List of works by Geoffrey Ian McFadden

A GFP-actin reporter line to explore microfilament dynamics across the malaria parasite lifecycle

scientific article published on 25 November 2011

A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver TRM Cell-Mediated Immunity against Malaria in Mice

scientific article published on 06 May 2020

A dual-targeted aminoacyl-tRNA synthetase in Plasmodium falciparum charges cytosolic and apicoplast tRNACys

scientific article (publication date: 15 March 2014)

A genetic screen in rodent malaria parasites identifies five new apicoplast putative membrane transporters, one of which is essential in human malaria parasites.

scientific article published on 13 September 2017

A mitochondrial protein affects cell morphology, mitochondrial segregation and virulence in Leishmania.

scientific article

A new marine prasinophyte genus alternates between a flagellate and a dominant benthic stage with microrhizoids for adhesion

scientific article published on 09 October 2019

A novel genetic technique in Plasmodium berghei allows liver stage analysis of genes required for mosquito stage development and demonstrates that de novo heme synthesis is essential for liver stage development in the malaria parasite

scientific article

A serine-arginine-rich (SR) splicing factor modulates alternative splicing of over a thousand genes in Toxoplasma gondii.

scientific article published on 13 April 2015

A type II pathway for fatty acid biosynthesis presents drug targets in Plasmodium falciparum

scientific article

Algal genomes reveal evolutionary mosaicism and the fate of nucleomorphs

scientific article

Alternative Splicing in Apicomplexan Parasites

article published in 2019

Alternative splicing is required for stage differentiation in malaria parasites.

scientific article published in August 2019

Alveolins, a new family of cortical proteins that define the protist infrakingdom Alveolata

scientific article (publication date: June 2008)

An Australian network to support the understanding and control of parasites.

scientific article published on 30 January 2006

An integrative bioinformatic predictor of protein sub-cellular localisation in malaria

scientific article published on 21 November 2011

Anti-plasmodial Effects of Zanthoxylum zanthoxyloides

scientific article published on 31 July 2019

Antimalarial activity of the anticancer histone deacetylase inhibitor SB939.

scientific article

Apicoplast

scientific article published on 01 March 2014

Apicoplast acetyl Co-A carboxylase of the human malaria parasite is not targeted by cyclohexanedione herbicides

scientific article (publication date: April 2014)

Apicoplast and mitochondrion in gametocytogenesis of Plasmodium falciparum.

scientific article

Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii.

scientific article

Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance inToxoplasma gondii

scholarly article by Sethu C. Nair et al published 30 April 2012 in Journal of Experimental Medicine

Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal/Plant-Like Glycerol 3-Phosphate Acyltransferase

scientific article

Atypical lipid composition in the purified relict plastid (apicoplast) of malaria parasites

scientific article published on 15 April 2013

Bed Nets, Insecticides, and Antimalarials: Where to Next?

scientific article published on 11 July 2019

CD8 T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver

article

CD8+ T cells from a novel T cell receptor transgenic mouse induce liver-stage immunity that can be boosted by blood-stage infection in rodent malaria

scientific article published on 22 May 2014

CRYPTOMONAD EVOLUTION: NUCLEAR 18S rDNA PHYLOGENY VERSUS CELL MORPHOLOGY AND PIGMENTATION1

scholarly article by James A. Deane et al published 19 December 2002 in Journal of Phycology

Calcium negatively regulates secretion from dense granules in Toxoplasma gondii.

scientific article

Characterisation of a Leishmania mexicana knockout lacking guanosine diphosphate-mannose pyrophosphorylase

scientific article published on July 2005

Characterization of TtALV2, an essential charged repeat motif protein of the Tetrahymena thermophila membrane skeleton

scientific article published on 19 April 2013

Characterization of the Plasmodium falciparum and P. berghei glycerol 3-phosphate acyltransferase involved in FASII fatty acid utilization in the malaria parasite apicoplast

scientific article (publication date: 20 June 2016)

