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List of works by Pieter Hiemstra

A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment

scientific article

A novel method for expansion and differentiation of mouse tracheal epithelial cells in culture.

scientific article

A phase I study for intravenous autologous mesenchymal stromal cell administration to patients with severe emphysema.

scientific article

Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPD

scientific article

Aberrant epithelial differentiation by cigarette smoke dysregulates respiratory host defence

scientific article published on 15 March 2018

Acute and chronic effects of treatment with mesenchymal stromal cells on LPS-induced pulmonary inflammation, emphysema and atherosclerosis development.

scientific article published on 14 September 2017

Airway Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease: Role of Cigarette Smoke Exposure

scientific article published on 21 September 2017

Airway Epithelial Cell Function and Respiratory Host Defense in Chronic Obstructive Pulmonary Disease.

scientific article published in May 2018

Airway and alveolar epithelial cells in culture

scientific article published on 07 November 2019

Airway gene expression in COPD is dynamic with inhaled corticosteroid treatment and reflects biological pathways associated with disease activity

scientific article published on 07 August 2013

Airway hyperresponsiveness in chronic obstructive pulmonary disease: A marker of asthma-chronic obstructive pulmonary disease overlap syndrome?

scientific article published on 24 May 2016

Airway inflammation in COPD after long-term withdrawal of inhaled corticosteroids

scientific article published on 3 January 2017

Airway inflammation in COPD after long-term withdrawal of inhaled corticosteroids

scientific article published on 15 June 2017

Anti-carbamylated protein antibodies: a specific hallmark for rheumatoid arthritis. Comparison to conditions known for enhanced carbamylation; renal failure, smoking and chronic inflammation

scientific article published on 29 April 2016

Antibacterial Defense of Human Airway Epithelial Cells from Chronic Obstructive Pulmonary Disease Patients Induced by Acute Exposure to Nontypeable Haemophilus influenzae: Modulation by Cigarette Smoke.

scientific article published on 8 February 2017

Antimicrobial Peptide P60.4Ac-Containing Creams and Gel for Eradication of Methicillin-Resistant Staphylococcus aureus from Cultured Skin and Airway Epithelial Surfaces

scientific article published on 25 April 2016

Antimicrobial Peptides and Innate Lung Defenses: Role in Infectious and Noninfectious Lung Diseases and Therapeutic Applications

scientific article

Antimicrobial peptide levels are linked to airway inflammation, bacterial colonisation and exacerbations in chronic obstructive pulmonary disease

scientific article published on 15 March 2017

Assembly 3: Basic and Translational Sciences.

scientific article published in March 2018

Associations of Serum 25(OH)D Concentrations with Lung Function, Airway Inflammation and Common Cold in the General Population

scientific article published on 3 January 2018

Asthma-COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease

scientific article published on April 2015

Author Correction: Osteopontin Expression in Small Airway Epithelium in Copd is Dependent on Differentiation and Confined to Subsets of Cells

scientific article published on 15 January 2020

Azithromycin differentially affects the IL-13-induced expression profile in human bronchial epithelial cells

scientific article published on 28 May 2016

Basic and translational research in the European Respiratory Journal.

scientific article

Basic science of electronic cigarettes: assessment in cell culture and in vivo models

scientific article

Bone Morphogenetic Protein 9 Protects against Neonatal Hyperoxia-Induced Impairment of Alveolarization and Pulmonary Inflammation

scientific article published on 13 July 2017

Bradykinin B2 receptor expression in the bronchial mucosa of allergic asthmatics: the role of NF-kB.

scientific article published on 20 November 2015

Cellular response of mucociliary differentiated primary bronchial epithelial cells to diesel exhaust

scientific article published on 17 May 2016

Childhood allergies and asthma: New insights on environmental exposures and local immunity at the lung barrier

scientific article

Cigarette smoke differentially affects IL-13-induced gene expression in human airway epithelial cells

scientific article published on 11 July 2017

Clinical and inflammatory determinants of bronchial hyperresponsiveness in COPD

scientific article published on 20 April 2012

Comparison of genome-wide gene expression profiling by RNA Sequencing <i>versus</i> microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide new insights?

