List of works - David E. Minnikin

7000 year-old tuberculosis cases from Hungary - Osteological and biomolecular evidence.

scientific article published on 12 February 2015

A migration-driven model for the historical spread of leprosy in medieval Eastern and Central Europe

scientific article published on 11 February 2015

A mycolic acid-specific CD1-restricted T cell population contributes to acute and memory immune responses in human tuberculosis infection

scientific article

A re-investigation of the mycolic acids of Mycobacterium avium

scientific article published on 31 May 2020

A simple mycobacterial monomycolated glycerol lipid has potent immunostimulatory activity

scientific article

A type II pathway for fatty acid biosynthesis presents drug targets in Plasmodium falciparum

scientific article

Acetylene-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme

scientific article

Adjuvant properties of a simplified C32 monomycolyl glycerol analogue

scientific article published on 11 February 2009

Analogues of thiolactomycin: potential drugs with enhanced anti-mycobacterial activity

scientific article published in October 2002

Ancient DNA analysis - An established technique in charting the evolution of tuberculosis and leprosy

scientific article published on 13 February 2015

Ancient mycobacterial lipids: Key reference biomarkers in charting the evolution of tuberculosis

scientific article published on 12 February 2015

Biomolecular archaeology of ancient tuberculosis: response to “Deficiencies and challenges in the study of ancient tuberculosis DNA” by Wilbur et al. (2009)

article

Biphenyl-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme

scientific article

Conformational behavior of oxygenated mycobacterial mycolic acids from Mycobacterium bovis BCG

scientific article published on 19 April 2007

Conformational folding of mycobacterial methoxy- and ketomycolic acids facilitated by α-methyl trans-cyclopropane groups rather than cis-cyclopropane units

scientific article

Detecting Ancient Tuberculosis

Detection and molecular characterization of 9,000-year-old Mycobacterium tuberculosis from a Neolithic settlement in the Eastern Mediterranean

scientific article

Detection and strain typing of ancient Mycobacterium leprae from a medieval leprosy hospital.

scientific article

Detection of Mycobacterium tuberculosis in sputum by gas chromatography-mass spectrometry of methyl mycocerosates released by thermochemolysis

scientific article

Development and optimization of a gas chromatography/mass spectrometry method for the analysis of thermochemolytic degradation products of phthiocerol dimycocerosate waxes found in Mycobacterium tuberculosis

scientific article published on November 2013

Development of sample clean up methods for the analysis of Mycobacterium tuberculosis methyl mycocerosate biomarkers in sputum extracts by gas chromatography-mass spectrometry

scientific article

Differential conformational behaviors of alpha-mycolic acids in Langmuir monolayers and computer simulations

scientific article published on 11 May 2010

Differential spontaneous folding of mycolic acids from Mycobacterium tuberculosis

scientific article published on 18 December 2013

Essentials in the use of mycolic acid biomarkers for tuberculosis detection: response to “High-throughput mass spectrometric analysis of 1400-year-old mycolic acids as biomarkers for ancient tuberculosis infection” by

scholarly article by David E. Minnikin et al published October 2010 in Journal of Archaeological Science

Facile synthesis of (Z)-tetracos-5-enoic acid and racemic cis-4-(2-octadecylcyclopropane-1-yl)-butanoic acid

scientific article published in November 2003

Genome-Wide Comparison of Medieval and Modern Mycobacterium leprae

scientific article (publication date: 13 June 2013)

Human tuberculosis predates domestication in ancient Syria

scientific article

Identification and structural characterization of an unusual mycobacterial monomeromycolyl-diacylglycerol

scientific article published in August 2005

Identification of a Desaturase Involved in Mycolic Acid Biosynthesis in Mycobacterium smegmatis

scientific article

Intracellular lipophilic inclusions of mycobacteria in vitro and in sputum

scientific article published on 01 October 2002

Lipid biomarkers provide evolutionary signposts for the oldest known cases of tuberculosis

scientific article

Location of functional groups in mycobacterial meromycolate chains; the recognition of new structural principles in mycolic acids

scientific article

LosA, a key glycosyltransferase involved in the biosynthesis of a novel family of glycosylated acyltrehalose lipooligosaccharides from Mycobacterium marinum

scientific article published on 28 October 2005

Loss of a mycobacterial gene encoding a reductase leads to an altered cell wall containing beta-oxo-mycolic acid analogs and accumulation of ketones

scientific article

MKAN27435 is required for the biosynthesis of higher subclasses of lipooligosaccharides in Mycobacterium kansasii

scientific article published on 20 April 2015

Metagenomic analysis of tuberculosis in a mummy.

