List of works by Shizuo Akira

'Toll' gates for future immunotherapy

scientific article published on January 2006

5'-Triphosphate RNA is the ligand for RIG-I

scientific article (publication date: 10 November 2006)

5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma

scientific article

A Lipopolysaccharide from Pantoea Agglomerans Is a Promising Adjuvant for Sublingual Vaccines to Induce Systemic and Mucosal Immune Responses in Mice via TLR4 Pathway

scientific article

A Polysaccharide Carrier to Effectively Deliver Native Phosphodiester CpG DNA to Antigen-Presenting Cells

article

A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.

scientific article

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

scientific article

A critical role of IL-33 in experimental allergic rhinitis

scholarly article by Yoko Haenuki et al published July 2012 in The Journal of Allergy and Clinical Immunology

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

scientific article

A new subset of CD103+CD8alpha+ dendritic cells in the small intestine expresses TLR3, TLR7, and TLR9 and induces Th1 response and CTL activity.

scientific article published on 27 April 2011

A noncoding RNA produced by arthropod-borne flaviviruses inhibits the cellular exoribonuclease XRN1 and alters host mRNA stability

scientific article

A novel unbiased measure for motif co-occurrence predicts combinatorial regulation of transcription

scientific article

A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA.

scientific article published on October 2009

A signaling polypeptide derived from an innate immune adaptor molecule can be harnessed as a new class of vaccine adjuvant

scientific article

A20 is a negative regulator of IFN regulatory factor 3 signaling.

scientific article published on February 2005

ASK1-p38 MAPK-p47phox activation is essential for inflammatory responses during tuberculosis via TLR2-ROS signalling

scientific article published on 19 November 2007

Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice

scientific article published on December 2009

Activation of MDA5 requires higher-order RNA structures generated during virus infection

scientific article

Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity

scientific article

Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses

scientific article

Airway epithelial indoleamine 2,3-dioxygenase inhibits CD4+ T cells during Aspergillus fumigatus antigen exposure

scientific article

Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice

scientific article

Akt Contributes to Activation of the TRIF-Dependent Signaling Pathways of TLRs by Interacting with TANK-Binding Kinase 1 ⬇️

scientific article published on November 24, 2010

Alveolar macrophage-derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes

scientific article published on 20 April 2015

An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence

scientific article

Antibody-antigen-adjuvant conjugates enable co-delivery of antigen and adjuvant to dendritic cells in cis but only have partial targeting specificity

scientific article

Antigen-specific T-cell responses to a recombinant fowlpox virus are dependent on MyD88 and interleukin-18 and independent of Toll-like receptor 7 (TLR7)- and TLR9-mediated innate immune recognition

scientific article published on 19 January 2011

Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells

scientific journal article

Apolipoprotein CIII Induces Monocyte Chemoattractant Protein-1 and Interleukin 6 Expression Via Toll-Like Receptor 2 Pathway in Mouse Adipocytes: Retracted ⬇️

scientific article published on September 9, 2010

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

scientific article

Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation

scientific article

Autophagy proteins control goblet cell function by potentiating reactive oxygen species production

scientific journal article

B cells enhance early innate immune responses during bacterial sepsis

scientific article

BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway

scientific article

Baculovirus induces type I interferon production through toll-like receptor-dependent and -independent pathways in a cell-type-specific manner

scientific article

Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome

scientific article published on 18 March 2014

CCAAT/enhancer-binding protein homologous protein (CHOP) regulates osteoblast differentiation

scientific article published on August 2006

CD44 participates in IP-10 induction in cells in which hepatitis C virus RNA is replicating, through an interaction with Toll-like receptor 2 and hyaluronan

scientific article

Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription

scientific article

Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and Toll-like receptors

scientific article

Completion of the entire hepatitis C virus life cycle in genetically humanized mice

scientific article published on 31 July 2013

Conditional Deletion of TAK1 in T Cells Reveals a Pivotal Role of TCRαβ+ Intraepithelial Lymphocytes in Preventing Lymphopenia-Associated Colitis

scientific article published on July 2015

Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice

scientific article published on 13 February 2012

Control of adipose tissue inflammation through TRB1.

scientific article

CpG-activated Thy1.2+ dendritic cells protect against lethal Listeria monocytogenes infection.

