List of works by Christian Hartinger

3-Hydroxyflavones vs. 3-hydroxyquinolinones: structure-activity relationships and stability studies on Ru(II)(arene) anticancer complexes with biologically active ligands

scientific article published on May 2013

5-Hydr-oxy-2-methyl-4H-pyran-4-one

scientific article

8th Asian Biological Inorganic Chemistry Conference

scientific article published on 01 July 2017

A Bioactive l-Phenylalanine-Derived Arene in Multitargeted Organoruthenium Compounds: Impact on the Antiproliferative Activity and Mode of Action

scientific article published on 27 June 2018

A Combined Spectroscopic and Protein Crystallography Study Reveals Protein Interactions of RhI(NHC) Complexes at the Molecular Level

scientific article published on 12 November 2020

A comparative study of adduct formation between the anticancer ruthenium(III) compound HInd trans-[RuCl4(Ind)2] and serum proteins.

scientific article

A glucose derivative as natural alternative to the cyclohexane-1,2-diamine ligand in the anticancer drug oxaliplatin?

scientific article

A new target for gold(I) compounds: Glutathione-S-transferase inhibition by auranofin

scientific article published on 24 August 2012

A one step/one pot synthesis of N,N-bis(phosphonomethyl)amino acids and their effects on adipogenic and osteogenic differentiation of human mesenchymal stem cells

scientific article

A ruthenium antimetastasis agent forms specific histone protein adducts in the nucleosome core

scientific article

A systematic capillary electrophoresis study on the effect of the buffer composition on the reactivity of the anticancer drug cisplatin to the DNA model 2'-deoxyguanosine 5'-monophosphate (dGMP).

scientific article

AAS, XRF, and MS Methods in Chemical Biology of Metal Complexes

Am(m)ines make the difference: organoruthenium am(m)ine complexes and their chemistry in anticancer drug development

scientific article published on 22 January 2013

An Organoruthenium Anticancer Agent Shows Unexpected Target Selectivity For Plectin.

scientific article published on 26 May 2017

An internal fluorescent probe based on anthracene to evaluate cation-anion interactions in imidazolium salts

scientific article published in June 2010

Analysis of platinum adducts with DNA nucleotides and nucleosides by capillary electrophoresis coupled to ESI-MS: indications of guanosine 5'-monophosphate O6-N7 chelation

scientific article published in November 2004

Analysis of ruthenium anticancer agents by MEEKC-UV and MEEKC-ICP-MS: impact of structural motifs on lipophilicity and biological activity

scientific article published on 5 February 2018

Anthracene-tethered ruthenium(II) arene complexes as tools to visualize the cellular localization of putative organometallic anticancer compounds

scientific article published on 06 March 2012

Anti-Inflammatory Oxicams as Multi-donor Ligand Systems: pH- and Solvent-Dependent Coordination Modes of Meloxicam and Piroxicam to Ru and Os.

scientific article published on 14 February 2017

Anticancer Ru(η6-p-cymene) complexes of 2-pyridinecarbothioamides: A structure-activity relationship study

scientific article published on 4 September 2017

Anticancer activity of Ru- and Os(arene) compounds of a maleimide-functionalized bioactive pyridinecarbothioamide ligand

scientific article

Anticancer activity of metal complexes: involvement of redox processes

scientific article published on 11 May 2011

Anticancer activity of methyl-substituted oxaliplatin analogs

scientific article published on 13 February 2012

Anticancer metallodrug research analytically painting the "omics" picture--current developments and future trends

scientific article published on 16 October 2012

Anticancer metallodrugs: where is the next cisplatin?

scientific article published on 7 February 2018

Anticancer organorhodium and -iridium complexes with low toxicity in vivo but high potency in vitro: DNA damage, reactive oxygen species formation, and haemolytic activity

scientific article published on 01 October 2019

Antitumor Metallodrugs that Target Proteins.

scientific article published in February 2018

Antitumor pentamethylcyclopentadienyl rhodium complexes of maltol and allomaltol: synthesis, solution speciation and bioactivity

scientific article published on 3 February 2014

Antitumour metal compounds: more than theme and variations

scientific article

Application of mass spectrometric techniques to delineate the modes-of-action of anticancer metallodrugs

scientific article published on July 2013

Aqueous chemistry and antiproliferative activity of a pyrone-based phosphoramidate Ru(arene) anticancer agent.

scientific article

AsBIC8 -8th Asia/Pacific Biological Inorganic Chemistry Conference.

