List of works - Uli Kazmaier

A small molecule inhibits protein disulfide isomerase and triggers the chemosensitization of cancer cells

scientific article

A straightforward approach towards 5-substituted thiazolylpeptides via the thio-Ugi-reaction

scientific article published on 7 October 2010

A straightforward approach towards combined α-amino and α-hydroxy acids based on Passerini reactions

scientific article published on 19 September 2011

A straightforward approach towards cyclic peptides via ring-closing metathesis--scope and limitations

scientific article published on 26 November 2004

A straightforward approach towards cyclic photoactivatable tubulysin derivatives

scientific article published on 04 September 2014

A straightforward approach towards glycoamino acids and glycopeptides via Pd-catalysed allylic alkylation

scientific article

A straightforward approach towards thiazoles and endothiopeptides via Ugi reaction

scientific article (publication date: 7 September 2005)

A straightforward protocol for one-pot allylic aminations/Stille couplings

scientific article published on 01 August 2009

A straightforward synthesis of polyketides via ester dienolate Matteson homologation

scientific article published on 22 October 2020

Actin stabilizing compounds show specific biological effects due to their binding mode

scientific article published on 05 July 2019

Allylations of chelated enolates using dienyl substrates

scientific article published on 10 January 2008

Allylic alkylation versus Michael induced ring closure: chelated enolates as versatile nucleophiles

scientific article published on 01 October 2004

Amino acids--valuable organocatalysts in carbohydrate synthesis

scientific article

An endothelial cell line infected by Kaposi's sarcoma-associated herpes virus (KSHV) allows the investigation of Kaposi's sarcoma and the validation of novel viral inhibitors in vitro and in vivo

scientific article published on 04 January 2019

Application of the Ester Enolate Claisen Rearrangement in the Synthesis of Amino Acids Containing Quaternary Carbon Centers ⬇️

scientific article published on May 31, 1996

Asymmetric chelated Claisen rearrangements in the presence of chiral ligands--scope and limitations

scientific article

Biosynthesis of 2-Alkyl-4(1H)-Quinolones in Pseudomonas aeruginosa: Potential for Therapeutic Interference with Pathogenicity

scientific article published on 18 March 2011

Bottromycins - biosynthesis, synthesis and activity

scientific article published in 2021

C-H Functionalization of N-Methylated Amino Acids and Peptides as Tool in Natural Product Synthesis: Synthesis of Abyssenine A and Mucronine E

scientific article published on 26 November 2018

Characterization of a novel type of oxidative decarboxylase involved in the biosynthesis of the styryl moiety of chondrochloren from an acylated tyrosine.

scientific article

Chelated Enolates of Amino Acid Esters-Efficient Nucleophiles in Palladium-Catalyzed Allylic Substitutions

scientific article published on 01 May 1999

Chemie für Biologen

Chemie im Alltag

German scholarly article

Co-delivery of pretubulysin and siEG5 to EGFR overexpressing carcinoma cells

scientific article published on 26 July 2019

Combination Chemotherapy of L1210 Tumors in Mice with Pretubulysin and Methotrexate Lipo-Oligomer Nanoparticles

scientific article published on 13 May 2019

Combined antitumoral effects of pretubulysin and methotrexate

Development of Catalysts for the Stereoselective Hydrogenation of α,β-Unsaturated Ketones ⬇️

scientific article published on May 15, 2012

Development of a new catalyst for the distannation of alkynes

scientific article published on 01 January 2003

Diastereotopos-differentiating allylic alkylation as a key step in the synthesis of gamma-glutamyl boletine

scientific article published on 26 November 2009

Direct Michael, aldol, and Mannich additions catalyzed by alkaline earth metals

scientific article published on 01 January 2009

Discovery of 23 natural tubulysins from Angiococcus disciformis An d48 and Cystobacter SBCb004.

scientific article published in March 2010

Discovery of the first small-molecule CsrA-RNA interaction inhibitors using biophysical screening technologies.

