List of works by Richard Flavell

A 55-kilodalton antigen encoded by a gene on a Borrelia burgdorferi 49-kilobase plasmid is recognized by antibodies in sera from patients with Lyme disease ⬇️

scientific article published on September 1, 1995

A Highly Efficient and Faithful MDS Patient-Derived Xenotransplantation Model for Pre-Clinical Studies

A Molecular Chipper technology for CRISPR sgRNA library generation and functional mapping of noncoding regions

scientific article

A Protective Function of IL-22BP in Ischemia Reperfusion and Acetaminophen-Induced Liver Injury.

scientific article published on 6 November 2017

A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress.

scientific article published on September 2017

A Salmonella protein causes macrophage cell death by inducing autophagy

scientific article

A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system

scientific article

A central role of CD40 ligand in the regulation of CD4+ T-cell responses

scientific article published on September 1996

A chromosomal Borrelia burgdorferi gene encodes a 22-kilodalton lipoprotein, P22, that is serologically recognized in Lyme disease

scientific article published on April 1994

A critical role of neural-specific JNK3 for ischemic apoptosis

scientific article

A crucial role of CD4 T cells as a functional source of CD154 in the initiation of insulin-dependent diabetes mellitus in the non-obese diabetic mouse

scientific article published on 01 March 2003

A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells

scientific article published on December 2004

A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells

A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells.

scientific article

A dual role for TNF-alpha in type 1 diabetes: islet-specific expression abrogates the ongoing autoimmune process when induced late but not early during pathogenesis

scientific article published on 01 June 2001

A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies

scientific article published in Nature Communications

A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen

scientific journal article

A monoclonal antibody to OspA inhibits association of Borrelia burgdorferi with human endothelial cells ⬇️

scientific article published on February 1, 1993

A mouse model for the human pathogen Salmonella typhi

scientific article published on October 2010

A non-redundant role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury

scientific journal article

A novel humanized mouse model with significant improvement of class-switched, antigen-specific antibody production

scientific article published on 11 January 2017

A novel role for the major histocompatibility complex class II transactivator CIITA in the repression of IL-4 production

scientific article published on 01 March 1999

A pathogenic role for T cell-derived IL-22BP in inflammatory bowel disease

scientific article published in October 2016

A pathway involving HDAC5, cFLIP and caspases regulates expression of the splicing regulator polypyrimidine tract binding protein in the heart.

scientific article published on 19 February 2013

A pool of central memory-like CD4 T cells contains effector memory precursors

scientific article published in March 2003

A protective function for interleukin 17A in T cell-mediated intestinal inflammation

scientific article published on June 2009

A role for IL-1 receptor-associated kinase-M in prostaglandin E2-induced immunosuppression post-bone marrow transplantation.

scientific article

A role for tumor necrosis factor receptor type 1 in gut-associated lymphoid tissue development: genetic evidence of synergism with lymphotoxin beta

scientific article published on June 1998

A scaffold protein, AHNAK1, is required for calcium signaling during T cell activation

scientific article published on January 2008

A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis

scientific article

A special collection of reviews on frontiers in immunology

scientific article published on 28 August 2020

A toll-like receptor that prevents infection by uropathogenic bacteria

scientific journal article

ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cells

scientific article

AIM2 Engages Active but Unprocessed Caspase-1 to Induce Noncanonical Activation of the NLRP3 Inflammasome.

scientific article

AMCase is a crucial regulator of type 2 immune responses to inhaled house dust mites

scientific article published on 18 May 2015

AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes.

scientific article published on September 1994

APOPTOSIS: Death of a Monopoly?

scientific article published on 01 May 2001

ASC/PYCARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infection

scientific article

Abnormal findings on multiparametric prostate magnetic resonance imaging predict subsequent biopsy upgrade in patients with low risk prostate cancer managed with active surveillance

scientific article published on October 2014

Abrogated transforming growth factor beta receptor II (TGFβRII) signalling in dendritic cells promotes immune reactivity of T cells resulting in enhanced atherosclerosis.

scientific article published on 21 May 2012

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

scientific journal article

Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome.

scientific article published on 26 January 2009

Acetylation of MKP-1 and the control of inflammation.

scientific article published on 14 October 2008

Acidic mammalian chitinase regulates epithelial cell apoptosis via a chitinolytic-independent mechanism

scientific article published on April 2009

Activation of CD4 T cells by Raf-independent effectors of Ras ⬇️

scientific article published on April 29, 2003

Activation of NF-kappaB promotes the transition of large, CD43+ pre-B cells to small, CD43- pre-B cells

scientific article published on 20 May 2005

Activation of mast cells by double-stranded RNA: evidence for activation through Toll-like receptor 3.

scientific article published in July 2004

Activation of p38 Mitogen-Activated Protein Kinase Contributes to the Early Cardiodepressant Action of Tumor Necrosis Factor

article

Activation of the STAT Signaling Pathway Can Cause Expression of Caspase 1 and Apoptosis ⬇️

scientific article published on September 1, 1997

Activation of the p38 mitogen-activated protein kinase pathway arrests cell cycle progression and differentiation of immature thymocytes in vivo

scientific article

Activin a promotes the TGF-beta-induced conversion of CD4+CD25- T cells into Foxp3+ induced regulatory T cells

scientific article

Adaptive and innate transforming growth factor beta signaling impact herpes simplex virus 1 latency and reactivation

scientific article

Adenosine is required for sustained inflammasome activation via the A₂A receptor and the HIF-1α pathway

scientific article published on January 2013

Adenosine metabolism and murine strain-specific IL-4-induced inflammation, emphysema, and fibrosis

scientific article

Adoptive transfer of CD8(+) T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice

scientific article published on June 2008

All's well that ends dead

scientific article published in Nature

Alpha-4 integrins and VCAM-1, but not MAdCAM-1, are essential for recruitment of mast cell progenitors to the inflamed lung

scientific article published on 2 May 2006

Alternative activation of macrophages by IL-4 requires SHIP degradation.

scientific article

Amino acid polymorphisms altering the glycosylation of IL-2 do not protect from type 1 diabetes in the NOD mouse.

scientific article published on 22 June 2009

Amino-termini isoforms of the Slack K+ channel, regulated by alternative promoters, differentially modulate rhythmic firing and adaptation

scientific article published on 11 September 2008

Amyloid beta-induced neuronal death is bax-dependent but caspase-independent.

scientific article published in April 2000

An Intrinsic Mechanism Predisposes Foxp3-Expressing Regulatory T Cells to Th2 Conversion In Vivo ⬇️

scientific article published on October 13, 2010

An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance

scientific article published on 12 March 2009

An ospA frame shift, identified from DNA in Lyme arthritis synovial fluid, results in an outer surface protein A that does not bind protective antibodies

scientific article published in December 1995

Analysis of microbiota alterations in inflammasome-deficient mice

scientific article

Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity

scientific article published on 20 November 2017

Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity

scientific article

Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-beta receptor II dominant-negative mice

scientific article published in August 2006

Antigen-mediated regulation in monoclonal gammopathies and myeloma.

scientific article published on 19 April 2018

Antimycin A induced cardioprotection is dependent on pre-ischemic p38-MAPK activation but independent of MKK3.

scientific article published in October 2005

Antiviral Peptides Targeting the West Nile Virus Envelope Protein

scientific article

Antiviral immunity: a link to bile acids

scientific article published on 01 March 2019

Antivirulence properties of an antifreeze protein

scientific article

Apoptosis in response to microbial infection induces autoreactive TH17 cells

scientific article published on 25 July 2016

Apoptosis is not required for mammalian neural tube closure.

scholarly article

Apoptosome-independent activation of the lysosomal cell death pathway by caspase-9.

scientific article

Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.

scientific article

Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9.

scientific article published on November 2007

Arthritogenic properties of double-stranded (viral) RNA.

scientific article published in May 2004

Arthropod- and host-specific Borrelia burgdorferi bbk32 expression and the inhibition of spirochete transmission

scientific article published in May 2000

Author Correction: Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function

scientific article published on 01 September 2019

Author Correction: Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity

scientific article published on 01 November 2019

Author Correction: metabolic signaling in T cells

correction of a scholarly article

Autocrine secretion of interferon gamma negatively regulates homing of immature B cells.

scientific article published on November 2000

Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation

scientific article published on March 2011

Autocrine/paracrine TGF-β1 inhibits Langerhans cell migration

scientific article

Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells

scientific article

Autoimmune lpr/lpr mice deficient in CD40 ligand: spontaneous Ig class switching with dichotomy of autoantibody responses

scientific article published on 01 July 1996

Autoimmunity without diabetes in transgenic mice expressing beta cell-specific CD86, but not CD80: parameters that trigger progression to diabetes

scientific article published on 01 September 1998

B cells suppress the inflammatory response in a mouse model of primary biliary cirrhosis.

scientific article published on 19 November 2008

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

scientific article (publication date: September 2001)

BRG1-mediated immune tolerance: facilitation of Treg activation and partial independence of chromatin remodelling

scientific article published on 15 January 2013

Bacterial Autoimmune Drug Metabolism Transforms an Immunomodulator into Structurally and Functionally Divergent Antibiotics

scientific article published on 25 February 2020

Bacterial flagellin stimulates Toll-like receptor 5-dependent defense against vancomycin-resistant Enterococcus infection.

scientific article

Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo.