scientific article published in August 2005

Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation

scientific journal article

Crucial role of gamma interferon-producing CD4+ Th1 cells but dispensable function of CD8+ T cell, B cell, Th2, and Th17 responses in the control of Brucella melitensis infection in mice

scientific article

Cutting edge: Role of TANK-binding kinase 1 and inducible IkappaB kinase in IFN responses against viruses in innate immune cells

scientific article

Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling

scientific journal article

Cutting edge: bacterial infection induces hematopoietic stem and progenitor cell expansion in the absence of TLR signaling

scientific article published on 03 February 2010

Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins

scientific article

DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking

scientific article published on 6 February 2013

DNA released from dying host cells mediates aluminum adjuvant activity

scholarly article by Thomas Marichal et al published 17 July 2011 in Nature Medicine

DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity

scientific article published on 9 January 2017

DNA-Encoded Flagellin Activates Toll-Like Receptor 5 (TLR5), Nod-like Receptor Family CARD Domain-Containing Protein 4 (NRLC4), and Acts as an Epidermal, Systemic, and Mucosal-Adjuvant

scientific article

Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans

scientific journal article

Deficiencies of myeloid differentiation factor 88, Toll-like receptor 2 (TLR2), or TLR4 produce specific defects in macrophage cytokine secretion induced by Helicobacter pylori

scientific article published on 12 March 2007

Deletion of TLR5 results in spontaneous colitis in mice

scientific article

Deletion of the kinase domain in death-associated protein kinase attenuates renal tubular cell apoptosis in chronic obstructive uropathy

scientific journal article

Deoxynucleic acids from Cryptococcus neoformans activate myeloid dendritic cells via a TLR9-dependent pathway

scientific article published on March 2008

Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.

scientific article published on 9 July 2006

Differential inductions of TNF-alpha and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides

scientific article published on March 2006

Differential role of MyD88 in macrophage-mediated responses to opportunistic fungal pathogens

scientific article published on September 2003

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

scientific article (publication date: 4 May 2006)

Differential roles of Toll-like receptors 2 and 4 in in vitro responses of macrophages to Legionella pneumophila

scientific article

Direct Melanoma Cell Contact Induces Stromal Cell Autocrine Prostaglandin E2-EP4 Receptor Signaling That Drives Tumor Growth, Angiogenesis, and Metastasis

scientific article

Direct stimulation of tlr5+/+ CD11c+ cells is necessary for the adjuvant activity of flagellin

scientific article published on June 2009

Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis

scientific article

Distinct roles for MyD88 and Toll-like receptors 2, 5, and 9 in phagocytosis of Borrelia burgdorferi and cytokine induction

scientific article published on 31 March 2008

Downstream signals for MyD88-mediated phagocytosis of Borrelia burgdorferi can be initiated by TRIF and are dependent on PI3K.

scientific article

E2 Polyubiquitin-conjugating enzyme Ubc13 in keratinocytes is essential for epidermal integrity

scientific article published on 27 July 2010

Emergent genome-wide control in wildtype and genetically mutated lipopolysaccarides-stimulated macrophages

scientific article

Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency

scientific article

Eosinophil depletion suppresses radiation-induced small intestinal fibrosis.

scientific article published in February 2018

Erratum: A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA

scholarly article published in Nature Immunology

Escherichia coli verotoxin 1 mediates apoptosis in human HCT116 colon cancer cells by inducing overexpression of the GADD family of genes and S phase arrest

scientific article published on 9 November 2005

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.

scientific article

Essential role of IPS-1 in innate immune responses against RNA viruses

scientific article published on 19 June 2006

Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling

scientific article

Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome

scientific article published on March 2010

FIP200 regulates targeting of Atg16L1 to the isolation membrane

scientific article

Flagellin enhances tumor-specific CD8⁺ T cell immune responses through TLR5 stimulation in a therapeutic cancer vaccine model

scientific article published on 2 July 2013

Genetic analysis of resistance to viral infection

scientific article published on October 2007

Glucocorticoids synergize with IL-1beta to induce TLR2 expression via MAP Kinase Phosphatase-1-dependent dual Inhibition of MAPK JNK and p38 in epithelial cells

