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List of works by Richard Hynes

10 nm filaments in normal and transformed cells ⬇️

scientific article published on January 1, 1978

A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis

scientific article

A difference between plasma and cellular fibronectins located with monoclonal antibodies ⬇️

scientific article published on 01 July 1981

A direct test of potential roles for beta3 and beta5 integrins in growth and metastasis of murine mammary carcinomas

scientific article published on 01 November 2005

A method for separating cells from early sea urchin embryos ⬇️

scientific article published on 01 March 1970

A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis

scientific journal article

A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy

scientific article

A single rat fibronectin gene generates three different mRNAs by alternative splicing of a complex exon

scientific article published on August 1984

A system for Cre-regulated RNA interference in vivo

scholarly article

Agrin in the Muscularis Mucosa Serves as a Biomarker Distinguishing Hyperplastic Polyps from Sessile Serrated Lesions

scientific article published on 18 December 2019

Alpha4beta1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development

scientific article

Alteration of cell-surface proteins by viral transformation and by proteolysis

scientific article

Alterations in surface proteins in chicken cells transformed by temperature-sensitive mutants of Rous sarcoma virus ⬇️

scientific article published on April 1, 1975

Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow

scientific article published on 2 January 2018

Alternative splicing of endothelial fibronectin is induced by disturbed hemodynamics and protects against hemorrhage of the vessel wall

scientific article

An angiogenic role for the α5β1 integrin in promoting endothelial cell proliferation during cerebral hypoxia ⬇️

scientific article published on June 18, 2012

An interaction between {alpha}v{beta}8 integrin and Band 4.1B via a highly conserved region of the Band 4.1 C-terminal domain

scientific article

Analyses of the role of endogenous SPARC in mouse models of prostate and breast cancer

scientific article published on 5 December 2007

Analysis of Repeated Motifs in the Talin Rod

article

Antibodies and methods for immunohistochemistry of extracellular matrix proteins

scientific article published on 03 May 2018

Astrocytes in culture synthesize and secrete a variant form of fibronectin

scientific article published on 01 August 1985

C3 component of complement secreted by established cell lines ⬇️

scientific article published on October 1, 1978

CD40L stabilizes arterial thrombi by a β3 integrin–dependent mechanism

scientific article published on 01 March 2002

CUB-domain-containing protein 1 (CDCP1) activates Src to promote melanoma metastasis

scientific article

Cancer Cell-Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma

scientific article published on 06 February 2020

Cellular and subcellular localization of lets protein in the nervous system ⬇️

scientific article published on December 8, 1978

Central Roles of α 5 β 1 Integrin and Fibronectin in Vascular Development in Mouse Embryos and Embryoid Bodies

scientific article published in June 2002

Changes in integrin receptors on oncogenically transformed cells

scientific article published in January 1989

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

scientific article

Comparative genomics of the eukaryotes

scientific article (publication date: 24 March 2000)

Complete replication of hepatitis C virus in cell culture

scientific article (publication date: 22 July 2005)

Comprehensive proteomic characterization of stem cell-derived extracellular matrices

scientific article published on 7 March 2017

Corrigendum: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis

scientific article published in December 2017

Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner ⬇️

scientific article published on May 27, 2011

Decreased plasma fibronectin leads to delayed thrombus growth in injured arterioles

scientific article published on 09 March 2006

Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins

scientific article

Deformability of Tumor Cells versus Blood Cells

scientific article

Density and cell cycle dependence of cell surface proteins in hamster fibroblasts ⬇️

scientific article published on October 1, 1974

Determination of 35 cell surface antigen levels in malignant pleural effusions identifies CD24 as a marker of disseminated tumor cells ⬇️

scientific article published on July 13, 2013

Developmental defects in mouse embryos lacking N-cadherin

scientific article

Developmentally regulated cell surface alterations in Dictyostelium discoideum ⬇️

scientific article published on September 27, 1974

Direct test of potential roles of EIIIA and EIIIB alternatively spliced segments of fibronectin in physiological and tumor angiogenesis

scientific article published on October 2004

Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere

scientific article

Distribution of fibronectin in the ectoderm of gastrulating chick embryos ⬇️

scientific article published on August 9, 1979

Drosophila PS1 integrin is a laminin receptor and differs in ligand specificity from PS2.