scientific article

Bcl-X(L)-caspase-9 interactions in the developing nervous system: evidence for multiple death pathways

scientific journal article

Bcl6 expression specifies the T follicular helper cell program in vivo

scientific article

Beneficial innate signaling interference for antibacterial responses by a Toll-like receptor-mediated enhancement of the MKP-IRF3 axis.

scientific article

Blockade of CD40 ligand-CD40 interaction impairs CD4+ T cell-mediated alloreactivity by inhibiting mature donor T cell expansion and function after bone marrow transplantation

scientific article published on 01 January 1997

Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology

scientific article published on June 2008

Borrelia burgdorferi P35 and P37 proteins, expressed in vivo, elicit protective immunity

scientific article published on May 1997

Borrelia burgdorferi erpT expression in the arthropod vector and murine host.

scientific article

Borrelia burgdorferi genes selectively expressed in the infected host

scientific article

Borrelia burgdorferi strain 25015: characterization of outer surface protein A and vaccination against infection ⬇️

scientific article published on April 1, 1992

Borrelia burgdorferi–Infected, Interleukin‐6–Deficient Mice Have Decreased Th2 Responses and Increased Lyme Arthritis

article

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

scientific article published on 7 January 2015

CD154-CD40-independent up-regulation of B7-2 on splenic antigen-presenting cells and efficient T cell priming by staphylococcal enterotoxin A

scientific article published on 01 July 2003

CD4 T-cell differentiation and inflammatory bowel disease

scientific article published on 08 April 2009

CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes

scientific article

CD4+ICOS+ T lymphocytes inhibit T cell activation 'in vitro' and attenuate autoimmune encephalitis 'in vivo'

scientific article published on 28 February 2008

CD40 AND CD154 IN CELL-MEDIATED IMMUNITY

scientific article

CD40 is expressed and functional on neuronal cells

scientific article

CD40 ligand-deficient mice generate a normal primary cytotoxic T-lymphocyte response but a defective humoral response to a viral infection

scientific article published in December 1996

CD40 ligand-mediated interactions are involved in the generation of memory CD8(+) cytotoxic T lymphocytes (CTL) but are not required for the maintenance of CTL memory following virus infection

scientific article

CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid beta-peptide.

scientific article

CD40-CD40 ligand costimulation is required for generating antiviral CD4 T cell responses but is dispensable for CD8 T cell responses

scientific article published on 01 September 1999

CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response.

scientific article published on May 1996

CD45 ligation expands Tregs by promoting interactions with DCs

scientific article

CD62L is required on effector cells for local interactions in the CNS to cause myelin damage in experimental allergic encephalomyelitis

scientific article published on 01 March 2001

CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.

scientific article

CD8 locus nuclear dynamics during thymocyte development

scientific article published on 19 April 2010

CFTR is a negative regulator of γδ T cell IFN-γ production and antitumor immunity

scientific article published on 15 July 2020

COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence.

scientific article

Canonical autophagy dependent on the class III phosphoinositide-3 kinase Vps34 is required for naive T-cell homeostasis.

scientific article

Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway

scientific article

Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3.

scientific article published on 23 October 2002

Carbon monoxide inhibits T lymphocyte proliferation via caspase-dependent pathway

scientific article

Carbon monoxide modulates Fas/Fas ligand, caspases, and Bcl-2 family proteins via the p38alpha mitogen-activated protein kinase pathway during ischemia-reperfusion lung injury

scientific article published on 10 April 2003

Caspase 6 regulates B cell activation and differentiation into plasma cells

scientific article

Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation

scientific article

Caspase knockouts: matters of life and death.

scientific article

Caspase regulation of genotoxin-induced neural precursor cell death

scientific article published in November 2003

Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo

scientific article

Caspase-1, Caspase-8, and Calpain Are Dispensable for IL-33 Release by Macrophages

scientific article published on 01 December 2009

Caspase-11 activation in response to bacterial secretion systems that access the host cytosol.

scientific article

Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila

scientific article published on 10 January 2013

Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo

scientific article published on November 1998

Caspase-3 gene knockout defines cell lineage specificity for programmed cell death signaling in the ovary

scientific article

Caspase-3 is a pivotal mediator of apoptosis during regression of the ovarian corpus luteum

scientific article published in April 2002

Caspase-3 is required for apoptosis-associated DNA fragmentation but not for cell death in neurons deprived of potassium

scientific article published on 01 January 2000

Caspases 3 and 7: key mediators of mitochondrial events of apoptosis

scientific journal article

Caspases and T lymphocytes: a flip of the coin?

scientific article

Cellular Stress-Induced Metabolites in <i>Escherichia coli</i>

scientific article published in 2022

Characterization of Autoinducer-3 Structure and Biosynthesis in E. coli ⬇️

scientific article published on 22 January 2020

Characterization of a 30-kDa Borrelia burgdorferi substrate-binding protein homologue ⬇️

scientific article published on November 1, 1996

Checks and Balances: IL-23 in the Intestine ⬇️

scientific article published on August 27, 2010

Chemical genetic analysis of the time course of signal transduction by JNK

scientific article published on 01 March 2006

Chitinase 3-like-1 promotes Streptococcus pneumoniae killing and augments host tolerance to lung antibacterial responses

scientific article published on July 2012

Chloroquine-induced neuronal cell death is p53 and Bcl-2 family-dependent but caspase-independent

scientific article published on October 2001

Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor

scientific article

Circuit Design Features of a Stable Two-Cell System

scientific article published on 30 January 2018

Cleavage of FLICE (caspase-8) by granzyme B during cytotoxic T lymphocyte-induced apoptosis

scientific article published on 01 December 1997

Coexpression of B7-1 and viral ("self") transgenes in pancreatic beta cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes

scientific article published in December 1995

Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells

scientific article

Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration

scientific article

Colitis Promotes a Pathological Condition of the Liver in the Absence of Foxp3+ Regulatory T Cells

scientific article published on 16 November 2018

Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy

scientific article published on 15 July 2012

Comparison of whole-cell antibodies and an antigenic flagellar epitope of Borrelia burgdorferi in serologic tests for diagnosis of Lyme borreliosis ⬇️

scientific article published on December 1, 1992

Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis

scientific journal article

Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow

scientific article

Conference highlight: do T cells care about the mitogen-activated protein kinase signalling pathways?

scientific article

Configuration-dependent Presentation of Multivalent IL-15:IL-15Rα Enhances the Antigen-specific T Cell Response and Anti-tumor Immunity

scientific article published on 30 December 2015

Constitutive homing of mast cell progenitors to the intestine depends on autologous expression of the chemokine receptor CXCR2.

scientific article published on 10 February 2005

Constitutively CD40-activated B cells regulate CD8 T cell inflammatory response by IL-10 induction

scientific article published on 25 February 2013

Contextual regulation of inflammation: a duet by transforming growth factor-beta and interleukin-10.

scientific article published on April 2008

Continuity and Change

Contribution of Fas to diabetes development

scholarly article

Control of T helper cell differentiation--in search of master genes

scientific article

Control of TH17 cells occurs in the small intestine.

scientific article

Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation

scientific article

Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection.

scientific article

Cooperation between multiple microbial pattern recognition systems is important for host protection against the intracellular pathogen Legionella pneumophila

scientific article

Correction for Gyrd-Hansen et al., "Apoptosome-Independent Activation of the Lysosomal Cell Death Pathway by Caspase-9".

scientific article published on 29 December 2017

Correction: Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

Corrigendum: Development and function of human innate immune cells in a humanized mouse model

scientific article published in December 2017

Corrigendum: NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells

scientific article published on 25 November 2015

Critical role for the beta regulatory subunits of Cav channels in T lymphocyte function

scientific article

Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure

scientific article published on 21 December 2006

Cutting edge: Nlrp10 is essential for protective antifungal adaptive immunity against Candida albicans

scientific journal article

Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation

scientific article

Cutting edge: critical role of inducible costimulator in germinal center reactions

scientific article published on 01 March 2001

Cutting edge: deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-beta sensitivity in vitro and in vivo

scientific article published on February 2006

Cutting edge: nucleotide-binding oligomerization domain 1-dependent responses account for murine resistance against Trypanosoma cruzi infection

article

Cutting edge: regulation of T cell trafficking and primary immune responses by sphingosine 1-phosphate receptor 1.

scientific article

DUSP10 regulates intestinal epithelial cell growth and colorectal tumorigenesis

scientific article

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

scientific article

Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice

scientific journal article

Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice

scientific article

Defective T Cell Differentiation in the Absence of Jnk1

scientific article published on 01 December 1998

Defective Th function induced by a dominant-negative cAMP response element binding protein mutation is reversed by Bcl-2

scientific article published on 01 August 2000

Defective p53 engagement after the induction of DNA damage in cells deficient in topoisomerase 3beta

scholarly article

Defective survival of naive CD8+ T lymphocytes in the absence of the beta3 regulatory subunit of voltage-gated calcium channels

scientific article published on 18 October 2009

Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation

scientific article published on 01 November 2000

Deficiency in the c-Jun NH2-terminal kinase signaling pathway confers susceptibility to hyperoxic lung injury in mice

scientific article published on 21 March 2003

Deficiency of the zinc finger protein ZPR1 causes neurodegeneration

scientific journal article

Deletion of TLR3 alters the pulmonary immune environment and mucus production during respiratory syncytial virus infection

scientific article published on February 2006

Deletion of interleukin (IL)-12p35 induces liver fibrosis in dominant-negative TGFβ receptor type II mice

scientific article

Deletion of interleukin-6 in mice with the dominant negative form of transforming growth factor beta receptor II improves colitis but exacerbates autoimmune cholangitis

scientific article

Demethylation of a specific hypersensitive site in the Th2 locus control region

scholarly article

Dendritic cell-mediated activation-induced cytidine deaminase (AID)-dependent induction of genomic instability in human myeloma.

