List of works - Valerie Mizrahi

2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization.

scientific article published on 9 March 2018

A PCR method for the sequence analysis of the gyrA, polA and rnhA gene segments from mycobacteria

scientific article

A derivative of Mycobacterium smegmatis mc(2)155 that lacks the duplicated chromosomal region

scientific article published on 15 December 2005

A high-throughput screen against pantothenate synthetase (PanC) identifies 3-biphenyl-4-cyanopyrrole-2-carboxylic acids as a new class of inhibitor with activity against Mycobacterium tuberculosis

scientific article (publication date: 2013)

A platform for genomics in South Africa

article

A pseudokinase debut at the mycobacterial cell wall

scientific article published on 24 January 2012

A riboswitch regulates expression of the coenzyme B12-independent methionine synthase in Mycobacterium tuberculosis: implications for differential methionine synthase function in strains H37Rv and CDC1551.

scientific article published on 16 February 2007

A vitamin B₁₂ transporter in Mycobacterium tuberculosis

scientific article published on 13 February 2013

Analysis of the RNA- and DNA-dependent DNA polymerase activities of point mutants of HIV-1 reverse transcriptase lacking ribonuclease H activity ⬇️

scientific article published on October 29, 1991

Analysis of the ribonuclease H activity of HIV-1 reverse transcriptase using RNA.DNA hybrid substrates derived from the gag region of HIV-1

scientific article published on 01 November 1989

Approaches to target identification and validation for tuberculosis drug discovery: a UCT perspective.

scientific article published on 02 March 2012

Arrayed CRISPRi and quantitative imaging describe the morphotypic landscape of essential mycobacterial genes

scientific article published on 06 November 2020

Bioluminescent Reporters for Rapid Mechanism of Action Assessment in Tuberculosis Drug Discovery

scientific article published on 29 August 2016

Changes in energy metabolism of Mycobacterium tuberculosis in mouse lung and under in vitro conditions affecting aerobic respiration

scientific article

Characterization of the cydAB-encoded cytochrome bd oxidase from Mycobacterium smegmatis.

scientific article

Cholesterol catabolism by Mycobacterium tuberculosis requires transcriptional and metabolic adaptations

scientific journal article

Cleavage of the moaX-encoded fused molybdopterin synthase from Mycobacterium tuberculosis is necessary for activity

scientific article

Cloning and sequence analysis of the gene encoding the DNA polymerase I from Mycobacterium tuberculosis ⬇️

scientific article published on October 16, 1995

Cloning, sequence analysis, overproduction in Escherichia coli and enzymatic characterization of the RNase HI from Mycobacterium smegmatis

scientific article published in November 1995

Complex genetics of drug resistance in Mycobacterium tuberculosis.

scientific article published in October 2013

Construction and application of mycobacterial reporter transposons

scientific article

Construction and phenotypic characterization of an auxotrophic mutant of Mycobacterium tuberculosis defective in L-arginine biosynthesis

scientific article

Construction by homologous recombination and phenotypic characterization of a DNA polymerase domain polA mutant of Mycobacterium smegmatis

scientific article published in October 1996

Correction for Arora et al., "Respiratory Flexibility in Response to Inhibition of Cytochrome c Oxidase in Mycobacterium tuberculosis".

scientific article published on 24 August 2017

DNA Replication Fidelity in the Mycobacterium tuberculosis Complex

scientific article published in January 2017

DNA alkylation damage as a sensor of nitrosative stress in Mycobacterium tuberculosis

scientific journal article

DNA metabolism in Mycobacterium leprae

scientific article

DNA metabolism in mycobacterial pathogenesis

scientific article published on January 2013

DNA metabolism in mycobacterium tuberculosis: implications for drug resistance and strain variability

scientific article

DNA repair in Mycobacterium tuberculosis. What have we learnt from the genome sequence?

scientific article

DNA-Dependent Binding of Nargenicin to DnaE1 Inhibits Replication in <i>Mycobacterium tuberculosis</i>

scientific article published on 10 February 2022

Death of Mycobacterium tuberculosis by L-arginine starvation

article published in the Proceedings of the National Academy of Sciences of the United States of America

Deoxy- and dideoxynucleotide discrimination and identification of critical 5' nuclease domain residues of the DNA polymerase I from Mycobacterium tuberculosis

scientific article published on December 1996

Depletion of resuscitation-promoting factors has limited impact on the drug susceptibility of Mycobacterium tuberculosis

scientific article published on 11 June 2010

Detection and treatment of subclinical tuberculosis

article

Detection of Mycobacterium tuberculosis bacilli in bio-aerosols from untreated TB patients

scholarly article by Benjamin Patterson et al published 8 June 2018 in Gates Open Research

