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List of works by Cornelis J. M. Melief

2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation

scientific article

A phase 1/2 study combining gemcitabine, Pegintron and p53 SLP vaccine in patients with platinum-resistant ovarian cancer.

scientific article published on 14 August 2015

A placebo-controlled randomized HPV16 synthetic long-peptide vaccination study in women with high-grade cervical squamous intraepithelial lesions

scientific article

Activation of Dendritic Cells That Cross-Present Tumor-Derived Antigen Licenses CD8+ CTL to Cause Tumor Eradication

Addition of interferon-α to the p53-SLP® vaccine results in increased production of interferon-γ in vaccinated colorectal cancer patients: a phase I/II clinical trial

scientific article published on 21 November 2012

Anti-Melanoma immunity and local regression of cutaneous metastases in melanoma patients treated with monobenzone and imiquimod; a phase 2 a trial

scientific article published on 15 January 2018

Antigen presentation by an immature myeloid dendritic cell line does not cause CTL deletion in vivo, but generates CD8+ central memory-like T cells that can be rescued for full effector function

scientific article published on July 2005

Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes

article

Antigen-antibody immune complexes empower dendritic cells to efficiently prime specific CD8+ CTL responses in vivo

scientific article published on March 2002

Antigen-specific active immunotherapy for ovarian cancer

scientific article

Antigen-specific active immunotherapy for ovarian cancer

scientific article (publication date: 16 July 2008)

Antitumor efficacy of wild-type p53-specific CD4(+) T-helper cells

scientific article published on 01 November 2002

Association of cervical cancer with the presence of CD4+ regulatory T cells specific for human papillomavirus antigens.

scholarly article

Autoimmune destruction of skin melanocytes by perilesional T cells from vitiligo patients.

scientific article published on 26 February 2009

Balancing between antitumor efficacy and autoimmune pathology in T-cell-mediated targeting of carcinoembryonic antigen

scientific article published on 01 October 2008

C3-symmetric peptide scaffolds are functional mimetics of trimeric CD40L.

scientific article published on December 2005

CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis.

scientific article

CD27-CD70 costimulation controls T cell immunity during acute and persistent cytomegalovirus infection.

scientific article published on 10 April 2013

CD4+ T cell help in cancer immunology and immunotherapy

scientific article published on 01 October 2018

CD4+T Cells Are Able to Promote Tumor Growth through Inhibition of Tumor-Specific CD8+T-Cell Responses in Tumor-Bearing Hosts

article

CD40 stimulation leads to effective therapy of CD40(-) tumors through induction of strong systemic cytotoxic T lymphocyte immunity

scientific article

CD40-mediated amplification of local immunity by epithelial cells is impaired by HPV.

scientific article

CD8 T-cell recognition of human 5T4 oncofetal antigen.

scientific article

CD8+ CTL priming by exact peptide epitopes in incomplete Freund's adjuvant induces a vanishing CTL response, whereas long peptides induce sustained CTL reactivity

scientific article

Cancer immunology

scientific article published on 01 February 2011

Cancer immunology: cat and mouse games

scientific article published on 01 September 2005

Cancer immunotherapy by dendritic cells

scientific article published on September 2008

Cancer: Precision T-cell therapy targets tumours

scientific article published in Nature

Cancer: immune pact with the enemy

scientific article published in December 2007

Characterization of antigen-specific immune responses induced by canarypox virus vaccines

scientific article

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

scientific article

Chemically synthesized protein as tumour-specific vaccine: immunogenicity and efficacy of synthetic HPV16 E7 in the TC-1 mouse tumour model

scientific article

Chirality of TLR-2 ligand Pam3CysSK4 in fully synthetic peptide conjugates critically influences the induction of specific CD8+ T-cells

scientific article

Circulating specific antibodies enhance systemic cross-priming by delivery of complexed antigen to dendritic cells in vivo

scientific article published on 01 March 2012

Colorectal cancer vaccines in clinical trials.