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

scientific journal article

Hematopoietic IKBKE limits the chronicity of inflammasome priming and metaflammation

scientific article

Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction

scientific article

Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines

scientific article

Histidine augments the suppression of hepatic glucose production by central insulin action

scientific article published on 08 March 2013

Host innate immune receptors and beyond: making sense of microbial infections

scientific article

Human gingival CD14(+) fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression

scientific article

IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-alpha production in macrophages

scientific article

IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions

scientific article

IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice

scientific article published on December 2007

IPS-1 signaling has a nonredundant role in mediating antiviral responses and the clearance of respiratory syncytial virus

scientific article

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

scientific article

Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity

scientific article published on 12 October 2009

Identification of a key pathway required for the sterile inflammatory response triggered by dying cells

scientific article

IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9

scientific journal article

Immune interventions of human diseases through toll-like receptors

scientific article published on January 2009

Immunogenicity of whole-parasite vaccines against Plasmodium falciparum involves malarial hemozoin and host TLR9.

scientific article published in January 2010

Immunological basis of M13 phage vaccine: Regulation under MyD88 and TLR9 signaling ⬇️

scientific article published on September 26, 2010

Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling

scientific article

Impaired autophagy in macrophages promotes inflammatory eye disease

scientific article published on 27 July 2016

In situ microscopy analysis reveals local innate immune response developed around Brucella infected cells in resistant and susceptible mice

scientific article

Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability

scientific article published on 16 September 2008

Induction of CXCL5 during inflammation in the rodent lung involves activation of alveolar epithelium

scientific journal article

Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of Plasmodium falciparum: cell signaling receptors, glycosylphosphatidylinositol (GPI) structural requirement, and regulation of GPI activity

scientific journal article

Induction of type I interferon by adenovirus-encoded small RNAs

scientific article

Inflammatory mediator TAK1 regulates hair follicle morphogenesis and anagen induction shown by using keratinocyte-specific TAK1-deficient mice

scientific article

Influenza A virus polymerase inhibits type I interferon induction by binding to interferon beta promoter stimulator 1.

scientific article published on 10 August 2010

Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon

scientific article

Inhibitory effect of Toll-like receptor 4 on fusion between phagosomes and endosomes/lysosomes in macrophages

scientific article published on February 2004

Innate and adaptive immune responses to viral infection and vaccination

scientific article published on 30 July 2011

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

scientific journal article

Innate immune control of nucleic acid-based vaccine immunogenicity

scientific article published on August 2009

Innate immune recognition of nucleic acids: beyond toll-like receptors

scientific article

Innate immune recognition of viral infection

scientific article

Innate immune recognition of, and regulation by, DNA.

scientific article published on 18 September 2006

Innate immune response induced by baculovirus attenuates transgene expression in mammalian cells

scientific article published on 11 December 2013

Innate immune response to viral infection

scientific article published on 09 August 2008

Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome

scientific article

Innate immunity

Innate lymphoid cells regulate intestinal epithelial cell glycosylation

scientific article

Intact TRL 9 and type I interferon signaling pathways are required to augment HSV-1 induced corneal CXCL9 and CXCL10.

scientific article

Interferon response factors 3 and 7 protect against Chikungunya virus hemorrhagic fever and shock

scientific article

Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets

scientific article

Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

scientific journal article

Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction

scientific article

Interleukin-18 Facilitates the Early Antimicrobial Host Response toEscherichia coliPeritonitis ⬇️

scientific article published on October 1, 2003

Interleukin-18 impairs the pulmonary host response to Pseudomonas aeruginosa

scientific article

Intracellular Mycobacterium avium intersect transferrin in the Rab11(+) recycling endocytic pathway and avoid lipocalin 2 trafficking to the lysosomal pathway

scientific article

Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation

scientific article

Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes

scientific article

Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers

scientific article published on 27 June 2002

Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses

scientific article

Leishmania major activates IL-1 alpha expression in macrophages through a MyD88-dependent pathway

scientific article published on July 2002

Leishmania-induced IRAK-1 inactivation is mediated by SHP-1 interacting with an evolutionarily conserved KTIM motif

scientific article

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5

scientific article

Leukemia inhibitory factor coordinates the down-regulation of the visual cycle in the retina and retinal-pigmented epithelium

scientific article

Limited role for interleukin-18 in the host protection response to pulmonary infection with Pseudomonas aeruginosa in mice

scientific article published on October 2004

Lipocalin 2 bolsters innate and adaptive immune responses to blood-stage malaria infection by reinforcing host iron metabolism

scientific article published in November 2012

Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium

scientific article

Lipopolysaccharide from Coxiella burnetii is involved in bacterial phagocytosis, filamentous actin reorganization, and inflammatory responses through Toll-like receptor 4.