scientific article

Distannylations and silastannylations of in situ generated allenes

scientific article published on 01 January 2008

Efficient 1,5-chirality transfer in palladium-catalyzed allylic alkylations of chelated amino acid ester enolates

scientific article published in May 2005

Efficient stereoselective syntheses of cyclic amino acids via Michael-induced ring-closing reactions

scientific article published on 01 July 2003

Element-organische Verbindungen

Folate receptor-directed orthogonal click-functionalization of siRNA lipopolyplexes for tumor cell killing in vivo

scientific article published on 19 March 2018

Heterologous expression of an orphan NRPS gene cluster from Paenibacillus larvae in Escherichia coli revealed production of sevadicin

scientific article published on 19 December 2014

Highly Regioselective Ruthenium-Catalyzed Allylic Alkylations of Chelated Enolates ⬇️

scientific article published on November 5, 2010

Highly diastereoselective anti-aldol reactions of glycolate titanium enolates

scientific article published on 01 February 2009

Highly stereoselective additions of tin enolates to nitroalkenes and subsequent conversion of the nitro group into a nitrile

scientific article published on 01 April 2005

Highly stereoselective allylic alkylations of peptides

scientific article published on 01 July 2006

Highly stereoselective modifications of peptides via Pd-catalyzed allylic alkylation of internal peptide amide enolates ⬇️

scientific article published on 01 October 2012

Highly stereoselective peptide modifications through Pd-catalyzed allylic alkylations of chelated peptide enolates

scientific article published on 01 January 2007

Influences on the regioselectivity of palladium-catalyzed allylic alkylations

scientific article published in January 2008

Isolation of an σ-alkyl iridium hydride complex, formed in the (semi)hydrogenation of an β-enamido ketone

scientific article published on 08 March 2013

Isomerization-free allylic alkylations of terminal pi-allyl palladium complexes

scientific article published on 01 November 2006

Matteson Homologation-Based Total Synthesis of Lagunamide A

scientific article published on 26 March 2018

Molybdenum-catalyzed hydrostannations of allenylcarbinols

scientific article published on 2 December 2004

Molybdenum-catalyzed stannylations as key steps in heterocyclic synthesis

scientific article published on 01 January 2004

Mono-selective β-C-H arylation of N-methylated amino acids and peptides promoted by the 2-(methylthio)aniline directing group

scientific article published on 01 June 2019

Novel Yeast Bioassay for High-Throughput Screening of Matrix Metalloproteinase Inhibitors ⬇️

scientific article published on October 14, 2011

Novel imidazol-1-ylmethyl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-ones as potent and selective CYP11B1 inhibitors for the treatment of Cushing's syndrome

scientific article published on 12 July 2012

Novel tubulin antagonist pretubulysin displays antivascular properties in vitro and in vivo

scientific article published on 27 November 2013

Organische Chemie

scientific article by Hans Peter Latscha, Uli Kazmaier, and Helmut Alfons Klein

Persistent inhibition of pore-based cell migration by sub-toxic doses of miuraenamide, an actin filament stabilizer

scientific article published on 27 November 2017

Pretubulysin derived probes as novel tools for monitoring the microtubule network via activity-based protein profiling and fluorescence microscopy

scientific article

Pretubulysin, a potent and chemically accessible tubulysin precursor from Angiococcus disciformis

scientific article

Pretubulysin: from hypothetical biosynthetic intermediate to potential lead in tumor therapy

scientific article

Recent Developments on the Synthesis and Bioactivity of Ilamycins/Rufomycins and Cyclomarins, Marine Cyclopeptides That Demonstrate Anti-Malaria and Anti-Tuberculosis Activity

scientific article published in 2021

Regio- and Stereoselective Modification of Chiral α-Amino Ketones by Pd-Catalyzed Allylic Alkylation

scientific article published on 23 June 2015

Regio- and stereoselective rhodium-catalyzed allylic alkylations of chelated enolates

scientific article published on 01 May 2006

Role of V-ATPase a3-Subunit in Mouse CTL Function

scientific article published on 08 April 2020

Ruthenium-catalyzed allylic alkylations of chelated enolates using vinyl dioxolanon-2-ones

scientific article published on 25 August 2014

Selective peptide modifications via ruthenium-catalyzed allylic alkylations

scientific article published on 21 August 2014

Sequence-Defined Oligoamide Drug Conjugates of Pretubulysin and Methotrexate for Folate Receptor Targeted Cancer Therapy

scientific article published on 30 March 2017

Simplified pretubulysin derivatives and their biological effects on cancer cells

scientific article published on 17 January 2014

Stannylated allyl carbonates as versatile building blocks for the diversity oriented synthesis of allylic amines and amides

scientific article published on 07 March 2011

Stereoselective Allylic Alkylations of Amino Ketones and Their Application in the Synthesis of Highly Functionalized Piperidines