Detection of bacilli in bio-aerosols from untreated TB patients

Diversity and disease pathogenesis in Mycobacterium tuberculosis

scientific article

DnaE2 polymerase contributes to in vivo survival and the emergence of drug resistance in Mycobacterium tuberculosis

scientific article

Drug-resistant tuberculosis: challenges and opportunities for diagnosis and treatment

scholarly article by Anastasia Koch et al published October 2018 in Current Opinion in Pharmacology

Effects of pyrazinamide on fatty acid synthesis by whole mycobacterial cells and purified fatty acid synthase I.

scientific article

Endoribonucleolytic cleavage of RNA: Oligodeoxynucleotide hybrids by the ribonuclease H activity of HIV-1 reverse transcriptase ⬇️

scientific article published on February 28, 1990

Essential roles for imuA'- and imuB-encoded accessory factors in DnaE2-dependent mutagenesis in Mycobacterium tuberculosis

scientific journal article

Expanding benzoxazole based inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitor structure-activity as potential anti-tuberculosis agents.

scientific article published on 10 May 2018

Expression of Mycobacterium smegmatis pyrazinamidase in Mycobacterium tuberculosis confers hypersensitivity to pyrazinamide and related amides

scientific article

Fragment-Based Approach to Targeting Inosine-5'-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis.

scientific article

Function and regulation of class I ribonucleotide reductase-encoding genes in mycobacteria

scientific journal article

Function of the cytochrome bc1-aa3 branch of the respiratory network in mycobacteria and network adaptation occurring in response to its disruption

scientific article

Functional characterization of a vitamin B12-dependent methylmalonyl pathway in Mycobacterium tuberculosis: implications for propionate metabolism during growth on fatty acids

scientific journal article

Genetics and tuberculosis, Cape Town, South Africa, 21 November 1997

scientific article published on 01 January 1997

Harnessing Biological Insight to Accelerate Tuberculosis Drug Discovery

scientific article published on 30 July 2019

Highlights from the first meeting of the Europe-Africa frontier research conference series infectious diseases: from basic to translational research

scientific article published in December 2009

IS1096-mediated DNA rearrangements play a key role in genome evolution of Mycobacterium smegmatis

Identification and validation of novel drug targets in Mycobacterium tuberculosis

scientific article

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria

scientific article published on 28 September 2016

Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis

scientific article (publication date: 2013)

In vitro analysis of rates and spectra of mutations in a polymorphic region of the Rv0746 PE_PGRS gene of Mycobacterium tuberculosis

scientific article published on 15 December 2006

Investigation into the nature of a Bacillus promoter cloned into a promoter-probe plasmid

scientific article published in September 1989

Kinetic mechanism of DNA polymerase I (Klenow).

scientific article published in December 1987

Lack of mismatch correction facilitates genome evolution in mycobacteria

scientific article published in September 2004

Making ends meet in mycobacteria

scientific article published on 24 November 2010

Mechanism of DNA polymerase I: exonuclease/polymerase activity switch and DNA sequence dependence of pyrophosphorolysis and misincorporation reactions

scientific article published on August 1986

Mechanism of the idling-turnover reaction of the large (Klenow) fragment of Escherichia coli DNA polymerase I.

scientific article published on January 1986

Molecular genetics of Mycobacterium tuberculosis in relation to the discovery of novel drugs and vaccines

scientific article published on January 2004

Molybdenum cofactor: a key component of Mycobacterium tuberculosis pathogenesis?

scientific article published on 15 January 2013

Mutagenesis of the conserved aspartic acid 443, glutamic acid 478, asparagine 494, and aspartic acid 498 residues in the ribonuclease H domain of p66/p51 human immunodeficiency virus type I reverse transcriptase. Expression and biochemical analysis.

scientific article

Mutants of Mycobacterium tuberculosis lacking three of the five rpf-like genes are defective for growth in vivo and for resuscitation in vitro

scientific article

Mycobacterial genetics in target validation.

scientific article

Mycobacterium tuberculosis and the host response

scientific article

Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure-Activity Relationship and Target Identification Studies.

