List of works - Oliver Smithies

A Chinese G gamma + (A gamma delta beta)zero thalassemia deletion: comparison to other deletions in the human beta-globin gene cluster and sequence analysis of the breakpoints

scientific article published on September 1985

A DNA insulator prevents repression of a targeted X-linked transgene but not its random or imprinted X inactivation

scholarly article

A comprehensive set of sequence analysis programs for the VAX

scientific article

A dominant positive and negative selectable gene for use in mammalian cells ⬇️

scientific article published on December 1, 1991

A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice

scientific article

A gene deletion ending within a complex array of repeated sequences 3' to the human beta-globin gene cluster

scientific article published on July 1986

A genetically clamped renin transgene for the induction of hypertension

scientific article

A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathy

scientific article

A simplified chloral hydrate electrophoresis system for analysis of biological membranes

scientific article

Aberrant renal vascular morphology and renin expression in mutant mice lacking angiotensin-converting enzyme

scientific article

Abolition of male sexual behaviors in mice lacking estrogen receptors alpha and beta (alpha beta ERKO).

scientific article published in December 2000

Absence of Macrophage Inflammatory Protein-1α Prevents the Development of Blinding Herpes Stromal Keratitis ⬇️

scientific article published on May 1, 1998

Accurate modification of a chromosomal plasmid by homologous recombination in human cells

scientific article

Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in males

scholarly article

Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene

scientific article published on December 1993

Altering the expression in mice of genes by modifying their 3' regions

scientific article published on April 2004

Amino acids as modulators of endothelium-derived nitric oxide

scientific article published on 28 March 2006

Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney

scholarly article

Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway

scientific article

Angiotensin-converting enzyme and male fertility ⬇️

scientific article published on March 3, 1998

Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury

scholarly article

Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene

scholarly article

Causative Effects of Genetically Determined High Maternal/Fetal Endothelin-1 on Preeclampsia-Like Conditions in Mice

scientific article published on 2 April 2018

Characterization of Prostaglandin H Synthase 2 Deficient Mice and Implications for Mechanisms of NSAID Action ⬇️

scientific article published on January 1, 1997

Clones from the human gene complex coding for salivary proline-rich proteins ⬇️

scientific article published on September 1, 1984

Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2

scientific article published on December 1998

Complementation of reduced survival, hypotension, and renal abnormalities in angiotensinogen-deficient mice by the human renin and human angiotensinogen genes

scientific article published on March 1997

Components of the major urinary protein complex of inbred mice: determination of NH2-terminal sequences and comparison with homologous components from wild mice

scientific article published in April 1974

Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignment

scientific article

Correction of a human beta S-globin gene by gene targeting

scientific article published on May 1991

Correction of factor IX deficiency in mice by embryonic stem cells differentiated in vitro

scientific article

Cotransformation and gene targeting in mouse embryonic stem cells ⬇️

scientific article published on May 1, 1991

Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes

scientific article

Decreased beta-adrenergic responsiveness following hypertrophy occurs only in cardiomyocytes that also re-express beta-myosin heavy chain

scientific article published on July 2009

Deletion and replacement of the mouse adult beta-globin genes by a "plug and socket" repeated targeting strategy

scientific article published on October 1994

Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor

scholarly article

Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system

scientific article

Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo

scholarly article

Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system

scientific article published on April 2005

Disturbed homeostasis in sodium-restricted mice heterozygous and homozygous for aldosterone synthase gene disruption

scientific article

Double-strand gap repair in a mammalian gene targeting reaction

scientific article published on September 1991

Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel

scientific article

Early days of gel electrophoresis.

scientific article published on January 1995

Efficient transformation and frequent single-site, single-copy insertion of DNA can be obtained in mouse erythroleukemia cells transformed by electroporation.

scientific article

Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade

scientific article published on 6 April 2015

Enhanced atherosclerosis and kidney dysfunction in eNOS(-/-)Apoe(-/-) mice are ameliorated by enalapril treatment

scientific article

Estrogen inhibits the vascular injury response in estrogen receptor beta-deficient female mice

scientific article published on December 1999

Estrogen receptor alpha is a major mediator of 17beta-estradiol's atheroprotective effects on lesion size in Apoe-/- mice

scientific article

Evidence for a novel natriuretic peptide receptor that prefers brain natriuretic peptide over atrial natriuretic peptide

scientific article

Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene

scholarly article

Failure of ductus arteriosus closure and remodeling in neonatal mice deficient in cyclooxygenase-1 and cyclooxygenase-2.