scientific article published on 21 February 2020

Stereoselective Backbone Modifications of Peptides via Chelate Enolate Claisen Rearrangement ⬇️

scientific article published on June 25, 1999

Stereoselective Modification of N-(α-Hydroxyacyl)-glycinesters via Palladium-Catalyzed Allylic Alkylation

scientific article published on 03 June 2019

Stereoselective Peptide Modifications via β-C(sp3)-H Arylations

scientific article published on 10 November 2016

Stereoselective Synthesis of Deuterium-Labeled (2S)-Cyclohexenyl Alanines, Biosynthetic Intermediates of Cinnabaramide

scientific article published on 19 November 2012

Stereoselective palladium-catalyzed allylic alkylations of peptideamide enolates ⬇️

scientific article published on 01 December 2010

Stereoselective syntheses and reactions of stannylated peptides

scientific article published on 01 January 2007

Stereoselective synthesis of deuterated β-cyclohexenylserine, a biosynthetic intermediate of the salinosporamides

scientific article published on 26 May 2011

Straightforward approach to iminoxazines and azetidinimines via 1,4-additions of chelated enolates toward nitroalkenes

scientific article published on 01 June 2005

Straightforward syntheses of furanomycin derivatives and their biological evaluation

scientific article published in December 2002

Structure, Total Synthesis, and Biosynthesis of Chloromyxamides: Myxobacterial Tetrapeptides Featuring an Uncommon 6-Chloromethyl-5-methoxypipecolic Acid Building Block

Syntheses and Evaluation of Simplified Pretubulysin Analogues

Syntheses and synthetic applications of stannylated allylic alcohols

scientific article published in March 2006

Syntheses of α-stannylated and α-iodinated enamides via molybdenum-catalyzed hydrostannation.

scientific article

Synthesis and Biological Evaluation of Pretubulysin and Derivatives

Synthesis of New Cyclomarin Derivatives and Their Biological Evaluation towards Mycobacterium Tuberculosis and Plasmodium Falciparum

scientific article published on 06 June 2019

Synthesis of Tubuphenylalanines via Ireland–Claisen Rearrangement ⬇️

scientific article published on October 4, 2012

Synthesis of amino acid derivatives via enantio- and diastereoselective Pd-catalyzed allylic substitutions with a non-stabilized enolate as nucleophile

scientific article

Synthesis of fully protected, reverse N-prenylated (2S,3R)-3-hydroxytryptophan, a unique building block of the cyclomarins

scientific article published on 31 July 2015

Synthesis of highly substituted pyroglutamates via a domino Michael addition-Claisen rearrangement-lactamisation approach

scientific article published on 28 October 2008

Synthesis of indoles and tryptophan derivatives via photoinduced nitrene C-H insertion

scientific article published on 01 March 2016

Synthesis of modified β-methoxyphenylalanines via diazonium chemistry and their incorporation in desoxycyclomarin analogues

scientific article published on 01 December 2018

Synthesis of pretubulysin-derivatives via the TubUgi-approach

scientific article published on 01 June 2015

Synthetic studies towards bottromycin ⬇️

scientific article published on January 1, 2012

Targeting the ER-mitochondria interface sensitizes leukemia cells towards cytostatics

scientific article published on 11 October 2018

The Allylic Alkylation of Ketone Enolates

scientific article published on 10 September 2020

The Solution Structure of a Copper(II) Compound of a New Cyclic Octapeptide by EPR Spectroscopy and Force Field Calculations ⬇️

scientific article published on December 28, 1998

The antibiotic cyclomarin blocks arginine-phosphate-induced millisecond dynamics in the N-terminal domain of ClpC1 from Mycobacterium tuberculosis.

scientific article

The pretubulysin-induced exposure of collagen is caused by endothelial cell retraction that results in an increased adhesion and decreased transmigration of tumor cells

scientific article published on 8 September 2017

Total Synthesis and Biological Evaluation of Modified Ilamycin Derivatives

scientific article published in 2022

Total Synthesis and Configurational Revision of Mozamide A, a Hydroxy-Brunsvicamide

scientific article published on 20 February 2019

Total Synthesis of Cyclomarin A, a Marine Cycloheptapeptide with Anti-Tuberculosis and Anti-Malaria Activity

scientific article published on 23 December 2015

Total Synthesis of Keramamides A and L from a Common Precursor by Late-Stage Indole Synthesis and Configurational Revision

scientific article published on 01 August 2018

Total Synthesis of Trapoxin A, a Fungal HDAC Inhibitor from Helicoma ambiens

scientific article published on 27 August 2018

Total syntheses and biological evaluation of miuraenamides

scientific article

Total synthesis of cyclomarins A, C and D, marine cyclic peptides with interesting anti-tuberculosis and anti-malaria activities

scientific article published on 31 May 2016

Total synthesis of desoxycyclomarin C and the cyclomarazines A and B

scientific article published on 31 May 2016

Total synthesis of the natural HDAC inhibitor Cyl-1.