scientific article published on 15 April 2021

Contribution of Host Defence Proteins and Peptides to Host-Microbiota Interactions in Chronic Inflammatory Lung Diseases

Correction: Susceptibility to chronic mucus hypersecretion, a genome wide association study

scientific article published on 29 May 2015

Defining asthma-COPD overlap syndrome: a population-based study.

scientific article published on May 2017

Diesel exhaust alters the response of cultured primary bronchial epithelial cells from patients with chronic obstructive pulmonary disease (COPD) to non-typeable Haemophilus influenzae

scientific article published on 28 January 2017

ERS International Congress, Madrid, 2019: highlights from the Basic and Translational Science Assembly

scientific article published on 01 January 2020

Effect of an Outpatient Pulmonary Rehabilitation Program on Exercise Tolerance and Asthma Control in Obese Asthma Patients.

scientific article

Effect of diesel exhaust generated by a city bus engine on stress responses and innate immunity in primary bronchial epithelial cell cultures

scientific article published in February 2018

Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in COPD

scientific article published on 25 April 2019

Effects of E-cigarette Use on Human Lung Tissue: On Harm Reduction and Causing Harm

scientific article published on 8 March 2018

Electronic cigarettes: a task force report from the European Respiratory Society

article

Farm dust reduces viral load in human bronchial epithelial cells by increasing barrier function and antiviral responses.

scientific article published on 6 February 2018

From the pathophysiology of the human lung alveolus to epigenetic editing: Congress 2018 highlights from ERS Assembly 3 "Basic and Translational Science."

article

Functional characterisation of bone marrow-derived mesenchymal stromal cells from COPD patients

scientific article

Genome-wide association analysis identifies six new loci associated with forced vital capacity

scientific article

High intensity training in obesity: a Meta-analysis.

scientific article published on 29 May 2017

High miR203a-3p and miR-375 expression in the airways of smokers with and without COPD

scientific article published on 04 April 2022

Host-microbe cross-talk in the lung microenvironment: implications for understanding and treating chronic lung disease

scientific article published on 19 May 2020

How to write a response to the reviewers of your manuscript

article by Pieter Hiemstra published December 2018 in Breathe

Human lung epithelial cell cultures for analysis of inhaled toxicants: Lessons learned and future directions.

scientific article published on 15 November 2017

IL-13 and the Airway Epithelium. It Is All in the Genes

article

In vitro modelling of alveolar repair at the air-liquid interface using alveolar epithelial cells derived from human induced pluripotent stem cells

scientific article published on 26 March 2020

Inhaled steroids modulate extracellular matrix composition in bronchial biopsies of COPD patients: a randomized, controlled trial

scientific article

Lung epithelial cells interact with immune cells and bacteria to shape the microenvironment in tuberculosis

scientific article published in 2022

Lung function decline in asthma patients with elevated bronchial CD8, CD4 and CD3 cells

scientific article published on 26 May 2016

Macrophage function in chronic obstructive pulmonary disease: The many faces of notch signalling.

scientific article

Mesenchymal stromal cells: a novel therapy for the treatment of chronic obstructive pulmonary disease?

scientific article published on 13 April 2018

MicroRNA-223 controls the expression of histone deacetylase 2: a novel axis in COPD.

scientific article

Microarray Gene Expression Analysis to Evaluate Cell Type Specific Expression of Targets Relevant for Immunotherapy of Hematological Malignancies.

scientific article

Microbes and asthma: Opportunities for intervention

scientific article

Mitochondria: at the crossroads of regulating lung epithelial cell function in chronic obstructive pulmonary disease

scientific article published on 06 November 2019

Multidrug resistance-associated protein 1 and lung function decline with or without long-term corticosteroids treatment in COPD ⬇️

scientific article published on September 12, 2012

Multidrug resistance-associated protein-1 (MRP1) genetic variants, MRP1 protein levels and severity of COPD.

scientific article

Murine models of cardiovascular comorbidity in chronic obstructive pulmonary disease.

