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List of works by Michael A. Fischbach

"Oncogenic shock": explaining oncogene addiction through differential signal attenuation

scientific article published on July 2006

A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors

scientific article published on 01 March 2020

A Cutibacterium acnes antibiotic modulates human skin microbiota composition in hair follicles ⬇️

scientific article published on 01 November 2020

A Phase-Variable Surface Layer from the Gut Symbiont Bacteroides thetaiotaomicron

scientific article

A Pressure Test to Make 10 Molecules in 90 Days: External Evaluation of Methods to Engineer Biology

scientific article published on 26 February 2018

A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes

scientific article published in November 2015

A biosynthetic gene cluster for the acetyl-CoA carboxylase inhibitor andrimid

scientific article published on August 2006

A biosynthetic pathway for a prominent class of microbiota-derived bile acids

scientific article

A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations

scientific article (publication date: 2 April 2010)

A family of pyrazinone natural products from a conserved nonribosomal peptide synthetase in Staphylococcus aureus.

scientific article published in September 2010

A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites.

scientific article

A gut-derived metabolite alters brain activity and anxiety behaviour in mice

scientific article

A mass spectrometry-guided genome mining approach for natural product peptidogenomics

scientific article published on 9 October 2011

A metabolic pathway for bile acid dehydroxylation by the gut microbiome

scientific article published on 17 June 2020

A metabolomics pipeline for the mechanistic interrogation of the gut microbiome

scientific article published in 2021

A protein interaction surface in nonribosomal peptide synthesis mapped by combinatorial mutagenesis and selection

scientific article published on 27 March 2006

A singular enzymatic megacomplex from Bacillus subtilis

scholarly article

A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics.

scientific article

A systematic computational analysis of biosynthetic gene cluster evolution: lessons for engineering biosynthesis

scientific article

Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry

scientific article published on February 2006

Antibiotics from microbes: converging to kill.

scientific article published on 18 August 2009

Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.

scientific article

Association of the PTPN22 R620W polymorphism with anti-topoisomerase I- and anticentromere antibody-positive systemic sclerosis

scientific article

Atlas of gut microbe-derived products from aromatic amino acids and risk of cardiovascular morbidity and mortality

scientific article published on 21 June 2023

Author Correction: Bile acid metabolites control TH17 and Treg cell differentiation

scientific article published on 01 March 2020

Bacterially Derived Tryptamine Increases Mucus Release by Activating a Host Receptor in a Mouse Model of Inflammatory Bowel Disease

scientific article published on 13 November 2020

BiG-MAP: an Automated Pipeline To Profile Metabolic Gene Cluster Abundance and Expression in Microbiomes

scientific article published on 28 September 2021

Bifidobacterium alters the gut microbiota and modulates the functional metabolism of T regulatory cells in the context of immune checkpoint blockade

scientific article published on 19 October 2020

Bile acid metabolites control TH17 and Treg cell differentiation

scientific article published on 27 November 2019

Bile acids profile, histopathological indices and genetic variants for non-alcoholic fatty liver disease progression

scientific article published on 01 December 2020

Biochemistry. Directing biosynthesis

scientific article published in October 2006

Biosynthetic tailoring of microcin E492m: post-translational modification affords an antibacterial siderophore-peptide conjugate

scientific article published on 31 October 2007

Bromoenterobactins as potent inhibitors of a pathogen-associated, siderophore-modifying C-glycosyltransferase.

scientific article

Cell-based therapeutics: the next pillar of medicine

scientific article published on April 2013

Clinical and genetic factors predictive of mortality in early systemic sclerosis

scientific article

Combination therapies for combating antimicrobial resistance ⬇️

scientific article published on September 6, 2011

Community health care: therapeutic opportunities in the human microbiome.

scientific article published on April 2011

Computational approaches to natural product discovery

scientific article

Computational genomic discovery of diverse gene clusters harbouring Fe-S flavoenzymes in anaerobic gut microbiota

scientific article published on 14 May 2020

Contextual control of skin immunity and inflammation by Corynebacterium.

