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List of works by Alan R. Brash

12- and 15-Lipoxygenase products of arachidonic acid at the platelet/vascular interface

book chapter

15-Lipoxygenase metabolism of 2-arachidonylglycerol. Generation of a peroxisome proliferator-activated receptor alpha agonist

scientific article in 2002

15-Lipoxygenase-2 expression in benign and neoplastic sebaceous glands and other cutaneous adnexa

scientific article in 2001

15-lipoxygenase-2 (15-LOX-2) is expressed in benign prostatic epithelium and reduced in prostate adenocarcinoma

scientific article in 1999

15S-Hydroxyeicosatetraenoic acid activates peroxisome proliferator-activated receptor gamma and inhibits proliferation in PC3 prostate carcinoma cells.

scientific article in 2001

7-HETE, 10-HETE, and 13-HETE Are Major Products of NADPH-Dependent Arachidonic Acid Metabolism in Rat Liver Microsomes: Analysis of Their Stereochemistry, and the Stereochemistry of Their Acid-Catalyzed Rearrangement ⬇️

scientific article published on August 20, 1995

8R-Lipoxygenase-catalyzed synthesis of a prominent cis-epoxyalcohol from dihomo-γ-linolenic acid: a distinctive transformation compared with S-lipoxygenases

scientific article published in 2011

8S-lipoxygenase products activate peroxisome proliferator-activated receptor alpha and induce differentiation in murine keratinocytes

scientific journal article in 2000

A 12 R -lipoxygenase in human skin: Mechanistic evidence, molecular cloning, and expression ⬇️

scientific article published on June 9, 1998

A 49-kDa mini-lipoxygenase from Anabaena sp. PCC 7120 retains catalytically complete functionality

scientific article published in 2007

A Catalase-related Hemoprotein in Coral Is Specialized for Synthesis of Short-chain Aldehydes: DISCOVERY OF P450-TYPE HYDROPEROXIDE LYASE ACTIVITY IN A CATALASE.

scientific article published in 2015

A Covalent Linker Allows for Membrane Targeting of an Oxylipin Biosynthetic Complex † ‡

scientific article in 2008

A comparison of t-butyldimethylsilyl and trimethylsilyl ether derivatives for the characterization of urinary metabolites of prostaglandin F2alpha by gas chromatography mass spectrometry

scientific article in 1978

A comprehensive model of positional and stereo control in lipoxygenases

scientific article in 2005

A critical role of non-active site residues on cyclooxygenase helices 5 and 6 in the control of prostaglandin stereochemistry at carbon 15.

scientific article in 2007

A fungal catalase reacts selectively with the 13S fatty acid hydroperoxide products of the adjacent lipoxygenase gene and exhibits 13S-hydroperoxide-dependent peroxidase activity

scientific article published in 2017

A mouse mutation in the 12R-lipoxygenase, Alox12b, disrupts formation of the epidermal permeability barrier

scientific article published in 2007

A new method for the determination of the major metabolite of prostaglandin F2alpha in human urine based on stable isotope dilution and gas chromatography-mass spectrometry

scientific article in 1976

A secondary isotope effect in the lipoxygenase reaction

scientific article in 1986

A short-chain aldehyde is a major lipoxygenase product in arachidonic acid-stimulated porcine leukocytes

scientific article in 1986

A single active site residue directs oxygenation stereospecificity in lipoxygenases: stereocontrol is linked to the position of oxygenation

scholarly article

Absolute configuration of cis-12-oxophytodienoic acid of flaxseed: implications for the mechanism of biosynthesis from the 13(S)-hydroperoxide of linolenic acid

scientific article in 1988

Activation of soluble guanylate cyclase by arachidonic acid and 15-lipoxygenase products

scientific article in 1986

Acute renal artery constriction increases renal prostaglandin I2 biosynthesis and renin release in the conscious dog

scientific article published in 1982

Allene Oxide Biosynthesis and Metabolism

book chapter

Allene oxide and aldehyde biosynthesis in starfish oocytes ⬇️

scientific article published on December 5, 1991

Allene oxide synthases and allene oxides

scientific article in 2002

Allene oxide synthesis by a natural fusion protein with lipoxygenase and catalase-related domains

book chapter

Allene oxide synthesis by a naturally fusion protein with lipoxygenase and catalase-related domains

book chapter

Allene oxides as intermediates in biosynthesis of ketols and cyclopentenones

scientific article in 1989

Alterations in lipoxygenase and cyclooxygenase-2 catalytic activity and mRNA expression in prostate carcinoma

