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List of works by Majlinda Lako

13 years of cultured limbal epithelial cell therapy: a review of the outcomes.

scientific article published on April 2011

3D culture of human pluripotent stem cells in RGD-alginate hydrogel improves retinal tissue development.

scientific article published on 4 November 2016

A Novel Role for miR-1305 in Regulation of Pluripotency-Differentiation Balance, Cell Cycle, and Apoptosis in Human Pluripotent Stem Cells

scientific article published on 24 June 2016

A critical role for p38MAPK signalling pathway during reprogramming of human fibroblasts to iPSCs.

scientific article

A gene related to Caenorhabditis elegans spermatogenesis factor fer-1 is mutated in limb-girdle muscular dystrophy type 2B

scientific article

A human iPSC model of Ligase IV deficiency reveals an important role for NHEJ-mediated-DSB repair in the survival and genomic stability of induced pluripotent stem cells and emerging haematopoietic progenitors.

scientific article

A novel mammalian wnt gene, WNT8B, shows brain-restricted expression in early development, with sharply delimited expression boundaries in the developing forebrain

scientific article

A novel model of urinary tract differentiation, tissue regeneration, and disease: reprogramming human prostate and bladder cells into induced pluripotent stem cells

scientific article published on 06 April 2013

A putative role for the immunoproteasome in the maintenance of pluripotency in human embryonic stem cells.

scientific article published in July 2012

Activation of autophagy reverses progressive and deleterious protein aggregation in PRPF31 patient-induced pluripotent stem cell-derived retinal pigment epithelium cells

scientific article published on 01 March 2022

Activation of p53 by nutlin leads to rapid differentiation of human embryonic stem cells.

scientific article

Aging of Stem and Progenitor Cells: Mechanisms, Impact on Therapeutic Potential, and Rejuvenation

scientific article published on 09 June 2015

An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays Characteristic Features of Age-Related Macular Degeneration and Indicates a Beneficial Role for UV Light Exposure. ⬇️

scientific article published on 15 September 2017

An autogeneic feeder cell system that efficiently supports growth of undifferentiated human embryonic stem cells.

scientific article published on March 2005

An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells

scientific article

An important role for adenine, cholera toxin, hydrocortisone and triiodothyronine in the proliferation, self-renewal and differentiation of limbal stem cells in vitro.

scientific article published on 28 September 2016

An integrated transcriptional analysis of the developing human retina

scientific article published on 29 January 2019

An investigation of donor and culture parameters which influence epithelial outgrowths from cultured human cadaveric limbal explants.

scientific article published in May 2013

Analysis of human ES cell differentiation establishes that the dominant isoforms of the lncRNAs RMST and FIRRE are circular.

scientific article

Balancing work and life: a conversation with Margaret "Peggy" Goodell.

scientific article published in June 2009

Balancing work and life: finding our inspirations

scientific article published on 01 April 2009

Brief Report: Inhibition of miR-145 Enhances Reprogramming of Human Dermal Fibroblasts to Induced Pluripotent Stem Cells.

scientific article

Brief report: human pluripotent stem cell models of fanconi anemia deficiency reveal an important role for fanconi anemia proteins in cellular reprogramming and survival of hematopoietic progenitors.

scientific article published in May 2013

CD200 Expression Marks a Population of Quiescent Limbal Epithelial Stem Cells with Holoclone Forming Ability

scientific article published on 01 October 2018

CDK1 plays an important role in the maintenance of pluripotency and genomic stability in human pluripotent stem cells

scientific article

CRX Expression in Pluripotent Stem Cell-Derived Photoreceptors Marks a Transplantable Subpopulation of Early Cones

scientific article published on 30 January 2019

Cellular regeneration strategies for macular degeneration: past, present and future.

scientific article

Characterisation of Wnt gene expression during the differentiation of murine embryonic stem cells in vitro: role of Wnt3 in enhancing haematopoietic differentiation.

scientific article

Characterization of human embryonic stem cell lines by the International Stem Cell Initiative

scientific article

Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of age-related macular degeneration by restoring lysosomal function

scientific article published on 20 August 2020

Concise Review: Cardiac Disease Modeling Using Induced Pluripotent Stem Cells.

