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List of works by Christina Smolke

A computational workflow for the expansion of heterologous biosynthetic pathways to natural product derivatives

scientific article published on 19 March 2021

A high-throughput, quantitative cell-based screen for efficient tailoring of RNA device activity

scientific article

A microbial biomanufacturing platform for natural and semisynthetic opioids

scientific article

A modular and extensible RNA-based gene-regulatory platform for engineering cellular function

scholarly article

A multiplexed, automated evolution pipeline enables scalable discovery and characterization of biosensors

scientific article published on 04 March 2021

A quantitative framework for the forward design of synthetic miRNA circuits

scientific article published on 14 September 2014

A synthetic library of RNA control modules for predictable tuning of gene expression in yeast

scientific article

A system for multilocus chromosomal integration and transformation-free selection marker rescue

scientific article

A versatile cis-blocking and trans-activation strategy for ribozyme characterization

scientific article published on 15 November 2012

A yeast-based rapid prototype platform for gene control elements in mammalian cells.

scientific article published on 17 January 2013

Advancing secondary metabolite biosynthesis in yeast with synthetic biology tools

scientific article

Anti-CRISPR-mediated control of gene editing and synthetic circuits in eukaryotic cells

scientific article published in Nature Communications

Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways.

scientific article published on 18 September 2011

Biosynthesis of medicinal tropane alkaloids in yeast

scientific article published on 02 September 2020

Building outside of the box: iGEM and the BioBricks Foundation

scientific article

Cell biology. Bringing it together with RNA

scientific article published on 01 July 2011

Cell biology. It's the DNA that counts

scientific article published in May 2009

Codeine-binding RNA aptamers and rapid determination of their binding constants using a direct coupling surface plasmon resonance assay

scientific article

Combinatorial engineering of intergenic regions in operons tunes expression of multiple genes

scientific article

Complete biosynthesis of noscapine and halogenated alkaloids in yeast.

scientific article published on 2 April 2018

Complete biosynthesis of opioids in yeast

scientific article

Construction of ligand-responsive microRNAs that operate through inhibition of Drosha processing.

scientific article published in January 2014

Control of alphavirus-based gene expression using engineered riboswitches

scientific article published on 23 May 2015

De novo production of the key branch point benzylisoquinoline alkaloid reticuline in yeast

scientific article

Design and Construction of Generalizable RNA-Protein Hybrid Controllers by Level-Matched Genetic Signal Amplification

scientific article published on 9 November 2016

Design of small molecule-responsive microRNAs based on structural requirements for Drosha processing

scientific article

Design principles for riboswitch function

scientific article

Discovery of a previously unknown biosynthetic capacity of naringenin chalcone synthase by heterologous expression of a tomato gene cluster in yeast

scientific article published on 30 October 2020

Dynamically reshaping signaling networks to program cell fate via genetic controllers

scientific article

Effect of copy number and mRNA processing and stabilization on transcript and protein levels from an engineered dual-gene operon

scientific article

Effect of gene location, mRNA secondary structures, and RNase sites on expression of two genes in an engineered operon

scientific article published in December 2002

Engineering a microbial biosynthesis platform for de novo production of tropane alkaloids

scientific article published on 12 August 2019

Engineering a microbial platform for de novo biosynthesis of diverse methylxanthines

scientific article

Engineering biological systems with synthetic RNA molecules

scientific article published on September 2011

Engineering biosynthesis of the anticancer alkaloid noscapine in yeast

scientific article published on 05 July 2016

Engineering dynamic cell cycle control with synthetic small molecule-responsive RNA devices

scientific article

Engineering life: building a fab for biology

scientific article

Engineering ligand-responsive RNA controllers in yeast through the assembly of RNase III tuning modules

scientific article

Engineering strategies for the fermentative production of plant alkaloids in yeast

scientific article published on 14 May 2015

Facile characterization of aptamer kinetic and equilibrium binding properties using surface plasmon resonance.