scientific article in 2001

An ancient relative of cyclooxygenase in cyanobacteria is a linoleate 10S-dioxygenase that works in tandem with a catalase-related protein with specific 10S-hydroperoxide lyase activity

scientific article in 2014

Analysis of 12/15-lipoxygenase metabolism of EPA and DHA with special attention to authentication of docosatrienes

scientific article published in 2021

Analysis of a specific oxygenation reaction of soybean lipoxygenase-1 with fatty acids esterified in phospholipids

scientific article in1987

Analysis of cyclooxygenase-substrate interactions using stereospecifically-labeled arachidonic acids

scientific article in 2002

Analysis of urinary metabolites of thromboxane and prostacyclin by negative-ion chemical-ionization gas chromatography/mass spectrometry

scientific article published on 01 January 1985

Analysis of urinary metabolites of thromboxane and prostacyclin by negative-ion chemical-ionization gas chromatography/mass spectrometry.

book chapter

Application of deuterium labelling in studies of the biosynthesis and metabolism of prostaglandin F2α in man

book chapter

Applications of Stereospecifically‐Labeled Fatty Acids in Oxygenase and Desaturase Biochemistry ⬇️

scientific article published on October 5, 2011

Arachidonate 12-lipoxygenase purified from porcine leukocytes by immunoaffinity chromatography and its reactivity with hydroperoxyeicosatetraenoic acids

scientific article published in 1986

Arachidonic Metabolites: Prostaglandins, Prostacyclin, Thromboxane and Leukotrienes.

book chapter

Arachidonic acid 15-lipoxygenase products from human eosinophils

scientific article published on 01 June 1982

Arachidonic acid as a bioactive molecule

scientific article in 2001

Arachidonic acid metabolism in rabbit renal cortex. Formation of two novel dihydroxyeicosatrienoic acids

scientific article in 1981

Aspirin inhibits endogenous prostacyclin and thromboxane biosynthesis in man

scientific article published on January 1, 1983

Autoxidation of methyl linoleate: identification of the bis-allylic 11-hydroperoxide

scientific article in 2000

Autoxidative transformation of chiral omega6 hydroxy linoleic and arachidonic acids to chiral 4-hydroxy-2E-nonenal

scientific article published in 2004

Biogenesis of volatile aldehydes from fatty acid hydroperoxides: molecular cloning of a hydroperoxide lyase (CYP74C) with specificity for both the 9- and 13-hydroperoxides of linoleic and linolenic acids

scientific article published in 2001

Biosynthesis of a linoleic acid allylic epoxide: mechanistic comparison with its chemical synthesis and leukotriene A biosynthesis

scientific article published in 2009

Biosynthesis, isolation, and NMR analysis of leukotriene A epoxides: substrate chirality as a determinant of the cis or trans epoxide configuration ⬇️

scientific article published on December 13, 2012

Catalytic activities of mammalian epoxide hydrolases with cis and trans fatty acid epoxides relevant to skin barrier function

scientific article published in 2018

Challenging the evidence for hepoxilin A3 being a mediator of neutrophil epithelial transmigration

scientific article published on 01 October 2020

Characterization of HETEs and related conjugated dienes by UV spectroscopy

scientific article in 1988

Characterization of the coral allene oxide synthase active site with UV-visible absorption, magnetic circular dichroism, and electron paramagnetic resonance spectroscopy: evidence for tyrosinate ligation to the ferric enzyme heme iron

scientific article published in 2001

Comparison of the effects of selective inhibition of thromboxane synthase with those of inhibition of the cyclooxygenase enzyme in man.

scientific article published in 1984

Conjugated triene metabolites of arachidonic acid derived from dioxygenation at carbon-15: origin from eosinophil and mechanisms of biosynthesis

scientific article published on January 1, 1983

Control of oxygenation in lipoxygenase and cyclooxygenase catalysis

scientific article published in 2007

Control of prostaglandin stereochemistry at the 15-carbon by cyclooxygenases-1 and -2. A critical role for serine 530 and valine 349

scientific article in 2002

Coordination modes of tyrosinate-ligated catalase-type heme enzymes: magnetic circular dichroism studies of Plexaura homomalla allene oxide synthase, Mycobacterium avium ssp. paratuberculosis protein-2744c, and bovine liver catalase in their ferric

scientific article published in 2011

Crystal structure of a lipoxygenase in complex with substrate: the arachidonic acid-binding site of 8R-lipoxygenase.