scientific article

Dapdiamides, tripeptide antibiotics formed by unconventional amide ligases ⬇️

scientific article

Depletion of microbiome-derived molecules in the host using Clostridium genetics

scientific article published on 01 December 2019

Diet rapidly and reproducibly alters the human gut microbiome

scientific article (publication date: 23 January 2014)

Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes

scientific article

Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine

scientific article

Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases

scientific article

Draft genome sequence of Streptomyces clavuligerus NRRL 3585, a producer of diverse secondary metabolites. ⬇️

scientific article

Dyeing to learn more about the gut microbiota.

scientific article

Dynamic control of liquid-core/liquid-cladding optical waveguides.

scholarly article

Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation

scientific article published on 11 February 2020

Eating for two: how metabolism establishes interspecies interactions in the gut

scientific article published on October 2011

Enzymatic tailoring of enterobactin alters membrane partitioning and iron acquisition

scientific article published on 01 February 2006

Erratum: Skin microbiota–host interactions

scientific article published in Nature

Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lantibiotics ⬇️

scientific article published on 22 December 2020

Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans

scientific article

Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against Trypanosoma brucei

scientific article published on 13 August 2015

Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion

scientific article published on 01 June 2018

HUMAN MICROBIOTA. Small molecules from the human microbiota

scientific article (publication date: 24 July 2015)

How pathogenic bacteria evade mammalian sabotage in the battle for iron

scientific article

IMG-ABC: A Knowledge Base To Fuel Discovery of Biosynthetic Gene Clusters and Novel Secondary Metabolites

scientific article published on 14 July 2015

Identification of human skin microbiome odorants that manipulate mosquito landing behavior

In vitro characterization of IroB, a pathogen-associated C-glycosyltransferase.

scientific article

In vitro characterization of salmochelin and enterobactin trilactone hydrolases IroD, IroE, and Fes.

scientific article published on August 2005

Inhibitors of sterol biosynthesis as Staphylococcus aureus antibiotics.

scientific article published on January 2008

Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis

scientific article

Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters ⬇️

scientific article published in July 2014

Key applications of plant metabolic engineering

scientific article published on 10 June 2014

Localized protein interaction surfaces on the EntB carrier protein revealed by combinatorial mutagenesis and selection.

scientific article

MAIT cells are imprinted by the microbiota in early life and promote tissue repair

scientific article published on 01 October 2019

Major histocompatibility complex (MHC) class II alleles, haplotypes and epitopes which confer susceptibility or protection in systemic sclerosis: analyses in 1300 Caucasian, African-American and Hispanic cases and 1000 controls

scientific article

Mammalian Lipopolysaccharide Receptors Incorporated into the Retroviral Envelope Augment Virus Transmission.

scientific article published on October 2015

Mapping the Genetic Landscape of Human Cells

scientific article published on 19 July 2018

Mapping the T cell repertoire to a complex gut bacterial community

scientific article published on 16 August 2023

MetaQuery: a web server for rapid annotation and quantitative analysis of specific genes in the human gut microbiome.

scientific article published on 22 June 2015

Microbe-derived uremic solutes enhance thrombosis potential in the host

scientific article published on 19 December 2023

Microbial Transplantation With Human Gut Commensals Containing CutC Is Sufficient to Transmit Enhanced Platelet Reactivity and Thrombosis Potential

scientific article published on 01 October 2018

Microbiome: Focus on Causation and Mechanism

scientific article published on 01 August 2018

Microbiota-targeted therapies: an ecological perspective

scientific article published on June 2012

Minimum Information about a Biosynthetic Gene cluster.

scientific article published on August 2015

Mixing with bubbles: a practical technology for use with portable microfluidic devices

scientific article published on 15 December 2005

Modulation of a Circulating Uremic Solute via Rational Genetic Manipulation of the Gut Microbiota.

scientific article published on 24 November 2016

Molecular analysis of model gut microbiotas by imaging mass spectrometry and nanodesorption electrospray ionization reveals dietary metabolite transformations

scientific article

Molecular insights into the biosynthesis of guadinomine: a type III secretion system inhibitor

scientific article

Natural products version 2.0: connecting genes to molecules.