scientific article published on 28 May 2015

Concise Review: Getting to the Core of Inherited Bone Marrow Failures.

scientific article

Concise Review: Putting a Finger on Stem Cell Biology: Zinc Finger Nuclease‐Driven Targeted Genetic Editing in Human Pluripotent Stem Cells ⬇️

scientific article published on July 1, 2011

Concise review: the epigenetic contribution to stem cell ageing: can we rejuvenate our older cells?

scientific article published on September 2014

Corneal epithelial stem cells: characterization, culture and transplantation.

scientific article published on January 2006

Correlated random walks of human embryonic stem cells in vitro

scientific article published on 13 June 2018

Deconstructing Retinal Organoids: Single Cell RNA-Seq Reveals the Cellular Components of Human Pluripotent Stem Cell-Derived Retina

scientific article published on 12 January 2019

Defining the optimal cryoprotectant and concentration for cryopreservation of limbal stem cells

scientific article published on 31 July 2018

Derivation and functional analysis of patient-specific induced pluripotent stem cells as an in vitro model of chronic granulomatous disease

scientific article published on April 2012

Derivation, growth and applications of human embryonic stem cells.

scientific article published in September 2004

Developing a simple method to enhance the generation of cone and rod photoreceptors in pluripotent stem cell-derived retinal organoids

scientific article published on 31 October 2019

Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency.

scientific article published on 20 September 2016

Differences in the Activity of Endogenous Bone Morphogenetic Protein Signaling Impact on the Ability of Induced Pluripotent Stem Cells to Differentiate to Corneal Epithelial-Like Cells.

scientific article published on 11 December 2017

Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa ⬇️

scientific article published in Nature Communications

Downregulation of NANOG induces differentiation of human embryonic stem cells to extraembryonic lineages

scientific article

Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells

scientific article published on 29 November 2007

Dynamics of single human embryonic stem cells and their pairs: a quantitative analysis

scientific article

Editorial: Our top 10 developments in stem cell biology over the last 30 years

scientific article published in January 2012

Efficient hematopoietic differentiation of human embryonic stem cells on stromal cells derived from hematopoietic niches.

scientific article

Efficient stage-specific differentiation of human pluripotent stem cells toward retinal photoreceptor cells.

scientific article published on April 2012

Endothelial Differentiation G Protein-Coupled Receptor 5 Plays an Important Role in Induction and Maintenance of Pluripotency

scientific article published on 07 February 2019

Engraftment's Holy Grail: is one signal enough?

scientific article published in November 2014

Epigenetic landscaping during hESC differentiation to neural cells.

scientific article

Epigenetic marking prepares the human HOXA cluster for activation during differentiation of pluripotent cells.

scientific article

Epigenetic modification is central to genome reprogramming in somatic cell nuclear transfer.

scientific article

Ethical and Safety Issues of Stem Cell-Based Therapy.

scientific article published in January 2018

Expression and functional analysis of G1 to S regulatory components reveals an important role for CDK2 in cell cycle regulation in human embryonic stem cells

scientific article published on 22 September 2008

Expression of GFP under the control of the RNA helicase VASA permits fluorescence-activated cell sorting isolation of human primordial germ cells.

scientific article

Extracellular matrix component expression in human pluripotent stem cell-derived retinal organoids recapitulates retinogenesis in vivo and reveals an important role for IMPG1 and CD44 in the development of photoreceptors and interphotoreceptor matri

scientific article published on 17 May 2018

G1 to S phase cell cycle transition in somatic and embryonic stem cells.

scientific article published on July 2008

Gamma-irradiated human amniotic membrane decellularised with sodium dodecyl sulfate is a more efficient substrate for the ex vivo expansion of limbal stem cells

scientific article

Gelsolin dysfunction causes photoreceptor loss in induced pluripotent cell and animal retinitis pigmentosa models.

scientific article published on 16 August 2017

Generating inner ear organoids containing putative cochlear hair cells from human pluripotent stem cells

scholarly article by Minjin Jeong et al published 11 September 2018 in Cell Death and Disease