scientific article published on June 2011

Combination vaccine based on citrullinated vimentin and enolase peptides induces potent CD4-mediated anti-tumor responses

scientific article published on 01 June 2020

Competition-based cellular peptide binding assay for HLA class I.

scientific article published on September 2004

Competition-based cellular peptide binding assays for 13 prevalent HLA class I alleles using fluorescein-labeled synthetic peptides

scientific article published on February 2003

Conference scene: Immune signatures in the tumor and beyond

scientific article published in August 2012

Controlled local delivery of CTLA-4 blocking antibody induces CD8+ T-cell-dependent tumor eradication and decreases risk of toxic side effects.

scientific article published on 20 June 2013

Correction: Systems Analysis of MVA-C Induced Immune Response Reveals Its Significance as a Vaccine Candidate against HIV/AIDS of Clade C

scientific article published in PLoS ONE

Correction: Systems Analysis of MVA-C Induced Immune Response Reveals Its Significance as a Vaccine Candidate against HIV/AIDS of Clade C.

scientific article published on 17 May 2012

DC-induced CD8(+) T-cell response is inhibited by MHC class II-dependent DX5(+)CD4(+) Treg

scientific article published in July 2009

DNA/long peptide vaccination against conserved regions of SIV induces partial protection against SIVmac251 challenge

scientific article published on November 2013

Dendritic Cells as Carriers for a Cytotoxic T-Lymphocyte Epitope-Based Peptide Vaccine in Protection Against a Human Papillomavirus Type 16-Induced Tumor

Dendritic cell immunotherapy: mapping the way.

scientific article published on May 2004

Dendritic cells in cancer immunotherapy

scientific article published on 01 January 2008

Dendritic cells process synthetic long peptides better than whole protein, improving antigen presentation and T-cell activation

scientific article published on 5 August 2013

Design and development of synthetic peptide vaccines: past, present and future

scientific article published on August 2007

Design of TLR2-ligand-synthetic long peptide conjugates for therapeutic vaccination of chronic HBV patients

scientific article published on 17 February 2020

Detection and functional analysis of CD8+ T cells specific for PRAME: a target for T-cell therapy

scientific article published in May 2006

Detection of human papillomavirus (HPV) 16-specific CD4+ T-cell immunity in patients with persistent HPV16-induced vulvar intraepithelial neoplasia in relation to clinical impact of imiquimod treatment

scientific article published in July 2005

Detection of human papillomavirus type 18 E6 and E7-specific CD4+ T-helper 1 immunity in relation to health versus disease

article

Differential expression regulation of the alpha and beta subunits of the PA28 proteasome activator in mature dendritic cells

scientific journal article

Differential kinetics of antigen-specific CD4+ and CD8+ T cell responses in the regression of retrovirus-induced sarcomas

scientific article published in September 2002

Distinct regulation and impact of type 1 T-cell immunity against HPV16 L1, E2 and E6 antigens during HPV16-induced cervical infection and neoplasia

scientific article published on 01 February 2006

Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells

scientific article published on 26 April 2007

Editorial: Novel Strategies for Anti-Tumor Vaccines

scientific article published on 01 January 2019

Effective CD8(+) T cell priming and tumor protection by enterotoxin B subunit-conjugated peptides targeted to dendritic cells

scientific article

Effective immunotherapy of cancer in MUC1-transgenic mice using clonal cytotoxic T lymphocytes directed against an immunodominant MUC1 epitope.

scientific article

Effective melanoma immunotherapy in mice by the skin-depigmenting agent monobenzone and the adjuvants imiquimod and CpG.