scientific article published in July 2013

Morphological and biomolecular evidence for tuberculosis in 8th century AD skeletons from Bélmegyer-Csömöki domb, Hungary

scientific article published on 13 February 2015

Mycobacterium leprae genotype amplified from an archaeological case of lepromatous leprosy in Central Asia

article

Mycobacterium tuberculosis complex lipid virulence factors preserved in the 17,000-year-old skeleton of an extinct bison, Bison antiquus

scientific article

Mycocerosic acid biomarkers for the diagnosis of tuberculosis in the Coimbra Skeletal Collection.

scientific article

Mycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis

scientific journal article

New members of the phthiocerol and phenolphthiocerol families from Mycobacterium marinum

Novel generation mycobacterial adjuvant based on liposome-encapsulated monomycoloyl glycerol from Mycobacterium bovis bacillus Calmette-Guérin.

scientific article published on 20 July 2009

Novel prenyl-linked benzophenone substrate analogues of mycobacterial mannosyltransferases.

scientific article published on September 2004

Osteological and biomolecular evidence of a 7000-year-old case of hypertrophic pulmonary osteopathy secondary to tuberculosis from neolithic hungary

scientific article

Osteological, biomolecular and geochemical examination of an early Anglo-Saxon case of lepromatous leprosy

scientific article published on 13 May 2015

Positive Diagnosis of Ancient Leprosy and Tuberculosis Using Ancient DNA and Lipid Biomarkers

scholarly article by Helen Donoghue et al published 15 October 2017 in Diversity

Ready Experimental Translocation of Mycobacterium canettii Yields Pulmonary Tuberculosis

scientific article published on 18 September 2017

Symmetrical and unsymmetrical analogues of isoxyl; active agents against Mycobacterium tuberculosis

article

Synthesis and properties of methyl 5-(1'R,2'S)-(2-octadecylcycloprop-1-yl)pentanoate and other omega-19 chiral cyclopropane fatty acids and esters related to mycobacterial mycolic acids

scientific article

Temperature dependence of the Langmuir monolayer packing of mycolic acids from Mycobacterium tuberculosis

scientific article published on 01 September 2005

The challenge of identifying tuberculosis proteins in archaeological tissues

scholarly article by Jessica Hendy published in February 2016

The methyl-branched fortifications of Mycobacterium tuberculosis

scientific article

The role of hydrophobicity in tuberculosis evolution and pathogenicity

scientific article published on 2 May 2017

The synthesis of (11R,12S)-lactobacillic acid and its enantiomer

The synthesis of both enantiomers of lactobacillic acid and mycolic acid analogues

The synthesis of methyl 4-(2-octadecylcyclopropen-l-yl)butanoate: a possible inhibitor in mycolic acid biosynthesis

The synthesis of single enantiomers of meromycolic acids from mycobacterial wax esters

The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system

scientific article published on 01 May 2020

Tuberculosis in Dr Granville's mummy: a molecular re-examination of the earliest known Egyptian mummy to be scientifically examined and given a medical diagnosis.

scientific article

Tuberculosis origin: The Neolithic scenario

scientific article

Verification of tuberculosis infection among Vác mummies (18th century CE, Hungary) based on lipid biomarker profiling with a new HPLC-HESI-MS approach

scientific article published on 08 December 2020

List of works by David E. Minnikin

7000 year-old tuberculosis cases from Hungary - Osteological and biomolecular evidence.

A migration-driven model for the historical spread of leprosy in medieval Eastern and Central Europe

A mycolic acid-specific CD1-restricted T cell population contributes to acute and memory immune responses in human tuberculosis infection

A re-investigation of the mycolic acids of Mycobacterium avium

A simple mycobacterial monomycolated glycerol lipid has potent immunostimulatory activity

A type II pathway for fatty acid biosynthesis presents drug targets in Plasmodium falciparum

Acetylene-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme

Adjuvant properties of a simplified C32 monomycolyl glycerol analogue

Analogues of thiolactomycin: potential drugs with enhanced anti-mycobacterial activity

Ancient DNA analysis - An established technique in charting the evolution of tuberculosis and leprosy

Ancient mycobacterial lipids: Key reference biomarkers in charting the evolution of tuberculosis

Biomolecular archaeology of ancient tuberculosis: response to “Deficiencies and challenges in the study of ancient tuberculosis DNA” by Wilbur et al. (2009)

Biphenyl-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme

Conformational behavior of oxygenated mycobacterial mycolic acids from Mycobacterium bovis BCG

Conformational folding of mycobacterial methoxy- and ketomycolic acids facilitated by α-methyl trans-cyclopropane groups rather than cis-cyclopropane units

Detecting Ancient Tuberculosis

Detection and molecular characterization of 9,000-year-old Mycobacterium tuberculosis from a Neolithic settlement in the Eastern Mediterranean

Detection and strain typing of ancient Mycobacterium leprae from a medieval leprosy hospital.