scholarly article

Fibrosis, not cell size, delineates beta-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo

scholarly article

GRAF3 serves as a blood volume-sensitive rheostat to control smooth muscle contractility and blood pressure

scientific article

Gene correction in hematopoietic progenitor cells by homologous recombination

scientific article published on December 2000

Gene targeting approaches to complex genetic diseases: atherosclerosis and essential hypertension

scientific article

Genetic contributions to generalized arousal of brain and behavior

scientific article

Genetic control of blood pressure and the angiotensinogen locus

scientific article

Genetic disruption of atrial natriuretic peptide causes pulmonary hypertension in normoxic and hypoxic mice

scientific article published in May 1999

Genetic variations in peroxisome proliferator-activated receptor gamma expression affect blood pressure

scientific article

Genetically determined angiotensin converting enzyme level and myocardial tolerance to ischemia ⬇️

scientific article published on July 28, 2010

Genetically increased angiotensin I-converting enzyme level and renal complications in the diabetic mouse

scientific article

Genotype/age interactions on aggressive behavior in gonadally intact estrogen receptor beta knockout (betaERKO) male mice

scientific article published in May 2002

Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells

scientific article

High Elmo1 expression aggravates and low Elmo1 expression prevents diabetic nephropathy

scientific article published on 8 February 2016

High incidence of XXY and XYY males among the offspring of female chimeras from embryonic stem cells

scientific article

High-voltage starch-gel electrophoresis in the study of post-albumin proteins and C'3 (�1e-globulin) polymorphism ⬇️

scientific article

Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice

scientific article published on 24 February 2005

Homologous recombination between plasmids in mammalian cells can be enhanced by treatment of input DNA ⬇️

scientific article published on May 1, 1984

Homology requirements for unequal crossing over in humans

scientific article

Human cysteine-proteinase inhibitors: nucleotide sequence analysis of three members of the cystatin gene family

scientific article

Human globin psi B2 is not a globin-related sequence

scientific article published on December 1982

Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2.

scientific article

Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination

scientific article

Increased susceptibility to heart failure in response to volume overload in mice lacking natriuretic peptide receptor-A gene

scientific article

Induction of hepatic differentiation in embryonic stem cells by co-culture with embryonic cardiac mesoderm

scientific article published in August 2003

Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during development

scientific article

Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination

scientific article

Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice

scientific article

Isolating gene-corrected stem cells without drug selection

scientific article

Kidney function in mice lacking aldosterone

scientific journal article

Length polymorphisms in human proline-rich protein genes generated by intragenic unequal crossing over

scientific article

Lethal thalassemia after insertional disruption of the mouse major adult beta-globin gene

scientific article

Leukocyte lipid body formation and eicosanoid generation: cyclooxygenase-independent inhibition by aspirin

scientific article published on October 1996

Lifelong genetic minipumps.

scientific article published on 7 December 2004

Low TGFβ1 expression prevents and high expression exacerbates diabetic nephropathy in mice

scientific article published on 20 April 2015

Low molecular weight urinary proteins. I. Partial amino acid sequences of the retinol-binding proteins of man and dog

scientific article published on December 15, 1975

Many protein products from a few loci: assignment of human salivary proline-rich proteins to specific loci

scientific article

Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death

scientific article

Minireview: Computer Simulations of Blood Pressure Regulation by the Renin-Angiotensin System ⬇️

scientific article published on June 1, 2003

Molecular genetics of the apolipoprotein B gene in pigs in relation to atherosclerosis

scientific article published in October 1988

Molecular phenotyping for analyzing subtle genetic effects in mice: application to an angiotensinogen gene titration

scientific article

Natriuretic peptide receptor 1 expression influences blood pressures of mice in a dose-dependent manner ⬇️

scientific article published on March 3, 1998

Nicotinamide benefits both mothers and pups in two contrasting mouse models of preeclampsia

scientific article

Npr1-regulated gene pathways contributing to cardiac hypertrophy and fibrosis

scientific article published in February 2007

Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney

scientific article

Permeation of macromolecules into the renal glomerular basement membrane and capture by the tubules

scientific article published on 28 February 2017

Polymorphisms in the human haptoglobin gene cluster: chromosomes with multiple haptoglobin-related (Hpr) genes

scientific article

Posttranscriptional compensation for heterozygous disruption of the kidney-specific NaK2Cl cotransporter gene

scientific article

Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice

scientific article

Primary aldosteronism and impaired natriuresis in mice underexpressing TGFβ1.