scientific article published on 17 November 2017

Nucleotide Metabolism and DNA Replication

scientific article published on October 2014

Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening

scientific article

Predictive modeling targets thymidylate synthase ThyX in Mycobacterium tuberculosis

scientific article published on 10 June 2016

Priming the tuberculosis drug pipeline: new antimycobacterial targets and agents.

scientific article published on 23 February 2018

Production of mutants in amino acid biosynthesis genes of Mycobacterium tuberculosis by homologous recombination

scientific article

Purification, gene cloning, targeted knockout, overexpression, and biochemical characterization of the major pyrazinamidase from Mycobacterium smegmatis.

scientific article

Rapid kinetic analysis of a point mutant of HIV-1 reverse transcriptase lacking ribonuclease H activity

scientific article published in June 1993

Rate-limiting steps in the DNA polymerase I reaction pathway

scientific article

Reaction intermediate analogues as bisubstrate inhibitors of pantothenate synthetase

scientific article

Real-Time Investigation of Tuberculosis Transmission: Developing the Respiratory Aerosol Sampling Chamber (RASC)

scientific article

Recombinant HIV-1 reverse transcriptase: purification, primary structure, and polymerase/ribonuclease H activities

scientific article

Respiratory flexibility in response to inhibition of cytochrome C oxidase in Mycobacterium tuberculosis

scientific article

Resuscitation-promoting factors as lytic enzymes for bacterial growth and signaling

scientific article published on 04 September 2009

Ribonucleotide Reduction in Mycobacterium tuberculosis : Function and Expression of Genes Encoding Class Ib and Class II Ribonucleotide Reductases ⬇️

scientific article published on November 1, 2003

Role of the DinB homologs Rv1537 and Rv3056 in Mycobacterium tuberculosis

scientific article

SOS induction in mycobacteria: analysis of the DNA-binding activity of a LexA-like repressor and its role in DNA damage induction of the recA gene from Mycobacterium smegmatis

scientific article

Setting Our Sights on Infectious Diseases

scientific article published on 06 December 2019

Shortening treatment for tuberculosis--to basics

scientific article

Site-directed mutagenesis of the conserved Asp-443 and Asp-498 carboxy-terminal residues of HIV-1 reverse transcriptase ⬇️

scientific article published on September 25, 1990

Staphylococcus aureus nuclease is a useful secretion reporter for mycobacteria

scientific article

Susceptibility of Mycobacterium tuberculosis cytochrome bd oxidase mutants to compounds targeting the terminal respiratory oxidase, cytochrome c.

scientific article

Synthesis and biological evaluation of 2-aminothiazole derivatives as antimycobacterial and antiplasmodial agents

scientific article published on 12 December 2013

Synthesis, Characterization, and Pharmacological Evaluation of Silicon-Containing Aminoquinoline Organometallic Complexes As Antiplasmodial, Antitumor, and Antimycobacterial Agents

scholarly article by Yiqun Li et al published 31 December 2012 in Organometallics

TB tools to tell the tale-molecular genetic methods for mycobacterial research

scientific article published in January 2005

Targeted gene knockout and essentiality testing by homologous recombination

scientific article published on January 2015

Targeting DNA Replication and Repair for the Development of Novel Therapeutics against Tuberculosis

scientific article published on 14 November 2017

The Coming of Age of Drug-Susceptibility Testing for Tuberculosis

scientific article published on 26 September 2018

The Influence of HIV on the Evolution of Mycobacterium tuberculosis

scientific article

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis

scientific article

The Mycobacterium tuberculosis protein serine/threonine kinase PknG is linked to cellular glutamate/glutamine levels and is important for growth in vivo

scientific journal article

The RLEP-flanked polA gene from Mycobacterium leprae is not transcribed in Mycobacterium smegmatis

scientific article published in March 1997

The application of tetracyclineregulated gene expression systems in the validation of novel drug targets in Mycobacterium tuberculosis

scientific article (publication date: 2015)

The carbon starvation-inducible genes Rv2557 and Rv2558 of Mycobacterium tuberculosis are not required for long-term survival under carbon starvation and for virulence in SCID mice

scientific journal article

The complex mechanism of antimycobacterial action of 5-fluorouracil

scientific article published on 24 December 2014

The dynamics of DNA polymerase-catalyzed reactions

scientific article published on January 1988

The impact of drug resistance on Mycobacterium tuberculosis physiology: what can we learn from rifampicin?

