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List of works by Mark H. Tuszynski

A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program

scientific article

A Unilateral Cervical Spinal Cord Contusion Injury Model in Non-Human Primates (Macaca mulatta).

scientific article published on 20 January 2016

A form of motor cortical plasticity that correlates with recovery of function after brain injury

scientific article

A novel inducible tyrosine kinase receptor to regulate signal transduction and neurite outgrowth.

scientific article published on September 2009

A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease

scientific article

A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium

scientific article published on May 2008

A shared neural ensemble links distinct contextual memories encoded close in time

scientific article

Activation of Intrinsic Growth State Enhances Host Axonal Regeneration into Neural Progenitor Cell Grafts

Adeno-Associated Viral Vector (Serotype 2)-Nerve Growth Factor for Patients With Alzheimer Disease: A Randomized Clinical Trial

scientific article published on 26 March 2018

Adult rat myelin enhances axonal outgrowth from neural stem cells.

scientific article

Age-related cognitive deficits in rhesus monkeys mirror human deficits on an automated test battery

scientific article

Analysis of the behavioral, cellular and molecular characteristics of pain in severe rodent spinal cord injury

scientific article published on 22 January 2016

Animal models of neurologic disorders: a nonhuman primate model of spinal cord injury.

scientific article published in April 2012

Association of early experience with neurodegeneration in aged primates

scientific article

Astrocytes migrate from human neural stem cell grafts and functionally integrate into the injured rat spinal cord

scientific article published on 15 January 2019

Axon regeneration through scars and into sites of chronic spinal cord injury

scientific article

Axonal Regeneration through Regions of Chondroitin Sulfate Proteoglycan Deposition after Spinal Cord Injury: A Balance of Permissiveness and Inhibition ⬇️

scientific article published on October 15, 2003

Axonal growth and connectivity from neural stem cell grafts in models of spinal cord injury

scientific article published on 05 April 2014

BDNF gene delivery within and beyond templated agarose multi-channel guidance scaffolds enhances peripheral nerve regeneration

scientific article published on 20 October 2016

Bilateral corticospinal projections arise from each motor cortex in the macaque monkey: a quantitative study

scientific article published in May 2004

Biomimetic 3D-printed scaffolds for spinal cord injury repair

scientific article published on 14 January 2019

Bone Marrow Stromal Cell Intraspinal Transplants Fail to Improve Motor Outcomes in a Severe Model of Spinal Cord Injury

scientific article published on 28 September 2015

Brain derived neurotrophic factor release from layer-by-layer coated agarose nerve guidance scaffolds

scientific article published on 21 February 2015

Cellular GDNF delivery promotes growth of motor and dorsal column sensory axons after partial and complete spinal cord transections and induces remyelination.

scientific article

Challenges to the report of Nogo antibody effects in primates

scientific article published on 01 November 2006

Characterizing the degradation of alginate hydrogel for use in multilumen scaffolds for spinal cord repair

scientific article published on 21 October 2015

Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury.

scientific article published on 02 August 2009

Cholinergic systems are essential for late-stage maturation and refinement of motor cortical circuits

scientific article

Chondroitinase improves anatomical and functional outcomes after primate spinal cord injury

scientific article published on 24 June 2019

Clinical trials in spinal cord injury

scientific article

Combinatorial therapy with neurotrophins and cAMP promotes axonal regeneration beyond sites of spinal cord injury.

scientific article published in July 2004

Combined intrinsic and extrinsic neuronal mechanisms facilitate bridging axonal regeneration one year after spinal cord injury.

scientific article published on October 2009

Comprehensive Monosynaptic Rabies Virus Mapping of Host Connectivity with Neural Progenitor Grafts after Spinal Cord Injury

scientific article published on 3 May 2017

Concepts and methods for the study of axonal regeneration in the CNS

scientific article

Conditioning lesions before or after spinal cord injury recruit broad genetic mechanisms that sustain axonal regeneration: superiority to camp-mediated effects.