scientific article published on 15 March 2013

Prolactin alters blood pressure by modulating the activity of endothelial nitric oxide synthase

scientific article published on 17 October 2016

Quantification of myocyte chemotaxis: a role for FAK in regulating directional motility

scientific article

RNA repair restores hemoglobin expression in IVS2-654 thalassemic mice

scholarly article

Recombinant fragment assay for gene targetting based on the polymerase chain reaction

scientific article published on September 1988

Recombination and balanced chromosome polymorphism suggested by DNA sequences 5' to the human delta-globin gene

scientific article published on August 1983

Reduced angiotensinogen expression attenuates renal interstitial fibrosis in obstructive nephropathy in mice

scientific article

Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II.

scientific article

Regulated expression of genes inserted at the human chromosomal beta-globin locus by homologous recombination ⬇️

scientific article published on June 1, 1988

Regulation of blood pressure by the type 1A angiotensin II receptor gene

scientific article

Regulatory elements in the introns of the human HPRT gene are necessary for its expression in embryonic stem cells

scientific article

Ren1c homozygous null mice are hypotensive and polyuric, but heterozygotes are indistinguishable from wild-type

scientific article published on 24 November 2004

Replication of plasmid DNA in fertilized Xenopus eggs is sensitive to both the topology and size of the injected template

scientific article

Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase

scientific article

Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors

scientific article

Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2 ⬇️

scientific article published on October 28, 1997

Short gene conversions in the human fetal globin gene region: a by-product of chromosome pairing during meiosis?

scientific article

Single-copy transgenic mice with chosen-site integration

scientific article published on August 1996

Somatic mutations and proteins.

scientific article

Targeted gene duplication and disruption for analyzing quantitative genetic traits in mice

scientific article

Targeted mutation of the Hprt gene in mouse embryonic stem cells

scientific article

Testing an "in-out" targeting procedure for making subtle genomic modifications in mouse embryonic stem cells

scientific article published on March 1991

The kallikrein-kinin system and oxidative stress

scientific article

The kallikrein-kinin system in health and in diseases of the kidney

scientific article published on 04 February 2009

The kallikrein–kinin system in diabetic nephropathy ⬇️

scientific article published on February 8, 2012

The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension

scientific journal article

The structure and evolution of the human salivary proline-rich protein gene family

scientific article

The whole of a scientific career: an interview with Oliver Smithies

scientific article published in May 2015

Theodore Cooper Memorial Lecture. A mouse view of hypertension

scientific article published on December 1997

Therapeutic benefits in thalassemic mice transplanted with long-term−cultured bone marrow cells ⬇️

scientific article published on December 22, 2010

Tissue-specific regulation of ACE/ACE2 and AT1/AT2 receptor gene expression by oestrogen in apolipoprotein E/oestrogen receptor-alpha knock-out mice

scientific article published on 11 January 2008

Toward an animal model of cystic fibrosis: targeted interruption of exon 10 of the cystic fibrosis transmembrane regulator gene in embryonic stem cells

scientific article published on December 1991

Transforming growth factor beta1 and aldosterone

scientific article

Transforming growth factor-β1 and diabetic nephropathy

scientific article published on 30 December 2015

Two novel arrangements of the human fetal globin genes: G gamma-G gamma and A gamma-A gamma

scientific article

Uncompensated polyuria in a mouse model of Bartter's syndrome

scientific article

Using PAC nested deletions to order contigs and microsatellite markers at the high repetitive sequence containing Npr3 gene locus

scientific article

Ventricular expression of natriuretic peptides in Npr1(-/-) mice with cardiac hypertrophy and fibrosis

scientific article

Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice

scientific article

eNOS deficiency acts through endothelin to aggravate sFlt-1-induced pre-eclampsia-like phenotype

scientific article published on 26 January 2012

List of works by Oliver Smithies

A Chinese G gamma + (A gamma delta beta)zero thalassemia deletion: comparison to other deletions in the human beta-globin gene cluster and sequence analysis of the breakpoints

A DNA insulator prevents repression of a targeted X-linked transgene but not its random or imprinted X inactivation

A comprehensive set of sequence analysis programs for the VAX

A dominant positive and negative selectable gene for use in mammalian cells ⬇️

A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice

A gene deletion ending within a complex array of repeated sequences 3' to the human beta-globin gene cluster

A genetically clamped renin transgene for the induction of hypertension

A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathy

A simplified chloral hydrate electrophoresis system for analysis of biological membranes

Aberrant renal vascular morphology and renin expression in mutant mice lacking angiotensin-converting enzyme

Abolition of male sexual behaviors in mice lacking estrogen receptors alpha and beta (alpha beta ERKO).