Generation of Human Induced Pluripotent Stem Cells Using RNA-Based Sendai Virus System and Pluripotency Validation of the Resulting Cell Population

scientific article published on 20 February 2015

Genetic basis of inherited macular dystrophies and implications for stem cell therapy.

scientific article

Hair Follicle Dermal Cells Support Expansion of Murine and Human Embryonic and Induced Pluripotent Stem Cells and Promote Haematopoiesis in Mouse Cultures

article

Hematopoietic differentiation from human ESCs as a model for developmental studies and future clinical translations. Invited review following the FEBS Anniversary Prize received on 5 July 2009 at the 34th FEBS Congress in Prague.

scientific article

Hepatic differentiation of human iPSCs in different 3D models: A comparative study.

scientific article published on 16 October 2017

How to build a human

scientific article published on 24 August 2016

Human Retinal Organoids Provide a Suitable Tool for Toxicological Investigations: A Comprehensive Validation Using Drugs and Compounds Affecting the Retina

scientific article published on 01 March 2022

Human embryonal carcinoma stem cells expressing green fluorescent protein form functioning neurons in vitro: a research tool for co-culture studies.

scientific article published on December 2004

Human embryonic stem cells: biology and clinical implications.

scientific article

Human iPSC disease modelling reveals functional and structural defects in retinal pigment epithelial cells harbouring the m.3243A > G mitochondrial DNA mutation.

scientific article published on 26 September 2017

Human induced pluripotent stem cell lines show stress defense mechanisms and mitochondrial regulation similar to those of human embryonic stem cells

scientific article published on 01 April 2010

Human-Induced Pluripotent Stem Cells Generate Light Responsive Retinal Organoids with Variable and Nutrient-Dependent Efficiency

scientific article published on 13 August 2018

IGF-1 Signaling Plays an Important Role in the Formation of Three-Dimensional Laminated Neural Retina and Other Ocular Structures From Human Embryonic Stem Cells.

scientific article

Identification of a novel family of human endogenous retroviruses and characterization of one family member, HERV-K(C4), located in the complement C4 gene cluster.

scientific article published in December 1994

In search of the best candidate for regeneration of ischemic tissues: are embryonic/fetal stem cells more advantageous than adult counterparts?

scientific article published on 01 October 2005

Induced pluripotent stem cell modelling of HLHS underlines the contribution of dysfunctional NOTCH signalling to impaired cardiogenesis

scientific article published on 17 May 2017

Induced pluripotent stem cells : it looks simple but can looks deceive?

scientific article published on 01 May 2010

Insights into islet development and biology through characterization of a human iPSC-derived endocrine pancreas model

scientific article published on April 2016

Isolation and characterization of WNT8B, a novel human Wnt gene that maps to 10q24.

scientific article

Isolation of primordial germ cells from differentiating human embryonic stem cells

scientific article published on 18 September 2008

Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung

scientific article

JNK/SAPK Signaling Is Essential for Efficient Reprogramming of Human Fibroblasts to Induced Pluripotent Stem Cells

scientific article

Lab generated retina: realizing the dream.

scientific article published on 22 May 2014

Laminin γ3 plays an important role in retinal lamination, photoreceptor organisation and ganglion cell differentiation.

scientific article

Multiplex High-Throughput Targeted Proteomic Assay To Identify Induced Pluripotent Stem Cells

scientific article published on 6 February 2017

Neural development by transplanted human embryonal carcinoma stem cells expressing green fluorescent protein.

scientific article published on January 2005

Neural stem cells, a step closer to clinic? ⬇️

scientific article published on October 1, 2011

Non-invasive imaging of stem cells by scanning ion conductance microscopy: future perspective

scientific article

Outcomes of Penetrating Keratoplasty following Autologous Cultivated Limbal Epithelial Stem Cell Transplantation.

scientific article published on 13 February 2018

Overexpression of telomerase confers growth advantage, stress resistance, and enhanced differentiation of ESCs toward the hematopoietic lineage.

scientific article

Phenotypic characterization of murine primitive hematopoietic progenitor cells isolated on basis of aldehyde dehydrogenase activity.