scientific article published on 16 November 2017

Biodistribution of anti-diabetic Zn(II) complexes in human serum andin vitroprotein-binding studies by means of CZEâ ICP-MS

scientific article published on 01 December 2009

Biomolecule binding vs. anticancer activity: Reactions of Ru(arene)[(thio)pyr-(id)one] compounds with amino acids and proteins

scientific article published on 26 August 2011

Bioorganometallic chemistry--from teaching paradigms to medicinal applications

scientific article

CE in anticancer metallodrug research--an update

scientific article published on October 2007

CZE-ICP-MS as a tool for studying the hydrolysis of ruthenium anticancer drug candidates and their reactivity towards the DNA model compound dGMP.

scientific article published on 14 December 2007

Capillary electrophoresis hyphenated to inductively coupled plasma-mass spectrometry: a novel approach for the analysis of anticancer metallodrugs in human serum and plasma

scientific article published on May 2008

Capillary electrophoresis in anti-cancer metallodrug research: advances and future challenges

scientific article published on June 2003

Capillary electrophoresis in metallodrug development

scientific article published on September 2015

Capillary electrophoretic methods in the development of metal-based therapeutics and diagnostics: new methodology and applications

scientific article published on February 2012

Capillary zone electrophoresis and capillary zone electrophoresis–electrospray ionization mass spectrometry studies on the behavior of anticancer cis- and trans-[dihalidobis(2-propanone oxime)platinum(II)] complexes in aqueous solutions

scientific article published on 28 July 2012

Carbohydrate-metal complexes and their potential as anticancer agents

scientific article published on January 2008

Cellular accumulation and DNA interaction studies of cytotoxic trans-platinum anticancer compounds

scientific article published on 7 January 2012

Characterization of interactions between human serum albumin and tumor-inhibiting amino alcohol platinum(II) complexes using capillary electrophoresis.

scientific article published on 11 January 2007

Characterization of platinum anticancer drug protein-binding sites using a top-down mass spectrometric approach

scientific article published on 8 December 2007

Characterization of the binding sites of the anticancer ruthenium(III) complexes KP1019 and KP1339 on human serum albumin via competition studies

scientific article published on 18 October 2012

Characterizing activation mechanisms and binding preferences of ruthenium metallo-prodrugs by a competitive binding assay.

scientific article

Chemical imaging and assessment of cadmium distribution in the human body

scientific article published on 01 December 2019

Cobalt complexes as internal standards for capillary zone electrophoresis-mass spectrometry studies in biological inorganic chemistry.

scientific article published on 2 January 2017

Comparative binding of antitumor indazolium [trans-tetrachlorobis(1H-indazole)ruthenate(III)] to serum transport proteins assayed by capillary zone electrophoresis

scientific article published in June 2005

Comparative solution equilibrium studies of anticancer gallium(III) complexes of 8-hydroxyquinoline and hydroxy(thio)pyrone ligands.

scientific article

Coordination Chemistry of Organoruthenium Compounds with Benzoylthiourea Ligands and their Biological Properties

scientific article published on 14 February 2019

DNA Interactions of pH-Sensitive, Antitumor Bis(aminoalcohol)dichloroplatinum(II) Complexes†,‡

scientific article published on 01 December 2006

DNA damaging properties of single walled carbon nanotubes in human colon carcinoma cells.

scientific article

DNA interactions of dinuclear RuII arene antitumor complexes in cell-free media

scientific article published on 28 October 2008

DNA or protein? Capillary zone electrophoresis-mass spectrometry rapidly elucidates metallodrug binding selectivity

scientific article

Determination of binding constants and stoichiometries for platinum anticancer drugs and serum transport proteins by capillary electrophoresis using the Hummel-Dreyer method.

scientific article

Development of an experimental protocol for uptake studies of metal compounds in adherent tumor cells

scientific article

Development of anticancer agents: wizardry with osmium

scientific article

Editorial [Hot Topic: Metal Containing Complexes with Anticancer Properties (Guest Editors: A. Nazarov & C. Hartinger)]

scientific article published on 01 January 2011

Efficiently Detecting Metallodrug-Protein Adducts: Ion Trap versus Time-of-Flight Mass Analyzers

scientific article published on 18 March 2014

Electrophoretic separation techniques and their hyphenation to mass spectrometry in biological inorganic chemistry.

