List of works - James W. Fawcett

6-Sulphated chondroitins have a positive influence on axonal regeneration

scientific article (publication date: 2011)

A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells

scientific article (publication date: 5 May 2006)

A potential role for bone morphogenetic protein signalling in glial cell fate determination following adult central nervous system injury in vivo

scientific journal article

Adaptation of tape removal test for measurement of sensitivity in perineal area of rat

scientific article published on 09 November 2019

Age-related loss of axonal regeneration is reflected by the level of local translation

scientific article published on 13 January 2021

Aggrecan Directs Extracellular Matrix-Mediated Neuronal Plasticity.

scientific article published on 3 October 2018

Alpha9 integrin promotes neurite outgrowth on tenascin-C and enhances sensory axon regeneration

scientific journal article

An integrin approach to axon regeneration.

scientific article published on 23 December 2016

Antibody recognizing 4-sulfated chondroitin sulfate proteoglycans restores memory in tauopathy-induced neurodegeneration. ⬇️

scientific article published on 9 August 2017

Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression ⬇️

scientific article

Astrocyte-produced ephrins inhibit schwann cell migration via VAV2 signaling

scientific journal article

Axonal plasticity underpins the functional recovery following surgical decompression in a rat model of cervical spondylotic myelopathy

scientific article published on 23 August 2016

Axonal protein synthesis and degradation are necessary for efficient growth cone regeneration

scientific article

Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory. ⬇️

scientific article published on 28 June 2017

Building a bridge: engineering spinal cord repair

scientific article

Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans?

scientific article published on May 2007

Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity. ⬇️

scientific article

Chondroitin sulphate proteoglycans in the CNS injury response

scientific article

Chondroitinase ABC promotes functional recovery after spinal cord injury

scientific article (publication date: 11 April 2002)

Chondroitinase improves anatomical and functional outcomes after primate spinal cord injury

scientific article published on 24 June 2019

Chronic spinal hemisection in rats induces a progressive decline in transmission in uninjured fibers to motoneurons

scientific article

Composition of perineuronal net extracellular matrix in rat brain: a different disaccharide composition for the net-associated proteoglycans

scientific journal article

Differential regenerative ability of sensory and motor neurons.

scientific article published on 3 November 2016

Distribution and synthesis of extracellular matrix proteoglycans, hyaluronan, link proteins and tenascin-R in the rat spinal cord

scientific journal article

Dorsal Root Ganglion Injection and Dorsal Root Crush Injury as a Model for Sensory Axon Regeneration.

scientific article published on 3 May 2017

EFA6 regulates selective polarised transport and axon regeneration from the axon initial segment.

scientific article published on 21 September 2017

Identification of unique reciprocal and non reciprocal cross packaging relationships between HIV-1, HIV-2 and SIV reveals an efficient SIV/HIV-2 lentiviral vector system with highly favourable features for in vivo testing and clinical usage

scientific article

Inhibition of Semaphorin3A Promotes Ocular Dominance Plasticity in the Adult Rat Visual Cortex

scientific article published on 31 January 2019

Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts.

scientific article

Integrins promote axonal regeneration after injury of the nervous system.

scientific article published on 15 February 2018

Intrinsic Determinants of Axon Regeneration

article

Mechanical difference between white and gray matter in the rat cerebellum measured by scanning force microscopy.

scientific article

Mesenchymal stromal cells integrate and form longitudinally-aligned layers when delivered to injured spinal cord via a novel fibrin scaffold

scientific article

Motoneurons derived from induced pluripotent stem cells develop mature phenotypes typical of endogenous spinal motoneurons

scientific article

NG2 expression in glioblastoma identifies an actively proliferating population with an aggressive molecular signature.

scientific article

NOS1AP associates with Scribble and regulates dendritic spine development.

scientific article

Nck adaptor proteins control the organization of neuronal circuits important for walking

scientific article

Neurochemical biomarkers in spinal cord injury

scientific article published on 04 July 2019

Neuronal Pentraxin 2 Binds PNNs and Enhances PNN Formation

scientific article published on 20 October 2019

Optimization of adeno-associated viral vector-mediated transduction of the corticospinal tract: comparison of four promoters

scientific article published on 23 June 2020

PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS

scientific article published on 17 June 2020

Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration

scientific article

Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology

scientific article

Proteoglycans and brain repair.

scientific article published on February 2004

Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization

scientific article

Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS

scientific article published on 05 November 2020

Recent advances in the therapeutic uses of chondroitinase ABC

scientific article published on 06 August 2019

Regional Regulation of Purkinje Cell Dendritic Spines by Integrins and Eph/Ephrins.

scientific article

Retinal glia promote dorsal root ganglion axon regeneration

scientific article published on 27 March 2015

Secretion of a mammalian chondroitinase ABC aids glial integration at PNS/CNS boundaries

scientific article published on 09 July 2020

Selective rab11 transport and the intrinsic regenerative ability of CNS axons. ⬇️

scientific article

Subcellular profiling reveals distinct and developmentally regulated repertoire of growth cone mRNAs.

scientific article

Substrate Specificity and Biochemical Characteristics of an Engineered Mammalian Chondroitinase ABC

scientific article published on 19 April 2021

Synaptopodin-2 induces assembly of peripheral actin bundles and immature focal adhesions to promote lamellipodia formation and prostate cancer cell migration

scientific article

Targeting Chondroitin Sulfate Glycosaminoglycans to Treat Cardiac Fibrosis in Pathological Remodeling.

scientific article

Targeting chondroitinase ABC to axons enhances the ability of chondroitinase to promote neurite outgrowth and sprouting

scientific article published on 21 January 2020

The Paper that Restarted Modern Central Nervous System Axon Regeneration Research

scientific article published on 01 May 2018

The Struggle to Make CNS Axons Regenerate: Why Has It Been so Difficult?