scientific article

New antibiotics from bacterial natural products

scientific article published on December 2006

New ways to squash superbugs

scientific article published on 01 July 2009

Observing the invisible through imaging mass spectrometry, a window into the metabolic exchange patterns of microbes

scientific article

One pathway, many products

scientific article published on 01 July 2007

Perceived functioning has ethnic-specific associations in systemic sclerosis: another dimension of personalized medicine

scientific article

Plasma endogenous enkephalin levels in early systemic sclerosis: clinical and laboratory associations.

scientific article

Polymorphisms of endothelial nitric oxide synthase and angiotensin-converting enzyme in systemic sclerosis

scientific article published on 01 August 2005

Predictors of Fatigue Severity in Early Systemic Sclerosis: A Prospective Longitudinal Study of the GENISOS Cohort ⬇️

scientific article published on October 14, 2011

Production of α-galactosylceramide by a prominent member of the human gut microbiota ⬇️

scientific article (publication date: July 2013)

Prognostic Value of Gut Microbe‐Generated Metabolite Phenylacetylglutamine in Patients with Heart Failure

scientific article published on 20 December 2023

Prokaryotic gene clusters: a rich toolbox for synthetic biology.

scientific article published on December 2010

Propionibacterium-produced coproporphyrin III induces Staphylococcus aureus aggregation and biofilm formation

scientific article

Pulmonary involvement in systemic sclerosis: associations with genetic, serologic, sociodemographic, and behavioral factors

scientific article published on 01 March 2007

Quantification of bile acids: a mass spectrometry platform for studying gut microbe connection to metabolic diseases

scientific article published on 09 December 2019

Recovery of the Gut Microbiota after Antibiotics Depends on Host Diet, Community Context, and Environmental Reservoirs

scientific article published on 01 November 2019

Recovery of the Gut Microbiota after Antibiotics Depends on Host Diet, Community Context, and Environmental Reservoirs

scientific article published on 01 October 2020

Regulation of the nucleotide state of oncogenic ras proteins by nucleoside diphosphate kinase.

scientific article

Repurposing libraries of eukaryotic protein kinase inhibitors for antibiotic discovery

scientific article

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

scientific article

Separate influences of birth order and gravidity/parity on the development of systemic sclerosis

scientific article

Signaling in Host-Associated Microbial Communities.

scientific article

Skin microbiota-host interactions.

scientific article published in January 2018

Specific biochemical inactivation of oncogenic Ras proteins by nucleoside diphosphate kinase

scientific article

Strain dropouts reveal interactions that govern the metabolic output of the gut microbiome

scientific article published in June 2023

Structural characterization of enterobactin hydrolase IroE.

scientific article

Structurally diverse natural products that cause potassium leakage trigger multicellularity in Bacillus subtilis

scholarly article

Synthetic biology to access and expand nature's chemical diversity

scientific article

Synthetic microbes as drug delivery systems

scientific article published on 13 August 2014

Systemic sclerosis and lupus: points in an interferon-mediated continuum

scientific article

The Biosynthesis of Lipooligosaccharide from Bacteroides thetaiotaomicron.

scientific article

The evolution of gene collectives: How natural selection drives chemical innovation.

scholarly article

The gutSMASH web server: automated identification of primary metabolic gene clusters from the gut microbiota

scientific article published on 01 July 2021

The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis ⬇️

scholarly article

The natural history of antibiotics

scientific article

The next frontier of systems biology: higher-order and interspecies interactions.

scientific article

The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2.

scholarly article

The prevalence of species and strains in the human microbiome: a resource for experimental efforts

scientific article

Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin.

scholarly article

Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways.

scientific article published on 23 May 2008

Trehalose biosynthesis promotes Pseudomonas aeruginosa pathogenicity in plants

scientific article (publication date: March 2013)

What Lives On Our Skin: Ecology, Genomics and Therapeutic Opportunities Of the Skin Microbiome

scientific article published on December 2013

antiSMASH 2.0--a versatile platform for genome mining of secondary metabolite producers

scientific article published on 3 June 2013

antiSMASH 3.0-a comprehensive resource for the genome mining of biosynthetic gene clusters

scientific article published on 6 May 2015

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

scientific article published on 14 June 2011

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