scientific article published on 29 December 2011

Delivery of hyper-interleukin-6 to the injured spinal cord increases neutrophil and macrophage infiltration and inhibits axonal growth

scientific article published in December 2002

Development of a database for translational spinal cord injury research

scientific article

Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice

scientific article published on September 2013

Efficient Retrograde Neuronal Transduction Utilizing Self-complementary AAV1.

scientific article published in February 2008

Efficient retrograde neuronal transduction utilizing self-complementary AAV1

Endogenous neurogenesis replaces oligodendrocytes and astrocytes after primate spinal cord injury.

scientific article published in February 2006

Estradiol-induced modulation of estrogen receptor-beta and GABA within the adult neocortex: a potential transsynaptic mechanism for estrogen modulation of BDNF.

scientific article published in December 2006

Estrogen receptor-beta colocalizes extensively with parvalbumin-labeled inhibitory neurons in the cortex, amygdala, basal forebrain, and hippocampal formation of intact and ovariectomized adult rats.

scientific article

Extensive spinal decussation and bilateral termination of cervical corticospinal projections in rhesus monkeys

scientific article published on March 2009

Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury

scientific article

Freeze-dried agarose scaffolds with uniaxial channels stimulate and guide linear axonal growth following spinal cord injury.

scientific article published on 15 August 2005

Frontiers Of Spinal Cord And Spine Repair: Experimental Approaches for Repair of Spinal Cord Injury ⬇️

scientific article published on January 1, 2012

Gene therapy and cell transplantation for Alzheimer's disease and spinal cord injury

scientific article published in June 2004

Gene therapy for neurological disease

scientific article

Gene therapy, neurotrophic factors and spinal cord regeneration.

scientific article published on January 2012

Generation and post-injury integration of human spinal cord neural stem cells

scientific article published on 06 August 2018

Growth factor gene therapy for Alzheimer disease

scientific article

Growth factors and combinatorial therapies for CNS regeneration

scientific article published on 22 August 2007

Growth-factor gene therapy for neurodegenerative disorders

scientific article

Guest editorial: Opportunities in rehabilitation research.

scientific article

Guidance molecules in axon regeneration

scientific article published on 02 June 2010

Hierarchically Ordered Porous and High-Volume Polycaprolactone Microchannel Scaffolds Enhanced Axon Growth in Transected Spinal Cords

scientific article published on 20 January 2017

Hippocampal cell genesis does not correlate with spatial learning ability in aged rats.

scientific article

IGF-I gene delivery promotes corticospinal neuronal survival but not regeneration after adult CNS injury

scientific article published on 02 October 2008

Induction of bone marrow stromal cells to neurons: differentiation, transdifferentiation, or artifact?

scientific article

Induction of corticospinal regeneration by lentiviral trkB-induced Erk activation

scholarly article

Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts.

scientific article

Injured adult neurons regress to an embryonic transcriptional growth state

scientific article published on 15 April 2020

Introduction to neuroscience letters special issue: "Plasticity and regeneration after spinal cord injury".

scientific article published on 18 April 2017

Issues regarding gene therapy products for Parkinson's disease: the development of CERE-120 (AAV-NTN) as one reference point

scientific article published on January 2007

JNK3 perpetuates metabolic stress induced by Aβ peptides.

scientific article

Kinematic and EMG determinants in quadrupedal locomotion of a non-human primate (Rhesus).

scientific article published on 12 January 2005

Lesions of the Basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning

scientific article published on June 2003

Leveraging biomedical informatics for assessing plasticity and repair in primate spinal cord injury

scientific article published on 4 November 2014

Local and remote growth factor effects after primate spinal cord injury.

scientific article

Long-distance axonal growth from human induced pluripotent stem cells after spinal cord injury

scientific article

Long-distance growth and connectivity of neural stem cells after severe spinal cord injury.

scientific article

Long-term reversal of cholinergic neuronal decline in aged non-human primates by lentiviral NGF gene delivery

scientific article published on 25 October 2008

Low-density lipoprotein receptor-related protein 1 (LRP1)-dependent cell signaling promotes axonal regeneration

scientific article published on 18 July 2013

MR-guided delivery of AAV2-BDNF into the entorhinal cortex of non-human primates

scientific article published on 13 March 2018

Memory impairment in aged primates is associated with focal death of cortical neurons and atrophy of subcortical neurons.