scientific article

Effective therapeutic anticancer vaccines based on precision guiding of cytolytic T lymphocytes

scientific article published in October 2002

Effectiveness of slow-release systems in CD40 agonistic antibody immunotherapy of cancer

scientific article published on 07 February 2014

Efficient induction of antitumor immunity by synthetic toll-like receptor ligand-peptide conjugates

scientific article

Efficient tumor eradication by adoptively transferred cytotoxic T-cell clones in allogeneic hosts

scientific article published on 01 May 1996

Enhancement of proliferation and downregulation of TRAIL expression on CD8+ T cells by IL‐21 ⬇️

scientific article published on November 1, 2010

Escort service for cross-priming

scientific article published on 01 June 2005

Established human papillomavirus type 16-expressing tumors are effectively eradicated following vaccination with long peptides

scientific article published on July 2002

Evaluation of immunological cross-reactivity between clade A9 high-risk human papillomavirus types on the basis of E6-Specific CD4+ memory T cell responses

scientific article published on October 2010

Experience with Synthetic Vaccines for Cancer and Persistent Virus Infections in Nonhuman Primates and Patients

scientific article published on January 1, 2012

Expression of a natural tumor antigen by thymic epithelial cells impairs the tumor-protective CD4+ T-cell repertoire

scientific article published on 01 July 2005

Expression of cellular FLICE inhibitory protein, caspase-8, and protease inhibitor-9 in Ewing sarcoma and implications for susceptibility to cytotoxic pathways.

scientific article published on January 2007

Fcγ receptor IIb strongly regulates Fcγ receptor-facilitated T cell activation by dendritic cells

scientific article

Formation and phenotypic characterization of CD49a, CD49b and CD103 expressing CD8 T cell populations in human metastatic melanoma

scientific article published on 06 August 2018

Formation of Immune Complexes with a Tetanus-Derived B Cell Epitope Boosts Human T Cell Responses to Covalently Linked Peptides in an Ex Vivo Blood Loop System

scientific article published on 11 May 2018

Frequent detection of human papillomavirus 16 E2-specific T-helper immunity in healthy subjects

scientific article

Frequent display of human papillomavirus type 16 E6-specific memory t-Helper cells in the healthy population as witness of previous viral encounter

article

Future perspectives in melanoma research. Meeting report from the "Melanoma Bridge. Napoli, December 2nd-4th 2012".

scientific article published on 3 June 2013

HBV-Derived Synthetic Long Peptide Can Boost CD4+ and CD8+ T-Cell Responses in Chronic HBV Patients Ex Vivo

scientific article

HPV16 synthetic long peptide (HPV16-SLP) vaccination therapy of patients with advanced or recurrent HPV16-induced gynecological carcinoma, a phase II trial

scientific article

High Number of Intraepithelial CD8+Tumor-Infiltrating Lymphocytes Is Associated with the Absence of Lymph Node Metastases in Patients with Large Early-Stage Cervical Cancer

scientific article published on 01 January 2007

Highlights of the society for immunotherapy of cancer (SITC) 27th annual meeting

scientific article published on 29 May 2013

Human CD4+ T cells stimulated by conserved adenovirus 5 hexon peptides recognize cells infected with different species of human adenovirus

scientific article published in September 2006

Human Papillomavirus Downregulates the Expression of IFITM1 and RIPK3 to Escape from IFNγ- and TNFα-Mediated Antiproliferative Effects and Necroptosis

scientific article

Human Papillomavirus Type 16-Positive Cervical Cancer Is Associated with Impaired CD4+ T-Cell Immunity against Early Antigens E2 and E6

scientific article published on 01 August 2004

Human papilloma virus specific T cells infiltrating cervical cancer and draining lymph nodes show remarkably frequent use of HLA-DQ and -DP as a restriction element.

scientific article published in February 2008

Human papillomavirus (HPV) upregulates the cellular deubiquitinase UCHL1 to suppress the keratinocyte's innate immune response

scientific article

Human papillomavirus deregulates the response of a cellular network comprising of chemotactic and proinflammatory genes

scientific article

Humoral responses to HIVconsv induced by heterologous vaccine modalities in rhesus macaques

scientific article published on 11 March 2015

IgG-mediated anaphylaxis to a synthetic long peptide vaccine containing a B cell epitope can be avoided by slow-release formulation

scientific article published on 09 May 2014

Immune complex-loaded dendritic cells are superior to soluble immune complexes as antitumor vaccine

scientific article published on April 2006

Immune-escape markers in relation to clinical outcome of advanced melanoma patients following immunotherapy.