scientific article published on 12 March 2014

The resuscitation-promoting factors of Mycobacterium tuberculosis are required for virulence and resuscitation from dormancy but are collectively dispensable for growth in vitro

scientific article

The role of RelMtb-mediated adaptation to stationary phase in long-term persistence of Mycobacterium tuberculosis in mice

scientific journal article

The stringent response of Mycobacterium tuberculosis is required for long-term survival

scientific journal article

Translating genomics research into control of tuberculosis: lessons learned and future prospects

scientific article

Translational Research for Tuberculosis Elimination: Priorities, Challenges, and Actions

scientific article

Tuberculosis chemotherapy: the influence of bacillary stress and damage response pathways on drug efficacy

scientific article

Tuberculosis research--the way forward

scientific article published on 01 January 1996

Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis

scientific article published on 27 September 2016

VapC toxins from Mycobacterium tuberculosis are ribonucleases that differentially inhibit growth and are neutralized by cognate VapB antitoxins

scientific article

Variation among genome sequences of H37Rv strains of Mycobacterium tuberculosis from multiple laboratories

scientific article

Vitamin B(12) metabolism in Mycobacterium tuberculosis

scientific article

bis-Molybdopterin guanine dinucleotide is required for persistence of Mycobacterium tuberculosis in guinea pigs

scientific article

List of works by Valerie Mizrahi

2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization.

A PCR method for the sequence analysis of the gyrA, polA and rnhA gene segments from mycobacteria

A derivative of Mycobacterium smegmatis mc(2)155 that lacks the duplicated chromosomal region

A high-throughput screen against pantothenate synthetase (PanC) identifies 3-biphenyl-4-cyanopyrrole-2-carboxylic acids as a new class of inhibitor with activity against Mycobacterium tuberculosis

A platform for genomics in South Africa

A pseudokinase debut at the mycobacterial cell wall

A riboswitch regulates expression of the coenzyme B12-independent methionine synthase in Mycobacterium tuberculosis: implications for differential methionine synthase function in strains H37Rv and CDC1551.

A vitamin B₁₂ transporter in Mycobacterium tuberculosis

Analysis of the RNA- and DNA-dependent DNA polymerase activities of point mutants of HIV-1 reverse transcriptase lacking ribonuclease H activity ⬇️

Analysis of the ribonuclease H activity of HIV-1 reverse transcriptase using RNA.DNA hybrid substrates derived from the gag region of HIV-1

Approaches to target identification and validation for tuberculosis drug discovery: a UCT perspective.

Arrayed CRISPRi and quantitative imaging describe the morphotypic landscape of essential mycobacterial genes

Bioluminescent Reporters for Rapid Mechanism of Action Assessment in Tuberculosis Drug Discovery

Changes in energy metabolism of Mycobacterium tuberculosis in mouse lung and under in vitro conditions affecting aerobic respiration

Characterization of the cydAB-encoded cytochrome bd oxidase from Mycobacterium smegmatis.

Cholesterol catabolism by Mycobacterium tuberculosis requires transcriptional and metabolic adaptations

Cleavage of the moaX-encoded fused molybdopterin synthase from Mycobacterium tuberculosis is necessary for activity

Cloning and sequence analysis of the gene encoding the DNA polymerase I from Mycobacterium tuberculosis ⬇️

Cloning, sequence analysis, overproduction in Escherichia coli and enzymatic characterization of the RNase HI from Mycobacterium smegmatis

Complex genetics of drug resistance in Mycobacterium tuberculosis.

Construction and application of mycobacterial reporter transposons

Construction and phenotypic characterization of an auxotrophic mutant of Mycobacterium tuberculosis defective in L-arginine biosynthesis

Construction by homologous recombination and phenotypic characterization of a DNA polymerase domain polA mutant of Mycobacterium smegmatis

Correction for Arora et al., "Respiratory Flexibility in Response to Inhibition of Cytochrome c Oxidase in Mycobacterium tuberculosis".

DNA Replication Fidelity in the Mycobacterium tuberculosis Complex

DNA alkylation damage as a sensor of nitrosative stress in Mycobacterium tuberculosis

DNA metabolism in Mycobacterium leprae

DNA metabolism in mycobacterial pathogenesis

DNA metabolism in mycobacterium tuberculosis: implications for drug resistance and strain variability

DNA repair in Mycobacterium tuberculosis. What have we learnt from the genome sequence?