scientific article published on March 2004

Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces a cytotoxic T-cell response via MyD88.

scientific article published on 17 October 2007

Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway

scientific article

Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activation

scientific article

Manifold mechanisms of Toll-like receptor-ligand recognition

scientific article

Manipulation of host innate immune responses by the malaria parasite

scientific article published on 26 April 2007

Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice

scientific article

Microsomal prostaglandin E synthase-1 enhances bone cancer growth and bone cancer-related pain behaviors in mice

scientific article published on 12 February 2011

Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis

scientific article

Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury

scholarly article

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

scientific journal article

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

scientific article

Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response

scientific article published on 17 February 2017

Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages

scientific article

Molecular and cellular mechanisms of DNA vaccines

scientific article

MyD88 but not TRIF is essential for osteoclastogenesis induced by lipopolysaccharide, diacyl lipopeptide, and IL-1alpha

scientific article

MyD88 deficiency results in tissue-specific changes in cytokine induction and inflammation in interleukin-18-independent mice infected with Borrelia burgdorferi

scientific article

MyD88 primes macrophages for full-scale activation by interferon-gamma yet mediates few responses to Mycobacterium tuberculosis

scientific article

MyD88 protects from lethal encephalitis during infection with vesicular stomatitis virus

scientific article published on September 2007

MyD88 signaling inhibits protective immunity to the gastrointestinal helminth parasite Heligmosomoides polygyrus

scientific article

MyD88 signaling is indispensable for primary influenza A virus infection but dispensable for secondary infection

scientific article

MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals

scientific article

NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.

scholarly article

NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection

scientific article

NO is a macrophage autonomous modifier of the cytokine response to streptococcal single-stranded RNA

scientific article published on 19 December 2011

Natural killer cell and macrophage cooperation in MyD88-dependent innate responses to Plasmodium falciparum

scientific article

Negative Regulators in Toll-like Receptor Responses ⬇️

scientific article published on November 1, 2010

Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1.

scientific article

Negative regulation of melanoma differentiation-associated gene 5 (MDA5)-dependent antiviral innate immune responses by Arf-like protein 5B

scientific article

Negative regulation of platelet clearance and of the macrophage phagocytic response by the transmembrane glycoprotein SHPS-1.

scientific article

Nitrogen dioxide promotes allergic sensitization to inhaled antigen

scientific article

Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist

scientific article

Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly

scientific article published on 4 August 2008

Novel bacterial lipoprotein structures conserved in low-GC content gram-positive bacteria are recognized by Toll-like receptor 2.

scientific article published on 2 February 2012

Novel strategies to improve DNA vaccine immunogenicity

scientific article published on December 2011

Nucleic acid sensing by T cells initiates Th2 cell differentiation

scientific article published on 10 April 2014

Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

scientific article

Olfactory plays a key role in spatiotemporal pathogenesis of cerebral malaria

scientific article published on May 2014

Oncolytic Reovirus Inhibits Immunosuppressive Activity of Myeloid-Derived Suppressor Cells in a TLR3-Dependent Manner.

scientific article published on 19 March 2018

Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways

scientific article

Osteoclast differentiation is impaired in the absence of inhibitor of kappa B kinase alpha

scientific journal article

PI3K integrates the action of insulin and leptin on hypothalamic neurons

scientific article

Papillomavirus capsid mutation to escape dendritic cell-dependent innate immunity in cervical cancer

scientific article

Papillomavirus-like particles stimulate murine bone marrow-derived dendritic cells to produce alpha interferon and Th1 immune responses via MyD88.

scientific article published on October 2004

Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane

scientific article

Pathways regulating cytosolic phospholipase A2 activation and eicosanoid production in macrophages by Candida albicans

scientific article

Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation

scientific article published on June 2006

Phosphoproteomic analysis of kinase-deficient mice reveals multiple TAK1 targets in osteoclast differentiation

scientific article published on 20 June 2015

Physical and functional interactions between ZIP kinase and UbcH5

scientific article

Pivotal Advance: Toll-like receptor regulation of scavenger receptor-A-mediated phagocytosis

scientific article published on 26 December 2008

Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists

scientific article published on 11 January 2010

Plasmacytoid dendritic cells delineate immunogenicity of influenza vaccine subtypes

scientific article published in March 2010

Plasmacytoid dendritic cells promote host defense against acute pneumovirus infection via the TLR7-MyD88-dependent signaling pathway

scientific article

Plasmodium products persist in the bone marrow and promote chronic bone loss.