scientific article published on May 2004

Methods for functional assessment after C7 spinal cord hemisection in the rhesus monkey.

scientific article

Molecular and Cellular Mechanisms of Axonal Regeneration After Spinal Cord Injury

scientific article published on 22 December 2015

Motor axonal regeneration after partial and complete spinal cord transection

scientific article

Motor cortex maturation is associated with reductions in recurrent connectivity among functional subpopulations and increases in intrinsic excitability

scientific article published in March 2015

Myelination of axons emerging from neural progenitor grafts after spinal cord injury

scientific article published on 8 July 2017

NG2 is a major chondroitin sulfate proteoglycan produced after spinal cord injury and is expressed by macrophages and oligodendrocyte progenitors.

scientific article published in April 2002

NGF is essential for hippocampal plasticity and learning

scientific article

NT-3 gene delivery elicits growth of chronically injured corticospinal axons and modestly improves functional deficits after chronic scar resection.

scientific article published in May 2003

Nerve Growth Factor Gene Therapy: Activation of Neuronal Responses in Alzheimer Disease

scientific article

Nerve growth factor gene delivery: animal models to clinical trials

scientific article published on August 2007

Nerve growth factor gene therapy for Alzheimer's disease

scientific article published in August 2002

Nerve growth factor gene therapy in Alzheimer disease

scientific article published on April 2007

Nerve growth factor is primarily produced by GABAergic neurons of the adult rat cortex

scientific article

Nerve growth factor: from animal models of cholinergic neuronal degeneration to gene therapy in Alzheimer's disease

scientific article

Netrin-1 is a novel myelin-associated inhibitor to axon growth.

scientific article

Neural Stem Cell Grafts Form Extensive Synaptic Networks that Integrate with Host Circuits after Spinal Cord Injury

scientific article published on 30 July 2020

Neural stem cell dissemination after grafting to CNS injury sites.

scientific article

Neural stem cells in models of spinal cord injury

scientific article published on 28 July 2014

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

scientific article

Neurotrophic factors, gene therapy, and neural stem cells for spinal cord repair

scientific article

Neurotrophin-3 gradients established by lentiviral gene delivery promote short-distance axonal bridging beyond cellular grafts in the injured spinal cord.

scientific article published in September 2006

Neurotrophins: potential therapeutic tools for the treatment of spinal cord injury.

scientific article published on October 2011

New strategies in neural repair.

scientific article

Nucleus hears axon's pain

scientific article published in March 2004

Olfactory ensheathing cells do not exhibit unique migratory or axonal growth-promoting properties after spinal cord injury.

scientific article

Oriented Nanofibrous Polymer Scaffolds Containing Protein-Loaded Porous Silicon Generated by Spray Nebulization.

scientific article published on 24 January 2018

Origins of Neural Progenitor Cell-Derived Axons Projecting Caudally after Spinal Cord Injury

scientific article published on 13 June 2019

Performance of locomotion and foot grasping following a unilateral thoracic corticospinal tract lesion in monkeys (Macaca mulatta).

scientific article

Peripheral nerve growth within a hydrogel microchannel scaffold supported by a kink-resistant conduit

scientific article published on 14 August 2017

Physical positioning markedly enhances brain transduction after intrathecal AAV9 infusion

scientific article published on 14 November 2018

Postmortem Analysis in a Clinical Trial of AAV2-NGF Gene Therapy for Alzheimer's Disease Identifies a Need for Improved Vector Delivery

scientific article published on 30 March 2020

Potential therapeutic uses of BDNF in neurological and psychiatric disorders ⬇️

scientific article published on March 1, 2011

Proceedings of the Meeting of the American Society for Neural Transplantation and Repair (ASNTR), 1999.

scientific article published in September 2000

Prolonged human neural stem cell maturation supports recovery in injured rodent CNS.

scientific article published on 21 August 2017

Promotion of survival and differentiation of neural stem cells with fibrin and growth factor cocktails after severe spinal cord injury

scientific article published on 27 July 2014

Pronounced species divergence in corticospinal tract reorganization and functional recovery after lateralized spinal cord injury favors primates.