scientific article published on 10 January 2012

Deprivation of MKK7 in cardiomyocytes provokes heart failure in mice when exposed to pressure overload

scientific article

Despite high levels of expression in thymic epithelial cells, miR-181a1 and miR-181b1 are not required for thymic development.

scientific article published on 27 June 2018

Detecting "different": Pyrin senses modified GTPases

scientific article published on 5 August 2014

Detrimental contribution of the Toll-like receptor (TLR)3 to influenza A virus-induced acute pneumonia

scientific article

Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis.

scientific article

Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation

scientific article published on 18 May 2020

Development and function of human innate immune cells in a humanized mouse model

scientific article

Development of Humanized Mouse Models for Studying Human NK Cells in Health and Disease

scientific article published on 01 January 2022

Development of autoimmune diabetes in the absence of detectable IL-17A in a CD8-driven virally induced model

scientific article

Development of autoreactive diabetogenic T cells in the thymus of NOD mice

scientific article published on 08 December 2004

Differential expression of Borrelia burgdorferi genes during erythema migrans and Lyme arthritis

scientific article published on 01 October 1998

Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis

scientific article published on 15 July 2002

Differential transcription directed by discrete gamma interferon promoter elements in naive and memory (effector) CD4 T cells and CD8 T cells

scientific article published on January 1997

Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2.

scientific article published in October 1998

Direct physical interaction involving CD40 ligand on T cells and CD40 on B cells is required to propagate MMTV

scientific article published on 01 July 1995

Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch

scientific journal article

Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection.

scientific article published in March 1996

Disruption of Myosin 1e promotes podocyte injury

scientific journal article

Disruption of TGF-β signaling in T cells accelerates atherosclerosis ⬇️

scientific article published on October 20, 2003

Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes

scientific article

Distal enhancer elements transcribe intergenic RNA in the IL-10 family gene cluster

scientific article published on 01 December 2005

Distinct Microbial Communities Trigger Colitis Development upon Intestinal Barrier Damage via Innate or Adaptive Immune Cells.

scientific article published in October 2017

Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function

scientific article published on 19 June 2019

Divergent Effects of miR-181 Family Members on Myocardial Function Through Protective Cytosolic and Detrimental Mitochondrial microRNA Targets.

scientific article published on 27 February 2017

Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia

scientific article (publication date: 8 August 2003)

Does Toll-like receptor 3 play a biological role in virus infections?

scientific article published in May 2004

Drak2 contributes to West Nile virus entry into the brain and lethal encephalitis

scientific article

Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses

scholarly article

Dynamic signaling by T follicular helper cells during germinal center B cell selection.

scientific article published on August 2014

Dynamin 2-dependent endocytosis is required for sustained S1PR1 signaling

scientific article published on 17 March 2014

Dynamin 2-dependent endocytosis sustains T-cell receptor signaling and drives metabolic reprogramming in T lymphocytes

scientific article

E3 ubiquitin ligase GRAIL controls primary T cell activation and oral tolerance

scientific article (publication date: 29 September 2009)

ESCaping rejection: A step forward for embryonic-stem-cell-based regenerative medicine.

scientific article published in January 2014

Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis

scientific article

Editing the Mouse Genome Using the CRISPR-Cas9 System

scientific article

Effect of Bavachinin and its derivatives on T cell differentiation

scientific article published on 4 February 2014

Effector CD4+ T cell expression signatures and immune-mediated disease associated genes

scientific article

Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection

scientific article published on 01 August 2019

Efficacy of human Lyme disease vaccine formulations in a mouse model

scientific article published on May 1995

Efficient differentiation and function of human macrophages in humanized CSF-1 mice

scientific article published on 25 July 2011

Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice ⬇️

scientific article published on June 15, 1992

Endoplasmic reticulum stress-induced death of mouse embryonic fibroblasts requires the intrinsic pathway of apoptosis.

scientific article published on 19 March 2007

Endothelial cells require STAT3 for protection against endotoxin-induced inflammation

scientific article

Enhanced anti-serpin antibody activity inhibits autoimmune inflammation in type 1 diabetes

scientific article

Enhancement of IFNγ Production by Distinct Commensals Ameliorates Salmonella-Induced Disease

scientific article published on June 2017

Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity

scientific article published on 01 February 2020

Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity

scientific article published on 01 January 2020

Epigenetic and transcriptional programs lead to default IFN-gamma production by gammadelta T cells

scientific article published on 01 March 2007

Epigenetic regulation of Ifng expression

scientific article published on 01 July 2007

Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis

scientific article

Epithelial endoplasmic reticulum stress orchestrates a protective IgA response

scientific article published on 01 March 2019

Essential roles for Cavβ2 and Cav1 channels in thymocyte development and T cell homeostasis

scientific article published on 20 October 2015

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

scientific article

Evaluation of a lyme disease enzyme immunoassay using the 41-G fragment of flagellin ⬇️

scientific article published on 01 July 1995

Evasion of protective immunity by Borrelia burgdorferi by truncation of outer surface protein B ⬇️

scientific article published on May 1, 1993

Excessive Th1 responses due to the absence of TGF-β signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis

scientific article published on 8 April 2013

Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress

scientific article published on 24 February 2016

Executioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart

scientific article

Expression Efficiency of Multiple Il9 Reporter Alleles Is Determined by Cell Lineage

scientific article published on 21 May 2020

Expression of activated CDC42 induces T cell apoptosis in thymus and peripheral lymph organs via different pathways

scientific article published on 01 December 1999

Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness

scientific article

Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse

scientific journal article

Expression of the co-stimulator molecule B7-1 in pancreatic beta-cells accelerates diabetes in the NOD mouse

scientific article published on 01 March 1995

Expression of transgene encoded TGF-beta in islets prevents autoimmune diabetes in NOD mice by a local mechanism.

scientific article published in August 2002

Extended lifespan and reduced adiposity in mice lacking the FAT10 gene

scientific article published on 24 March 2014

FAT10/diubiquitin-like protein-deficient mice exhibit minimal phenotypic differences

scientific journal article

FLUshing in the bathroom

scientific article

Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis

scientific article published on 11 April 2005

Functional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivo

scientific article

GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells.

scientific article published on 25 March 2004

GADD45gamma mediates the activation of the p38 and JNK MAP kinase pathways and cytokine production in effector TH1 cells

scientific article published on 01 May 2001

Gadd45 beta and Gadd45 gamma are critical for regulating autoimmunity

scientific article

Gadd45beta is important for perpetuating cognate and inflammatory signals in T cells

scientific article published on 14 December 2003

Gatekeeper role of brain antigen-presenting CD11c+ cells in neuroinflammation.

scientific article published on 26 November 2015

Generation of Genetically Modified Mice Using the CRISPR-Cas9 Genome-Editing System

scientific article published on February 2016

Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease

scientific article

Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype

scientific article published on 12 September 2016

Glucocorticoids suppress inflammation via the upregulation of negative regulator IRAK-M.

scientific article

Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA.

scientific article

Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.

scientific article

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.

scientific article published on 17 April 2009

Gut microbiota translocation to the pancreatic lymph nodes triggers NOD2 activation and contributes to T1D onset

scientific article published on 20 June 2016

HER2 joins AKT to inhibit STING immunity

scientific article published on 01 August 2019

HSP70 enhances macrophage phagocytosis by interaction with lipid raft-associated TLR-7 and upregulating p38 MAPK and PI3K pathways

scientific article published on 18 September 2006

Harnessing the power of regulatory T-cells to control autoimmune diabetes: overview and perspective

scientific article published on 20 November 2017

Helicobacter pylori-induced Th17 responses modulate Th1 cell responses, benefit bacterial growth, and contribute to pathology in mice

article

Helper requirements for generation of effector CTL to islet beta cell antigens

scientific article published in May 2004

Homeobox protein Hhex negatively regulates Treg cells by inhibiting Foxp3 expression and function

scientific article published on 02 December 2019

How are T(H)1 and T(H)2 effector cells made?

scientific article published on 15 April 2009

How to define biomarkers of human T cell aging and immunocompetence?

scientific article published on 4 June 2013

Human CD4 restores normal T cell development and function in mice deficient in murine CD4.

scientific article published on April 1994

Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung

scientific article

Human exposure to a granulocytic Ehrlichia and other tick-borne agents in Connecticut

scientific article

Human hemato-lymphoid system mice: current use and future potential for medicine

scientific article

Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo

scientific article

Humanized hemato-lymphoid system mice

scientific article

Humanized mice for modeling human infectious disease: challenges, progress, and outlook.

scientific article published on July 2009

Humanized mouse model supports development, function, and tissue residency of human natural killer cells

scientific article

Hypersensitive site 6 of the Th2 locus control region is essential for Th2 cytokine expression

scientific article published on 8 April 2013

Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions

scientific article published on 19 December 2004

Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice

scientific journal article

Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain

scientific article published on November 2004

ICOS controls effector function but not trafficking receptor expression of kidney-infiltrating effector T cells in murine lupus

scientific article published on April 2009

ICOS mediates the development of insulin-dependent diabetes mellitus in nonobese diabetic mice

scientific article published on 01 March 2008

ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity

scientific article published on 3 November 2008

IL-1 receptor-associated kinase M is a central regulator of osteoclast differentiation and activation

scientific article

IL-10 Receptor Signaling Empowers Regulatory T Cells to Control Th17 Responses and Protect from GN

scientific article published on 04 June 2018

IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo

scientific article published on 21 December 2016

IL-10 Signaling Blockade Controls Murine West Nile Virus Infection

scientific article (publication date: October 2009)