scientific article

PolyI:C-induced reduction in uptake of soluble antigen is independent of dendritic cell activation

scientific article

Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense ⬇️

scientific article published on August 19, 2010

Potent antimycobacterial activity of mouse secretory leukocyte protease inhibitor

scientific journal article

Potential link between the immune system and metabolism of nucleic acids

scientific article published on 06 August 2008

Prevention of intestinal allergy in mice by rflaA:Ova is associated with enforced antigen processing and TLR5-dependent IL-10 secretion by mDC

scientific article

Prion pathogenesis in the absence of Toll-like receptor signalling

scientific article

Prostaglandin E(2) exerts homeostatic regulation of pulmonary vascular remodeling in allergic airway inflammation

scientific article published on January 2010

Prostaglandin E₂ is critical for the development of niacin-deficiency-induced photosensitivity via ROS production

scientific article published on 17 October 2013

Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4.

scholarly article

Protein kinase C zeta plays an essential role for Mycobacterium tuberculosis-induced extracellular signal-regulated kinase 1/2 activation in monocytes/macrophages via Toll-like receptor 2.

scientific article published on 22 August 2006

Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity

scientific article

Proteolytic processing of Stat6 signaling in mast cells as a negative regulatory mechanism

scientific journal article

RAE1 ligands for the NKG2D receptor are regulated by STING-dependent DNA sensor pathways in lymphoma

scientific article

RIG-I detects mRNA of intracellular Salmonella enterica serovar Typhimurium during bacterial infection

scientific article published on April 2014

Rapid host defense against Aspergillus fumigatus involves alveolar macrophages with a predominance of alternatively activated phenotype

scientific article

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus

scientific article

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production

scientific article

Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice

scientific journal article

Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta

scientific article

Regulation of hematopoiesis by the K63-specific ubiquitin-conjugating enzyme Ubc13.

scientific article

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5.

scientific article published on 30 May 2008

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2

scientific article

Regulation of lipopolysaccharide-induced translation of tumor necrosis factor-alpha by the toll-like receptor 4 adaptor protein TRAM.

scientific article

Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney

scientific article

Requirement for DNA CpG content in TLR9-dependent dendritic cell activation induced by DNA-containing immune complexes

scientific article

Retinal cell type-specific prevention of ischemia-induced damages by LPS-TLR4 signaling through microglia

scientific article published on 13 May 2013

Role for MyD88-independent, TRIF pathway in lipid A/TLR4-induced endotoxin tolerance

scientific article published on September 2007

Role of Adrenomedullin in Lyme Disease ⬇️

scientific article published on October 4, 2010

Role of MyD88 and Toll-like receptors 2 and 4 in the sensing of Parachlamydia acanthamoebae

scientific article

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

scientific journal article

Role of mouse and human autophagy proteins in IFN-γ-induced cell-autonomous responses against Toxoplasma gondii

scientific article published on 21 February 2014

Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus

scientific article published on 30 March 2009

Role of zinc-finger anti-viral protein in host defense against Sindbis virus

scientific article

Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA

scientific journal article

Roles of mPGES-1, an inducible prostaglandin E synthase, in enhancement of LPS-induced lymphangiogenesis in a mouse peritonitis model

scientific article published on 9 October 2015

Roles of toll-like receptors in C-C chemokine production by renal tubular epithelial cells

scientific article published on August 2002

Route to Discovering the Immunogenic Properties of DNA from TLR9 to Cytosolic DNA Sensors

STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury

scientific article published on July 2008

Sepsis-Induced Osteoblast Ablation Causes Immunodeficiency

scientific article published on 14 June 2016

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

scientific article

Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis

scientific article published on 10 April 2008

Signaling flux redistribution at toll-like receptor pathway junctions

scientific article

Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms

article

Simultaneous blocking of human Toll-like receptors 2 and 4 suppresses myeloid dendritic cell activation induced by Mycobacterium bovis bacillus Calmette-Guérin peptidoglycan

scientific article

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

scientific article (publication date: February 2002)