scientific article published on 24 April 2018

Transcriptional effects of actin-binding compounds: the cytoplasm sets the tone

scientific article published on 11 September 2018

Via Ugi reactions to conformationally fixed cyclic peptides

scientific article published on 01 March 2003

[(p-Cymene)RuCl2 ]2 : an efficient catalyst for highly regioselective allylic alkylations of chelated amino acid ester enolates

scientific article published on 07 July 2014

List of works by Uli Kazmaier

A small molecule inhibits protein disulfide isomerase and triggers the chemosensitization of cancer cells

A straightforward approach towards 5-substituted thiazolylpeptides via the thio-Ugi-reaction

A straightforward approach towards combined α-amino and α-hydroxy acids based on Passerini reactions

A straightforward approach towards cyclic peptides via ring-closing metathesis--scope and limitations

A straightforward approach towards cyclic photoactivatable tubulysin derivatives

A straightforward approach towards glycoamino acids and glycopeptides via Pd-catalysed allylic alkylation

A straightforward approach towards thiazoles and endothiopeptides via Ugi reaction

A straightforward protocol for one-pot allylic aminations/Stille couplings

A straightforward synthesis of polyketides via ester dienolate Matteson homologation

Actin stabilizing compounds show specific biological effects due to their binding mode

Allylations of chelated enolates using dienyl substrates

Allylic alkylation versus Michael induced ring closure: chelated enolates as versatile nucleophiles

Amino acids--valuable organocatalysts in carbohydrate synthesis

An endothelial cell line infected by Kaposi's sarcoma-associated herpes virus (KSHV) allows the investigation of Kaposi's sarcoma and the validation of novel viral inhibitors in vitro and in vivo

Application of the Ester Enolate Claisen Rearrangement in the Synthesis of Amino Acids Containing Quaternary Carbon Centers ⬇️

Asymmetric chelated Claisen rearrangements in the presence of chiral ligands--scope and limitations

Biosynthesis of 2-Alkyl-4(1H)-Quinolones in Pseudomonas aeruginosa: Potential for Therapeutic Interference with Pathogenicity

Bottromycins - biosynthesis, synthesis and activity

C-H Functionalization of N-Methylated Amino Acids and Peptides as Tool in Natural Product Synthesis: Synthesis of Abyssenine A and Mucronine E

Characterization of a novel type of oxidative decarboxylase involved in the biosynthesis of the styryl moiety of chondrochloren from an acylated tyrosine.

Chelated Enolates of Amino Acid Esters-Efficient Nucleophiles in Palladium-Catalyzed Allylic Substitutions

Chemie für Biologen

Chemie im Alltag

Co-delivery of pretubulysin and siEG5 to EGFR overexpressing carcinoma cells

Combination Chemotherapy of L1210 Tumors in Mice with Pretubulysin and Methotrexate Lipo-Oligomer Nanoparticles

Combined antitumoral effects of pretubulysin and methotrexate

Development of Catalysts for the Stereoselective Hydrogenation of α,β-Unsaturated Ketones ⬇️

Development of a new catalyst for the distannation of alkynes

Diastereotopos-differentiating allylic alkylation as a key step in the synthesis of gamma-glutamyl boletine

Direct Michael, aldol, and Mannich additions catalyzed by alkaline earth metals

Discovery of 23 natural tubulysins from Angiococcus disciformis An d48 and Cystobacter SBCb004.

Discovery of the first small-molecule CsrA-RNA interaction inhibitors using biophysical screening technologies.

