientific article published on July 28, 2010

On the way to becoming an MD (Dr. med.): What kind of support do doctoral students need? Part 1: Survey and development of a program

scientific article

Optimization of individualized graft composition: CD3/CD19 depletion combined with CD34 selection for haploidentical transplantation

scientific article published on 27 June 2016

Osteosarcoma in patients with Rothmund-Thomson syndrome

scientific article published on 31 December 2014

Osteosarcoma in very young children: experience of the Cooperative Osteosarcoma Study Group

scientific article

Outcome of relapse after allogeneic HSCT in children with ALL enrolled in the ALL-SCT 2003/2007 trial

scientific article published on 28 November 2017

Outcome, Treatment, and Treatment Failures in Patients Suffering Localized Embryonal Paratesticular Rhabdomyosarcoma: Results From the "Cooperative Weichteilsarkom Studiengruppe" Trials CWS-86, -91, -96, and -2002P.

scientific article published on December 2016

Outcomes of treatment for relapsed acute lymphoblastic leukaemia in children with Down syndrome ⬇️

scientific article published on April 18, 2013

Overcrowding in a neonatal intermediate care unit: impact on the incidence of multidrug-resistant gram-negative organisms.

scientific article

Pediatric Acute Lymphoblastic Leukemia: Efficacy and safety of recombinant E. coli-asparaginase in infants (less than one year of age) with acute lymphoblastic leukemia ⬇️

scientific article published on June 10, 2013

Phase II window study on rituximab in newly diagnosed pediatric mature B-cell non-Hodgkin's lymphoma and Burkitt leukemia

scientific article published on June 2010

Population pharmacokinetics of high-dose etoposide in children receiving different conditioning regimens

scientific article published on January 2002

Population pharmacokinetics of oral busulfan in children

scientific article published on 17 June 2003

Pre-Emptive Immunotherapy for Clearance of Molecular Disease in Childhood Acute Lymphoblastic Leukemia after Transplantation

scientific article published on 11 October 2016

Preemptive immunotherapy in childhood acute myeloid leukemia for patients showing evidence of mixed chimerism after allogeneic stem cell transplantation

scientific article published on 26 September 2011

Primary Metastatic Synovial Sarcoma: Experience of the CWS Study Group

scientific article

Primary intracranial soft tissue sarcoma in children and adolescents: a cooperative analysis of the European CWS and HIT study groups

scientific article published on 11 December 2012

Prognostic value of minimal residual disease quantification before allogeneic stem-cell transplantation in relapsed childhood acute lymphoblastic leukemia: the ALL-REZ BFM Study Group

scientific article published on 8 December 2008

Prospective evaluation of cisplatin- and carboplatin-mediated ototoxicity in paediatric and adult soft tissue and osteosarcoma patients

scientific article

Protocol II vs protocol III given twice during reinduction therapy in children with medium-risk ALL.

scientific article published on 22 September 2017

Radical Surgery Improves Survival in Patients with Stage 4 Neuroblastoma

scientific article

Randomized trial comparing liposomal daunorubicin with idarubicin as induction for pediatric acute myeloid leukemia: results from Study AML-BFM 2004.

scientific article published on 23 May 2013

Results and factors influencing outcome after fully haploidentical hematopoietic stem cell transplantation in children with very high-risk acute lymphoblastic leukemia: impact of center size: an analysis on behalf of the Acute Leukemia and Pediatric

scientific article published on 29 December 2009

Retransplantation with stem cells from mismatched related donors after graft rejection in pediatric patients

scientific article published on 19 September 2007

Rhinocerebral zygomycosis in a young girl undergoing allogeneic stem cell transplantation for severe aplastic anaemia

scientific article published in January 2006

Rhizopus oryzae hyphae are damaged by human natural killer (NK) cells, but suppress NK cell mediated immunity

scientific article published on 2 November 2012

Risk-adjusted outcome measurement in pediatric allogeneic stem cell transplantation

scientific article published in March 2008

Risk-adjusted therapy of acute lymphoblastic leukemia can decrease treatment burden and improve survival: treatment results of 2169 unselected pediatric and adolescent patients enrolled in the trial ALL-BFM 95.

