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List of works by Karl Lenhard Rudolph

A 'telomere-associated secretory phenotype' cooperates with BCR-ABL to drive malignant proliferation of leukemic cells

scientific article published on 7 March 2014

A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage.

scientific article published on 11 September 2014

A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage

scientific journal article

A dual role of p21 in stem cell aging.

scientific article published on April 2007

A telomerase-dependent conditionally replicating adenovirus for selective treatment of cancer

scientific article published on 01 June 2003

ATM-dependent phosphorylation of SNEVhPrp19/hPso4 is involved in extending cellular life span and suppression of apoptosis

scientific article published on April 2012

Aging stem cells: transcriptome meets epigenome meets methylome

scientific article published on 01 May 2014

Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer

scientific article

Alterations of the systemic environment are the primary cause of impaired B and T lymphopoiesis in telomere-dysfunctional mice

scientific article published on 02 December 2009

Aneuploidy-inducing gene knockdowns overlap with cancer mutations and identify Orp3 as a B-cell lymphoma suppressor

scientific article published on 28 October 2019

Are aging biomarkers clinically relevant in oncogeriatrics? ⬇️

scientific article published on 02 September 2012

Author Correction: Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation

scientific article published on 30 April 2020

Author Correction: Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals

scientific article published on 01 August 2019

Author Correction: Per2 induction limits lymphoid-biased haematopoietic stem cells and lymphopoiesis in the context of DNA damage and ageing

scientific article published on 01 June 2019

CEBP factors regulate telomerase reverse transcriptase promoter activity in whey acidic protein-T mice during mammary carcinogenesis

scientific article

CHK2-independent induction of telomere dysfunction checkpoints in stem and progenitor cells

scientific article

Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation

scientific article published on 03 December 2006

Cell intrinsic and extrinsic mechanisms of stem cell aging depend on telomere status

scientific article published on 03 July 2008

Cellular and epigenetic drivers of stem cell ageing

scientific article published on 01 September 2018

Chemoocclusion vs chemoperfusion for treatment of advanced hepatocellular carcinoma: a randomised trial

scientific article published on 20 December 2005

Chitinase enzyme activity in CSF is a powerful biomarker of Alzheimer disease

scientific article published on 8 February 2012

Clinical features, etiology, and survival of hepatocellular carcinoma among different countries

scientific article published on 01 February 2002

Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells

scientific article published in August 2013

Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation

scientific article published on 07 December 2018

Comparison of the uptake of methacrylate-based nanoparticles in static and dynamic in vitro systems as well as in vivo.

scientific article published on 12 August 2015

Contrasting effects of telomere shortening on organ homeostasis, tumor suppression, and survival during chronic liver damage

scientific article published in February 2005

Correction for: Sod2 haploinsufficiency does not accelerate aging of telomere dysfunctional mice

scientific article published on 06 December 2019

Correction: Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging

scientific article published on 01 January 2021

DNA damage checkpoints in stem cells, ageing and cancer.

scientific article published on September 2012

Determining the influence of telomere dysfunction and DNA damage on stem and progenitor cell aging: what markers can we use?

scientific article published on 11 September 2008

Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging

scientific article published on 7 March 2016

Differential impact of telomere dysfunction on initiation and progression of hepatocellular carcinoma.

scientific article published in August 2003

Differential regulation of extracellular matrix synthesis during liver regeneration after partial hepatectomy in rats

scientific article published on 01 November 1999

Disruption of Trp53 in livers of mice induces formation of carcinomas with bilineal differentiation

scientific article published on 15 February 2012

Effect of cytotoxic chemotherapy on markers of molecular age in patients with breast cancer

scientific article

Enhanced telomere rejuvenation in pluripotent cells reprogrammed via nuclear transfer relative to induced pluripotent stem cells

scientific article

Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals

scientific article

Establishment of immortalized multipotent hematopoietic progenitor cell lines by retroviral-mediated gene transfer of beta-catenin

scientific article published on February 2008

Exonuclease 1 is essential for maintaining genomic stability and the proliferative capacity of neural but not hematopoietic stem cells

scientific article published on 10 November 2013

Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice

scientific article

Expression of the lymphoid enhancer factor 1 is required for normal hematopoietic stem and progenitor cell function.