scientific article published on 06 August 2019

The challenge of recruitment for neurotherapeutic clinical trials in spinal cord injury

scientific article published on 08 April 2019

The kinesin-2 family member KIF3C regulates microtubule dynamics and is required for axon growth and regeneration

scientific journal article

The role of chondroitin sulfate proteoglycans in regeneration and plasticity in the central nervous system

scientific article

The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function

scientific article published on 01 July 2019

Trafficking and processing of bacterial proteins by mammalian cells: Insights from chondroitinase ABC.

scientific article published on 9 November 2017

Versican is upregulated in CNS injury and is a product of oligodendrocyte lineage cells

scientific journal article

List of works by James W. Fawcett

6-Sulphated chondroitins have a positive influence on axonal regeneration

A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells

A potential role for bone morphogenetic protein signalling in glial cell fate determination following adult central nervous system injury in vivo

Adaptation of tape removal test for measurement of sensitivity in perineal area of rat

Age-related loss of axonal regeneration is reflected by the level of local translation

Aggrecan Directs Extracellular Matrix-Mediated Neuronal Plasticity.

Alpha9 integrin promotes neurite outgrowth on tenascin-C and enhances sensory axon regeneration

An integrin approach to axon regeneration.

Antibody recognizing 4-sulfated chondroitin sulfate proteoglycans restores memory in tauopathy-induced neurodegeneration. ⬇️

Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression ⬇️

Astrocyte-produced ephrins inhibit schwann cell migration via VAV2 signaling

Axonal plasticity underpins the functional recovery following surgical decompression in a rat model of cervical spondylotic myelopathy

Axonal protein synthesis and degradation are necessary for efficient growth cone regeneration

Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory. ⬇️

Building a bridge: engineering spinal cord repair

Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans?

Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity. ⬇️

Chondroitin sulphate proteoglycans in the CNS injury response

Chondroitinase ABC promotes functional recovery after spinal cord injury

Chondroitinase improves anatomical and functional outcomes after primate spinal cord injury

Chronic spinal hemisection in rats induces a progressive decline in transmission in uninjured fibers to motoneurons

Composition of perineuronal net extracellular matrix in rat brain: a different disaccharide composition for the net-associated proteoglycans

Differential regenerative ability of sensory and motor neurons.

Distribution and synthesis of extracellular matrix proteoglycans, hyaluronan, link proteins and tenascin-R in the rat spinal cord

Dorsal Root Ganglion Injection and Dorsal Root Crush Injury as a Model for Sensory Axon Regeneration.

EFA6 regulates selective polarised transport and axon regeneration from the axon initial segment.

Identification of unique reciprocal and non reciprocal cross packaging relationships between HIV-1, HIV-2 and SIV reveals an efficient SIV/HIV-2 lentiviral vector system with highly favourable features for in vivo testing and clinical usage

Inhibition of Semaphorin3A Promotes Ocular Dominance Plasticity in the Adult Rat Visual Cortex

Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts.

Integrins promote axonal regeneration after injury of the nervous system.

Intrinsic Determinants of Axon Regeneration

Mechanical difference between white and gray matter in the rat cerebellum measured by scanning force microscopy.

Mesenchymal stromal cells integrate and form longitudinally-aligned layers when delivered to injured spinal cord via a novel fibrin scaffold

Motoneurons derived from induced pluripotent stem cells develop mature phenotypes typical of endogenous spinal motoneurons

NG2 expression in glioblastoma identifies an actively proliferating population with an aggressive molecular signature.

NOS1AP associates with Scribble and regulates dendritic spine development.

Nck adaptor proteins control the organization of neuronal circuits important for walking

Neurochemical biomarkers in spinal cord injury

Neuronal Pentraxin 2 Binds PNNs and Enhances PNN Formation

Optimization of adeno-associated viral vector-mediated transduction of the corticospinal tract: comparison of four promoters

PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS

Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration

Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology

Proteoglycans and brain repair.

Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization

Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS

Recent advances in the therapeutic uses of chondroitinase ABC

Regional Regulation of Purkinje Cell Dendritic Spines by Integrins and Eph/Ephrins.

Retinal glia promote dorsal root ganglion axon regeneration

Secretion of a mammalian chondroitinase ABC aids glial integration at PNS/CNS boundaries

Selective rab11 transport and the intrinsic regenerative ability of CNS axons. ⬇️

Subcellular profiling reveals distinct and developmentally regulated repertoire of growth cone mRNAs.

Substrate Specificity and Biochemical Characteristics of an Engineered Mammalian Chondroitinase ABC

Synaptopodin-2 induces assembly of peripheral actin bundles and immature focal adhesions to promote lamellipodia formation and prostate cancer cell migration

Targeting Chondroitin Sulfate Glycosaminoglycans to Treat Cardiac Fibrosis in Pathological Remodeling.

Targeting chondroitinase ABC to axons enhances the ability of chondroitinase to promote neurite outgrowth and sprouting

The Paper that Restarted Modern Central Nervous System Axon Regeneration Research

The Struggle to Make CNS Axons Regenerate: Why Has It Been so Difficult?

The challenge of recruitment for neurotherapeutic clinical trials in spinal cord injury

The kinesin-2 family member KIF3C regulates microtubule dynamics and is required for axon growth and regeneration

The role of chondroitin sulfate proteoglycans in regeneration and plasticity in the central nervous system

The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function

Trafficking and processing of bacterial proteins by mammalian cells: Insights from chondroitinase ABC.

Versican is upregulated in CNS injury and is a product of oligodendrocyte lineage cells