Characterization of the apicoplast-localized enzyme TgUroD in Toxoplasma gondii reveals a key role of the apicoplast in heme biosynthesis

scientific article published on 30 December 2019

Characterization of the chloroquine resistance transporter homologue in Toxoplasma gondii

scientific article

Characterization of two malaria parasite organelle translation elongation factor G proteins: the likely targets of the anti-malarial fusidic acid

scientific article (publication date: 2011)

Characterization of two putative protein translocation components in the apicoplast of Plasmodium falciparum

scientific article (publication date: August 2009)

Chemobiosynthesis of new antimalarial macrolides.

scientific article published on 3 December 2012

Ciliate pellicular proteome identifies novel protein families with characteristic repeat motifs that are common to alveolates

scientific article

Comment on "A green algal apicoplast ancestor"

scientific article published on 01 July 2003

Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates

scientific article published on 18 September 2017

Complete nucleotide sequence of the chlorarachniophyte nucleomorph: nature's smallest nucleus

scientific article

Defining the timing of action of antimalarial drugs against Plasmodium falciparum

scientific article published on 14 January 2013

Development of a Novel CD4+ TCR Transgenic Line That Reveals a Dominant Role for CD8+ Dendritic Cells and CD40 Signaling in the Generation of Helper and CTL Responses to Blood-Stage Malaria

scientific article published on 30 October 2017

Development of the endoplasmic reticulum, mitochondrion and apicoplast during the asexual life cycle of Plasmodium falciparum.

scientific article published in July 2005

Diatom genomics: genetic acquisitions and mergers.

scientific article

Differential gene transfers and gene duplications in primary and secondary endosymbioses

scientific article

Dimeric cyclohexane-1,3-dione oximes inhibit wheat acetyl-CoA carboxylase and show anti-malarial activity.

scientific article published on 8 June 2010

Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum

scientific article published in January 2003

Division and Adaptation to Host Environment of Apicomplexan Parasites Depend on Apicoplast Lipid Metabolic Plasticity and Host Organelle Remodeling

scientific article published on 01 March 2020

Dual targeting of aminoacyl-tRNA synthetases to the apicoplast and cytosol in Plasmodium falciparum

scientific article (publication date: February 2012)

Dynamin: the endosymbiosis ring of power?

scholarly article

Endosymbiosis undone by stepwise elimination of the plastid in a parasitic dinoflagellate

scientific article

Erratum to: Natural products from Zanthoxylum heitzii with potent activity against the malaria parasite

scientific article published on 17 November 2016

Evidence for Golgi-independent transport from the early secretory pathway to the plastid in malaria parasites

scientific article published on 20 June 2006

Evolution of galactoglycerolipid biosynthetic pathways--from cyanobacteria to primary plastids and from primary to secondary plastids

scientific article published on 02 March 2014

Evolution of malaria parasite plastid targeting sequences

scholarly article

Evolution: Of X-Cells and X-Men.

scientific article published in June 2017

Evolution: red algal genome affirms a common origin of all plastids

scientific article

Evolutionary pressures on apicoplast transit peptides

scientific article

Fatty acid metabolism in the Plasmodium apicoplast: Drugs, doubts and knockouts.

scientific article published on January 2015

From the genome to the phenome: tools to understand the basic biology of Plasmodium falciparum

scientific article published on 16 October 2014

Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes

scientific article

Gamete fusion: key protein identified.

scientific article published in July 2008

Genome sequence of the human malaria parasite Plasmodium falciparum

scientific article

Glycolipid-peptide vaccination induces liver-resident memory CD8+ T cells that protect against rodent malaria

scientific article published on 01 June 2020

Host biotin is required for liver stage development in malaria parasites.

scientific article published on 26 February 2018

Identification of plant-like galactolipids in Chromera velia, a photosynthetic relative of malaria parasites

scientific article

Inhibition of dendritic cell maturation by malaria is dose dependent and does not require Plasmodium falciparum erythrocyte membrane protein 1

scientific article published on 30 April 2007

Inhibition of malaria parasite development by a cyclic peptide that targets the vital parasite protein SERA5.

scientific article

Is the Mitochondrion a Good Malaria Drug Target?