scientific article in 2014

Cytochrome P450-dependent transformations of 15R- and 15S-hydroperoxyeicosatetraenoic acids: stereoselective formation of epoxy alcohol products

scientific article in 1996

Cytochrome P450-type Hydroxylation and Epoxidation in a Tyrosine-liganded Hemoprotein, Catalase-related Allene Oxide Synthase ⬇️

scientific article published on May 24, 2012

Demonstration of HNE-related aldehyde formation via lipoxygenase-catalyzed synthesis of a bis-allylic dihydroperoxide intermediate

scientific article published in 2013

Derivatization and analysis of leukotrienes by desorption-chemical ionization mass spectrometry at subnanomole level

scientific article in 1983

Detection and cellular localization of 12R-lipoxygenase in human tonsils

scientific article in 2001

Detection and subcellular localization of two 15S-lipoxygenases in human cornea

scientific article in 2005

Detection of the 15-acetate of prostaglandin E2 methyl ester as a prominent component of the prostaglandins in the gorgonian coral Plexaura homomalla

scientific article published in 2002

Detection, assay, and isolation of allene oxide synthase

scientific article in 1996

Differential Expression of Genes in the Endometrium at Implantation: Upregulation of a Novel Member of the E2 Class of Ubiquitin-Conjugating Enzymes1

scholar article in 2003

Differential effects of lipoxygenase products on FMLP and LTB4 evoked neutrophil aggregation

scientific article in 1985

Dioxygenase activity of epidermal lipoxygenase-3 unveiled: typical and atypical features of its catalytic activity with natural and synthetic polyunsaturated fatty acids

scientific article in 2010

Dioxygenase and leukotriene A synthase activities of arachidonate 5- and 12-lipoxygenases purified from porcine leukocytes

scientific article in 1987

Discovery of 5R-lipoxygenase activity in oocytes of the surf clam, Spisula solidissima ⬇️

scientific article published on June 2, 1997

Discovery of a second 15S-lipoxygenase in humans

scientific article in 1997

Eggs of the sea urchin, Strongylocentrotus purpuratus, contain a prominent (11R) and (12R) lipoxygenase activity

scientific article in 1987

Elevated expression of 12/15-lipoxygenase and cyclooxygenase-2 in a transgenic mouse model of prostate carcinoma ⬇️

scientific article published on May 1, 2003

Enantiomeric separation of hydroxy and hydroperoxy eicosanoids by chiral column chromatography

scientific article published in 2007

Enantiomeric separation of hydroxy eicosanoids by chiral column chromatography: effect of the alcohol modifier

scientific article published in 2000

Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man ⬇️

scientific article published on March 1, 1983

Endogenous prostacyclin and Thromboxane biosynthesis during chronic Vitamin E therapy in man.

scientific article published in 1982

Endogenous prostacyclin biosynthesis and platelet function during selective inhibition of thromboxane synthase in man.

scientific article in 1983

Endogenous prostacyclin production in human pregnancy.

book chapter

Endometrial prostaglandins and phospholipase activity related to implantation in rabbits: effects of dexamethasone

scientific article in 1984

Enhancement of chemotactic factor-stimulated neutrophil oxidative metabolism by leukotriene B4 ⬇️

scientific article published on October 1, 1984

Enzymatic lipid peroxidation: a step in the breakdown of mitochondria during the maturation of red blood cells

scientific article in 1988

Enzymatic synthesis of a bicyclobutane fatty acid by a hemoprotein lipoxygenase fusion protein from the cyanobacterium Anabaena PCC 7120.

scholarly article

Epidermal lipoxygenase products of the hepoxilin pathway selectively activate the nuclear receptor PPARalpha

scientific article in 2007

Epoxide hydrolase 3 (Ephx3) gene disruption reduces ceramide linoleate epoxide hydrolysis and impairs skin barrier function

scientific article published on 17 December 2020

Epoxide intermediates in the lipoxygenase metabolism of polyunsaturated lipids

book chapter

Estimated rate of prostacyclin secretion into the circulation of normal man

scientific article in 1981

Evidence for a lipoxygenase mechanism in the biosynthesis of epoxide and dihydroxy leukotrienes from 15(S)-hydroperoxyicosatetraenoic acid by human platelets and porcine leukocytes ⬇️