scientific article

Immunotherapy for persistent viral infections and associated disease ⬇️

scientific article published on January 10, 2011

Immunotherapy of cancer through targeting of the p53 tumor antigen.

scientific article

Immunotherapy of established (pre)malignant disease by synthetic long peptide vaccines

scientific article published on May 2008

Improved innate and adaptive immunostimulation by genetically modified HIV-1 protein expressing NYVAC vectors

scientific article (publication date: 15 February 2011)

Improved peptide vaccine strategies, creating synthetic artificial infections to maximize immune efficacy

scientific article published on 12 August 2006

In Vivo Triggering Through 4-1BB Enables Th-Independent Priming of CTL in the Presence of an Intact CD28 Costimulatory Pathway

scientific article published on 01 April 2002

Induction of Tumor-Specific CD4+ and CD8+ T-Cell Immunity in Cervical Cancer Patients by a Human Papillomavirus Type 16 E6 and E7 Long Peptides Vaccine

scientific article published on 01 January 2008

Induction of p53-specific immune responses in colorectal cancer patients receiving a recombinant ALVAC-p53 candidate vaccine

scientific article published on 01 May 2002

Induction of p53-specific immunity by a p53 synthetic long peptide vaccine in patients treated for metastatic colorectal cancer

scientific article published on 01 February 2009

Inflammasome-Dependent Induction of Adaptive NK Cell Memory

scientific article published on 6 June 2016

Ins and outs of dendritic cells

scientific article

Intraocular tumor antigen drains specifically to submandibular lymph nodes, resulting in an abortive cytotoxic T cell reaction.

scientific article published on February 2004

Linking T cell epitopes to a common linear B cell epitope: A targeting and adjuvant strategy to improve T cell responses

scientific article published on 22 November 2017

Local Activation of CD8 T Cells and Systemic Tumor Eradication without Toxicity via Slow Release and Local Delivery of Agonistic CD40 Antibody ⬇️

scientific article published on March 9, 2011

Local targets for immune therapy to cancer: Tumor draining lymph nodes and tumor microenvironment ⬇️

scientific article published on August 16, 2012

Long peptides induce polyfunctional T cells against conserved regions of HIV-1 with superior breadth to single-gene vaccines in macaques.

scientific article

MHC II in dendritic cells is targeted to lysosomes or T cell-induced exosomes via distinct multivesicular body pathways.

scientific article published on 14 July 2009

Macrophages are vital in spontaneous intraocular tumor eradication

scientific article published on July 2006

Magnitude and polarization of P53-specific T-helper immunity in connection to leukocyte infiltration of colorectal tumors.

scientific article

Maintenance of immune tolerance depends on normal tissue homeostasis

scientific article published on October 2005

Migration or evasion

scientific article published on 01 January 2010

Mini‐review: Regulation of cytotoxic T lymphocyte responses by dendritic cells: peaceful coexistence of cross‐priming and direct priming? ⬇️

scientific article published on October 1, 2003

Multiple CD4 and CD8 T-cell activation parameters predict vaccine efficacy in vivo mediated by individual DC-activating agonists

scientific article published on 7 November 2006

Mutation-specific T cells for immunotherapy of gliomas.

scientific article

N-tetradecylcarbamyl lipopeptides as novel agonists for Toll-like receptor 2.

scientific article

NK cells recognize and lyse Ewing sarcoma cells through NKG2D and DNAM-1 receptor dependent pathways

scientific article

New approaches in vaccine-based immunotherapy for human papillomavirus-induced cancer.