scientific article published on 18 March 2016

Neutrophil-derived alpha defensins control inflammation by inhibiting macrophage mRNA translation

scientific article published on 4 April 2016

Osteopontin Expression in Small Airway Epithelium in Copd is Dependent on Differentiation and Confined to Subsets of Cells

scientific article published on 29 October 2019

Parallel activities and interactions between antimicrobial peptides and complement in host defense at the airway epithelial surface

scientific article

Pre-surgical Pulmonary Rehabilitation in Asthma Patients Undergoing Bariatric Surgery.

scientific article

Prediction of Long-Term Benefits of Inhaled Steroids by Phenotypic Markers in Moderate-to-Severe COPD: A Randomized Controlled Trial

scientific article published on 10 December 2015

Predictive value of eosinophils and neutrophils on clinical effects of ICS in COPD

scientific article published on 26 April 2018

Proinflammatory Cytokines Impair Vitamin D-Induced Host Defense in Cultured Airway Epithelial Cells

scientific article published on 23 February 2017

Pulmonary function, exhaled nitric oxide and symptoms in asthma patients with obesity: a cross-sectional study

scientific article

Regeneration of the lung: Lung stem cells and the development of lung mimicking devices

scientific article

Regulation of YKL-40 expression by corticosteroids: effect on pro-inflammatory macrophages in vitro and its modulation in COPD in vivo.

scientific article

Reprogramming of cellular metabolism: driver for airway remodelling in COPD?

scientific article

Response to Comment on “Therapeutic Application of an Extract ofHelicobacter pyloriAmeliorates the Development of Allergic Airway Disease”

article

Short-term and long-term effect of a high intensity pulmonary rehabilitation program in obese patients with asthma: a randomised controlled trial

scientific article published on 16 April 2020

Small Airways Dysfunction and Neutrophilic Inflammation in Bronchial Biopsies and BAL in COPD

scholarly article by Thérèse S. Lapperre et al published January 2007 in Chest

Smoking cessation and bronchial epithelial remodelling in COPD: a cross-sectional study

scientific article

Smoking status and anti-inflammatory macrophages in bronchoalveolar lavage and induced sputum in COPD.

scientific article

Standard radiotherapy but not chemotherapy impairs systemic immunity in non-small cell lung cancer.

scientific article

Steroid resistance in COPD? Overlap and differential anti-inflammatory effects in smokers and ex-smokers

scientific article

Susceptibility to chronic mucus hypersecretion, a genome wide association study

scientific article

TGF-β activation impairs fibroblast ability to support adult lung epithelial progenitor cell organoid formation

scientific article published on 10 April 2019

The Dutch National Program for Respiratory Research

scientific article published in May 2016

The Effects of Selective Hematopoietic Expression of Human IL-37 on Systemic Inflammation and Atherosclerosis in LDLr-Deficient Mice

scientific article

The effect of tiotropium in combination with olodaterol on house dust mite-induced allergic airway disease

scientific article

The innate immune function of airway epithelial cells in inflammatory lung disease

scientific article

The licorice pentacyclic triterpenoid component 18β-glycyrrhetinic acid enhances the activity of antibiotics against strains of methicillin-resistant Staphylococcus aureus

scientific article published on 15 January 2016

The positive prognostic effect of stromal CD8+ tumor-infiltrating T cells is restrained by the expression of HLA-E in non-small cell lung carcinoma

scientific article published on 7 December 2015

Therapeutic Application of an Extract of Helicobacter pylori Ameliorates the Development of Allergic Airway Disease

scientific article published on 19 January 2018

Toll-Like Receptor (TLR2 and TLR4) Polymorphisms and Chronic Obstructive Pulmonary Disease ⬇️

scientific article published on August 28, 2012

Translation of in vitro findings to patients with asthma: a timely and compelling challenge

scientific article published on 10 October 2019

Use of airway epithelial cell culture to unravel the pathogenesis and study treatment in obstructive airway diseases

scientific article

Xenobiotic metabolism in differentiated human bronchial epithelial cells

scientific article published on 13 October 2016

microRNA profiling in lung tissue and bronchoalveolar lavage of cigarette smoke-exposed mice and in COPD patients: a translational approach.

scientific article published on 9 October 2017

microRNA–mRNA regulatory networks underlying chronic mucus hypersecretion in COPD

scientific article published on 06 September 2018

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