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List of works by Zsuzsanna Izsvák

A Combined In Vivo HSC Transduction/Selection Approach Results in Efficient and Stable Gene Expression in Peripheral Blood Cells in Mice

scientific article published on 10 November 2017

A Helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes

scientific article

A Multiple Piccolino-RIBEYE Interaction Supports Plate-Shaped Synaptic Ribbons in Retinal Neurons

scientific article published on 29 January 2019

A Novel Gene Controls a New Structure: PiggyBac Transposable Element-Derived 1, Unique to Mammals, Controls Mammal-Specific Neuronal Paraspeckles

scientific article published in 2022

A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains.

scientific article

A simple approach for multi-targeted shRNA-mediated inducible knockdowns using Sleeping Beauty vectors

scientific article published in PLoS ONE

A single amino acid switch converts the Sleeping Beauty transposase into an efficient unidirectional excisionase with utility in stem cell reprogramming

scientific article published on 01 January 2020

A whole lotta jumpin' goin' on: new transposon tools for vertebrate functional genomics.

scientific article

Antiangiogenic and Neurogenic Activities of Sleeping Beauty-Mediated PEDF-Transfected RPE Cells In Vitro and In Vivo

scientific article

Applying a "double-feature" promoter to identify cardiomyocytes differentiated from human embryonic stem cells following transposon-based gene delivery.

scientific article published on May 2009

Author Correction: Human somatic cell mutagenesis creates genetically tractable sarcomas

scientific article published on 01 April 2020

Author Correction: Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression

scientific article published on 01 August 2019

Author Correction: Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells

scientific article published in Nature Communications

Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery

scientific article

Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery

Cell division promotes efficient retrotransposition in a stable L1 reporter cell line

scientific article published on 6 March 2013

Chromosomal transposition of a Tc1/mariner-like element in mouse embryonic stem cells ⬇️

scientific article published on September 1, 1998

Common physical properties of DNA affecting target site selection of sleeping beauty and other Tc1/mariner transposable elements.

scientific article published in October 2002

Comparative analysis of transposable element vector systems in human cells

scientific article

Comparative genomic integration profiling of Sleeping Beauty transposons mobilized with high efficacy from integrase-defective lentiviral vectors in primary human cells

scientific article

Correction: Genomic Analysis of Sleeping Beauty Transposon Integration in Human Somatic Cells

scientific article published on 30 January 2020

Correction: Hybrid Adeno-Associated Viral Vectors Utilizing Transposase-Mediated Somatic Integration for Stable Transgene Expression in Human Cells

scientific article published on 30 January 2020

Correction: Hybrid Adeno-Associated Viral Vectors Utilizing Transposase-Mediated Somatic Integration for Stable Transgene Expression in Human Cells.

scientific article published on 19 November 2013

Correction: Integration Profile and Safety of an Adenovirus Hybrid-Vector Utilizing Hyperactive Sleeping Beauty Transposase for Somatic Integration

scientific article published on 04 February 2020

Correction: Reliable transgene-independent method for determining sleeping beauty transposon copy numbers.

scientific article published on 15 March 2013

Correction: Suicidal Autointegration of Sleeping Beauty and piggyBac Transposons in Eukaryotic Cells

scientific article published on 23 September 2019

Correction: Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats

scientific article published on 16 January 2020

Corrigendum to "How to tame an endogenous retrovirus: HERVH and the evolution of human pluripotency" [Curr Opin Virol 25 (August 2017) 49-58]

scientific article published on 04 April 2020

Corrigendum: Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites

scientific article published on 01 February 2020

Critical role for Piccolo in synaptic vesicle retrieval

scientific article published on 10 May 2019

Curative in vivo hematopoietic stem cell gene therapy of murine thalassemia using large regulatory elements

scientific article published on 20 August 2020

DANA elements: a family of composite, tRNA-derived short interspersed DNA elements associated with mutational activities in zebrafish (Danio rerio)

scientific article (publication date: 6 February 1996)

Development of hyperactive sleeping beauty transposon vectors by mutational analysis

scientific article

Disturbed Placental Imprinting in Preeclampsia Leads to Altered Expression of DLX5, a Human-Specific Early Trophoblast Marker

scientific article published on 13 September 2017

Downregulation of Plzf Gene Ameliorates Metabolic and Cardiac Traits in the Spontaneously Hypertensive Rat.