scientific article published on 14 August 2013

Feedback between p21 and reactive oxygen production is necessary for cell senescence

scientific article

Functionality, growth and accelerated aging of tissue engineered living autologous vascular grafts

scientific article published on 18 August 2012

Gadd45a regulates hematopoietic stem cell stress responses in mice.

scientific article

Gene dosage reductions of Trf1 and/or Tin2 induce telomere DNA damage and lymphoma formation in aging mice

scientific article published on 2 July 2015

Gene dosage reductions of Trf1 and/or Tin2 induce telomere DNA damage and lymphoma formation in aging mice

scientific article

Gene expression profile at the G1/S transition of liver regeneration after partial hepatectomy in mice

scientific article published on 08 November 2004

Genome instability of ageing stem cells--Induction and defence mechanisms

scientific article published on 7 February 2015

Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice

scientific article

Hepatocellular carcinoma and octreotide: treatment results in prospectively assigned patients with advanced tumor and cirrhosis stage

scientific article published in September 2005

Hepatocellular carcinoma in Germany: a retrospective epidemiological study from a low-endemic area.

scientific article published in July 2000

Hepatocellular carcinoma: epidemiology and molecular carcinogenesis

scientific article

Hepatocellular telomere shortening correlates with chromosomal instability and the development of human hepatoma

scientific article published on 01 July 2004

Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis

scientific article published on 01 July 2002

Identification of ageing-associated naturally occurring peptides in human urine

scientific article published on 29 September 2015

Identification of dynamic driver sets controlling phenotypical landscapes

scientific article published in 2022

Immunoaging induced by hematopoietic stem cell aging.

scientific article published on August 2011

Impact of genomic damage and ageing on stem cell function

scientific article

Impact papers on aging in 2009.

scientific article

Impaired endothelial repair capacity of early endothelial progenitor cells in prehypertension: relation to endothelial dysfunction

scientific article published on 10 May 2010

Improve organ health by chewing up old proteins?

scientific article published on 01 January 2009

Increased reprogramming capacity of mouse liver progenitor cells, compared with differentiated liver cells, requires the BAF complex

scientific article published on 12 January 2012

Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery

article

Inhibition of wild-type p53-induced phosphatase 1 promotes liver regeneration in mice by direct activation of mammalian target of rapamycin

scientific article published on 25 March 2015

Interventions to Slow Aging in Humans: Are We Ready?

scientific article

K-ras mutations in the bile of patients with primary sclerosing cholangitis

scientific article published on March 2001

Keeping your senescent cells under control

scientific article published on 6 May 2009

Lentiviral in situ targeting of stem cells in unperturbed intestinal epithelium

scientific article published in 2023

Lifestyle impacts on the aging-associated expression of biomarkers of DNA damage and telomere dysfunction in human blood

scientific article

Lin28a--boost your energy for youthful regeneration.

scientific article published on 19 December 2013

Lineage-specific pleiotropy in immune aging

scientific article published on 01 March 2011

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

article

Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors

scientific article published on 27 December 2012

Merging models of hepatitis C virus pathogenesis

scientific article

Mitogen stimulation cooperates with telomere shortening to activate DNA damage responses and senescence signaling

scientific article

Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization

scientific article

PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling

scientific article published on 27 May 2022

Per2 induction limits lymphoid-biased haematopoietic stem cells and lymphopoiesis in the context of DNA damage and ageing

scientific article published on 18 April 2016

Phase II study of systemic gemcitabine chemotherapy for advanced unresectable hepatobiliary carcinomas

scientific article

Phosphatase Wip1 controls antigen-independent B-cell development in a p53-dependent manner

scientific article published on 26 May 2015

Plasma N-acetyl-glucosaminidase in advanced gastro-intestinal adenocarcinoma correlates with age, stage and outcome

scientific article published on January 2015

Prospective analysis of German patients with hepatocellular carcinoma undergoing transcatheter arterial chemoembolization with or without prophylactic antibiotic therapy

scientific article published on 01 July 2005

Protein kinase D2 is an essential regulator of murine myoblast differentiation

scientific article

Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease

scholarly article

Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction.