IL-10 from CD4CD25Foxp3CD127 adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection

scientific article

IL-10 mediated regulation of liver inflammation during acute murine cytomegalovirus infection

scientific article

IL-10 signaling in CD4+ T cells is critical for the pathogenesis of collagen-induced arthritis

scientific article published on 22 December 2011

IL-10 suppression of NK/DC crosstalk leads to poor priming of MCMV-specific CD4 T cells and prolonged MCMV persistence.

scientific article

IL-10-producing forkhead box protein 3-negative regulatory T cells inhibit B-cell responses and are involved in systemic lupus erythematosus.

scientific article

IL-12/23p40-dependent clearance of Anaplasma phagocytophilum in the murine model of human anaplasmosis

scientific article

IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice

scientific article

IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy

scientific article published on 24 June 2020

IL-22 and inflammation: leukin' through a glass onion

scientific article published on December 2008

IL-22 deficiency alters colonic microbiota to be transmissible and colitogenic.

scientific article

IL-22 promotes fibroblast-mediated wound repair in the skin

scientific article

IL-22 signaling contributes to West Nile encephalitis pathogenesis

scientific article

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

scientific journal article

IL-4 induces a suppressive IL-10-producing CD8+ T cell population via a Cdkn2a-dependent mechanism.

scientific article published on 14 June 2013

IL-9 regulates allergen-specific Th1 responses in allergic contact dermatitis

scientific article

IL22BP Mediates the Anti-Tumor Effects of Lymphotoxin Against Colorectal Tumors in Mice and Humans

scientific article published on 18 June 2020

IL9 leads to airway inflammation by inducing IL13 expression in airway epithelial cells

scientific article published on 13 November 2006

IQGAP1 is important for activation of caspase-1 in macrophages and is targeted by Yersinia pestis type III effector YopM.

scientific article

IRAK-M is a negative regulator of Toll-like receptor signaling

scientific article

IRAK-M promotes alternative macrophage activation and fibroproliferation in bleomycin-induced lung injury

scientific article

Identification of a Borrelia burgdorferi OspA T cell epitope that promotes anti-OspA IgG in mice

scientific article published on 01 December 1996

Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter

scientific article

Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome.

scientific article

Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells

scientific article

Immunity, microbiota and kidney disease

scientific article published on 01 May 2019

Immunoglobulin A Targets a Unique Subset of the Microbiota in Inflammatory Bowel Disease

scientific article published on 31 December 2020

Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease

scientific article

Immunology. CD8alphaalpha and T cell memory.

scientific article published in April 2004

Immunology: cascade into clarity.

scientific article published in January 2008

Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking

scientific article

Impaired T cell-mediated macrophage activation in CD40 ligand-deficient mice

scientific article published on 01 January 1996

Impaired basophil induction leads to an age-dependent innate defect in type 2 immunity during helminth infection in mice

scientific article published on 11 March 2011

Impaired primary T cell responses in L-selectin-deficient mice

scientific article

Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand

scientific article

Improved regenerative myogenesis and muscular dystrophy in mice lacking Mkp5.

scientific article published on April 2013

Improving human hemato-lymphoid-system mice by cytokine knock-in gene replacement

scientific article published on 21 June 2011

In the absence of a CD40 signal, B cells are tolerogenic.

scientific article

In vivo diabetogenic action of CD4+ T lymphocytes requires Fas expression and is independent of IL-1 and IL-18.

scientific article published on 13 April 2011

Inability of truncated recombinant Osp A proteins to elicit protective immunity to Borrelia burgdorferi in mice

scientific article published on 01 July 1993

Inactivation of JNK1 enhances innate IL-10 production and dampens autoimmune inflammation in the brain

scholarly article

Inducible costimulator is essential for collagen-induced arthritis

scientific article

Induction of hepatitis by JNK-mediated expression of TNF-alpha

scientific article published on January 2009

Induction of insulitis by glutamic acid decarboxylase peptide-specific and HLA-DQ8-restricted CD4(+) T cells from human DQ transgenic mice

scientific article published on September 1998

Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease.

scientific article published on 22 December 2008

Inflammasome activation and metabolic disease progression

scientific article

Inflammasome activation by Campylobacter jejuni.

scientific article published on 29 September 2014

Inflammasome activation in infected macrophages drives COVID-19 pathology

scientific article published in June 2022

Inflammasome activation mediates inflammation and outcome in humans and mice with pneumococcal meningitis

scientific article

Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response

scientific article published on 22 November 2011

Inflammasome recognition of influenza virus is essential for adaptive immune responses

scientific article published on 12 January 2009

Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy

scientific article (publication date: 18 May 2009)

Inflammasome-derived IL-1β production induces nitric oxide-mediated resistance to Leishmania

scientific article published on 9 June 2013

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

scientific journal article

Inflammasome-mediated regulation of hepatic stellate cells

scientific article published on 9 April 2009

Inflammasome-mediated suppression of inflammation-induced colorectal cancer progression is mediated by direct regulation of epithelial cell proliferation

scientific article published on 15 June 2011

Inflammasomes

scientific article

Inflammasomes and intestinal homeostasis: regulating and connecting infection, inflammation and the microbiota

scientific article

Inflammasomes and metabolic disease

scientific article

Inflammasomes in health and disease

scientific article (publication date: 18 January 2012)

Inflammasomes: far beyond inflammation

scientific article published on 19 March 2012

Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms

scientific article

Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4.

scientific article

Inflammatory regulation by TLR3 in acute hepatitis

scientific article published on 26 August 2009

Inhibition of NF-kappaB activity and enhancement of apoptosis by the neuropeptide calcitonin gene-related peptide

scientific article published on 01 May 2000

Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease

scientific article

Innate immune cells in inflammation and cancer

scientific article

Innate immune receptors: key regulators of metabolic disease progression

scientific article published on June 2013

Innate immune recognition of flagellin limits systemic persistence of Brucella

scientific article

Innate immunity and apoptosis in IBD.

scientific article published on February 2004

Innate instruction of adaptive immunity revisited: the inflammasome

scientific article published on May 2009

Innate recognition of non-self nucleic acids.

scientific article published on 10 March 2008

Innate sensors of pathogen and stress: linking inflammation to obesity

scientific article published on August 2013

Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells

scientific article

Interaction of the c-Jun/JNK pathway and cyclin-dependent kinases in death of embryonic cortical neurons evoked by DNA damage

scientific article published on 28 June 2002

Interchromosomal association and gene regulation in trans

scientific article

Interchromosomal associations between alternatively expressed loci

scientific article

Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway

scientific article

Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells

scientific article

Interleukin 1 receptor-associated kinase m impairs host defense during pneumococcal pneumonia

scientific article published on 5 April 2012

Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense.

scientific article published on 2 February 2012

Interleukin-1 receptor and caspase-1 are required for the Th17 response in nitrogen dioxide-promoted allergic airway disease

scientific article published on May 2013

Interleukin-1 receptor-associated kinase M-deficient mice demonstrate an improved host defense during Gram-negative pneumonia

scientific article published on 25 September 2012

Interleukin-1 receptor-associated kinase-M suppresses systemic lupus erythematosus.

scientific article published on 29 August 2011

Interleukin-13 mediates a fundamental pathway for airway epithelial mucus induced by CD4 T cells and interleukin-9.

scientific article published in November 2002

Interleukin-17A Promotes CD8+ T Cell Cytotoxicity To Facilitate West Nile Virus Clearance

scientific article published on 19 October 2016

Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation

scientific article

Intestinal IFN-γ-producing Tr1-cells co-express CCR5 and PD-1, and down-regulate IL-10 in the inflamed gut of IBD patients.

scientific article published on 21 January 2018

Intestinal type 1 regulatory T cells migrate to periphery to suppress diabetogenic T cells and prevent diabetes development.

scientific article published on 11 September 2017

Intracellular debugging

scientific article published in July 2003

Invariant chain controls H2-M proteolysis in mouse splenocytes and dendritic cells

scientific article

Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria

scholarly article

JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate.

scientific article

JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation

scientific article published on 06 December 2012

JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure

scientific article

JNK is required for effector T-cell function but not for T-cell activation

scientific journal article

JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species

scientific article

JNK regulates autocrine expression of TGF-beta1.

scientific article

JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease

scholarly article

JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance.

scientific article published on November 2005

JNK1 is required for T cell-mediated immunity against Leishmania major infection.

scientific article published in September 2000

JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration

scientific article published on 5 November 2008

JNK2 is a positive regulator of the cJun transcription factor

scientific article published on 01 September 2006

JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response

scientific article published on March 2007

JNK3 contributes to c-Jun activation and apoptosis but not oxidative stress in nerve growth factor-deprived sympathetic neurons

scientific article published in July 2001

JunD mediates survival signaling by the JNK signal transduction pathway

scientific article published in June 2003

KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity

scientific article published on 03 April 2018

Kinetic analysis of genomewide gene expression reveals molecule circuitries that control T cell activation and Th1/2 differentiation

scholarly article

Kv1.3 channel gene-targeted deletion produces "Super-Smeller Mice" with altered glomeruli, interacting scaffolding proteins, and biophysics.