scientific article published in August 2015

Rebuilding the brain: resurgence of fetal grafting

scientific article published on 01 October 2007

Regenerating Corticospinal Axons Innervate Phenotypically Appropriate Neurons within Neural Stem Cell Grafts

Regeneration of long-tract axons through sites of spinal cord injury using templated agarose scaffolds.

scientific article published on 17 June 2010

Regulated lentiviral NGF gene transfer controls rescue of medial septal cholinergic neurons

scientific article published on June 2005

Rehabilitation drives enhancement of neuronal structure in functionally relevant neuronal subsets

scientific article published on 22 February 2016

Reorganization of Recurrent Layer 5 Corticospinal Networks Following Adult Motor Training

scientific article published on 04 April 2019

Restorative effects of human neural stem cell grafts on the primate spinal cord

scientific article published on 26 February 2018

Rodent Neural Progenitor Cells Support Functional Recovery After Cervical Spinal Cord Contusion

scientific article published on 26 December 2017

Sexual dimorphism of detrusor function demonstrated by urodynamic studies in rhesus macaques

scientific article published on 30 September 2020

SnoN facilitates axonal regeneration after spinal cord injury

scientific article

Spinal cord injury elicits expression of keratan sulfate proteoglycans by macrophages, reactive microglia, and oligodendrocyte progenitors.

scientific article published in June 2002

Spinal cord injury: plasticity, regeneration and the challenge of translational drug development

scientific article published on 30 October 2008

Spinal cord reconstitution with homologous neural grafts enables robust corticospinal regeneration

scientific article published on 28 March 2016

Spontaneous and augmented growth of axons in the primate spinal cord: effects of local injury and nerve growth factor-secreting cell grafts

scientific article published in July 2002

Spontaneous and neurotrophin-induced axonal plasticity after spinal cord injury

scientific article

Stem cells: cross-talk and developmental programs

scientific article

Striatal delivery of CERE-120, an AAV2 vector encoding human neurturin, enhances activity of the dopaminergic nigrostriatal system in aged monkeys

scientific article

Structural plasticity within highly specific neuronal populations identifies a unique parcellation of motor learning in the adult brain ⬇️

scientific article published on January 21, 2011

Templated agarose scaffolds for the support of motor axon regeneration into sites of complete spinal cord transection

scientific article published on 23 November 2012

Templated agarose scaffolds support linear axonal regeneration

scientific article

Thalamocortical Projections onto Behaviorally Relevant Neurons Exhibit Plasticity during Adult Motor Learning

scientific article published on 2 March 2016

The ageless question--what accounts for age-related cognitive decline?

scientific article published on 12 May 2004

The basal forebrain cholinergic system is essential for cortical plasticity and functional recovery following brain injury

scientific article published in April 2005

The basal forebrain cholinergic system is required specifically for behaviorally mediated cortical map plasticity.

scientific article published in May 2009

The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury

scientific article (publication date: August 2003)

The fabrication and characterization of linearly oriented nerve guidance scaffolds for spinal cord injury

scientific article published on December 2004

Therapeutic potential of CERE-110 (AAV2-NGF): targeted, stable, and sustained NGF delivery and trophic activity on rodent basal forebrain cholinergic neurons

scientific article published on 19 March 2008

Therapeutic potential of nervous system growth factors for neurodegenerative disease

scientific article published on January 2002

Time Controlled Protein Release from Layer-by-Layer Assembled Multilayer Functionalized Agarose Hydrogels

scientific article

Time Controlled Release of Arabinofuranosylcytosine (Ara-C) from Agarose Hydrogels using Layer-by-Layer Assembly: An In Vitro Study ⬇️

scientific article published on January 28, 2011

Transcriptomic Approaches to Neural Repair

scientific article

Transgene expression, bioactivity, and safety of CERE-120 (AAV2-neurturin) following delivery to the monkey striatum

scientific article published on 26 August 2008

Transient demyelination increases the efficiency of retrograde AAV transduction

scientific article

Transient growth factor delivery sustains regenerated axons after spinal cord injury.

scientific article published in September 2007

Unconstrained three-dimensional reaching in rhesus monkeys

scientific article

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