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

scientific article

Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex

scientific article published on September 2005

Stat-3 is required for pulmonary homeostasis during hyperoxia

scientific article published on January 2004

Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms ⬇️

scientific article published on October 1, 2003

Stimulation of human Toll-like receptor (TLR) 2 and TLR6 with membrane lipoproteins of Mycoplasma fermentans induces apoptotic cell death after NF-kappa B activation

scientific article published on February 2004

Structural basis for the regulation of enzymatic activity of Regnase-1 by domain-domain interactions

scientific article

Suppressor of cytokine signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK-STAT

scientific article

Synthesis and in vitro characterization of antigen-conjugated polysaccharide as a CpG DNA carrier

scientific article published on September 2006

Systems biology approaches to toll-like receptor signaling

scientific article

TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.

scientific article published on 30 January 2006

TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis

scientific article

TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis

scientific article

TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis

scientific article

TANK-binding kinase 1-dependent or -independent signaling elicits the cell-type-specific innate immune responses induced by the adenovirus vector

scientific article published on 20 October 2015

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

scientific article published in Nature

TLR ignores methylated RNA?

scientific article

TLR signaling pathways

scientific article

TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification

scientific article

TLR4 ligands induce IFN-alpha production by mouse conventional dendritic cells and human monocytes after IFN-beta priming

scientific article

TLR4 signaling mediates inflammation and tissue injury in nephrotoxicity

scientific article published on 6 February 2008

TLR5 functions as an endocytic receptor to enhance flagellin-specific adaptive immunity

scientific article published on 3 December 2010

TLR5-deficient mice lack basal inflammatory and metabolic defects but exhibit impaired CD4 T cell responses to a flagellated pathogen

scientific article

TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus

scientific article published on December 2008

TLR9 and endogenous adjuvants of the whole blood-stage malaria vaccine

scientific article published on July 2010

TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus

scientific article published on 9 March 2015

TNF-alpha from inflammatory dendritic cells (DCs) regulates lung IL-17A/IL-5 levels and neutrophilia versus eosinophilia during persistent fungal infection

scientific article

TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation

scientific article

TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF

scientific article

TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway

scientific article published on 4 November 2008

TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA.

scientific article

TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and -independent humoral immune responses

scientific article

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta

scientific journal article

TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway

scientific journal article

TRIF signaling is essential for TLR4-driven IgE class switching

scientific article

TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

scientific journal article

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes

scientific journal article

Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis

scientific article published on 07 December 2009

Targeting dendritic cell signaling to regulate the response to immunization

scientific article published on 7 January 2008

Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

scientific article published on 6 November 2006

Th2 allergic immune response to inhaled fungal antigens is modulated by TLR-4-independent bacterial products

scientific article published on March 2009

The Atg5 Atg12 conjugate associates with innate antiviral immune responses

scholarly article

The C/EBP beta isoform 34-kDa LAP is responsible for NF-IL-6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing

scientific journal article

The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1

scientific article

The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses

scientific article published on September 2017

The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.

scientific article

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

scientific article

The TNF family member 4-1BBL sustains inflammation by interacting with TLR signaling components during late-phase activation

scientific article published on October 2013

The TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signaling

scientific article

The Triacylated ATP Binding Cluster Transporter Substrate-binding Lipoprotein of Staphylococcus aureus Functions as a Native Ligand for Toll-like Receptor 2

scientific article published on 12 January 2009

The chemotherapeutic agent DMXAA as a unique IRF3-dependent type-2 vaccine adjuvant

scientific article

The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis

scientific article

The early activation of CD8+ T cells is dependent on type I IFN signaling following intramuscular vaccination of adenovirus vector

scientific article

The enzyme Cyp26b1 mediates inhibition of mast cell activation by fibroblasts to maintain skin-barrier homeostasis

scientific article

The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation

scientific article

The malarial metabolite hemozoin and its potential use as a vaccine adjuvant

scientific article published on 24 April 2010

The microRNA miR-485 targets host and influenza virus transcripts to regulate antiviral immunity and restrict viral replication

scientific article

The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction

scientific article

The nuclear IkappaB protein IkappaBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria

scientific article

The protective role of TLR6 in a mouse model of asthma is mediated by IL-23 and IL-17A.