scientific article published on May 1, 1983

Evidence for an ionic intermediate in the transformation of fatty acid hydroperoxide by a catalase-related allene oxide synthase from the Cyanobacterium Acaryochloris marina

scientific article in 2009

Evidence of a cyclooxygenase-related prostaglandin synthesis in coral. The allene oxide pathway is not involved in prostaglandin biosynthesis

scientific article published in 1999

Expression of a Flax Allene Oxide Synthase cDNA Leads to Increased Endogenous Jasmonic Acid (JA) Levels in Transgenic Potato Plants but Not to a Corresponding Activation of JA-Responding Genes

scientific article

Formation of 4-hydroxynonenal from cardiolipin oxidation: Intramolecular peroxyl radical addition and decomposition ⬇️

scientific article published on January 1, 2011

Formation of a cyclopropyl eicosanoid via an allene oxide in the coral Plexaura homomalla: Implications for the biosynthesis of 5,6-trans-prostaglandin A2

scientific article published in 1989

Formation of a cyclopropyl epoxide via a leukotriene A synthase-related pathway in an anaerobic reaction of soybean lipoxygenase-1 with 15S-hydroperoxyeicosatetraenoic acid: evidence that oxygen access is a determinant of secondary reactions [...]

scientific article in 2010

Formation of a novel dihydroxy acid from arachidonic acid by lipoxygenase-catalyzed double oxygenation in rat mononuclear cells and human leukocytes.

scientific article in 1982

Formation of an allene oxide from (8R)-8-hydroperoxy-eicosatetraenoic acid in the coral Plexaura homomalla.

scientific article published in 1989

Formation of epoxyalcohols by a purified allene oxide synthase. Implications for the mechanism of allene oxide synthesis

scientific article published in 1993

Formation of lipoxin B by the pure reticulocyte lipoxygenase via sequential oxygenation of the substrate

scientific article in 1987

Formation of prostaglandin A analogues via an allene oxide

scientific article published in 1990

Functional expression and cellular localization of a mouse epidermal lipoxygenase

scientific journal article in 1996

GC-MS Analysis of urinary metabolites of eicosanoids

book chapter

High-performance liquid chromatography for chiral analysis of eicosanoids

scientific article published in 1990

Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin

scientific article in 2006

Human cyclo-oxygenase-1 and an alternative splice variant: contrasts in expression of mRNA, protein and catalytic activities

scientific article published in 2005

Identification and characterization of an arachidonate 11R-lipoxygenase.

scientific article published in 2005

Identification of Two Cyclooxygenase Active Site Residues, Leucine 384 and Glycine 526, That Control Carbon Ring Cyclization in Prostaglandin Biosynthesis ⬇️

scientific article published on October 31, 2003

Identification of a Naturally Occurring Peroxidase-Lipoxygenase Fusion Protein ⬇️

scientific article published on September 26, 1997

Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2

scientific article in 2000

Identification of lipoxygenase products from arachidonic acid metabolism in stimulated murine eosinophils

scientific article in 1983

Identification of the peroxidation products of 13-hydroxy-gamma-linolenate and 15-hydroxyarachidonate: mechanistic studies on the formation of leukotriene-like diols

scientific article in 2007

Incorporation of 12(S)-hydroxyeicosatetraenoic acid into the phosphatidylcholine signaling pathway

scientific article in 1996

Increased Prostacyclin Biosynthesis in Patients with Severe Atherosclerosis and Platelet Activation ⬇️

scientific article published on April 26, 1984

Increased prostaglandin production in ulcerative colitis

scientific article in 1977

Induction of apoptosis in colorectal carcinoma cells treated with 4-hydroxy-2-nonenal and structurally related aldehydic products of lipid peroxidation

scientific article published in 2004

Influence of selenium status on activity of phospholipid hydroperoxide glutathione peroxidase in rat liver and testis in comparison with other selenoproteins

scientific article published in 1996

Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors

scientific article published in 2002

Inhibitory effects of a novel Val to Thr mutation on the distal heme of human catalase

scientific article published in 2014

Insights from the X-ray crystal structure of coral 8R-lipoxygenase: calcium activation via a C2-like domain and a structural basis of product chirality

scientific article in 2005

Interleukin-4 induces 15-lipoxygenase-1 expression in human orbital fibroblasts from patients with Graves disease. Evidence for anatomic site-selective actions of Th2 cytokines.