scientific article published in January 2004

Platform to study intracellular polystyrene nanoplastic pollution and clinical outcomes

scientific article published on 02 July 2020

Pluripotent Stem Cell-Derived Hematopoietic Progenitors Are Unable to Downregulate Key Epithelial-Mesenchymal Transition-Associated miRNAs.

scientific article

Potential for pharmacological manipulation of human embryonic stem cells.

scientific article published on May 2013

Preferential amplification of a human mitochondrial DNA deletion in vitro and in vivo

scientific article published on 29 January 2018

Primordial Germ Cells: Current Knowledge and Perspectives

scientific article

Putative role of hyaluronan and its related genes, HAS2 and RHAMM, in human early preimplantation embryogenesis and embryonic stem cell characterization.

scientific article published on 13 September 2007

Rapid establishment of the European Bank for induced Pluripotent Stem Cells (EBiSC) - the Hot Start experience

scientific article

Reproducibility of Molecular Phenotypes after Long-Term Differentiation to Human iPSC-Derived Neurons: A Multi-Site Omics Study

article

Response to letter by Hallam et al.

scientific article

Retinoid supplementation of differentiating human neural progenitors and embryonic stem cells leads to enhanced neurogenesis in vitro

scientific article published on 9 September 2010

Room temperature shipment does not affect the biological activity of pluripotent stem cell-derived retinal organoids

scientific article published on 01 June 2020

Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage

scientific article

Searching the unknown with gene trapping

scientific article published on 06 July 2000

Silencing of the expression of pluripotent driven-reporter genes stably transfected into human pluripotent cells

scientific article published on 01 July 2008

Special Series: Stem Cells and Hearing Loss

scientific article published in 2021

Special Series: Transplantation of Stem Cells into the Eye

scientific article published on 22 August 2018

Stem Cell-Based Therapy in Transplantation and Immune-Mediated Diseases

scientific article published on 6 September 2017

Stem Cells' position statement on hESC research

scientific article published on 01 September 2010

Stem Cells, Inflammation, and Fibrosis.

scientific article published on 24 February 2016

Stem cells as new agents for the treatment of infertility: current and future perspectives and challenges

scientific article

Successful application of ex vivo expanded human autologous oral mucosal epithelium for the treatment of total bilateral limbal stem cell deficiency

scientific article published in August 2014

Successful clinical implementation of corneal epithelial stem cell therapy for treatment of unilateral limbal stem cell deficiency.

scientific article

The Application of Biomaterials to Tissue Engineering Neural Retina and Retinal Pigment Epithelium

scientific article published on 02 September 2018

The Role of Nerve Growth Factor in Maintaining Proliferative Capacity, Colony-Forming Efficiency, and the Limbal Stem Cell Phenotype

scholarly article by Sai Kolli et al published January 2019 in Stem Cells

The future of human nuclear transfer?

scientific article published on January 2006

The mitochondrial protein CHCHD2 primes the differentiation potential of human induced pluripotent stem cells to neuroectodermal lineages.

scientific article published on 17 October 2016

The role of PI3K/AKT, MAPK/ERK and NFkappabeta signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis.

scientific article

Tissue engineering using pluripotent stem cells: multidisciplinary approaches to accelerate bench-to-bedside transition.

scientific article

Towards optimisation of induced pluripotent cell culture: Extracellular acidification results in growth arrest of iPSC prior to nutrient exhaustion.

scientific article published on 15 August 2017

Using Zinc Finger Nuclease Technology to Generate CRX-Reporter Human Embryonic Stem Cells as a Tool to Identify and Study the Emergence of Photoreceptors Precursors During Pluripotent Stem Cell Differentiation.

scientific article published on 26 November 2015

iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors

scientific article published on 26 January 2018

mTert expression correlates with telomerase activity during the differentiation of murine embryonic stem cells.

scientific article published in October 2000

pRB-Depleted Pluripotent Stem Cell Retinal Organoids Recapitulate Cell State Transitions of Retinoblastoma Development and Suggest an Important Role for pRB in Retinal Cell Differentiation

scientific article published on 01 April 2022

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