scientific article

The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets

scientific article

The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection

scientific article

The second messenger phosphatidylinositol-5-phosphate facilitates antiviral innate immune signaling

scientific article published on August 2013

The toll-like receptor 3-mediated antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic mice

scientific article published on 9 November 2011

The transcription factor Jdp2 controls bone homeostasis and antibacterial immunity by regulating osteoclast and neutrophil differentiation

scientific article

The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA

scientific article

Therapeutic targeting of Toll-like receptors

Toll or toll-free adjuvant path toward the optimal vaccine development

scientific article published on 17 March 2007

Toll-IL-1 receptor domain-containing adaptor protein is critical for early lung immune responses against Escherichia coli lipopolysaccharide and viable Escherichia coli

scientific article

Toll-like receptor 2 deficiency is associated with enhanced severity of group B streptococcal disease

scientific article published on 29 January 2009

Toll-like receptor 2 is required for optimal control of Listeria monocytogenes infection

scientific article published on April 2004

Toll-like receptor 2 mediates apolipoprotein CIII-induced monocyte activation

scientific article

Toll-like receptor 2 plays a role in the early inflammatory response to murine pneumococcal pneumonia but does not contribute to antibacterial defense

scientific article published on March 2004

Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-gamma-induced apoptosis in primary pancreatic beta-cells

scientific journal article

Toll-like receptor 4 mediates the antitumor host response induced by a 55-kilodalton protein isolated from Aeginetia indica L., a parasitic plant

scientific article

Toll-like receptor 5-deficient mice have dysregulated intestinal gene expression and nonspecific resistance to Salmonella-induced typhoid-like disease

scientific article published on 14 January 2008

Toll-like receptor 7 (TLR7) modulates anti-nucleosomal autoantibody isotype and renal complement deposition in mice exposed to syngeneic late apoptotic cells

scientific article

Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice

scientific article published on September 2006

Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin

scientific article published on January 2005

Toll-like receptor 9 prevents cardiac rupture after myocardial infarction in mice independently of inflammation

scientific article

Toll-like receptor 9-dependent activation of myeloid dendritic cells by Deoxynucleic acids from Candida albicans

scientific article published on 11 May 2009

Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells

scientific article

Toll-like receptor adaptor molecules enhance DNA-raised adaptive immune responses against influenza and tumors through activation of innate immunity

scientific article

Toll-like receptor downstream signaling

scientific article

Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: implications for vaccines

scholarly article

Toll-like receptor signalling

scientific article

Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice

scientific article

Toll-like receptor-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and -independent pathways

scientific journal article

Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment

scientific article

Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3... ⬇️

scientific article published on October 15, 2003

Toxoplasma gondii genotype determines MyD88-dependent signaling in infected macrophages

scientific article published on August 2006

Toxoplasma gondii-derived heat shock protein HSP70 functions as a B cell mitogen

scientific article published on October 2002

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

scientific article

Two mechanistically and temporally distinct NF-kappaB activation pathways in IL-1 signaling

scientific article published on 20 October 2009

Type I interferon modulates monocyte recruitment and maturation in chronic inflammation

scientific article published on October 2009

Type I interferon signaling regulates Ly6C(hi) monocytes and neutrophils during acute viral pneumonia in mice

scientific article

Type-I IFN signaling is required for the induction of antigen-specific CD8+ T cell responses by adenovirus vector vaccine in the gut-mucosa

article

Type-I interferon is critical for FasL expression on lung cells to determine the severity of influenza

scientific article

Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections

scientific article

West Nile virus noncoding subgenomic RNA contributes to viral evasion of the type I interferon-mediated antiviral response

scientific article

ZIP kinase triggers apoptosis from nuclear PML oncogenic domains

scientific article

Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay

scientific journal article

Zinc-finger antiviral protein mediates retinoic acid inducible gene I-like receptor-independent antiviral response to murine leukemia virus

scientific article published on 08 July 2013

iNOS-producing inflammatory dendritic cells constitute the major infected cell type during the chronic Leishmania major infection phase of C57BL/6 resistant mice

scientific article

p62 Plays a Specific Role in Interferon-γ-Induced Presentation of a Toxoplasma Vacuolar Antigen

scientific article published on 30 September 2015

Paulina is supported by:

About Paulina

Help