scientific article published in November 1994

Effects of LETS glycoprotein on cell motility

scientific article published on June 1, 1978

Efficient and stable expression of recombinant fibronectin polypeptides

scientific article

Elements regulating an alternatively spliced exon of the rat fibronectin gene

scientific article published on September 1993

Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during development

scientific article

Endothelium-derived fibronectin regulates neonatal vascular morphogenesis in an autocrine fashion

scientific article published on 30 June 2017

Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins

scientific article published on 01 January 2002

Enrichment of Extracellular Matrix Proteins from Tissues and Digestion into Peptides for Mass Spectrometry Analysis

scientific article

Essential roles of fibronectin in the development of the left-right embryonic body plan

scientific article

Evolving policy with science

scientific article

Expression of normal and mutant avian integrin subunits in rodent cells

scientific article

Extensive disulfide bonding at the mammalian cell surface ⬇️

scientific article published on July 1, 1977

Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters

scientific article published on 11 March 2014

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

scientific article

Fibronectin localization in the rat glomerulus

scientific article

Fibronectin regulates assembly of actin filaments and focal contacts in cultured cells via the heparin-binding site in repeat III13.

scientific article published on May 1999

Fibronectin-coated beads are endocytosed by cells and align with microfilament bundles

scientific article published on 01 August 1982

GPR56 Regulates VEGF Production and Angiogenesis during Melanoma Progression ⬇️

scientific article published on August 15, 2011

GPR56 plays varying roles in endogenous cancer progression

scientific article

GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis

scientific article

Gene expression changes in an animal melanoma model correlate with aggressiveness of human melanoma metastases

scientific article published on May 2008

Genetic ablation of alphav integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma

scientific article published on 8 May 2008

Genomic analysis of metastasis reveals an essential role for RhoC

scientific article (publication date: 3 August 2000)

Heart development in fibronectin-null mice is governed by a genetic modifier on chromosome four

scientific article published on 02 June 2007

Identification and characterization of alternatively spliced fibronectin mRNAs expressed in early Xenopus embryos

scientific article

Identification of the peptide sequences within the EIIIA (EDA) segment of fibronectin that mediate integrin alpha9beta1-dependent cellular activities.

scientific article

Immunocytochemical localization of fibronectin in embryonic chick trunk and area vasculosa

scientific article published on 01 March 1981

Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy

scientific article published on 09 February 2016

In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling

scientific article published on 13 June 2013

In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis

scientific article

Increased primary tumor growth in mice null for beta3- or beta3/beta5-integrins or selectins

scholarly article

Integrin receptors are required for cell survival and proliferation during development of the peripheral glial lineage

scientific article published in May 2001

Integrin-dependent and -independent functions of astrocytic fibronectin in retinal angiogenesis.

scientific article

Integrin-mediated Signals Regulated by Members of the Rho Family of GTPases ⬇️

scientific article published on July 27, 1998

Integrin-targeted cancer immunotherapy elicits protective adaptive immune responses

scientific article

Integrin-α5β1 is not required for mural cell functions during development of blood vessels but is required for lymphatic-blood vessel separation and lymphovenous valve formation

scientific article

Integrins: bidirectional, allosteric signaling machines

scientific article (publication date: 20 September 2002)

Interaction of fibronectin with its receptor on platelets

scientific article published on 01 September 1985

Intravital imaging of metastasis in adult Zebrafish.

scientific article published on 25 September 2017

Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet

scientific article published on 01 August 2019

Knockout of the gene encoding the extracellular matrix protein SNED1 results in early neonatal lethality and craniofacial malformations

scientific article published on 04 October 2020

Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE.

scientific article

Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles

scientific article

Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways

scientific article published on 21 November 2016

Maximizing response to intratumoral immunotherapy in mice by tuning local retention

scientific article published on 10 January 2022

Mena binds α5 integrin directly and modulates α5β1 function ⬇️

scientific article published on August 20, 2012

Mesodermal development in mouse embryos mutant for fibronectin

scientific article published on 01 October 1996

Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin

scientific article

Multiple sites of alternative splicing of the rat fibronectin gene transcript

scientific article

Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in immunocompetent mice

scientific article published on 01 April 2019

Natural killer cells require selectins for suppression of subcutaneous tumors

scientific article published on 03 March 2009

Nephronectin is Correlated with Poor Prognosis in Breast Cancer and Promotes Metastasis via its Integrin-Binding Motifs

scientific article published on 11 March 2018

Noninvasive imaging of tumor progression, metastasis, and fibrosis using a nanobody targeting the extracellular matrix

scientific article published on 08 May 2019

Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils

scientific article published in December 2017

PF4 Promotes Platelet Production and Lung Cancer Growth

scientific article published on November 2016

Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen

scientific journal article

Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin

scientific article

Plasma fibronectin promotes thrombus growth and stability in injured arterioles

scientific article

Platelets guide the formation of early metastatic niches

scientific article

Precocious mammary gland development in P-cadherin-deficient mice.