scientific article published in 2006

Intermolecular peroxyl radical reactions during autoxidation of hydroxy and hydroperoxy arachidonic acids generate a novel series of epoxidized products

scientific article published in 2008

Intravenous prostacyclin in thrombotic thrombocytopenia Purpura

book chapter

Investigation of a second 15S-lipoxygenase in humans and its expression in epithelial tissues

scientific article in 1999

Investigation of a second 15S-lipoxygenase in humans and its expression in epithelial tissues.

book chapter

Investigation of substrate binding and product stereochemistry issues in two linoleate 9-lipoxygenases

scientific article in 2008

Investigation of the allene oxide pathway in the coral Plexaura homomalla: Formation of novel ketols and isomers of prostaglandin A2 from 15-hydroxyeicosatetraenoic acid ⬇️

scientific article published on November 1, 1991

Investigation of the chemical conversion of hydroperoxyeicosatetraenoate to leukotriene epoxide using stereospecifically labeled arachidonic acid. Comparison with the enzymatic reaction

scientific article in 1985

Investigation of the mechanism of biosynthesis of 8-hydroxyeicosatetraenoic acid in mouse skin.

scientific article published in 1991

Investigation of the oxygenation of phospholipids by the porcine leukocyte and human platelet arachidonate 12-lipoxygenases

scientific article published in 1993

Investigation of the selectivity of hydrogen abstraction in the nonenzymatic formation of hydroxyeicosatetraenoic acids and leukotrienes by autoxidation

scientific article in 1985

Investigations of the biological activity of leukotriene A4 in human polymorphonuclear leukocytes

scientific article in 1985

Isolation and characterization of natural allene oxides: unstable intermediates in the metabolism of lipid hydroperoxides

scientific article in 1988

Isolation and characterization of two geometric allene oxide isomers synthesized from 9S-hydroperoxylinoleic acid by cytochrome P450 CYP74C3: stereochemical assignment of natural fatty acid allene oxides

scientific article published in 2013

Lipidomic and transcriptional analysis of the linoleoyl-omega-hydroxyceramide biosynthetic pathway in human psoriatic lesions

scientific article published in 2021

Lipoxin syntheses by arachidonate 12- and 5-lipoxygenases purified from porcine leukocytes

scientific article in 1988

Lipoxin synthesis by arachidonate 12-and 5-lipoxygenases purified from porcine leukocytes.

book chapter

Lipoxin synthesis by arachidonate 12-lipoxygenase purified from porcine leukocytes

scientific article in 1987

Lipoxygenase catalyzed oxygenation of hydroxy fatty acids to lipoxins

scientific article in 1988

Lipoxygenase catalyzed oxygenation of hydroxy fatty acids to lipoxins

book chapter

Lipoxygenase metabolism of endogenous and exogenous arachidonate in leukocytes: GC-MS analyses of incubations in H2(18)O buffers

scientific article in 1986

Lipoxygenase metabolism of polyunsaturated fatty acids in oocytes of the frog Xenopus laevis

scientific article in 1989

Lipoxygenase-catalyzed formation of R-configuration hydroperoxides

scientific article in 2002

Lipoxygenase-catalyzed transformation of epoxy fatty acids to hydroxy-endoperoxides: a potential P450 and lipoxygenase interaction ⬇️

scientific article in 2014

Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope

scientific article in 2011

Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate

scientific article in1999

Mammalian Arachidonate 12-Lipoxygenases ⬇️

scientific article published on January 1, 1997

Measurement of 5,8,11, 14-icosatetraynoic acid in plasma by gas-liquid chromatography ⬇️

scientific article published on March 1, 1981

Measurement of urinary 2,3-dinor-thromboxane B2 and thromboxane B2 using bonded-phase phenylboronic acid columns and capillary gas chromatography--negative-ion chemical ionization mass spectrometry

scientific article in 1985

Mechanism of biosynthesis of 11R-and 12R-hydroxyeicosatetraenoic acids by eggs of the sea urchin Strongylocentrotus purpuratus

scientific article in 1989

Mechanism of transformation of 15(S)-hydroperoxyeicosatetraenoic acid to 15-series leukotrienes by purified porcine leukocyte 12-lipoxygenase

scientific article in 1987

Mechanistic aspects of CYP74 allene oxide synthases and related cytochrome P450 enzymes

scientific article in 2009

Mechanistic studies of the dioxygenase and leukotriene synthase activities of the porcine leukocyte 12S-lipoxygenase

scientific article published in 1989

Metabolic disposition of prostacyclin in humans ⬇️

scientific article published on July 1, 1983

Metabolic fate of thromboxane A2 and prostacyclin

scientific article published on January 1, 1982

Metabolic fate of thromboxane A2 and prostacyclin.

