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List of works by Hugo J. Bellen

A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function

scientific article published in December 1996

A Notch updated

scientific article published on 02 March 2009

A Syndromic Neurodevelopmental Disorder Caused by De Novo Variants in EBF3

scientific journal article

A TRPV channel in Drosophila motor neurons regulates presynaptic resting Ca2+ levels, synapse growth, and synaptic transmission

scientific article published on 30 October 2014

A cell cycle-independent, conditional gene inactivation strategy for differentially tagging wild-type and mutant cells.

scientific article

A cis-regulatory map of the Drosophila genome.

scientific article

A drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases

scientific journal article

A gene-specific T2A-GAL4 library for Drosophila.

scientific article published on 22 March 2018

A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene

scientific article

A kinase-dependent feedforward loop affects CREBB stability and long term memory formation.

scientific article published on 23 February 2018

A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila

scientific article

A mitocentric view of Parkinson's disease.

scientific article published on 05 May 2014

A molecularly defined duplication set for the X chromosome of Drosophila melanogaster

scientific article

A mutation in EGF repeat-8 of Notch discriminates between Serrate/Jagged and Delta family ligands

scientific article

A novel neuronal pathway for visually guided escape in Drosophila melanogaster

scientific article

A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila.

scientific article

A role for Drosophila SMC4 in the resolution of sister chromatids in mitosis.

scientific article published in March 2001

A synaptic vesicle-associated Ca2+ channel promotes endocytosis and couples exocytosis to endocytosis.

scientific article

A voltage-gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis

scientific article

Aberrant lysosomal carbohydrate storage accompanies endocytic defects and neurodegeneration in Drosophila benchwarmer

scientific article

Absence of synaptotagmin disrupts excitation-secretion coupling during synaptic transmission.

scientific article published in October 1994

Activity-independent prespecification of synaptic partners in the visual map of Drosophila

scientific article published on September 2006

Aging Fly Cell Atlas identifies exhaustive aging features at cellular resolution

scientific article published on 15 June 2023

An Assay to DetectIn VivoY Chromosome Loss inDrosophilaWing Disc Cells ⬇️

scientific article published on September 1, 2012

An efficient CRISPR-based strategy to insert small and large fragments of DNA using short homology arms

scientific article published on 01 November 2019

An expanded toolkit for gene tagging based on MiMIC and scarless CRISPR tagging in

article

Ari-1 Regulates Myonuclear Organization Together with Parkin and Is Associated with Aortic Aneurysms.

scientific article published in April 2018

BIOSAFETY. Safeguarding gene drive experiments in the laboratory

scientific article

Bi-allelic Loss-of-Function Variants in DNMBP Cause Infantile Cataracts

scientific article published on 01 October 2018

Biallelic Mutations in ATP5F1D, which Encodes a Subunit of ATP Synthase, Cause a Metabolic Disorder

scientific article published on 16 February 2018

Building dialogues between clinical and biomedical research through cross-species collaborations.

scientific article published on June 2017

Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants

scientific article published in November 1994

Cell adhesion, the backbone of the synapse: "vertebrate" and "invertebrate" perspectives

scientific article published on October 2009

Chemical mutagens, transposons, and transgenes to interrogate gene function in Drosophila melanogaster

scientific article

Chromatid segregation at anaphase requires the barren product, a novel chromosome-associated protein that interacts with Topoisomerase II.

scientific article published in December 1996

Clinically severe CACNA1A alleles affect synaptic function and neurodegeneration differentially.

scientific article published on 24 July 2017

Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis

scientific article published on 01 December 2018

Control of Synaptic Connectivity by a Network of Drosophila IgSF Cell Surface Proteins

scientific article

Correction: the retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration

scientific article published on 28 May 2015

Crag is a GEF for Rab11 required for rhodopsin trafficking and maintenance of adult photoreceptor cells ⬇️

scientific article published on December 4, 2012

Dap160/intersectin acts as a stabilizing scaffold required for synaptic development and vesicle endocytosis

scientific article published in July 2004

Deciphering the function of neurexins at cellular junctions

scientific article published on May 1997

Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models

scientific article

Disruptive mutations in TANC2 define a neurodevelopmental syndrome associated with psychiatric disorders

scientific article published on 15 October 2019

Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients

scientific article

Drosophila Crumbs is a positional cue in photoreceptor adherens junctions and rhabdomeres

scientific article (publication date: 14 March 2002)

Drosophila EHBP1 regulates Scabrous secretion during Notch-mediated lateral inhibition.

scientific article published on 20 June 2013

Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity

scientific article published in November 2006

Drosophila P elements preferentially transpose to replication origins.

scientific article

Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11.