scientific article

Isolating the Plasmodium falciparum Apicoplast Using Magnetic Beads

scientific article published on 01 January 2018

Jam packed genomes--a preliminary, comparative analysis of nucleomorphs

scientific article

Leishmania adaptor protein-1 subunits are required for normal lysosome traffic, flagellum biogenesis, lipid homeostasis, and adaptation to temperatures encountered in the mammalian host.

scientific article published on 30 May 2008

Liver-Resident Memory CD8+ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection

scientific article published on 17 September 2016

Liver-Resident Memory CD8+ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection

scientific article published on 01 October 2019

Localization of organellar proteins in Plasmodium falciparum using a novel set of transfection vectors and a new immunofluorescence fixation method

scientific article (publication date: September 2004)

Loss of nucleosomal DNA condensation coincides with appearance of a novel nuclear protein in dinoflagellates

scientific article

Lysine acetylation in sexual stage malaria parasites is a target for antimalarial small molecules.

scientific article

Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum ⬇️

scientific article

Malaria parasite colonisation of the mosquito midgut--placing the Plasmodium ookinete centre stage

scientific article published on 03 March 2012

Malaria, Plasmodium falciparum and its apicoplast

scientific article

Malaria: differential parasite drive.

scientific article published in December 2007

Membrane protein SMP-1 is required for normal flagellum function in Leishmania

scientific article published on 19 January 2010

Membrane transporters in the relict plastid of malaria parasites

scientific article (publication date: 20 June 2006)

Metabolic maps and functions of the Plasmodium mitochondrion

scientific article (publication date: July 2006)

Mitochondrial ATP synthase is dispensable in blood-stage Plasmodium berghei rodent malaria but essential in the mosquito phase

scientific article

Molecular Phylogeny of Chlorarachniophytes Based on Plastid rRNA and rbcL Sequences

scholarly article by Geoffrey I. McFadden et al published April 1995 in Archiv für Protistenkunde

More plastids in human parasites?

scientific article published on February 2004

N-terminal positively charged amino acids, but not their exact position, are important for apicoplast transit peptide fidelity in Toxoplasma gondii

scientific article published on 28 August 2006

Natural products from Zanthoxylum heitzii with potent activity against the malaria parasite

scientific article

New proteins in the apicoplast membranes: time to rethink apicoplast protein targeting.

scientific article published on 5 April 2009

Organelle division: dynamin-related proteins in apicomplexans

scientific article published in April 2009

Origin and evolution of plastids and photosynthesis in eukaryotes

scientific article (publication date: April 2014)

Parasites resistant to the antimalarial atovaquone fail to transmit by mosquitoes

scientific article

Phenotypic variation of Plasmodium falciparum merozoite proteins directs receptor targeting for invasion of human erythrocytes ⬇️

scientific article (publication date: 3 March 2003)

Plasmodium berghei Hsp90 contains a natural immunogenic I-A<sup>b</sup>-restricted antigen common to rodent and human Plasmodium species

scientific article published on 30 June 2021

Plasmodium falciparum Rab1A Localizes to Rhoptries in Schizonts

scientific article (publication date: 2016)

Plasmodium falciparum apicoplast drugs: targets or off-targets?

scientific article

Plasmodium falciparumgrowth is arrested by monoterpenes from eucalyptus oil

Plastid evolution

scientific article

Processing of an apicoplast leader sequence in Plasmodium falciparum and the identification of a putative leader cleavage enzyme

scientific article (publication date: 28 June 2002)

Properties and prediction of mitochondrial transit peptides from Plasmodium falciparum

scientific article (publication date: December 2003)

Protein targeting to destinations of the secretory pathway in the malaria parasite Plasmodium falciparum

scientific article published on 7 July 2006

Protein targeting to the malaria parasite plastid.

scientific article published on 13 November 2007

Quantitative analysis of Plasmodium ookinete motion in three dimensions suggests a critical role for cell shape in the biomechanics of malaria parasite gliding motility

scientific article

Retargeting azithromycin analogues to have dual-modality antimalarial activity

scientific article published on 29 September 2020

Rewiring and regulation of cross-compartmentalized metabolism in protists

scientific article (publication date: 12 March 2010)