book chapter

Metabolism of linoleic and arachidonic acids in VX2 carcinoma tissue: identification of monohydroxy octadecadienoic acids and monohydroxy eicosatetraenoic acids

scientific article in 1980

Metabolite measurement as an index of prostaglandin biosynthesis in vivo

book chapter

Modulation of human neutrophil function by monohydroxy-eicosatetraenoic acids ⬇️

scientific article published on April 1, 1980

Molecular Cloning and Functional Expression of a Phorbol Ester-inducible 8S-Lipoxygenase from Mouse Skin ⬇️

scientific article published on September 26, 1997

Molecular Cloning of a Second Human 15S-Lipoxygenase and Its Murine Homologue, an 8S-Lipoxygenase: Their Relationship to Other Mammalian Lipoxygenases

book chapter

Molecular cloning of a second human 15S-lipoxygenase and its murine homologue, an 8S-lipoxygenase. Their relationship to other mammalian lipoxygenases.

scientific article in 1999

Molecular cloning of an allene oxide synthase: a cytochrome P450 specialized for the metabolism of fatty acid hydroperoxides

scientific article published in 1993

Molecular dynamics simulations of arachidonic acid-derived pentadienyl radical intermediate complexes with COX-1 and COX-2: insights into oxygenation regio- and stereoselectivity

scientific article in 2006

Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3

scientific article in 2005

Non-cyclooxygenase prostaglandin biosynthesis: Formation of PGA3 isomers via an allene oxide

book chapter

Novel leukotrienes and lipoxygenase product from rat mononuclear cells

book chapter

Novel leukotrienes and lipoxygenase products from arachidonic acid

scientific article published on January 1, 1982

Novel transformations of HPETEs by cytochrome P450s

scientific article published in 1994

Novel transformations of HPETEs by cytochrome P450s

book chapter

Occurrence of lipoxygenase products in membranes of rabbit reticulocytes. Evidence for a role of the reticulocyte lipoxygenase in the maturation of red cells

scientific article published in1990

Omega-3 fatty acids are oxygenated at the n-7 carbon by the lipoxygenase domain of a fusion protein in the cyanobacterium Acaryochloris marina

scientific article published in 2009

On non-cyclooxygenase prostaglandin synthesis in the sea whip coral, Plexaura homomalla: an 8(R)-lipoxygenase pathway leads to formation of an alpha-ketol and a Racemic prostanoid

scientific article in 1987

On singular or dual positional specificity of lipoxygenases. The number of chiral products varies with alignment of methylene groups at the active site of the enzyme

scientific article published on 01 September 1990

On the basis for the positional specificity and stereo specificity of lipoxygenases

book chapter

On the evolutionary origin of cyclooxygenase (COX) isozymes: characterization of marine invertebrate COX genes points to independent duplication events in vertebrate and invertebrate lineages.

scientific article in 2004

On the mechanism of biosynthesis of 5- and 15-series leukotrienes ⬇️

scientific article published on September 1, 1984

On the relationship of coral allene oxide synthase to catalase. A single active site mutation that induces catalase activity in coral allene oxide synthase.

scientific article published in 2006

On the relationships of substrate orientation, hydrogen abstraction, and product stereochemistry in single and double dioxygenations by soybean lipoxygenase-1 and its Ala542Gly mutant

scientific article in 2005

On the role of molecular oxygen in lipoxygenase activation: comparison and contrast of epidermal lipoxygenase-3 with soybean lipoxygenase-1. ⬇️

scientific article in 2010

Oxidation of C18 Hydroxy-Polyunsaturated Fatty Acids to Epoxide or Ketone by Catalase-Related Hemoproteins Activated with Iodosylbenzene.