Detection of Mycobacterium tuberculosis in sputum by gas chromatography-mass spectrometry of methyl mycocerosates released by thermochemolysis

Development and optimization of a gas chromatography/mass spectrometry method for the analysis of thermochemolytic degradation products of phthiocerol dimycocerosate waxes found in Mycobacterium tuberculosis

Development of sample clean up methods for the analysis of Mycobacterium tuberculosis methyl mycocerosate biomarkers in sputum extracts by gas chromatography-mass spectrometry

Differential conformational behaviors of alpha-mycolic acids in Langmuir monolayers and computer simulations

Differential spontaneous folding of mycolic acids from Mycobacterium tuberculosis

Essentials in the use of mycolic acid biomarkers for tuberculosis detection: response to “High-throughput mass spectrometric analysis of 1400-year-old mycolic acids as biomarkers for ancient tuberculosis infection” by

Facile synthesis of (Z)-tetracos-5-enoic acid and racemic cis-4-(2-octadecylcyclopropane-1-yl)-butanoic acid

Genome-Wide Comparison of Medieval and Modern Mycobacterium leprae

Human tuberculosis predates domestication in ancient Syria

Identification and structural characterization of an unusual mycobacterial monomeromycolyl-diacylglycerol

Identification of a Desaturase Involved in Mycolic Acid Biosynthesis in Mycobacterium smegmatis

Intracellular lipophilic inclusions of mycobacteria in vitro and in sputum

Lipid biomarkers provide evolutionary signposts for the oldest known cases of tuberculosis

Location of functional groups in mycobacterial meromycolate chains; the recognition of new structural principles in mycolic acids

LosA, a key glycosyltransferase involved in the biosynthesis of a novel family of glycosylated acyltrehalose lipooligosaccharides from Mycobacterium marinum

Loss of a mycobacterial gene encoding a reductase leads to an altered cell wall containing beta-oxo-mycolic acid analogs and accumulation of ketones

MKAN27435 is required for the biosynthesis of higher subclasses of lipooligosaccharides in Mycobacterium kansasii

Metagenomic analysis of tuberculosis in a mummy.

Morphological and biomolecular evidence for tuberculosis in 8th century AD skeletons from Bélmegyer-Csömöki domb, Hungary

Mycobacterium leprae genotype amplified from an archaeological case of lepromatous leprosy in Central Asia

Mycobacterium tuberculosis complex lipid virulence factors preserved in the 17,000-year-old skeleton of an extinct bison, Bison antiquus

Mycocerosic acid biomarkers for the diagnosis of tuberculosis in the Coimbra Skeletal Collection.

Mycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis

New members of the phthiocerol and phenolphthiocerol families from Mycobacterium marinum

Novel generation mycobacterial adjuvant based on liposome-encapsulated monomycoloyl glycerol from Mycobacterium bovis bacillus Calmette-Guérin.

Novel prenyl-linked benzophenone substrate analogues of mycobacterial mannosyltransferases.

Osteological and biomolecular evidence of a 7000-year-old case of hypertrophic pulmonary osteopathy secondary to tuberculosis from neolithic hungary

Osteological, biomolecular and geochemical examination of an early Anglo-Saxon case of lepromatous leprosy

Positive Diagnosis of Ancient Leprosy and Tuberculosis Using Ancient DNA and Lipid Biomarkers

Ready Experimental Translocation of Mycobacterium canettii Yields Pulmonary Tuberculosis

Symmetrical and unsymmetrical analogues of isoxyl; active agents against Mycobacterium tuberculosis

Synthesis and properties of methyl 5-(1'R,2'S)-(2-octadecylcycloprop-1-yl)pentanoate and other omega-19 chiral cyclopropane fatty acids and esters related to mycobacterial mycolic acids

Temperature dependence of the Langmuir monolayer packing of mycolic acids from Mycobacterium tuberculosis

The challenge of identifying tuberculosis proteins in archaeological tissues

The methyl-branched fortifications of Mycobacterium tuberculosis

The role of hydrophobicity in tuberculosis evolution and pathogenicity

The synthesis of (11R,12S)-lactobacillic acid and its enantiomer

The synthesis of both enantiomers of lactobacillic acid and mycolic acid analogues

The synthesis of methyl 4-(2-octadecylcyclopropen-l-yl)butanoate: a possible inhibitor in mycolic acid biosynthesis

The synthesis of single enantiomers of meromycolic acids from mycobacterial wax esters

The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system

Tuberculosis in Dr Granville's mummy: a molecular re-examination of the earliest known Egyptian mummy to be scientifically examined and given a medical diagnosis.

Tuberculosis origin: The Neolithic scenario

Verification of tuberculosis infection among Vác mummies (18th century CE, Hungary) based on lipid biomarker profiling with a new HPLC-HESI-MS approach