scientific article published on February 2004

LACC1 bridges NOS2 and polyamine metabolism in inflammatory macrophages

scientific article published on 17 August 2022

Lack of Sprouty 1 and 2 enhances survival of effector CD8 T cells and yields more protective memory cells

article published in the Proceedings of the National Academy of Sciences of the United States of America

Legionella pneumophila Strain 130b Evades Macrophage Cell Death Independent of the Effector SidF in the Absence of Flagellin

scientific article

Life, death, and miracles: Th17 cells in the intestine

scientific article published on September 2012

Local expression of transgene encoded TNF alpha in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells

scientific article

Long-range intrachromosomal interactions in the T helper type 2 cytokine locus

scientific article published on 19 September 2004

Long-term activation of TLR3 by poly(I:C) induces inflammation and impairs lung function in mice

scientific article published on June 2009

Long-term consumption of caffeine-free high sucrose cola beverages aggravates the pathogenesis of EAE in mice

scientific article

Long-term protection of mice from Lyme disease by vaccination with OspA ⬇️

scientific article published on March 1, 1992

Loss of Mcl-1 protein and inhibition of electron transport chain together induce anoxic cell death

scientific article published on 4 December 2006

Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination

scientific article

Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development.

scientific article

LoxP-FRT Trap (LOFT): a simple and flexible system for conventional and reversible gene targeting ⬇️

scientific article

Lyme borreliosis in transgenic mice tolerant to Borrelia burgdorferi OspA or B.

scientific article published on October 1995

Lyme borreliosis in transgenic mice tolerant to OspA from Borrelia burgdorferi 25015

scientific article published on 01 April 1997

Lymphotoxin-alpha- and lymphotoxin-beta-deficient mice differ in susceptibility to scrapie: evidence against dendritic cell involvement in neuroinvasion.

scientific article

Lymphotoxin-beta-deficient mice show defective antiviral immunity.

scientific article published on July 1999

MAP kinases in the immune response

scientific article

MAPK Phosphatase 5 Expression Induced by Influenza and Other RNA Virus Infection Negatively Regulates IRF3 Activation and Type I Interferon Response.

scientific article published on 11 March 2015

MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3.

scientific article published on 2 April 2007

MEKK4 signaling regulates filamin expression and neuronal migration.

scientific article published on December 2006

METTL3-mediated m<sup>6</sup>A RNA methylation promotes the anti-tumour immunity of natural killer cells

scientific article published on 17 September 2021

MHC class II expression through a hitherto unknown pathway supports T helper cell-dependent immune responses: implications for MHC class II deficiency

scientific journal article

MKK3 mitogen-activated protein kinase pathway mediates carbon monoxide-induced protection against oxidant-induced lung injury

scientific article published in December 2003

MKK3 signalling plays an essential role in leukocyte-mediated pancreatic injury in the multiple low-dose streptozotocin model

scientific article

MKK3-p38 signaling promotes apoptosis and the early inflammatory response in the obstructed mouse kidney

scientific article published on 08 August 2007

MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines

scientific article

Macrophage IL-12p70 signaling prevents HSV-1-induced CNS autoimmunity triggered by autoaggressive CD4+ Tregs

scientific article

Macrophage and T cell produced IL-10 promotes viral chronicity

scientific article

Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells.

scientific article published on 11 May 2017

Macrophage phenotype controls long-term AKI outcomes--kidney regeneration versus atrophy

scientific article published on 05 December 2013

Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy in mice

scientific article published on 08 October 2020

Macrophages sense and kill bacteria through carbon monoxide-dependent inflammasome activation

scientific article

Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases

scientific article published on 21 August 2009

Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis

scientific article

Map kinase phosphatase 5 protects against sepsis-induced acute lung injury

scientific article

Maturation modulates caspase-1-independent responses of dendritic cells to Anthrax lethal toxin

scientific article

Mechanism of p38 MAP kinase activation in vivo.

scientific article

Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation

scientific article

Mechanisms of programmed cell death in the developing brain

scientific article

Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity

scientific article published on 21 August 2019

Membrane-cytoskeletal crosstalk mediated by myosin-I regulates adhesion turnover during phagocytosis

Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology ⬇️

scientific article

Metabolic signaling in T cells

scientific article published on 24 July 2020

Mex3B: a coreceptor to present dsRNA to TLR3.

scientific article

MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis

scientific article published on 12 May 2015

Mice lacking endogenous IL-10-producing regulatory B cells develop exacerbated disease and present with an increased frequency of Th1/Th17 but a decrease in regulatory T cells.

scientific article published on 4 April 2011

Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression

scientific article published on 01 February 1996

Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC.

scientific article

Microbiota Normalization Reveals that Canonical Caspase-1 Activation Exacerbates Chemically Induced Intestinal Inflammation.

scientific article published on June 2017

Microbiota keep the intestinal clock ticking

scientific article published in May 2013

Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling.

scientific article published in December 2015

Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression

scientific article published in Nature Communications

Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer

scientific journal article

Microenvironment-dependent growth of preneoplastic and malignant plasma cells in humanized mice.

scientific article published on 10 October 2016

Microglia recognize double-stranded RNA via TLR3.

scientific article published in March 2006

Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis

scholarly article

Modulation of cell adhesion and motility in the immune system by Myo1f

scientific journal article

Molar tooth development in caspase-3 deficient mice.

scientific article published in January 2006

Molecular and functional heterogeneity of IL-10-producing CD4 T cells

scientific article published in Nature Communications

Molecular basis of T-cell differentiation

scientific article

Molecular biology. Managing associations between different chromosomes

scientific article published on 01 April 2006

Molecular characterization of the humoral response to the 41-kilodalton flagellar antigen of Borrelia burgdorferi, the Lyme disease agent.

scientific article published on October 1991

Molecular mapping of Osp-A mediated immunity against Borrelia burgdorferi, the agent of Lyme disease ⬇️

scientific article published on September 15, 1991

Molecular mechanism of NLRP3 inflammasome activation

scientific article published on 30 June 2010

Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3)

scientific journal article

Mouse pulmonary interstitial macrophages mediate the pro-tumorigenic effects of IL-9

scientific article published in 2022

Multiple MyD88-dependent responses contribute to pulmonary clearance of Legionella pneumophila

scientific article published on 8 September 2008

Multisite phosphorylation regulates Bim stability and apoptotic activity

scientific article published on May 2008

Murine Lyme arthritis development mediated by p38 mitogen-activated protein kinase activity

scientific article

Murine autoimmune cholangitis requires two hits: cytotoxic KLRG1(+) CD8 effector cells and defective T regulatory cells

scientific article

Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease

scientific article

MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice

scientific article

Myeloid Leukemia Development in c-Cbl RING Finger Mutant Mice Is Dependent on FLT3 Signaling ⬇️

scientific article published on October 19, 2010

Myosin VI regulates gene pairing and transcriptional pause release in T cells

scientific article

NALP3: a key player in caspase-1 activation

scientific article published on January 2006

NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development

scientific article published on 01 November 2000

NF-kappa B-inducing kinase regulates selected gene expression in the Nod2 signaling pathway

scientific article

NK cell receptor NKG2D enforces proinflammatory features and pathogenicity of Th1 and Th17 cells

scientific article published on 01 August 2020

NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease

scientific article published in Nature Communications

NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells

scientific journal article

NLRP3 deficiency protects from type 1 diabetes through the regulation of chemotaxis into the pancreatic islets.

scientific article

NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy

scientific article

NLRP6 and Dysbiosis: Avoiding the Luring Attraction of Over-Simplification

scientific article published on 01 April 2018

NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion

scientific journal article

NOD2 Signaling Contributes to Host Defense in the Lungs against Escherichia coli Infection

scientific article published in 2013

NOD2 regulates CXCR3-dependent CD8+ T cell accumulation in intestinal tissues with acute injury

scientific article

NOD2 signaling contributes to host defense in the lungs against Escherichia coli infection

scientific article

NOD2, the gene responsible for familial granulomatous uveitis, in a mouse model of uveitis

scientific article published on April 2008

NOD2-deficient mice have impaired resistance to Mycobacterium tuberculosis infection through defective innate and adaptive immunity

scientific article published in November 2008

Natural killer T cells exacerbate liver injury in a transforming growth factor beta receptor II dominant-negative mouse model of primary biliary cirrhosis

scientific article published in February 2008

Natural regulatory T cells control the development of atherosclerosis in mice

article

Naturally activated V gamma 4 gamma delta T cells play a protective role in tumor immunity through expression of eomesodermin.

scientific article published on 04 June 2010

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

scientific article

Neonatal tumor necrosis factor alpha promotes diabetes in nonobese diabetic mice by CD154-independent antigen presentation to CD8(+) T cells.

scientific article

Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis

scientific article

New insights into insulin dependent diabetes mellitus from studies with transgenic mouse models

scientific article

Nlrp3 prevents early renal interstitial edema and vascular permeability in unilateral ureteral obstruction

scientific article published on 15 January 2014

Nlrp6 regulates intestinal antiviral innate immunity

scientific article published on 22 October 2015

Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells

scientific article

No Oxygen? No Glucose? No Problem: Fatty Acid Catabolism Enhances Effector CD8+ TILs.

scientific article published in September 2017

Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract

scientific journal article

Nonspecific proliferative responses of murine lymphocytes to Borrelia burgdorferi antigens

scientific article published on 01 March 1992

Notch controls the magnitude of T helper cell responses by promoting cellular longevity.

scientific article

Novel Borrelia burgdorferi isolates from Ixodes scapularis and Ixodes dentatus ticks feeding on humans.