scientific article published in 2017

Oxygenation of biological membranes by the pure reticulocyte lipoxygenase

scientific article published in 1990

PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis

scientific article published in 2017

Pharmacokinetics of indomethacin in premature infants with symptomatic patient ductus arteriosus

book chapter

Pharmacokinetics of indomethacin in the neonate. Relation of plasma indomethacin levels to response of the ductus arteriosus

scientific article in 1981

Preparation and assay of monohydroxy-eicosatetraenoic acids

scientific article in 1980

Proceedings: Applications of liquid-gel partition chromatography in the prostaglandin field

scientific article in 1974

Prostacyclin production during pregnancy: comparison of production during normal pregnancy and pregnancy complicated by hypertension

scientific article in 1982

Prostaglandin D2 is released during acute allergic bronchospasm in man

scientific article in 1985

Purification and catalytic activities of the two domains of the allene oxide synthase-lipoxygenase fusion protein of the coral Plexaura homomalla

scientific article in 1999

Purification and characterization of recombinant histidine-tagged human platelet 12-lipoxygenase expressed in a baculovirus/insect cell system

scientific article in 1993

Purification and molecular cloning of an 8R-lipoxygenase from the coral Plexaura homomalla reveal the related primary structures of R- and S-lipoxygenases

scientific article published in 1996

Purification of an allene oxide synthase and identification of the enzyme as a cytochrome P-450.

scientific article in 1991

Purification, molecular cloning, and expression of the gene encoding fatty acid 13-hydroperoxide lyase from guava fruit (Psidium guajava)

scientific article in 2000

Quantitation of Urinary Prostacyclin Metabolites in Man: Estimates of the rate of Secretion of Prostacyclin into the general circulation.

book chapter

Quantitation of the major urinary metabolite of PGF2 alpha in the human by GC-MS

scientific article in 1982

Quantitation of two dinor metabolites of prostacyclin by GC-MS

scientific article in 1982

Quantitative analysis of two dinor urinary metabolites of prostaglandin I2

scientific article in 1981

Quantitative aspects of prostacyclin metabolism in humans

scientific article published on January 1, 1983

Quantitative determination of the major metabolite of prostaglandins F1alpha and F2alpha in human urine by stable isotope dilution and combined gas chromatography--mass spectrometry

scientific article published on August 1, 1976

Rabbit reticulocyte lipoxygenase catalyzes specific 12(S) and 15(S) oxygenation of arachidonoyl-phosphatidylcholine

scientific article published in 1988

Reduced 15-lipoxygenase-2 immunostaining in prostate adenocarcinoma: correlation with grade and expression in high-grade prostatic intraepithelial neoplasia

scientific article in 2000

Release of prostaglandin D2 into human airways during acute antigen challenge

scientific article published in1986

Resolution of enantiomers of hydroxyeicosatetraenoate derivatives by chiral phase high-pressure liquid chromatography.

scientific article in 1988

Revising the structure of a new eicosanoid from human platelets to 8,9-11,12-diepoxy-13-hydroxyeicosadienoic acid.

scientific article published in 2019

Robust inhibitory effects of conjugated linolenic acids on a cyclooxygenase-related linoleate 10S-dioxygenase: Comparison with COX-1 and COX-2.

scientific article published in 2015

Role of an 8-Lipoxygenase in the Maturation of Starfish Oocytes

book chapter

Role of the conserved distal heme asparagine of coral allene oxide synthase (Asn137) and human catalase (Asn148): mutations affect the rate but not the essential chemistry of the enzymatic transformations

scientific article published in 2008

Routes to 4-hydroxynonenal: fundamental issues in the mechanisms of lipid peroxidation

scientific article in 2008

SDR9C7 catalyzes critical dehydrogenation of acylceramides for skin barrier formation

scientific article published on 01 February 2020

Site-directed mutagenesis studies on a putative fifth iron ligand of mouse 8S-lipoxygenase: retention of catalytic activity on mutation of serine-558 to asparagine, histidine, or alanine

scientific article published in 2001

Specific lipoxygenase attack on arachidonate and linoleate esterified in phosphatidylcholine: Precedent for an alternative mechanism in activation of icosanoid biosynthesis

book chapter

Specific lipoxygenase attack on arachidonate and linoleate esterified in phosphatidylcholine: precedent for an alternative mechanism in activation of icosanoid biosynthesis

scientific article in 1985

Specific short-chain aldehydes are cleavage products of the transformation of arachidonic acid to hydroperoxyeicosatetraenoic acids and leukotrienes

scientific article in 1987

Stereocontrolled synthesis of four isomeric linoleate triols of relevance to skin barrier formation and function

scientific article published in 2018

Stereoselective hydrogen abstraction in leukotriene A4 synthesis by purified 5-lipoxygenase of porcine leukocytes

scientific article in 1986

Stereospecific induction of starfish oocyte maturation by (8R)-hydroxyeicosatetraenoic acid