scientific article published on January 2014

Fluorescence detection of a protein-bound 2Fe2S cluster

scientific article published on March 2009

Frameworks for programming biological function through RNA parts and devices

scientific article published on March 2009

From DNA to targeted therapeutics: bringing synthetic biology to the clinic

scientific article published on October 2011

Functional selection and systematic analysis of intronic splicing elements identify active sequence motifs and associated splicing factors

scientific article

Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems

scientific article

High-throughput cellular RNA device engineering.

scientific article published on 10 August 2015

High-throughput enzyme evolution in Saccharomyces cerevisiae using a synthetic RNA switch.

scientific article

Higher-order cellular information processing with synthetic RNA devices

scientific article

Identification and treatment of heme depletion attributed to overexpression of a lineage of evolved P450 monooxygenases

scientific article

In Vitro Screening and in Silico Modeling of RNA-Based Gene Expression Control

scientific article published on 11 September 2015

In vivo fluorescent detection of Fe-S clusters coordinated by human GRX2.

scientific article

Interview with Christina Smolke

scientific article published on 01 December 2017

Kinetic and equilibrium binding characterization of aptamers to small molecules using a label-free, sensitive, and scalable platform

scientific article published on 14 March 2014

Mammalian synthetic biology for studying the cell.

scientific article published on 08 December 2016

Massively parallel RNA device engineering in mammalian cells with RNA-Seq

scientific article published on 23 September 2019

Model-driven generation of artificial yeast promoters

scientific article published on 30 April 2020

Model-guided design of ligand-regulated RNAi for programmable control of gene expression

scientific article published on 28 October 2008

Molecular tools for chemical biotechnology.

scientific article published on 23 March 2013

Opportunities in the design and application of RNA for gene expression control

scientific article

Optimization of yeast-based production of medicinal protoberberine alkaloids.

scientific article

Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae

scientific article

Production of the cyanogenic glycoside dhurrin in yeast

article

Programmable ligand-controlled riboregulators of eukaryotic gene expression

scientific article published on 20 February 2005

Programmable mutually exclusive alternative splicing for generating RNA and protein diversity.

scientific article published on 17 June 2019

Protein-responsive ribozyme switches in eukaryotic cells

scientific article

RNA Switches for Synthetic Biology

scientific article published on 02 January 2019

RNA as a versatile and powerful platform for engineering genetic regulatory tools

scientific article published on January 2007

Rational design and tuning of ribozyme-based devices

scientific article

Realizing the potential of synthetic biology

scientific article published on 12 March 2014

Regulation of T cell proliferation with drug-responsive microRNA switches.

scientific article published on 13 December 2017

Reprogramming cellular behavior with RNA controllers responsive to endogenous proteins

scientific article

Strategies for microbial synthesis of high-value phytochemicals.

scientific article published on 22 March 2018

Synthetic RNA modules for fine-tuning gene expression levels in yeast by modulating RNase III activity

scientific article

Synthetic RNA switches as a tool for temporal and spatial control over gene expression

scientific article

Synthetic RNA switches for yeast metabolic engineering: screening recombinant enzyme libraries

scientific article published on January 2014

Synthetic biology strategies for microbial biosynthesis of plant natural products

article

Synthetic biology strategies toward heterologous phytochemical production

scientific article published on 01 September 2018

Synthetic biology: advancing biological frontiers by building synthetic systems

scientific article published on 20 February 2012

Synthetic biology: advancing the design of diverse genetic systems

scientific article published on 13 February 2013

Synthetic biology: emerging methodologies to catalyze the metabolic engineering design cycle

scientific article published on 23 March 2012

Synthetic control of a fitness tradeoff in yeast nitrogen metabolism

scientific article published on 02 January 2009

Synthetic feedback control using an RNAi-based gene-regulatory device

scientific article

The regulatory roles of the galactose permease and kinase in the induction response of the GAL network in Saccharomyces cerevisiae

scientific article

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