scientific article published on March 1996

Novel antagonist antibody to TLR3 blocks poly(I:C)-induced inflammation in vivo and in vitro

scientific article published on 2 November 2010

Nuclear receptor CAR represses TNFalpha-induced cell death by interacting with the anti-apoptotic GADD45B

scientific article

Oct-1 regulates IL-17 expression by directing interchromosomal associations in conjunction with CTCF in T cells

scientific article published on 6 March 2014

Opposing effects of TGF-beta and IL-15 cytokines control the number of short-lived effector CD8+ T cells

scientific article published on July 2009

Oral vaccination with an attenuated Salmonella typhimurium strain expressing Borrelia burgdorferi OspA prevents murine Lyme borreliosis

scientific article

OspA vaccination of mice with established Borrelia burgdorferi infection alters disease but not infection.

scientific article

OspB antibody prevents Borrelia burgdorferi colonization of Ixodes scapularis

scientific article published on March 2004

OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands ⬇️

scientific article

Outer surface proteins E and F of Borrelia burgdorferi, the agent of Lyme disease

scientific article

Overexpression of IL-7R alpha provides a competitive advantage during early T-cell development.

scientific article published on 30 October 2003

Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome.

scientific article

Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation

scientific article published in January 2018

PTPN22 inhibition resets defective human central B cell tolerance

scientific article published on 22 July 2016

Pancreatic infiltration but not diabetes occurs in the relative absence of MHC class II-restricted CD4 T cells: studies using NOD/CIITA-deficient mice

scientific article published on 01 April 1999

Pancreatic islet expression of chemokine CCL2 suppresses autoimmune diabetes via tolerogenic CD11c+ CD11b+ dendritic cells

scientific article published on 10 February 2012

Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche

scientific article published on 01 April 2020

Partial destruction of Borrelia burgdorferi within ticks that engorged on OspE- or OspF-immunized mice

scientific article published on May 1994

Peripheral blood CD34+ cells efficiently engraft human cytokine knock-in mice

scientific article published on 19 August 2016

Peripherally Induced Tolerance Depends on Peripheral Regulatory T Cells That Require Hopx To Inhibit Intrinsic IL-2 Expression

scientific article

Pharmacological postconditioning effect of muramyl dipeptide is mediated through RIP2 and TAK1

scientific article published on 12 February 2009

Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity

scientific article published on July 1996

Phosphatidylserine receptor is required for clearance of apoptotic cells

scientific journal article

Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation.

scientific article published in June 2005

Plasticity of Th17 Cells in Autoimmune Kidney Diseases

scientific article

Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis

scientific article

Plexin-B1 plays a redundant role during mouse development and in tumour angiogenesis

scientific article

Polarization of IL-4- and IFN-gamma-producing CD4+ T cells following activation of naive CD4+ T cells.

scientific article published in February 1997

PolyI:C-induced reduction in uptake of soluble antigen is independent of dendritic cell activation

scientific article

Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens

scientific article

Polyethyleneimine is a potent systemic adjuvant for glycoprotein antigens

scientific article published on 20 May 2014

Positive signaling through CD72 induces mitogen-activated protein kinase activation and synergizes with B cell receptor signals to induce X-linked immunodeficiency B cell proliferation.

scientific article

Post-infarction remodeling is independent of mitogen-activated protein kinase kinase 3 (MKK3)

scientific article published in June 2007

Praziquantel facilitates IFN-γ-producing CD8+ T cells (Tc1) and IL-17-producing CD8+ T cells (Tc17) responses to DNA vaccination in mice

scientific article

Preferential presence of decorin-binding protein B (BBA25) and BBA50 antibodies in cerebrospinal fluid of patients with neurologic Lyme disease

scientific article published in March 2004

Prenatal acetaminophen affects maternal immune and endocrine adaptation to pregnancy, induces placental damage, and impairs fetal development in mice

scientific article published on 4 August 2015

Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling

scholarly article

Producing GM-CSF: a unique T helper subset?

scientific article published on 21 November 2014

Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells.

scientific article

Programmed cell death in mouse brain development

scientific article

Programmed cell death of developing mammalian neurons after genetic deletion of caspases.

scientific article published in July 2001

Prominent T lymphocyte response to Borrelia burgdorferi from peripheral blood of unexposed donors.

scientific article published in February 1994

Prostaglandin F2alpha- and FAS-activating antibody-induced regression of the corpus luteum involves caspase-8 and is defective in caspase-3 deficient mice

scientific article

Protection against antigenically variable Borrelia burgdorferi conferred by recombinant vaccines

scientific article

Protection of mice against the Lyme disease agent by immunizing with recombinant OspA

scientific article published on 01 October 1990

Protection of mice from Lyme borreliosis by oral vaccination with Escherichia coli expressing OspA.

scientific article

Protective Function of Mitogen-Activated Protein Kinase Phosphatase 5 in Aging- and Diet-Induced Hepatic Steatosis and Steatohepatitis

scientific article published on 01 March 2019

Protective antibodies develop, and murine Lyme arthritis regresses, in the absence of MHC class II and CD4+ T cells

scientific article published on 01 December 1997

Protective antibodies in murine Lyme disease arise independently of CD40 ligand

scientific article published on 01 July 1996

Protective immunity in lyme borreliosis

scientific article published in April 1993

Proteolytic regulation of nuclear factor of activated T (NFAT) c2 cells and NFAT activity by caspase-3.

scientific article published on 2 February 2006

Publisher Correction: HER2 joins AKT to inhibit STING immunity

scientific article published on 01 October 2019

Publisher Correction: Subsets of ILC3-ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues

scientific article published on 01 October 2019

Publisher Correction: TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer

scientific article published on 06 November 2020

Pulmonary overexpression of IL-9 induces Th2 cytokine expression, leading to immune pathology

scientific article

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

scientific article

RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.

scientific article published on 18 February 2009

RIP2 contributes to Nod signaling but is not essential for T cell proliferation, T helper differentiation or TLR responses

scientific article published in January 2008

RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.

scientific article

Rabies virus is recognized by the NLRP3 inflammasome and activates interleukin-1β release in murine dendritic cells

scientific article published on 13 March 2013

Rapid induction of a novel costimulatory activity on B cells by CD40 ligand.

scientific article published on November 1995

Reactive oxygen species and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase mediate hyperoxia-induced cell death in lung epithelium

scientific article published on March 2003

Reactivity of white-footed mouse and raccoon sera to whole cell and recombinant antigens of Borrelia burgdorferi

scientific article published on 01 July 1995

Recent advances in IL-22 biology.

scientific article published on March 2011

Recent advances in dynamic m6A RNA modification

scientific article

Receptor interacting protein-2 contributes to host defense against Anaplasma phagocytophilum infection

scientific article

Receptor-interacting protein 2 controls pulmonary host defense to Escherichia coli infection via the regulation of interleukin-17A.

scientific article published on 15 August 2011

Reciprocal regulation of CD30 expression on CD4+ T cells by IL-4 and IFN-gamma

scientific article published on 01 March 1997

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

scientific article (publication date: 18 October 2001)

Recognition of single-stranded RNA viruses by Toll-like receptor 7

scientific article

Reconstitution of invariant chain function in transgenic mice in vivo by individual p31 and p41 isoforms

scientific article published on 01 September 1995

Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

scientific article (publication date: 7 August 1998)

Regulated overexpression of interleukin 11 in the lung. Use to dissociate development-dependent and -independent phenotypes

scientific article

Regulating human Th17 cells via differential expression of IL-1 receptor

scientific article

Regulation of Adipose Tissue Inflammation and Insulin Resistance by MAPK Phosphatase 5.

scientific article published on 28 April 2015

Regulation of CD4+ T cell differentiation.

scientific article published on January 1995

Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation

scientific article

Regulation of c-Jun NH(2)-terminal kinase (Jnk) gene expression during T cell activation

scientific article

Regulation of immune response and inflammatory reactions against viral infection by VCAM-1.

scientific article published on 23 January 2008

Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5

scientific journal article

Regulation of the Th2 cytokine locus by a locus control region

scientific article published on 01 July 2003

Regulation of the antimicrobial response by NLR proteins.

scientific article published on May 2011

Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase-3 activation

scientific article

Regulatory T cell-derived IL-10 ameliorates crescentic GN.

scientific article published on 2 May 2013

Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression

scientific article published in Nature

Renalase deficiency aggravates ischemic myocardial damage

scientific journal article

Reprogramming the signalling requirement for AP-1 (activator protein-1) activation during differentiation of precursor CD4+ T-cells into effector Th1 and Th2 cells

scientific article published in February 1997

Required roles of Bax and JNKs in central and peripheral nervous system death of retinoblastoma-deficient mice.

scientific article published on 5 November 2007

Requirement for AHNAK1-mediated calcium signaling during T lymphocyte cytolysis

scholarly article

Requirement for CD154 in the progression of atherosclerosis.

scientific article published in November 1999

Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis

scientific article published in September 1996

Requirement of JIP scaffold proteins for NMDA-mediated signal transduction

scientific article

Requirement of JIP1-mediated c-Jun N-terminal kinase activation for obesity-induced insulin resistance

scientific article

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

scientific article (publication date: 5 May 2000)

Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression

scientific journal article

Requirement of the JIP1 scaffold protein for stress-induced JNK activation

scientific journal article

Requirement of voltage-gated calcium channel beta4 subunit for T lymphocyte functions

scientific journal article

Resemble and Inhibit: when RLR meets TGF-β.