scientific article

Drosophila Ten-m and filamin affect motor neuron growth cone guidance.

scientific article

Drosophila VAP-33A directs bouton formation at neuromuscular junctions in a dosage-dependent manner

scientific article

Drosophila atonal fully rescues the phenotype of Math1 null mice: new functions evolve in new cellular contexts

scientific article published in September 2002

Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress

scientific article published on 8 April 2004

Drosophila tools and assays for the study of human diseases

scientific article

Dueling Ca2+ sensors in neurotransmitter release.

scientific article

Effect of Genetic Diagnosis on Patients with Previously Undiagnosed Disease

Embryonic cAMP and developmental potential in Drosophila melanogaster

scientific article published in June 1992

Emerging technologies for gene manipulation in Drosophila melanogaster

scientific article

Endocytosis and intracellular trafficking of Notch and its ligands

scientific article published on January 2010

Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release

scientific article (publication date: 5 April 2002)

Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development.

scientific article

Ero1L, a thiol oxidase, is required for Notch signaling through cysteine bridge formation of the Lin12-Notch repeats in Drosophila melanogaster

scientific article published on September 2008

Fighting anthrax with flies

scholarly article

FlyBase: a virtual Drosophila cornucopia

scientific article published in November 1995

Flying in the face of total disruption

scientific article published in March 2004

Fruit flies in biomedical research.

scientific article

Functional variants in TBX2 are associated with a syndromic cardiovascular and skeletal developmental disorder

scientific article published on 01 July 2018

Gene Tagging Strategies To Assess Protein Expression, Localization, and Function in Drosophila.

scientific article published on October 2017

Genetic Manipulation of Genes and Cells in the Nervous System of the Fruit Fly ⬇️

scientific article published on October 20, 2011

Genetic dissection of synaptic transmission in Drosophila

scientific article published on October 1997

Genetic strategies to tackle neurological diseases in fruit flies.

scientific article published on 8 November 2017

Genome-wide manipulations of Drosophila melanogaster with transposons, Flp recombinase, and ΦC31 integrase.

scientific article

Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation

scientific article

Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration

scientific article

Growth factor independence-1 is expressed in primary human neuroendocrine lung carcinomas and mediates the differentiation of murine pulmonary neuroendocrine cells.

scientific article

Hauling t-SNAREs on the microtubule highway

scientific article published on 01 October 2004

Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila

scientific article published in January 2002

Huntingtin functions as a scaffold for selective macroautophagy

scientific journal article

Huntingtin-interacting protein 14, a palmitoyl transferase required for exocytosis and targeting of CSP to synaptic vesicles

scientific article published on 24 December 2007

IRF2BPL Is Associated with Neurological Phenotypes

IRF2BPL Is Associated with Neurological Phenotypes

scientific article published on 01 September 2018

Ig Superfamily Ligand and Receptor Pairs Expressed in Synaptic Partners in Drosophila

scientific article published on December 2015

Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress

scientific article published on 15 July 2015

Importin 13 regulates neurotransmitter release at the Drosophila neuromuscular junction

scientific article

Interactions between the Ig-Superfamily Proteins DIP-α and Dpr6/10 Regulate Assembly of Neural Circuits

scientific article published on 19 November 2018

Internalization is required for proper Wingless signaling in Drosophila melanogaster

scientific article

Invertebrate versus vertebrate neurogenesis: variations on the same theme?

scientific article

Large-scale identification of chemically induced mutations in Drosophila melanogaster.

scientific article

Localization of BRRN1, the Human Homologue ofDrosophila barr,to 2q11.2 ⬇️

scientific article published on December 1, 1997

Loss of Frataxin activates the iron/sphingolipid/PDK1/Mef2 pathway in mammals

scientific article

Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration.

scientific article

Loss of IRF2BPL impairs neuronal maintenance through excess Wnt signaling

scientific article published on 19 January 2022

Loss of Nardilysin, a Mitochondrial Co-chaperone for α-Ketoglutarate Dehydrogenase, Promotes mTORC1 Activation and Neurodegeneration

scientific journal article

Loss of proteins associated with amyotrophic lateral sclerosis affects lysosomal acidification via different routes

scientific article published on 28 April 2019

Loss-of-function variants in TIAM1 are associated with developmental delay, intellectual disability, and seizures

scientific article published on 02 March 2022

Low doses of the neonicotinoid insecticide imidacloprid induce ROS triggering neurological and metabolic impairments in Drosophila

scientific article published on 28 September 2020

Lysosomal Degradation Is Required for Sustained Phagocytosis of Bacteria by Macrophages.