scientific article

SMAC Mimetic BV6 Enables Sensitization of Resistant Tumor Cells but also Affects Cytokine-Induced Killer (CIK) Cells: A Potential Challenge for Combination Therapy

scientific article published on 18 July 2014

Sequential anti-cytomegalovirus response monitoring may allow prediction of cytomegalovirus reactivation after allogeneic stem cell transplantation

scientific article

Smac Mimetic-Induced Upregulation of CCL2/MCP-1 Triggers Migration and Invasion of Glioblastoma Cells and Influences the Tumor Microenvironment in a Paracrine Manner

scientific article published on June 2015

Smac mimetic and glucocorticoids synergize to induce apoptosis in childhood ALL by promoting ripoptosome assembly

scientific article published on 22 May 2014

Specific phenotype and function of CD56-expressing innate immune cell subsets in human thymus

scientific article published on 28 June 2016

Stem cell transplantation for polycythemia vera

scholarly article by Harald Reinhard et al published January 2008 in Pediatric Blood Cancer

Stem-cell transplantation in children with acute lymphoblastic leukemia: A prospective international multicenter trial comparing sibling donors with matched unrelated donors-The ALL-SCT-BFM-2003 trial

scientific article published on 9 March 2015

Superiority of allogeneic hematopoietic stem-cell transplantation compared with chemotherapy alone in high-risk childhood T-cell acute lymphoblastic leukemia: results from ALL-BFM 90 and 95.

scientific article published in December 2006

Synovial Sarcoma Recurrence in Children and Young Adults

scientific article

The Smac Mimetic BV6 Improves NK Cell-Mediated Killing of Rhabdomyosarcoma Cells by Simultaneously Targeting Tumor and Effector Cells

scientific article published on 7 March 2017

The cytotoxic potential of interleukin-15-stimulated cytokine-induced killer cells against leukemia cells

scientific article published on 6 October 2011

The impact of local control in the treatment of type II/III pleuropulmonary blastoma. Experience of the Cooperative Weichteilsarkom Studiengruppe (CWS).

scientific article published on 19 January 2017

The impact of the methotrexate administration schedule and dose in the treatment of children and adolescents with B-cell neoplasms: a report of the BFM Group Study NHL-BFM95.

scientific article

The landscape of genomic alterations across childhood cancers

scientific article published on 28 February 2018

The price of hope: is autologous cord blood storage necessary and useful?

scientific article published on 11 December 2009

The prognostic impact of SYT-SSX fusion type and histological grade in pediatric patients with synovial sarcoma treated according to the CWS (Cooperative Weichteilsarkom Studie) trials

scientific article published on 13 September 2016

The prognostic value of early radiographic response in children and adolescents with embryonal rhabdomyosarcoma stage IV, metastases confined to the lungs: A report from the Cooperative Weichteilsarkom Studiengruppe (CWS).

scientific article published on 17 March 2017

The role of matched sibling donor allogeneic stem cell transplantation in pediatric high-risk acute myeloid leukemia: results from the AML-BFM 98 study

scientific article published on 20 September 2011

Topotecan and etoposide in the treatment of relapsed high-risk neuroblastoma: results of a phase 2 trial

scientific article

Toxicity and pharmacokinetics of i.v. busulfan in children before stem cell transplantation

scientific article published in March 2005

Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed

scientific article

Treatment and outcome of patients suffering from perineal/perianal rhabdomyosarcoma: results from the CWS trials--retrospective clinical study

scientific article

Treatment of Infantile Inflammatory Bowel Disease and Autoimmunity by Allogeneic Stem Cell Transplantation in LPS-Responsive Beige-Like Anchor Deficiency

scientific article

Treatment of children with metastatic soft tissue sarcoma with oral maintenance compared to high dose chemotherapy: report of the HD CWS-96 trial

scientific article

Tumorigenic and anti-proliferative properties of the TALE-transcription factors MEIS2D and MEIS2A in neuroblastoma

scientific article

Tunneled central venous catheters in children with malignant and chronic diseases: A comparison of open vs. percutaneous implantation

scientific article published on 30 January 2017

Unrelated donor stem cell transplantation compared with chemotherapy for children with acute lymphoblastic leukemia in a second remission: a matched-pair analysis ⬇️

scientific article published on May 15, 2003

Use of allogeneic hematopoietic stem-cell transplantation based on minimal residual disease response improves outcomes for children with relapsed acute lymphoblastic leukemia in the intermediate-risk group

scientific article published on 17 June 2013

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