scientific article published on 19 May 2015

New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer

scientific article

Novel TLR2-binding adjuvant induces enhanced T cell responses and tumor eradication

article

Novel insights into the HLA class I immunopeptidome and T-cell immunosurveillance

scientific article published on 24 May 2017

P53-specific T cell responses in patients with malignant and benign ovarian tumors: implications for p53 based immunotherapy

scientific article published in August 2007

Peptide vaccination after T-cell transfer causes massive clonal expansion, tumor eradication, and manageable cytokine storm

scientific article published on 12 October 2010

Peptide vaccination with an anchor-replaced CTL epitope protects against human papillomavirus type 16-induced tumors expressing the wild-type epitope

scientific article published on November 1998

Phase I Immunotherapeutic Trial with Long Peptides Spanning the E6 and E7 Sequences of High-Risk Human Papillomavirus 16 in End-Stage Cervical Cancer Patients Shows Low Toxicity and Robust Immunogenicity

article

Prediction of the immunogenic potential of frameshift-mutated antigens in microsatellite instable cancer

scientific article published in August 2008

Prognostic value of tumor-infiltrating dendritic cells in colorectal cancer: role of maturation status and intratumoral localization

scientific article published on 01 April 2005

Prospects of combinatorial synthetic peptide vaccine-based immunotherapy against cancer

scientific article published on April 2013

Rapid enrichment of human papillomavirus (HPV)-specific polyclonal T cell populations for adoptive immunotherapy of cervical cancer.

scientific article published on March 2005

Reactive oxygen species as an initiator of toxic innate immune responses in retort to SARS-CoV-2 in an ageing population, consider N-acetylcysteine as early therapeutic intervention

scientific article published on 18 June 2020

Recombinant adenovirus-transduced human dendritic cells engineered to secrete interleukin-10 (IL-10) suppress Th1-type responses while selectively activating IL-10—producing CD4+ T cells

article

Reduced human leukocyte antigen expression in advanced-stage Ewing sarcoma: implications for immune recognition

scientific article published on June 2009

Revival of the regulatory T cell: new targets for drug development

scientific article published on April 2004

SPI-CI and SPI-6 cooperate in the protection from effector cell-mediated cytotoxicity

scientific journal article

Safety in numbers

scientific article published on 01 July 2005

Safety of intravenous administration of a canarypox virus encoding the human wild-type p53 gene in colorectal cancer patients

scientific article published on July 2003

Scientific contributions toward successful cancer immunotherapy in The Netherlands.

scientific article published on 16 October 2014

Selective Activation of Oxygen-Deprived Tumor-Infiltrating Lymphocytes through Local Intratumoral Delivery of CD137 Monoclonal Antibodies ⬇️

scientific article published on 01 July 2012

Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants

scientific article

Self-tolerance does not restrict the CD4+ T-helper response against the p53 tumor antigen

scientific article published on 01 February 2008

Skin reactions to human papillomavirus (HPV) 16 specific antigens intradermally injected in healthy subjects and patients with cervical neoplasia

scientific article published on 01 July 2008

Skin-Depigmenting Agent Monobenzone Induces Potent T-Cell Autoimmunity toward Pigmented Cells by Tyrosinase Haptenation and Melanosome Autophagy

scientific article published on 17 February 2011

Smart delivery of vaccines

scientific article published on 01 June 2018

Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells

scientific article

Strong vaccine responses during chemotherapy are associated with prolonged cancer survival

scientific article published on 01 March 2020

Structured reporting of T cell assay results

scientific article published on 15 July 2013

Success or failure of vaccination for HPV16-positive vulvar lesions correlates with kinetics and phenotype of induced T-cell responses

scientific article

Summit on cell therapy for cancer: The importance of the interaction of multiple disciplines to advance clinical therapy

scientific article

Superior induction of anti-tumor CTL immunity by extended peptide vaccines involves prolonged, DC-focused antigen presentation

scientific article

Synthesis of 2-alkoxy-8-hydroxyadenylpeptides: towards synthetic epitope-based vaccines

scientific article published on 11 April 2006

Synthetic Vaccine for the Treatment of Lesions Caused by High Risk Human Papilloma Virus ⬇️

scientific article published on September 1, 2011

Synthetic long peptide booster immunization in rhesus macaques primed with replication-competent NYVAC-C-KC induces a balanced CD4/CD8 T-cell and antibody response against the conserved regions of HIV-1.