scientific article published in 1986

Stereospecific removal of the DR hydrogen atom at the 10-carbon of arachidonic acid in the biosynthesis of leukotriene A4 by human leukocytes ⬇️

scientific article published on November 25, 1982

Stereospecificity of hydrogen abstraction in the conversion of arachidonic acid to 15R-HETE by aspirin-treated cyclooxygenase-2. Implications for the alignment of substrate in the active site

scientific article in 2000

Steric analysis of epoxyalcohol and trihydroxy derivatives of 9-hydroperoxy-linoleic acid from hematin and enzymatic synthesis

scientific article published in 2013

Stimulation by lipoxygenase products of superoxide anion production in FMLP-treated neutrophils

scientific article in 1985

Straight phase separation of prostaglandin methyl esters on lipophilic gels ⬇️

scientific article published on March 10, 1974

Structural and functional comparison of 15S- and 15R-specific cyclooxygenases from the coral Plexaura homomalla

scientific article

Structure-function features of flaxseed allene oxide synthase

scientific article in 1995

Studies of prostaglandins and sulphasalazine in ulcerative colitis

scientific article in 1981

Synthesis and applications of stereospecifically (3)H-labeled arachidonic acids as mechanistic probes for lipoxygenase and cyclooxygenase catalysis

scientific article in 2000

Synthesis of 10(S)-Hydroxyeicosatetraenoic Acid: A Novel Cytochrome P-450 Metabolite of Arachidonic Acid

scientific article published in 1996

Synthesis of dihydroperoxides of linoleic and linolenic acids and studies on their transformation to 4-hydroperoxynonenal

scientific article published in 2005

Systemic prostaglandin I2 synthesis is normal in patients with Bartter's syndrome ⬇️

scientific article published on August 13, 1983

Systemic synthesis of prostaglandin I2 following sustained infusion of angiotensin II in conscious dogs

scientific article in 1986

The 1.85 Å Structure of an 8 R -Lipoxygenase Suggests a General Model for Lipoxygenase Product Specificity

scientific article in 2009

The 5-lipoxygenase and 15-lipoxygenase of neutrophils and eosinophils

scientific article published in January 1985

The Precise Structures and Stereochemistry of Trihydroxy-linoleates Esterified in Human and Porcine Epidermis and Their Significance in Skin Barrier Function: IMPLICATION OF AN EPOXIDE HYDROLASE IN THE TRANSFORMATIONS OF LINOLEATE.

scientific article published in 2016

The Structure of Human 5-Lipoxygenase ⬇️

scientific article published on January 14, 2011

The Thr-His Connection on the Distal Heme of Catalase-Related Hemoproteins: A Hallmark of Reaction with Fatty Acid Hydroperoxides

scientific article published in 2016

The VX-2 carcinoma: humoral effects and arachidonic acid metabolism

scientific article in 1980

The basis of prostaglandin synthesis in coral: molecular cloning and expression of a cyclooxygenase from the Arctic soft coral Gersemia fruticosa

scientific article in 2001

The discovery and early structural studies of arachidonic acid

scientific article published in 2016

The effect of indomethacin on the biosynthesis and metabolism of prostaglandin F2alpha in man

scientific article in 1978

The effects of saponins on the transporting epithelium of isolated frog skin ⬇️

scientific article published on November 1, 1970

The hepoxilin connection in the epidermis

scientific article in 2007

The identification of 5β,7α-dihydroxy-11-oxotetranor-prostane-1, 16-dioic acid as a urinary metabolite of prostaglandin F2α in the rat ⬇️

scientific article published on February 26, 1979

The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier

scientific article in 2014

The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase

scientific article in 2003

The origin of 15R-prostaglandins in the Caribbean coral Plexaura homomalla: molecular cloning and expression of a novel cyclooxygenase

scientific article

The structure and peroxidase activity of a 33-kDa catalase-related protein fromMycobacterium avium ssp.paratuberculosis

scientific article in 2009

The structure of coral allene oxide synthase reveals a catalase adapted for metabolism of a fatty acid hydroperoxide

scientific article in 2004

Two distinct pathways of formation of 4-hydroxynonenal. Mechanisms of nonenzymatic transformation of the 9- and 13-hydroperoxides of linoleic acid to 4-hydroxyalkenals

scientific article in 2001

Upregulation of 8-lipoxygenase in the dermatitis of IkappaB-alpha-deficient mice

scientific article published in 2004

mechanism of rearrangement of vinyl allene oxides to 2-cyclopenten-1-one

book chapter

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