scientific article

Elucidation of the interactions of an anticancer ruthenium complex in clinical trials with biomolecules utilizing capillary electrophoresis hyphenated to inductively coupled plasma-mass spectrometry. Short communication

scientific article published in August 2008

Emerging protein targets for anticancer metallodrugs: inhibition of thioredoxin reductase and cathepsin B by antitumor ruthenium(II)-arene compounds

scientific article published on 4 October 2008

Extravasation of Pt-based chemotherapeutics - bioimaging of their distribution in resectates using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS).

scientific article published on March 2015

Ferrocenyl Paclitaxel and Docetaxel Derivatives: Impact of an Organometallic Moiety on the Mode of Action of Taxanes.

scientific article

Fragmentation methods on the balance: unambiguous top–down mass spectrometric characterization of oxaliplatin–ubiquitin binding sites

scientific article published on 08 November 2011

From Catalysis to Cancer: Toward Structure-Activity Relationships for Benzimidazol-2-ylidene-Derived N-Heterocyclic-Carbene Complexes as Anticancer Agents

scientific article published on 08 November 2018

From bench to bedside--preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A).

scientific article

From hydrolytically labile to hydrolytically stable Ru(II)-arene anticancer complexes with carbohydrate-derived co-ligands.

scientific article published on 14 October 2010

Functionalization of Ruthenium(II)(η6 -p-cymene)(3-hydroxy-2-pyridone) Complexes with (Thio)Morpholine: Synthesis and Bioanalytical Studies

scientific article published on 05 April 2017

Gel electrophoresis in combination with laser ablation-inductively coupled plasma mass spectrometry to quantify the interaction of cisplatin with human serum albumin

scientific article published on 21 May 2019

Gold(III) compounds as anticancer agents: relevance of gold-protein interactions for their mechanism of action

scientific article published on 28 November 2007

Half-sandwich ruthenium(II) biotin conjugates as biological vectors to cancer cells

scientific article

High resolution mass spectrometry for studying the interactions of cisplatin with oligonucleotides

scientific article

Hydrolysis study of the bifunctional antitumour compound RAPTA-C, [Ru(η6-p-cymene)Cl2(pta)]

scientific article published on 21 May 2008

Hydroxyquinoline-derived anticancer organometallics: Introduction of amphiphilic PTA as an ancillary ligand increases their aqueous solubility

scientific article published on 18 July 2019

Hyphenation of capillary electrophoresis to inductively coupled plasma mass spectrometry with a modified coaxial sheath-flow interface

scientific article published on 16 May 2018

Identification of the structural determinants for anticancer activity of a ruthenium arene peptide conjugate

scientific article published on 27 May 2013

In vitro anticancer activity and biologically relevant metabolization of organometallic ruthenium complexes with carbohydrate-based ligands

scientific article

In-flow SAXS investigation of whey protein isolate hydrolyzed by bromelain

scientific article published in 2021

Influence of extracellular pH on the cytotoxicity, cellular accumulation, and DNA interaction of novel pH-sensitive 2-aminoalcoholatoplatinum(II) complexes

scientific article published on 26 January 2013

Influence of the Arene Ligand and the Leaving Group on the Anticancer Activity of (Thio)maltol Ruthenium(II)–(η6-Arene) Complexes

Influence of the π-coordinated arene on the anticancer activity of ruthenium(II) carbohydrate organometallic complexes

scientific article

Interactions of antitumor metallodrugs with serum proteins: advances in characterization using modern analytical methodology.

scientific article published on June 2006

Interactions of the carrier ligands of antidiabetic metal complexes with human serum albumin: A combined spectroscopic and separation approach with molecular modeling studies

scientific article published on 21 June 2011

Is the reactivity of M(II)-arene complexes of 3-hydroxy-2(1H)-pyridones to biomolecules the anticancer activity determining parameter?

scientific article published on September 2010

KP1019, a new redox-active anticancer agent--preclinical development and results of a clinical phase I study in tumor patients

scientific article published on October 2008

LC– and CZE–ICP-MS approaches for the in vivo analysis of the anticancer drug candidate sodium trans-[tetrachloridobis(1H-indazole)ruthenate(iii)] (KP1339) in mouse plasma

scientific article published on 21 September 2011

Letters to a Young Chemist. Herausgegeben von Abhik Ghosh

Making organoruthenium complexes of 8-hydroxyquinolines more hydrophilic: impact of a novel l-phenylalanine-derived arene ligand on the biological activity.