scientific article published on December 2014

Restrictive clonal allocation in the chimeric mouse brain

scientific article

Retraction

scientific article published on 01 December 2005

Role of CD4+ T cells in pathogenesis associated with Leishmania amazonensis infection.

scientific article published in June 1997

Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice

scientific article published in December 2002

Role of IL-10 Receptor Signaling in the Function of CD4+ T-Regulatory Type 1 cells: T-Cell Therapy in Patients with Inflammatory Bowel Disease

scientific article published on 01 January 2018

Role of L-selectin in the development of autoimmune diabetes in non-obese diabetic mice

scientific article published on 01 February 2004

Role of MAPK kinase 6 in arthritis: distinct mechanism of action in inflammation and cytokine expression

scientific article published on 26 June 2009

Role of MKK3-p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db/db mice.

scientific article

Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades

scientific article

Role of OCT-1 and partner proteins in T cell differentiation

scientific article published on 25 April 2016

Role of TLR3 in the immunogenicity of replicon plasmid-based vaccines.

scientific article published on 04 December 2008

Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis

scientific article published on 04 May 2009

Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema

scientific article published in June 2005

Role of the Guanosine Triphosphatase Rac2 in T Helper 1 Cell Differentiation

scientific article published on 01 June 2000

Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis

scientific article

Role of the executioner caspases during lens development.

scientific article published on 30 June 2005

Role of the intestinal microbiome in liver disease

scientific article

Roles of OspA, OspB, and flagellin in protective immunity to Lyme borreliosis in laboratory mice ⬇️

scientific article published on February 1, 1992

Roles of mTORC1 and mTORC2 in controlling γδ T1 and γδ T17 differentiation and function

scientific article published on 30 January 2020

Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells

scientific article published on 21 November 2018

SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development

scientific article published in May 1998

SHIP represses the generation of IL-3-induced M2 macrophages by inhibiting IL-4 production from basophils.

scientific article published on 26 August 2009

STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity

scholarly article

STAT3 is required for Flt3L-dependent dendritic cell differentiation

scientific article published in December 2003

Salmonella Typhimurium type III secretion effectors stimulate innate immune responses in cultured epithelial cells

scientific article

Selection of variant Borrelia burgdorferi isolates from mice immunized with outer surface protein A or B.

scientific article

Sensing the enemy within

scientific article published in Nature

Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M.

scientific article

Sequential MyD88-independent and -dependent activation of innate immune responses to intracellular bacterial infection

scientific article published on 01 December 2003

Sera from patients with chronic Lyme disease protect mice from Lyme borreliosis

scientific article published on 01 March 1994

Serologic analysis of dogs, horses, and cottontail rabbits for antibodies to an antigenic flagellar epitope of Borrelia burgdorferi ⬇️

scientific article published on September 1, 1993

Serologic diagnosis of Lyme borreliosis by using enzyme-linked immunosorbent assays with recombinant antigens

scientific article

Serologic diagnosis of Lyme disease using recombinant outer surface proteins A and B and flagellin

scientific article published on 01 June 1992

Serologic diagnosis of canine and equine borreliosis: use of recombinant antigens in enzyme-linked immunosorbent assays

scientific article published on January 1997

Serologic response to the Borrelia burgdorferi flagellin demonstrates an epitope common to a neuroblastoma cell line ⬇️

scientific article published on January 1, 1993

Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in mice

scientific article

Shaping of Intestinal Microbiota in Nlrp6- and Rag2-Deficient Mice Depends on Community Structure

scientific article published in December 2017

Shigella-induced apoptosis is dependent on caspase-1 which binds to IpaB

scientific article

Signal transduction by MAP kinases in T lymphocytes

scientific article

Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes

scientific article published on 29 June 2009

Signaling and cell death in lymphocytes

scientific article

Signaling by the JNK group of MAP kinases. c-jun N-terminal Kinase

scientific article

Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease.

scientific article

Skin-resident innate lymphoid cells converge on a pathogenic effector state

scientific article published on 03 February 2021

Spatial proximity of homologous alleles and long noncoding RNAs regulate a switch in allelic gene expression

scientific article

Specific pathophysiological functions of JNK isoforms in the brain

scientific article published in January 2005

Strain-dependent neurodevelopmental abnormalities in caspase-3-deficient mice

scientific article published in August 2002

Studies on MAP Kinase signaling in the immune system.

scientific article

Subsets of ILC3-ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues

scientific article published on 17 June 2019

Sugar-coated regulation of T cells

scientific article

Sulfamethoxazole drug stress upregulates antioxidant immunomodulatory metabolites in Escherichia coli

scientific article published on 27 July 2020

Suppression of Ras-stimulated transformation by the JNK signal transduction pathway

scientific article

Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1

scientific article published on 11 July 2003

Suppression of p53-dependent senescence by the JNK signal transduction pathway

scholarly article

Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts.

scientific article published on 5 August 2002

T Cell Receptor Mediated Calcium Entry Requires Alternatively Spliced Cav1.1 Channels.

scientific article published on 27 January 2016

T cell unresponsiveness correlates with quantitative TCR levels in a transgenic model

article

T cells from epicutaneously immunized mice are prone to T cell receptor revision

scientific article

T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells

scientific article

T helper cell differentiation: regulation by cis elements and epigenetics

scientific article

T-cell TGF-β signaling abrogation restricts medulloblastoma progression.

scientific article

T-cells in Alzheimer's disease.

scientific article

TFH cells progressively differentiate to regulate the germinal center response

scientific article published on 29 August 2016

TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes

scholarly article

TGF-beta signaling in dendritic cells is a prerequisite for the control of autoimmune encephalomyelitis

scientific article

TGF-beta signaling is required for the function of insulin-reactive T regulatory cells

scientific article

TGF-beta, T-cell tolerance and immunotherapy of autoimmune diseases and cancer

scientific article published on March 2006

TGF-beta: a master of all T cell trades

scientific article

TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer

scientific article published on 25 May 2020

TGF-γ signaling is required for the function of insulin-reactive T regulatory cells.

scientific article published in June 2006

TH2, allergy and group 2 innate lymphoid cells

scientific article published on June 2013

TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease

scientific article published on 14 April 2008

TLR signaling prevents hyperoxia-induced lung injury by protecting the alveolar epithelium from oxidant-mediated death

scientific article

TLR-independent induction of dendritic cell maturation and adaptive immunity by negative-strand RNA viruses

scientific article published in December 2004

TLR11 activation of dendritic cells by a protozoan profilin-like protein.

scientific article

TLR3 deletion limits mortality and disease severity due to Phlebovirus infection.

scientific article published on November 2006

TLR3 is essential for the induction of protective immunity against Punta Toro Virus infection by the double-stranded RNA (dsRNA), poly(I:C12U), but not Poly(I:C): differential recognition of synthetic dsRNA molecules

scientific article

TLR8 Couples SOCS-1 and Restrains TLR7-Mediated Antiviral Immunity, Exacerbating West Nile Virus Infection in Mice

scientific article published on 21 October 2016

TLR8 deficiency leads to autoimmunity in mice

scientific article

TLR9 and the NLRP3 inflammasome link acinar cell death with inflammation in acute pancreatitis

scientific article

TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway

scientific article

TNF‐α impairs peripheral tolerance towards β‐cells, and local costimulation by B7.1 enhances the effector function of diabetogenic T cells ⬇️

scientific article published on May 1, 2003

TRANCE-RANK, a new signal pathway involved in lymphocyte development and T cell activation

scientific article published on April 1999

Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity

scientific article

Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction

scientific article published on December 1996

Targeted expression of calcitonin gene-related peptide to osteoblasts increases bone density in mice

scientific article

Targeted expression of the anti-apoptotic gene CrmA to NOD pancreatic islets protects from autoimmune diabetes.

scientific article published on 9 December 2005

Targeted expression of the neuropeptide calcitonin gene-related peptide to beta cells prevents diabetes in NOD mice.

scientific article published on February 1997

Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner

scientific article

Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation

scientific article

Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma

scientific article

Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region

scientific article published on 01 December 2004

Th9 Cells Drive Host Immunity against Gastrointestinal Worm Infection

scientific article published on October 2013

The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase

scientific article

The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection

scientific article published on 29 January 2006

The CD40 ligand. At the center of the immune universe?

scientific article published on February 1997

The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression

scientific article published in August 2017

The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury.

scientific article

The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells

scientific article published on April 2008

The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis

scientific article published on 13 November 2019

The Intestine: where amazing things happen.

scientific article

The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes

scientific article

The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development

scientific article published in April 1999

The NLR gene family: a standard nomenclature

scientific article

The Nalp3 inflammasome is essential for the development of silicosis

scientific article

The Role of Toll-Like Receptors 3 and 9 in the Development of Autoimmune Diabetes in NOD Mice

article

The Stromal Intervention: Regulation of Immunity and Inflammation at the Epithelial-Mesenchymal Barrier

scientific article published on January 2017

The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity

scientific article

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

scientific journal article

The c-Jun NH2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesis

scholarly article

The different faces of Notch in T-helper-cell differentiation

scientific article published on February 2009

The dual nature of TH17 cells: shifting the focus to function

article

The fate and lifespan of human monocyte subsets in steady state and systemic inflammation

scientific article

The fire within: microbes inflame tumors

scientific article

The hematopoiesis paradigm: clarity or ambiguity?

scientific article published in November 2008

The hook protein of Borrelia burgdorferi, encoded by the flgE gene, is serologically recognized in Lyme disease.