Distannylations and silastannylations of in situ generated allenes

Efficient 1,5-chirality transfer in palladium-catalyzed allylic alkylations of chelated amino acid ester enolates

Efficient stereoselective syntheses of cyclic amino acids via Michael-induced ring-closing reactions

Element-organische Verbindungen

Folate receptor-directed orthogonal click-functionalization of siRNA lipopolyplexes for tumor cell killing in vivo

Heterologous expression of an orphan NRPS gene cluster from Paenibacillus larvae in Escherichia coli revealed production of sevadicin

Highly Regioselective Ruthenium-Catalyzed Allylic Alkylations of Chelated Enolates ⬇️

Highly diastereoselective anti-aldol reactions of glycolate titanium enolates

Highly stereoselective additions of tin enolates to nitroalkenes and subsequent conversion of the nitro group into a nitrile

Highly stereoselective allylic alkylations of peptides

Highly stereoselective modifications of peptides via Pd-catalyzed allylic alkylation of internal peptide amide enolates ⬇️

Highly stereoselective peptide modifications through Pd-catalyzed allylic alkylations of chelated peptide enolates

Influences on the regioselectivity of palladium-catalyzed allylic alkylations

Isolation of an σ-alkyl iridium hydride complex, formed in the (semi)hydrogenation of an β-enamido ketone

Isomerization-free allylic alkylations of terminal pi-allyl palladium complexes

Matteson Homologation-Based Total Synthesis of Lagunamide A

Molybdenum-catalyzed hydrostannations of allenylcarbinols

Molybdenum-catalyzed stannylations as key steps in heterocyclic synthesis

Mono-selective β-C-H arylation of N-methylated amino acids and peptides promoted by the 2-(methylthio)aniline directing group

Novel Yeast Bioassay for High-Throughput Screening of Matrix Metalloproteinase Inhibitors ⬇️

Novel imidazol-1-ylmethyl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-ones as potent and selective CYP11B1 inhibitors for the treatment of Cushing's syndrome

Novel tubulin antagonist pretubulysin displays antivascular properties in vitro and in vivo

Organische Chemie

Persistent inhibition of pore-based cell migration by sub-toxic doses of miuraenamide, an actin filament stabilizer

Pretubulysin derived probes as novel tools for monitoring the microtubule network via activity-based protein profiling and fluorescence microscopy

Pretubulysin, a potent and chemically accessible tubulysin precursor from Angiococcus disciformis

Pretubulysin: from hypothetical biosynthetic intermediate to potential lead in tumor therapy

Recent Developments on the Synthesis and Bioactivity of Ilamycins/Rufomycins and Cyclomarins, Marine Cyclopeptides That Demonstrate Anti-Malaria and Anti-Tuberculosis Activity

Regio- and Stereoselective Modification of Chiral α-Amino Ketones by Pd-Catalyzed Allylic Alkylation

Regio- and stereoselective rhodium-catalyzed allylic alkylations of chelated enolates

Role of V-ATPase a3-Subunit in Mouse CTL Function

Ruthenium-catalyzed allylic alkylations of chelated enolates using vinyl dioxolanon-2-ones

Selective peptide modifications via ruthenium-catalyzed allylic alkylations

Sequence-Defined Oligoamide Drug Conjugates of Pretubulysin and Methotrexate for Folate Receptor Targeted Cancer Therapy

Simplified pretubulysin derivatives and their biological effects on cancer cells

Stannylated allyl carbonates as versatile building blocks for the diversity oriented synthesis of allylic amines and amides

Stereoselective Allylic Alkylations of Amino Ketones and Their Application in the Synthesis of Highly Functionalized Piperidines

Stereoselective Backbone Modifications of Peptides via Chelate Enolate Claisen Rearrangement ⬇️

Stereoselective Modification of N-(α-Hydroxyacyl)-glycinesters via Palladium-Catalyzed Allylic Alkylation

Stereoselective Peptide Modifications via β-C(sp3)-H Arylations

Stereoselective Synthesis of Deuterium-Labeled (2S)-Cyclohexenyl Alanines, Biosynthetic Intermediates of Cinnabaramide

Stereoselective palladium-catalyzed allylic alkylations of peptideamide enolates ⬇️

Stereoselective syntheses and reactions of stannylated peptides

Stereoselective synthesis of deuterated β-cyclohexenylserine, a biosynthetic intermediate of the salinosporamides

Straightforward approach to iminoxazines and azetidinimines via 1,4-additions of chelated enolates toward nitroalkenes

Straightforward syntheses of furanomycin derivatives and their biological evaluation

Structure, Total Synthesis, and Biosynthesis of Chloromyxamides: Myxobacterial Tetrapeptides Featuring an Uncommon 6-Chloromethyl-5-methoxypipecolic Acid Building Block