scientific article published on 23 January 2018

Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules

scientific article published on 14 October 2011

Maltol-derived ruthenium-cymene complexes with tumor inhibiting properties: the impact of ligand-metal bond stability on anticancer activity in vitro

scientific article published on November 2009

Mass spectrometric analysis of ubiquitin–platinum interactions of leading anticancer drugs: MALDI versus ESI

article

Metabolization of [Ru(eta(6)-C (6)H (5)CF (3))(pta)Cl (2)]: a cytotoxic RAPTA-type complex with a strongly electron withdrawing arene ligand

scientific article

Metal-Dependent Cytotoxic and Kinesin Spindle Protein Inhibitory Activity of Ru, Os, Rh, and Ir Half-Sandwich Complexes of Ispinesib-Derived Ligands

scientific article published on 01 October 2020

Metallomic study on the metabolism of RAPTA-C and cisplatin in cell culture medium and its impact on cell accumulation.

scientific article published on 27 February 2018

Metalloproteomics for molecular target identification of protein-binding anticancer metallodrugs

scientific article published on 16 October 2020

Monodentately-coordinated bioactive moieties in multimodal half-sandwich organoruthenium anticancer agents

scientific article published in 2021

Nitrile-functionalized pyrrolidinium ionic liquids as solvents for cross-coupling reactions involving in situ generated nanoparticle catalyst reservoirs

scientific article published on 21 December 2009

Organometallic Ruthenium and Osmium Compounds of Pyridin-2- and -4-ones as Potential Anticancer Agents

scientific article published on 01 September 2012

Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity

scientific article published on April 2013

Organoruthenium and Organoosmium Complexes of 2-Pyridinecarbothioamides Functionalized with a Sulfonamide Motif: Synthesis, Cytotoxicity and Biomolecule Interactions

scientific article published on 19 June 2018

Osmium(II)--versus ruthenium(II)--arene carbohydrate-based anticancer compounds: similarities and differences.

scientific article published on 2 July 2010

Pharmacokinetics of a novel anticancer ruthenium complex (KP1019, FFC14A) in a phase I dose-escalation study

scientific article

Phosphite-Derivatized Ruthenium-Carbohydrate Complexes in the Catalytic Hydration of Nitriles. Short Communication

scientific article published on 01 August 2008

Physicochemical Studies and Anticancer Potency of Ruthenium η-p-Cymene Complexes Containing Antibacterial Quinolones

scientific article published on 6 April 2011

Physicochemical studies on the copper(ii) binding by glycated collagen telopeptides

scientific article published on 01 March 2015

Platinum group metallodrug-protein binding studies by capillary electrophoresis - inductively coupled plasma-mass spectrometry: a further insight into the reactivity of a novel antitumor ruthenium(III) complex toward human serum proteins

scientific article published in March 2006

Platinum metallodrug-protein binding studies by capillary electrophoresis-inductively coupled plasma-mass spectrometry: characterization of interactions between Pt(II) complexes and human serum albumin.

scientific article published in July 2004

Platinum nanoparticles and their cellular uptake and DNA platination at non-cytotoxic concentrations

scientific article published on 13 January 2011

Polynuclear ruthenium, osmium and gold complexes. The quest for innovative anticancer chemotherapeutics

scientific article published on January 2011

Potent Inhibition of Thioredoxin Reductase by the Rh Derivatives of Anticancer M(arene/Cp*)(NHC)Cl2 Complexes

scientific article published on 19 February 2020

Probing the stability of serum protein–ruthenium(III) drug adducts in the presence of extracellular reductants using CE

scientific article published on 01 July 2007

Protein ruthenation and DNA alkylation: chlorambucil-functionalized RAPTA complexes and their anticancer activity

scientific article published in February 2015

Quantitative bioimaging by LA-ICP-MS: a methodological study on the distribution of Pt and Ru in viscera originating from cisplatin- and KP1339-treated mice.

scientific article

Quinoline-para-quinones and metals: coordination-assisted formation of quinoline-ortho-quinones

scientific article published on 11 January 2018

Redox behavior of tumor-inhibiting ruthenium(iii) complexes and effects of physiological reductants on their binding to GMP

scientific article published on 11 January 2006

Redox-active antineoplastic ruthenium complexes with indazole: correlation of in vitro potency and reduction potential

scientific article

Resistance against novel anticancer metal compounds: differences and similarities

scientific article published on February 2008

Reversion of Structure-Activity Relationships of Antitumor Platinum Complexes by Acetoxime but Not Hydroxylamine Ligands

scientific article published on 18 October 2006

Rollover Cyclometalated Bipyridine Platinum Complexes as Potent Anticancer Agents: Impact of the Ancillary Ligands on the Mode of Action