Absence of Macrophage Inflammatory Protein-1α Prevents the Development of Blinding Herpes Stromal Keratitis ⬇️

Accurate modification of a chromosomal plasmid by homologous recombination in human cells

Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in males

Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene

Altering the expression in mice of genes by modifying their 3' regions

Amino acids as modulators of endothelium-derived nitric oxide

Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney

Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway

Angiotensin-converting enzyme and male fertility ⬇️

Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury

Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene

Causative Effects of Genetically Determined High Maternal/Fetal Endothelin-1 on Preeclampsia-Like Conditions in Mice

Characterization of Prostaglandin H Synthase 2 Deficient Mice and Implications for Mechanisms of NSAID Action ⬇️

Clones from the human gene complex coding for salivary proline-rich proteins ⬇️

Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2

Complementation of reduced survival, hypotension, and renal abnormalities in angiotensinogen-deficient mice by the human renin and human angiotensinogen genes

Components of the major urinary protein complex of inbred mice: determination of NH2-terminal sequences and comparison with homologous components from wild mice

Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignment

Correction of a human beta S-globin gene by gene targeting

Correction of factor IX deficiency in mice by embryonic stem cells differentiated in vitro

Cotransformation and gene targeting in mouse embryonic stem cells ⬇️

Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes

Decreased beta-adrenergic responsiveness following hypertrophy occurs only in cardiomyocytes that also re-express beta-myosin heavy chain

Deletion and replacement of the mouse adult beta-globin genes by a "plug and socket" repeated targeting strategy

Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor

Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system

Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo

Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system

Disturbed homeostasis in sodium-restricted mice heterozygous and homozygous for aldosterone synthase gene disruption

Double-strand gap repair in a mammalian gene targeting reaction

Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel

Early days of gel electrophoresis.

Efficient transformation and frequent single-site, single-copy insertion of DNA can be obtained in mouse erythroleukemia cells transformed by electroporation.

Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade

Enhanced atherosclerosis and kidney dysfunction in eNOS(-/-)Apoe(-/-) mice are ameliorated by enalapril treatment

Estrogen inhibits the vascular injury response in estrogen receptor beta-deficient female mice

Estrogen receptor alpha is a major mediator of 17beta-estradiol's atheroprotective effects on lesion size in Apoe-/- mice

Evidence for a novel natriuretic peptide receptor that prefers brain natriuretic peptide over atrial natriuretic peptide

Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene

Failure of ductus arteriosus closure and remodeling in neonatal mice deficient in cyclooxygenase-1 and cyclooxygenase-2.

Fibrosis, not cell size, delineates beta-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo

GRAF3 serves as a blood volume-sensitive rheostat to control smooth muscle contractility and blood pressure

Gene correction in hematopoietic progenitor cells by homologous recombination

Gene targeting approaches to complex genetic diseases: atherosclerosis and essential hypertension

Genetic contributions to generalized arousal of brain and behavior

Genetic control of blood pressure and the angiotensinogen locus

Genetic disruption of atrial natriuretic peptide causes pulmonary hypertension in normoxic and hypoxic mice

Genetic variations in peroxisome proliferator-activated receptor gamma expression affect blood pressure

Genetically determined angiotensin converting enzyme level and myocardial tolerance to ischemia ⬇️

Genetically increased angiotensin I-converting enzyme level and renal complications in the diabetic mouse

Genotype/age interactions on aggressive behavior in gonadally intact estrogen receptor beta knockout (betaERKO) male mice

Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells

High Elmo1 expression aggravates and low Elmo1 expression prevents diabetic nephropathy

High incidence of XXY and XYY males among the offspring of female chimeras from embryonic stem cells

High-voltage starch-gel electrophoresis in the study of post-albumin proteins and C'3 (�1e-globulin) polymorphism ⬇️

Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice

Homologous recombination between plasmids in mammalian cells can be enhanced by treatment of input DNA ⬇️

Homology requirements for unequal crossing over in humans

Human cysteine-proteinase inhibitors: nucleotide sequence analysis of three members of the cystatin gene family

Human globin psi B2 is not a globin-related sequence

Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2.

Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination

Increased susceptibility to heart failure in response to volume overload in mice lacking natriuretic peptide receptor-A gene

Induction of hepatic differentiation in embryonic stem cells by co-culture with embryonic cardiac mesoderm

Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during development

Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination

Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice

Isolating gene-corrected stem cells without drug selection