scientific article

The immunoglobulin (IgG) antibody response to OspA and OspB correlates with severe and prolonged Lyme arthritis and the IgG response to P35 correlates with mild and brief arthritis

scientific article

The incidence of pulmonary embolism and associated FDG-PET findings in IV contrast-enhanced PET/CT.

scientific article published on June 2014

The induction and function of the anti-inflammatory fate of TH17 cells

scientific article published on 03 July 2020

The inflammasome in pathogen recognition and inflammation

scientific article published on 30 April 2007

The inflammasome: first line of the immune response to cell stress

scientific article

The intestinal microbiota in chronic liver disease

scientific article published on January 2013

The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function.

scientific article

The light and the dark sides of Interleukin-10 in immune-mediated diseases and cancer.

scientific article published on 08 March 2016

The lock-washer: a reconciliation of the RIG-I activation models

scientific article published on 6 May 2014

The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan.

scientific article published on 15 August 2016

The microRNA miR-181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis

scientific article published on 25 April 2013

The pattern recognition receptors Nod1 and Nod2 account for neutrophil recruitment to the lungs of mice infected with Legionella pneumophila

scientific article published on 2 June 2010

The polarization of immune cells in the tumour environment by TGFbeta

scientific article published on 09 July 2010

The presumptive phosphatidylserine receptor is dispensable for innate anti-inflammatory recognition and clearance of apoptotic cells

scientific article published on 29 November 2005

The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR.

scientific article published on 31 May 2009

The regulation of CD4 T cell differentiation

scientific article published on 01 September 1998

The role of CD40 ligand in costimulation and T-cell activation

scientific article

The role of CTCF in regulating nuclear organization

scientific article published on 17 March 2008

The role of Fas in autoimmune diabetes

scientific article published on 01 April 1997

The role of NOD-like Receptors in shaping adaptive immunity.

scientific article published on 09 February 2010

The role of RIP2 in p38 MAPK activation in the stressed heart

scientific article published on 29 February 2008

The role of cell death in regulating the size and shape of the mammalian forebrain

scientific article

The stumpy gene is required for mammalian ciliogenesis

scientific article

The tiny conductor: immune regulation via commensal organisms.

scientific article

The transcription cofactor Hopx is required for regulatory T cell function in dendritic cell–mediated peripheral T cell unresponsiveness ⬇️

scientific article published on August 29, 2010

The translation of non-canonical open reading frames controls mucosal immunity

scientific article published on 12 December 2018

The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight

scientific article (publication date: March 2003)

The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity

scientific article

Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation

scientific article published on 6 September 2009

Tissue immunogenicity: the role of MHC antigen and the lymphocyte costimulator B7-1

scientific article published on 01 December 1996

Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses

scientific article published on 01 August 2020

Toll-like Receptor 7 Mitigates Lethal West Nile Encephalitis via Interleukin 23-Dependent Immune Cell Infiltration and Homing

scientific article (publication date: 20 February 2009)

Toll-like receptor 3 is a potent negative regulator of axonal growth in mammals

scientific article

Toll-like receptor 3 is an essential component of the innate stress response in virus-induced cardiac injury

scientific article published on 25 August 2006

Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis

scientific article (publication date: December 2004)

Toll-like receptor 3 promotes cross-priming to virus-infected cells.

scientific article

Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.

scientific article

Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus

scientific article

Toll-like receptors 1 and 2 heterodimers alter Borrelia burgdorferi gene expression in mice and ticks

scientific article

Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection

scientific article

Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre

scientific article

Transcription mediated by NFAT is highly inducible in effector CD4+ T helper 2 (Th2) cells but not in Th1 cells

scientific article published on March 1997

Transcriptional Reprogramming during Effector-to-Memory Transition Renders CD4+ T Cells Permissive for Latent HIV-1 Infection

scientific article published in October 2017

Transcriptional regulation of th2 differentiation by inducible costimulator

scientific article published in June 2003

Transforming growth factor beta (TGF-beta) and autoimmunity

scientific article

Transforming growth factor-beta and the immune response: implications for anticancer therapy

scientific article published on September 2007

Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma

scientific article published on 24 April 2005

Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms

scientific article

Transforming growth factor-beta regulation of immune responses

scientific article

Transforming growth factor-beta suppresses the activation of CD8+ T-cells when naive but promotes their survival and function once antigen experienced: a two-faced impact on autoimmunity

scientific article published on 8 August 2008

Transforming growth factor-beta: recent advances on its role in immune tolerance

scientific article

Transforming growth factor-β signaling in T cells promotes stabilization of atherosclerotic plaques through an interleukin-17-dependent pathway

scientific article published in July 2013

Transgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/- mice improves engraftment of human hematopoietic cells in humanized mice.

scientific article

Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion

scientific article

Transgenic mice which overproduce Th2 cytokines develop spontaneous atopic dermatitis and asthma

scientific article published on 28 June 2004

Transgenic monocyte chemoattractant protein-1 (MCP-1) in pancreatic islets produces monocyte-rich insulitis without diabetes: abrogation by a second transgene expressing systemic MCP-1

scientific article published on 01 July 1997

Transgenic tumor necrosis factor (TNF)-alpha production in pancreatic islets leads to insulitis, not diabetes. Distinct patterns of inflammation in TNF-alpha and TNF-beta transgenic mice ⬇️

scientific article published on 01 May 1993

Transient subversion of CD40 ligand function diminishes immune responses to adenovirus vectors in mouse liver and lung tissues

scientific article published in September 1996

Transmissible inflammation-induced colorectal cancer in inflammasome-deficient mice

scientific article published on 07 May 2018

Transplant tolerance to pancreatic islets is initiated in the graft and sustained in the spleen

scientific article published on 8 July 2013

Treatment of allergic inflammation and hyperresponsiveness by a simple compound, Bavachinin, isolated from Chinese herbs

scientific article published on 09 September 2013

Truncated form of TGF-βRII, but not its absence, induces memory CD8+ T cell expansion and lymphoproliferative disorder in mice

scientific article published on 17 May 2013

Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections

scientific article published on 01 August 2007

Twisting the Th1/Th2 immune response via the retinoid X receptor: lessons from a genetic approach

scientific article

Type IV secretion-dependent activation of host MAP kinases induces an increased proinflammatory cytokine response to Legionella pneumophila

scientific article

Tyrosine phosphorylation of SHIP promotes its proteasomal degradation.

scientific article published on 18 March 2010

Unexpected protective role for Toll-like receptor 3 in the arterial wall

scientific article

Unraveling the genetics of autoimmunity

scientific article

Up-regulation of Hlx in immature Th cells induces IFN-gamma expression

scientific article published on 01 January 2004

Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways

scientific article published on 16 November 2003

Use of recombinant antigens of Borrelia burgdorferi in serologic tests for diagnosis of lyme borreliosis

scientific article published on February 1996

Vaccination against Lyme disease caused by diverse Borrelia burgdorferi

scientific article

Ventilator-induced lung injury is mediated by the NLRP3 inflammasome

scientific article published in May 2012

Viral infection switches non-plasmacytoid dendritic cells into high interferon producers.

scientific article

Virally induced inflammation triggers fratricide of Fas-ligand-expressing beta-cells

scientific article published in March 2004

Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo

scientific article published on 2 July 2009

Vγ4 γδ T cell-derived IL-17A negatively regulates NKT cell function in Con A-induced fulminant hepatitis

scientific article published on 10 October 2011

YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity

scientific article published on 19 February 2016

Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity

scientific article

ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8+ T cell fates

scientific article published on 15 February 2018

ZPR1 is essential for survival and is required for localization of the survival motor neurons (SMN) protein to Cajal bodies

scientific article

c-Cbl deficiency leads to diminished lymphocyte development and functions in an age-dependent manner

scientific article

c-Jun N-terminal kinase 3 deficiency protects neurons from axotomy-induced death in vivo through mechanisms independent of c-Jun phosphorylation.

scientific article published on 4 November 2004

c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activation

scientific article published on April 2002

c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 signaling pathways have divergent roles in CD8(+) T cell-mediated antiviral immunity.

scientific article

c-Jun NH(2)-terminal kinase inhibits targeting of the protein phosphatase calcineurin to NFATc1.

scientific article

c-Jun NH(2)-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor.

scientific article

c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression

scientific article published in July 2007

c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection

scientific article

cGAS activation in phased droplets

scholarly article by Yongbo Liu published in October 2018

hnRNPA2B1: a nuclear DNA sensor in antiviral immunity

scientific article published on 01 November 2019

inv(16) and NPM1mut AMLs engraft human cytokine knock-in mice

scientific article published on 31 August 2016

m(6)A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways

scientific article published on 09 August 2017

m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development

scientific article published on 31 May 2020

m6A mRNA methylation sustains Treg suppressive functions.

scientific article published on 5 January 2018

m<sup>6</sup>A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity

scientific article published on 01 November 2021

mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence

scientific article

miR-181 and metabolic regulation in the immune system.

scientific article

miR-181a Modulation of ERK-MAPK Signaling Sustains DC-SIGN Expression and Limits Activation of Monocyte-Derived Dendritic Cells

scientific article published on 01 March 2020

miR-181a/b downregulation exerts a protective action on mitochondrial disease models

scientific article published on 01 May 2019

miR-181b regulates vascular stiffness age dependently in part by regulating TGF-β signaling.

scientific article

p21 Ras/impedes mitogenic signal propagation regulates cytokine production and migration in CD4 T cells

scientific article

β-catenin mediates tumor-induced immunosuppression by inhibiting cross-priming of CD8⁺ T cells

scientific article published on 10 September 2013

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