scientific article published on 22 May 2017

MARRVEL: Integration of Human and Model Organism Genetic Resources to Facilitate Functional Annotation of the Human Genome

scientific article published on 03 May 2017

Mapping Drosophila mutations with molecularly defined P element insertions

scientific article

Mapping and identification of essential gene functions on the X chromosome of Drosophila

scientific article

Math1 is essential for genesis of cerebellar granule neurons

scientific article published in November 1997

Meaningless minis? Mechanisms of neurotransmitter-receptor clustering

scientific article

MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes

scientific article

Missense variants in the middle domain of DNM1L in cases of infantile encephalopathy alter peroxisomes and mitochondria when assayed in Drosophila

scientific article published on 29 February 2016

Mitochondrial fusion but not fission regulates larval growth and synaptic development through steroid hormone production

scientific article

Model Organisms Facilitate Rare Disease Diagnosis and Therapeutic Research

scientific article published on September 2017

Model organism databases are in jeopardy

scientific article published on 27 September 2021

Mutations affecting the pattern of the PNS in Drosophila reveal novel aspects of neuronal development

scientific article published in August 1994

Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components

scientific article published in April 2005

Mutations in neuromusculin, a gene encoding a cell adhesion molecule, cause nervous system defects

article

Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans

scientific article

NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration.

scientific article

NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies.

scientific article

NMNATs, evolutionarily conserved neuronal maintenance factors.

scientific article published on 20 August 2013

Neurexin IV, caspr and paranodin--novel members of the neurexin family: encounters of axons and glia

scientific article published in October 1998

Neuron-Subtype-Specific Expression, Interaction Affinities, and Specificity Determinants of DIP/Dpr Cell Recognition Proteins.

scientific article published on 19 November 2018

Neuroscience. The meaning of a mini

scientific article published in July 2001

Numb: "Adapting" notch for endocytosis.

scientific article

P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster.

scientific article

Peroxisomal biogenesis is genetically and biochemically linked to carbohydrate metabolism in Drosophila and mouse

scientific article

Pleiotropic neuropathological and biochemical alterations associated with Myo5a mutation in a rat Model.

scientific article published on 4 December 2017

Preface. Notch signaling

Presynaptic proteins involved in exocytosis in Drosophila melanogaster: a genetic analysis

scientific article published on January 1995

Pri sORF peptides induce selective proteasome-mediated protein processing

scientific article

Primordium specific requirement of the homeotic gene fork head in the developing gut of the Drosophila embryo

scientific article

Probing mechanisms that underlie human neurodegenerative diseases in Drosophila

scientific article published on 4 September 2012

Protein phosphatase 1ß limits ring canal constriction during Drosophila germline cyst formation

scientific article (publication date: 2013)

Quantitative analysis of bristle number in Drosophila mutants identifies genes involved in neural development

scientific article published in August 2003

ROP, the Drosophila Sec1 homolog, interacts with syntaxin and regulates neurotransmitter release in a dosage-dependent manner.

scientific article published on January 1998

Rab3 GTPase lands Bruchpilot.

scientific article published in December 2009

Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease

scientific article

Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain

scientific article published on 14 April 2020

Rhodopsin homeostasis and retinal degeneration: lessons from the fly.

scientific article published on 05 September 2013

Rich regulates target specificity of photoreceptor cells and N-cadherin trafficking in the Drosophila visual system via Rab6.

scientific article

Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling.

scientific article

Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors.

scientific article

Secreted VAPB/ALS8 major sperm protein domains modulate mitochondrial localization and morphology via growth cone guidance receptors.

scientific article published on 19 January 2012

Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin

scientific article published on 22 March 2006

Senseless physically interacts with proneural proteins and functions as a transcriptional co-activator.

scientific article published on 19 April 2006

Sequoia regulates cell fate decisions in the external sensory organs of adult Drosophila

scientific article published on 15 May 2009

Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila

scientific article published in December 2002

Shared mechanisms between Drosophila peripheral nervous system development and human neurodegenerative diseases

scientific article published on 22 April 2014

Spectraplakins promote microtubule-mediated axonal growth by functioning as structural microtubule-associated proteins and EB1-dependent +TIPs (tip interacting proteins).

scientific article published on July 2012

Sphingolipids in the Pathogenesis of Parkinson's Disease and Parkinsonism

scientific article published on 06 December 2018

Stringent analysis of gene function and protein-protein interactions using fluorescently tagged genes

scientific article published on 14 December 2011

Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm

scientific article published on January 2008

Survival of the fittest tools

scientific article

Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions

scientific article (publication date: 4 August 2005)

Synaptic vesicle retrieval: still time for a kiss

scientific article published in November 2002

Synaptic vesicle size and number are regulated by a clathrin adaptor protein required for endocytosis

scientific article

Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating

scientific article (publication date: 13 November 2003)