scientific article

Primordial germ cells of Xenopus embryos: The role of fibronectin in their adhesion during migration ⬇️

scientific article published on 01 December 1981

Protein 4.1B suppresses prostate cancer progression and metastasis

scholarly article

Proteomic Profiling of the ECM of Xenograft Breast Cancer Metastases in Different Organs Reveals Distinct Metastatic Niches

scientific article published on 04 February 2020

Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells

scientific article published on 04 September 2019

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

scientific article published on 10 January 2017

Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survival

scientific article

Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A2 but not for cytoskeletal organization

scientific article published on June 1996

Regulation of alternative pre-mRNA splicing by a novel repeated hexanucleotide element

scientific article published in July 1994

Relationships between fibronectin (LETS protein) and actin ⬇️

scientific article published on November 1, 1978

Repeating modular structure of the fibronectin gene: relationship to protein structure and subunit variation

scientific article

Restoration of normal morphology, adhesion and cytoskeleton in transformed cells by addition of a transformation-sensitive surface protein ⬇️

scientific article published on May 1, 1977

Retroviral expression of alternatively spliced forms of rat fibronectin

scientific article

SRC tyrosine kinase activates the YAP/TAZ axis and thereby drives tumor growth and metastasis

scientific article published on 17 December 2018

Selective ablation of v integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death

scientific article published on 02 December 2004

Spirochete-platelet attachment and thrombocytopenia in murine relapsing fever borreliosis.

scientific article

Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin

scientific article

Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins

scientific article published on 01 February 1996

Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis

scientific article

Temporal and spatial regulation of fibronectin in early Xenopus development

scientific article published on 01 March 1984

The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain ⬇️

scientific article published on August 13, 2012

The cytoskeletal protein talin contains at least two distinct vinculin binding domains

scientific article

The echinoderm adhesome

scientific article

The evolution of cell adhesion

scientific article

The extracellular matrix: Tools and insights for the "omics" era

scientific article

The genome of the sea urchin Strongylocentrotus purpuratus

scientific article

The integrin PSI domain has an endogenous thiol isomerase function and is a novel target for antiplatelet therapy

scientific article published on 25 January 2017

The lack of ADAM17 activity during embryonic development causes hemorrhage and impairs vessel formation

scientific article

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices

scientific article published on 9 December 2011

The scaffold protein IQGAP1 is crucial for extravasation and metastasis

scientific article published on 12 February 2020

The spatial and temporal expression patterns of integrin alpha9beta1 and one of its ligands, the EIIIA segment of fibronectin, in cutaneous wound healing

scientific article published on December 2004

The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins

scientific article

Therapeutic expression of the platelet-specific integrin, alphaIIbbeta3, in a murine model for Glanzmann thrombasthenia.

scientific article published on 21 June 2005

Three different fibronectin mRNAs arise by alternative splicing within the coding region ⬇️

scientific article published on December 1, 1983

Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia ⬇️

scientific article published on March 1, 1998

Toward Responsible Human Genome Editing

scientific article

Towards definition of an ECM parts list: an advance on GO categories.

scientific article published on September 2012

Transformed mammalian cells secrete specific proteins and phosphoproteins ⬇️

scientific article published on April 1, 1979

Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression

scientific article published on 25 January 2016

Tumor angiogenesis in the absence of fibronectin or its cognate integrin receptors

scientific article

Tumor-secreted vascular endothelial growth factor-C is necessary for prostate cancer lymphangiogenesis, but lymphangiogenesis is unnecessary for lymph node metastasis

scientific article published on 01 November 2005

Tumstatin, an endothelial cell-specific inhibitor of protein synthesis

scientific article

Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrins

scholarly article

Viral transformation of rat myoblasts: Effects on fusion and surface properties ⬇️

scientific article published on January 1, 1976

YAP Enhances Tumor Cell Dissemination by Promoting Intravascular Motility and Re-entry into Systemic Circulation

scientific article published on 26 June 2020

α4β1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development

α5 and αv integrins cooperate to regulate vascular smooth muscle and neural crest functions in vivo

scientific article

αV integrins in Schwann cells promote attachment to axons, but are dispensable in vivo

scientific article published on 03 August 2020

αv Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice

scientific article

αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells

scientific article published on 11 March 2016

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