scientific article published on 14 February 2018

Ruthenium versus platinum: interactions of anticancer metallodrugs with duplex oligonucleotides characterised by electrospray ionisation mass spectrometry

scientific article published on 07 March 2010

RutheniumII(η6-arene) complexes of thiourea derivatives: synthesis, characterization and urease inhibition

scientific article published on 16 June 2014

Serum-binding properties of isosteric ruthenium and osmium anticancer agents elucidated by SEC-ICP-MS

scientific article published on 25 August 2018

Solution equilibria of anticancer ruthenium(II)-(η(6)-p-cymene)-hydroxy(thio)pyr(id)one complexes: impact of sulfur vs. oxygen donor systems on the speciation and bioactivity

scientific article

Stability of an organometallic ruthenium-ubiquitin adduct in the presence of glutathione: relevance to antitumour activity

scientific article published on 23 August 2008

Structure-activity relationships for NAMI-A-type complexes (HL)[trans-RuCl4L(S-dmso)ruthenate(III)] (L = imidazole, indazole, 1,2,4-triazole, 4-amino-1,2,4-triazole, and 1-methyl-1,2,4-triazole): aquation, redox properties, protein binding, and anti

scientific article published on 3 April 2007

Structure-activity relationships for ruthenium and osmium anticancer agents - towards clinical development

scientific article published on 24 November 2017

Structure-activity relationships of targeted RuII(η6-p-cymene) anticancer complexes with flavonol-derived ligands

scientific article

Studies on the reactivity of organometallic Ru-, Rh- and Os-pta complexes with DNA model compounds

scientific article

Synthesis and in vitro Biological Evaluation of Ferrocenyl Side-Chain-Functionalized Paclitaxel Derivatives.

scientific article

Synthesis of ferrocenylglucose phosphonite and bisphosphinite: Pd(II) and Pt(II) complexes, Pd-catalyzed allylic alkylation

Synthesis, cytotoxicity, and COMPARE analysis of ferrocene and [3]ferrocenophane tetrasubstituted olefin derivatives against human cancer cells

scientific article published on December 2010

Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action

scientific article published on 9 February 2015

Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder.

scientific article published on 12 April 2012

The first example of MEEKC-ICP-MS coupling and its application for the analysis of anticancer platinum complexes

scientific article published on April 2010

The hydration of chloroacetonitriles catalyzed by mono- and dinuclear Ru(II)- and Os(II)-arene complexes.

scientific article published in October 2008

The metalation of hen egg white lysozyme impacts protein stability as shown by ion mobility mass spectrometry, differential scanning calorimetry, and X-ray crystallography

scientific article published on 31 March 2017

The ruthenium(II)-arene compound RAPTA-C induces apoptosis in EAC cells through mitochondrial and p53-JNK pathways

scientific article published on 3 July 2008

The serum protein binding of pharmacologically active gallium(III) compounds assessed by hyphenated CE-MS techniques.

scientific article published in August 2009

Thiourea-Derived Chelating Ligands and Their Organometallic Compounds: Investigations into Their Anticancer Activity

scientific article published on 11 August 2020

Towards targeting anticancer drugs: ruthenium(ii)-arene complexes with biologically active naphthoquinone-derived ligand systems.

scientific article

Transferring the concept of multinuclearity to ruthenium complexes for improvement of anticancer activity

scientific article

Trapping Unstable Benzoquinone Analogues by Coordination to a [(η5‐C5Me5)Ir] Fragment and the Anticancer Activity of the Resulting Complexes ⬇️

scientific article published on November 2, 2010

Tumour-inhibiting platinum(II) complexes with aminoalcohol ligands: biologically important transformations studied by micellar electrokinetic chromatography, nuclear magnetic resonance spectroscopy and mass spectrometry

scientific article published on 23 August 2005

Tuning of lipophilicity and cytotoxic potency by structural variation of anticancer platinum(IV) complexes

scientific article published on October 2010

Tuning the hydrophobicity of ruthenium(II)-arene (RAPTA) drugs to modify uptake, biomolecular interactions and efficacy

scientific article published on 26 September 2007

Understanding the interactions of diruthenium anticancer agents with amino acids

scientific article published on 25 July 2018

Unexpected arene ligand exchange results in the oxidation of an organoruthenium anticancer agent: the first X-ray structure of a protein-Ru(carbene) adduct.

scientific article published in May 2018

{(1R,2R,4R)-4-methyl-1,2-cyclohexanediamine}oxalatoplatinum(II): a novel enantiomerically pure oxaliplatin derivative showing improved anticancer activity in vivo

scientific article

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