Syncrip/hnRNP Q influences synaptic transmission and regulates BMP signaling at the Drosophila neuromuscular synapse

scientific article

Syntaxin 1A interacts with multiple exocytic proteins to regulate neurotransmitter release in vivo

scientific article published in July 1999

Syntaxin and synaptobrevin function downstream of vesicle docking in Drosophila

scientific article published on September 1995

TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS

scientific article published on 10 December 2020

Tailoring uniform coats for synaptic vesicles during endocytosis.

scientific article

Ten years of enhancer detection: lessons from the fly.

scientific article

The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins

scientific article

The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes

scientific article

The BMP signaling pathway at the Drosophila neuromuscular junction and its links to neurodegenerative diseases.

scientific article published on 09 September 2010

The C8ORF38 homologue Sicily is a cytosolic chaperone for a mitochondrial complex I subunit ⬇️

scientific article published on March 18, 2013

The Drosophila Gene Disruption Project: Progress Using Transposons With Distinctive Site Specificities ⬇️

scientific article published on April 21, 2011

The Drosophila deoxyhypusine hydroxylase homologue nero and its target eIF5A are required for cell growth and the regulation of autophagy.

scientific article published on 22 June 2009

The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals

scientific article

The Fruit Fly: A Model Organism to Study the Genetics of Alcohol Abuse and Addiction? ⬇️

scientific article published on June 12, 1998

The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D.

scientific article

The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission.

scientific article published in December 2017

The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders

article by A Jeremy Willsey et al published 26 July 2018 in Cell

The amyotrophic lateral sclerosis 8 protein, VAP, is required for ER protein quality control

scientific article

The dynamin-binding domains of Dap160/intersectin affect bulk membrane retrieval in synapses

scientific article published on 15 January 2013

The expanding neurological phenotype of DNM1L-related disorders

scientific article published on 01 April 2018

The ins and outs of Wingless signaling.

scientific article published on January 2004

The nicotinic acetylcholine receptor Dalpha7 is required for an escape behavior in Drosophila

scientific article

The retromer complex in development and disease

scientific article

The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration

scientific article (publication date: April 2014)

The v-ATPase V0 subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila.

scientific article

The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival

scientific journal article

Thirty-one flavors of Drosophila rab proteins.

scientific article published on 3 April 2007

Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis.

scientific article

Tissue distribution of PEBBLE RNA and pebble protein during Drosophila embryonic development

scientific article published in February 2000

Transgenesis upgrades for Drosophila melanogaster.

scientific article

Tweek, an evolutionarily conserved protein, is required for synaptic vesicle recycling

scientific article published on July 2009

Two Drosophila learning mutants, dunce and rutabaga, provide evidence of a maternal role for cAMP on embryogenesis

scientific article published on June 1987

Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification

scientific article published on 25 February 2019

Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination

scientific article

Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease

scientific article published on 23 June 2016

Using Drosophila to drive the diagnosis and understand the mechanisms of rare human diseases

scientific article published on 28 September 2020

Using Drosophila to study mechanisms of hereditary hearing loss.

scientific article published on 31 May 2018

V-ATPase V0 sector subunit a1 in neurons is a target of calmodulin

scientific article published on 12 October 2007

VAMP associated proteins are required for autophagic and lysosomal degradation by promoting a PtdIns4P-mediated endosomal pathway

scientific article published on 20 February 2019

VAPB/ALS8 MSP ligands regulate striated muscle energy metabolism critical for adult survival in caenorhabditis elegans

scientific article

Versatile P[acman] BAC libraries for transgenesis studies in Drosophila melanogaster

scientific article

Visual impairment and progressive phthisis bulbi caused by recessive pathogenic variant in MARK3

scientific article published on 01 August 2018

WAC Regulates mTOR Activity by Acting as an Adaptor for the TTT and Pontin/Reptin Complexes

scientific article published on January 2016

dEHBP1 controls exocytosis and recycling of Delta during asymmetric divisions

scientific article

miR-9a Minimizes the Phenotypic Impact of Genomic Diversity by Buffering a Transcription Factor

miR-9a minimizes the phenotypic impact of genomic diversity by buffering a transcription factor

scientific article published on December 2013

rop, a Drosophila homolog of yeast Sec1 and vertebrate n-Sec1/Munc-18 proteins, is a negative regulator of neurotransmitter release in vivo

scientific article published in November 1994

senseless Repression of rough Is Required for R8 Photoreceptor Differentiation in the Developing Drosophila Eye ⬇️

scientific article published on November 8, 2001

straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit

scientific article published on April 2008

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