SMP-1, a member of a new family of small myristoylated proteins in kinetoplastid parasites, is targeted to the flagellum membrane in Leishmania

scientific article

Sequence Variability of Three Alleles of the Self-Incompatibility Gene of Nicotiana alata

article

Sequential Membrane Rupture and Vesiculation during Plasmodium berghei Gametocyte Egress from the Red Blood Cell

scientific article published on 23 February 2018

Shikimate pathway in apicomplexan parasites

scientific article published in Nature

Sodium-dependent uptake of inorganic phosphate by the intracellular malaria parasite

scientific article (publication date: 5 October 2006)

Spatial localisation of actin filaments across developmental stages of the malaria parasite

scientific article (publication date: 2012)

Structured illumination microscopy reveals actin I localization in discreet foci in Plasmodium berghei gametocytes

scientific article published on 10 August 2017

Sulfonylpiperazine compounds prevent Plasmodium falciparum invasion of red blood cells through interference with actin-1/profilin dynamics

scientific article published in 2023

Symbiotic lifestyle triggers drastic changes in the gene expression of the algal endosymbiont Breviolum minutum (Symbiodiniaceae)

scientific article published on 12 December 2019

Synthesis and antimalarial activity of prodigiosenes

scientific article published on 01 June 2014

Targeting Protein Translation in Organelles of the Apicomplexa

scientific article published on 25 October 2016

Targeting apicoplasts in malaria parasites.

scientific article published on 11 December 2012

Targeting of a Transporter to the Outer Apicoplast Membrane in the Human Malaria Parasite Plasmodium falciparum

scientific article

The Clp chaperones and proteases of the human malaria parasite Plasmodium falciparum

scientific article

The Complete Chloroplast Genome of the Chlorarachniophyte Bigelowiella natans: Evidence for Independent Origins of Chlorarachniophyte and Euglenid Secondary Endosymbionts

scientific article

The Import of Proteins into the Mitochondrion of Toxoplasma gondii

scientific article (publication date: 9 September 2016)

The Plasmodium translocon of exported proteins (PTEX) component thioredoxin-2 is important for maintaining normal blood-stage growth

scientific article (publication date: September 2013)

The Plasmodium translocon of exported proteins component EXP2 is critical for establishing a patent malaria infection in mice

scientific article published on 8 September 2015

The apicoplast: A plastid in Plasmodium falciparum and other apicomplexan parasites

scientific article published on January 1, 2003

The apicoplast: a review of the derived plastid of apicomplexan parasites.

scientific article

The carbon and energy sources of the non-photosynthetic plastid in the malaria parasite

scientific article published on 4 December 2009

The chloroplast protein translocation complexes of Chlamydomonas reinhardtii: a bioinformatic comparison of Toc and Tic components in plants, green algae and red algae

scientific article published on May 2008

The cryptomonad nucleomorph

scientific article published on 21 August 2017

The effects of anti-bacterials on the malaria parasite Plasmodium falciparum.

scientific article published on 9 January 2007

The evolution of organellar metabolism in unicellular eukaryotes

scientific article published on March 2010

The human malaria parasite Plasmodium falciparum possesses two distinct dihydrolipoamide dehydrogenases

scientific article (publication date: 2005)

The malaria parasite Plasmodium falciparum has only one pyruvate dehydrogenase complex, which is located in the apicoplast

scientific article (publication date: 2005)

The metabolic roles of the endosymbiotic organelles of Toxoplasma and Plasmodium spp

scientific article

The use and abuse of heme in apicomplexan parasites.

scientific article published on 16 March 2012

Tic22 Is an Essential Chaperone Required for Protein Import into the Apicoplast

scientific article

Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast

scientific article published in March 2004

Validation of Putative Apicoplast-Targeting Drugs Using a Chemical Supplementation Assay in Cultured Human Malaria Parasites.

scientific article published on 6 November 2017

Ycf93 (Orf105), a small apicoplast-encoded membrane protein in the relict plastid of the malaria parasite Plasmodium falciparum that is conserved in Apicomplexa

scientific article

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