scientific article published on 4 December 2011

Quantitative proteomic profiling of tumor cell response to telomere dysfunction using isotope-coded protein labeling (ICPL) reveals interaction network of candidate senescence markers ⬇️

scientific article published on August 19, 2013

Quiescence: Good and Bad of Stem Cell Aging

scientific article published on 24 June 2019

ROS induced DNA damage and checkpoint responses: influences on aging?

scientific article published on 10 October 2010

Regeneration in starved planarians depends on TRiC/CCT subunits modulating the unfolded protein response

scientific article published on 30 June 2021

Regeneration of the exocrine pancreas is delayed in telomere-dysfunctional mice

scientific article

Region-Specific Proteome Changes of the Intestinal Epithelium during Aging and Dietary Restriction

scientific article published on 01 April 2020

Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit

scientific article

Rho GTPase and Wnt signaling pathways in hepatocarcinogenesis

scientific article published on 01 March 2008

Role of telomere dysfunction in aging and its detection by biomarkers.

scientific article published on 08 August 2009

SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling

scientific article published on 01 April 2016

Senescence and apoptosis block hematopoietic activation of quiescent hematopoietic stem cells with short telomeres

scientific article published on 16 September 2014

Short telomeres and prognosis of hypertension in a chinese population.

scientific article

Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay

scientific article published on 14 March 2015

Sod2 haploinsufficiency does not accelerate aging of telomere dysfunctional mice

scientific article

Substantial telomere shortening in the substantia nigra of telomerase-deficient mice does not increase susceptibility to MPTP-induced dopamine depletion

scientific article published in March 2014

Systems biology to battle vascular disease

scientific article published on 03 February 2010

Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion.

scientific article published on 27 March 2015

Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion.

scientific article published on October 2017

Telomerase activity, telomere length, and apoptosis: a comparison between acquired cholesteatoma and squamous cell carcinoma

scientific article published on 01 September 2002

Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma

scientific article published on November 2005

Telomerase deficiency impairs glucose metabolism and insulin secretion

scientific article

Telomerase deletion limits progression of p53-mutant hepatocellular carcinoma with short telomeres in chronic liver disease

scientific article published on 26 January 2007

Telomerase gene mutations are associated with cirrhosis formation

scientific article published in May 2011

Telomerase-dependent virotherapy overcomes resistance of hepatocellular carcinomas against chemotherapy and tumor necrosis factor-related apoptosis-inducing ligand by elimination of Mcl-1.

scientific article published on August 2005

Telomere Dysfunction, Chromosomal Instability and Cancer.

scientific article published on January 2015

Telomere dysfunction alters the chemotherapeutic profile of transformed cells

scholarly article

Telomere dysfunction and DNA damage checkpoints in diseases and cancer of the gastrointestinal tract.

scientific article published on 18 July 2009

Telomere dysfunction and evolution of intestinal carcinoma in mice and humans

scientific journal article

Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

scientific article (publication date: September 2000)

Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment

scientific article published on 07 May 2007

Telomere dysfunction puts the brakes on oncogene-induced cancers

scientific article published on 29 May 2012

Telomere dysfunction triggers developmentally regulated germ cell apoptosis.

scientific article

Telomere dysfunction-related serological markers are associated with type 2 diabetes.

scientific article

Telomere dysfunctional environment induces loss of quiescence and inherent impairments of hematopoietic stem cell function

scientific article published on 22 February 2012

Telomere length is reset during early mammalian embryogenesis.

scientific article

Telomere length regulation during cloning, embryogenesis and ageing.

scientific article

Telomere length, telomerase activity and osteogenic differentiation are maintained in adipose-derived stromal cells from senile osteoporotic SAMP6 mice.

scientific article

Telomere shortening and ageing.

scientific article published on October 2007

Telomere shortening and inactivation of cell cycle checkpoints characterize human hepatocarcinogenesis.