scientific article published on 9 February 2015

Systems analysis of MVA-C induced immune response reveals its significance as a vaccine candidate against HIV/AIDS of clade C.

scientific article

T-Cell Immune Function in Tumor, Skin, and Peripheral Blood of Advanced Stage Melanoma Patients: Implications for Immunotherapy

scientific article published on 12 July 2011

TLR2 ligand-synthetic long peptide conjugates effectively stimulate tumor-draining lymph node T cells of cervical cancer patients

scientific article

Targeting the PD-1/PD-L1 Axis in Human Vitiligo

scientific article published on 06 November 2020

The detection of circulating human papillomavirus-specific T cells is associated with improved survival of patients with deeply infiltrating tumors

scientific article published on 05 April 2010

The distinct role of T cell costimulation in antiviral immunity

scientific article published on 11 July 2013

The interferon-related developmental regulator 1 is used by human papillomavirus to suppress NFκB activation.

scientific article

The long-term immune response after HPV16 peptide vaccination in women with low-grade pre-malignant disorders of the uterine cervix: a placebo-controlled phase II study

scientific article published on 15 November 2013

The need for improvement of the treatment of advanced and metastatic cervical cancer, the rationale for combined chemo-immunotherapy

scientific article published on February 2014

The simultaneous ex vivo detection of low-frequency antigen-specific CD4+ and CD8+ T-cell responses using overlapping peptide pools.

scientific article

The status of HPV16-specific T-cell reactivity in health and disease as a guide to HPV vaccine development

scientific article

The tumoricidal activity of memory CD8+ T cells is hampered by persistent systemic antigen, but full functional capacity is regained in an antigen-free environment

scientific article published in May 2004

The viral context instructs the redundancy of costimulatory pathways in driving CD8(+) T cell expansion.

scientific article

Therapeutic Peptide Vaccine-Induced CD8 T Cells Strongly Modulate Intratumoral Macrophages Required for Tumor Regression.

scientific article published on 17 April 2015

Therapeutic cancer vaccines

scientific article published on 27 July 2015

Therapeutic vaccination against human papilloma virus induced malignancies ⬇️

scientific article published on January 13, 2011

Treatment Regimen, Surgical Outcome, and T-cell Differentiation Influence Prognostic Benefit of Tumor-Infiltrating Lymphocytes in High-Grade Serous Ovarian Cancer.

scientific article published on 18 September 2015

Treatment of Established Lesions Caused by High-risk Human Papilloma Virus Using a Synthetic Vaccine ⬇️

scientific article published on April 1, 2012

Tumor Eradication by Cisplatin Is Sustained by CD80/86-Mediated Costimulation of CD8+ T Cells

scientific article published on 28 August 2016

Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy

scientific article published on 15 January 2019

Tumor-Expressed B7-H1 and B7-DC in Relation to PD-1+ T-Cell Infiltration and Survival of Patients with Cervical Carcinoma

scientific article published on 13 October 2009

Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia

scientific article published on November 2009

Vaccination against Oncoproteins of HPV16 for Noninvasive Vulvar/Vaginal Lesions: Lesion Clearance Is Related to the Strength of the T-Cell Response.

scientific article published on 26 January 2016

Vaccination for treatment and prevention of cancer in animal models.

scientific article

Vaccine-induced effector-memory CD8+ T cell responses predict therapeutic efficacy against tumors.

scientific article published on 22 August 2012

Vaccine-induced tumor necrosis factor-producing T cells synergize with cisplatin to promote tumor cell death

scientific article published on 12 December 2014

Vaccines for established cancer: overcoming the challenges posed by immune evasion

scientific article published on 11 March 2016

“License to Kill” Reflects Joint Action of CD4 and CD8 T Cells ⬇️

scientific article published on June 19, 2013

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