DNA-Dependent Binding of Nargenicin to DnaE1 Inhibits Replication in <i>Mycobacterium tuberculosis</i>

Death of Mycobacterium tuberculosis by L-arginine starvation

Deoxy- and dideoxynucleotide discrimination and identification of critical 5' nuclease domain residues of the DNA polymerase I from Mycobacterium tuberculosis

Depletion of resuscitation-promoting factors has limited impact on the drug susceptibility of Mycobacterium tuberculosis

Detection and treatment of subclinical tuberculosis

Detection of Mycobacterium tuberculosis bacilli in bio-aerosols from untreated TB patients

Detection of bacilli in bio-aerosols from untreated TB patients

Diversity and disease pathogenesis in Mycobacterium tuberculosis

DnaE2 polymerase contributes to in vivo survival and the emergence of drug resistance in Mycobacterium tuberculosis

Drug-resistant tuberculosis: challenges and opportunities for diagnosis and treatment

Effects of pyrazinamide on fatty acid synthesis by whole mycobacterial cells and purified fatty acid synthase I.

Endoribonucleolytic cleavage of RNA: Oligodeoxynucleotide hybrids by the ribonuclease H activity of HIV-1 reverse transcriptase ⬇️

Essential roles for imuA'- and imuB-encoded accessory factors in DnaE2-dependent mutagenesis in Mycobacterium tuberculosis

Expanding benzoxazole based inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitor structure-activity as potential anti-tuberculosis agents.

Expression of Mycobacterium smegmatis pyrazinamidase in Mycobacterium tuberculosis confers hypersensitivity to pyrazinamide and related amides

Fragment-Based Approach to Targeting Inosine-5'-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis.

Function and regulation of class I ribonucleotide reductase-encoding genes in mycobacteria

Function of the cytochrome bc1-aa3 branch of the respiratory network in mycobacteria and network adaptation occurring in response to its disruption

Functional characterization of a vitamin B12-dependent methylmalonyl pathway in Mycobacterium tuberculosis: implications for propionate metabolism during growth on fatty acids

Genetics and tuberculosis, Cape Town, South Africa, 21 November 1997

Harnessing Biological Insight to Accelerate Tuberculosis Drug Discovery

Highlights from the first meeting of the Europe-Africa frontier research conference series infectious diseases: from basic to translational research

IS1096-mediated DNA rearrangements play a key role in genome evolution of Mycobacterium smegmatis

Identification and validation of novel drug targets in Mycobacterium tuberculosis

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria

Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis

In vitro analysis of rates and spectra of mutations in a polymorphic region of the Rv0746 PE_PGRS gene of Mycobacterium tuberculosis

Investigation into the nature of a Bacillus promoter cloned into a promoter-probe plasmid

Kinetic mechanism of DNA polymerase I (Klenow).

Lack of mismatch correction facilitates genome evolution in mycobacteria

Making ends meet in mycobacteria

Mechanism of DNA polymerase I: exonuclease/polymerase activity switch and DNA sequence dependence of pyrophosphorolysis and misincorporation reactions

Mechanism of the idling-turnover reaction of the large (Klenow) fragment of Escherichia coli DNA polymerase I.

Molecular genetics of Mycobacterium tuberculosis in relation to the discovery of novel drugs and vaccines

Molybdenum cofactor: a key component of Mycobacterium tuberculosis pathogenesis?

Mutagenesis of the conserved aspartic acid 443, glutamic acid 478, asparagine 494, and aspartic acid 498 residues in the ribonuclease H domain of p66/p51 human immunodeficiency virus type I reverse transcriptase. Expression and biochemical analysis.

Mutants of Mycobacterium tuberculosis lacking three of the five rpf-like genes are defective for growth in vivo and for resuscitation in vitro

Mycobacterial genetics in target validation.

Mycobacterium tuberculosis and the host response

Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure-Activity Relationship and Target Identification Studies.

Nucleotide Metabolism and DNA Replication

Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening

Predictive modeling targets thymidylate synthase ThyX in Mycobacterium tuberculosis

Priming the tuberculosis drug pipeline: new antimycobacterial targets and agents.

Production of mutants in amino acid biosynthesis genes of Mycobacterium tuberculosis by homologous recombination

Purification, gene cloning, targeted knockout, overexpression, and biochemical characterization of the major pyrazinamidase from Mycobacterium smegmatis.

Rapid kinetic analysis of a point mutant of HIV-1 reverse transcriptase lacking ribonuclease H activity

Rate-limiting steps in the DNA polymerase I reaction pathway

Reaction intermediate analogues as bisubstrate inhibitors of pantothenate synthetase