scientific article published in April 2007

Telomere shortening correlates with increasing aneuploidy of chromosome 8 in human hepatocellular carcinoma

scientific article published on 01 September 2005

Telomere shortening impairs organ regeneration by inhibiting cell cycle re-entry of a subpopulation of cells

scientific article

Telomere shortening impairs regeneration of the olfactory epithelium in response to injury but not under homeostatic conditions

scientific article

Telomere shortening in leukocyte subpopulations in depression.

scientific article

Telomere shortening is associated with reduced duodenal HCOFormula secretory but normal gastric acid secretory capacity in aging mice

scientific article

Telomere shortening leads to earlier age of onset in ALS mice

scientific article published on February 2016

Telomere shortening of epithelial cells characterises the adenoma-carcinoma transition of human colorectal cancer

scientific article published in September 2003

Telomere shortening reduces Alzheimer's disease amyloid pathology in mice

scientific article published on 14 June 2011

Telomere stability--Wnt it or lose it

scientific article published on 19 March 2013

Telomere structural dynamics in genome integrity control and carcinogenesis

scientific article published on January 2005

Telomeres and telomerase in aging, regeneration and cancer.

scientific article

Telomeres and telomerase in cancer stem cells.

scientific article

Telomeres and telomerase in stem cells during aging and disease.

scientific article published on January 2006

Telomeres and telomerase influence the course of human diseases, aging and carcinogenesis

scientific article published on 01 March 2005

Telomeres and telomerase: a dual role in hepatocarcinogenesis

scientific article

Telomeres and telomerase: new targets for the treatment of liver cirrhosis and hepatocellular carcinoma.

scientific article published in September 2004

Telomeres shorten while Tert expression increases during ageing of the short-lived fish Nothobranchius furzeri

scientific article

Telomeres, telomerase and cancer: an endless search to target the ends.

scientific article published on 10 September 2004

The GAPs between hepatocellular carcinoma and RAS

scientific article published on 19 September 2010

The cellular level of telomere dysfunction determines induction of senescence or apoptosis in vivo.

scientific article

The role of telomere shortening in somatic stem cells and tissue aging: lessons from telomerase model systems

scientific article published on August 2012

The role of telomeres in stem cells and cancer

scientific article

The use of urinary proteomics in the assessment of suitability of mouse models for ageing

scientific article

Tnfaip2/exoc3-driven lipid metabolism is essential for stem cell differentiation and organ homeostasis

scientific article published on 10 December 2020

Transient telomere dysfunction induces chromosomal instability and promotes carcinogenesis

scientific article published on 01 January 2021

Transient telomere dysfunction induces chromosomal instability and promotes carcinogenesis.

scientific article

VEGFR2 Signaling Prevents Colorectal Cancer Cell Senescence to Promote Tumorigenesis in Mice With Colitis.

scientific article published on 19 March 2015

Wip1 deficiency impairs haematopoietic stem cell function via p53 and mTORC1 pathways.

scientific article

Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage

scientific article published on October 2017

Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage.

scientific article

Wound healing defect of Vav3-/- mice due to impaired {beta}2-integrin-dependent macrophage phagocytosis of apoptotic neutrophils

scientific article published on 15 January 2009

[Hepatocellular carcinoma: diagnosis and multi-modality therapy]

scientific article published on 01 October 1997

[Telomere dysfunction and telomerase: implications for human pathophysiology during ageing and chronic diseases]

scientific article published on 01 September 2006

[[Cancer and aging--biological mechanisms]

scientific article published on 25 September 2009

p16 and ARF: activation of teenage proteins in old age.

scientific article

p21 promotes sustained liver regeneration and hepatocarcinogenesis in chronic cholestatic liver injury

scientific article published on 3 October 2013

p21 shapes cancer evolution.

scientific article published in June 2016

p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice

article published in 2009

p53 mutation pattern and expression of c-erbB2 and c-met in gastric cancer: relation to histological subtypes, Helicobacter pylori infection, and prognosis

scientific article

p53 represses CAAT enhancer-binding protein (C/EBP)-dependent transcription of the albumin gene. A molecular mechanism involved in viral liver infection with implications for hepatocarcinogenesis

scientific article published in November 1999

pH-sensitive packaging of cationic particles by an anionic block copolymer shell

scientific article published in 2022

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