scientific article published on 10 April 2017

Efficient Non-Viral T-Cell Engineering by Sleeping Beauty Minicircles Diminishing DNA Toxicity and miRNAs Silencing the Endogenous T-Cell Receptors

scientific article published on 21 March 2018

Efficient Non-viral Gene Delivery into Human Hematopoietic Stem Cells by Minicircle Sleeping Beauty Transposon Vectors.

scientific article published on 31 January 2018

Efficient generation of osteoclasts from human induced pluripotent stem cells and functional investigations of lethal CLCN7 ‐related osteopetrosis

Efficient stable gene transfer into human cells by the Sleeping Beauty transposon vectors.

scientific article published on 15 July 2009

Emerging potential of transposons for gene therapy and generation of induced pluripotent stem cells

scientific article published on 26 May 2009

Engineering of PEDF-Expressing Primary Pigment Epithelial Cells by the SB Transposon System Delivered by pFAR4 Plasmids

scientific article published on 10 February 2017

Excision efficiency is not strongly coupled to transgenic rate: cell type-dependent transposition efficiency of sleeping beauty and piggyBac DNA transposons

scientific article

Frog Prince transposon-based RNAi vectors mediate efficient gene knockdown in human cells

scientific article published on 2 September 2005

Full-length Dysferlin Transfer by the Hyperactive Sleeping Beauty Transposase Restores Dysferlin-deficient Muscle

scientific article published on 19 January 2016

Gateway-compatible transposon vector to genetically modify human embryonic kidney and adipose-derived stromal cells.

scientific article published on 7 March 2012

Gene Therapy with the Sleeping Beauty Transposon System

scientific article published on 27 September 2017

Generating knockout rats by transposon mutagenesis in spermatogonial stem cells

scientific article

Generation of an immortalized mesenchymal stem cell line producing a secreted biosensor protein for glucose monitoring

scientific article published on 26 September 2017

Generation of human induced pluripotent stem cell line from a patient with a long QT syndrome type 2.

scientific article published on 6 January 2016

Genetic applications of transposons and other repetitive elements in zebrafish

scientific article published on 01 January 1999

Genome-wide Profiling Reveals Remarkable Parallels Between Insertion Site Selection Properties of the MLV Retrovirus and the piggyBac Transposon in Primary Human CD4(+) T Cells.

scientific article published on 12 January 2016

Genomic analysis of Sleeping Beauty transposon integration in human somatic cells

scientific article

Germline transgenesis in pigs by cytoplasmic microinjection of Sleeping Beauty transposons.

scientific article published on 13 March 2014

Germline transgenesis in rabbits by pronuclear microinjection of Sleeping Beauty transposons.

scientific article published on 13 March 2014

Germline transgenesis in rodents by pronuclear microinjection of Sleeping Beauty transposons.

scientific article published on 13 March 2014

Germline transgenesis of the chordate Ciona intestinalis with hyperactive variants of sleeping beauty transposable element

scientific article published on 14 November 2012

Germline transgenic pigs by Sleeping Beauty transposition in porcine zygotes and targeted integration in the pig genome

scientific article (publication date: 2011)

Gibbon genome and the fast karyotype evolution of small apes

scientific article

Going non-viral: the Sleeping Beauty transposon system breaks on through to the clinical side

scientific article published on 12 April 2017

Healing the wounds inflicted by sleeping beauty transposition by double-strand break repair in mammalian somatic cells

scientific article published in January 2004

Herpes simplex virus/Sleeping Beauty vector-based embryonic gene transfer using the HSB5 mutant: loss of apparent transposition hyperactivity in vivo

scientific article

How to tame an endogenous retrovirus: HERVH and the evolution of human pluripotency

scientific article published on 24 July 2017

Human Endogenous Retrovirus K Rec forms a Regulatory Loop with MITF that Opposes the Progression of Melanoma to an Invasive Stage

scientific article published on 13 November 2020

Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors

scientific article published on 09 April 2020

Human endogenous retrovirus K (HML-2) RNA and protein expression is a marker for human embryonic and induced pluripotent stem cells.

scientific article published on 24 October 2013

Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders

scientific article published on 25 January 2017

Human satellite cells have regenerative capacity and are genetically manipulable.

scientific article

Human somatic cell mutagenesis creates genetically tractable sarcomas

scientific article published on 17 August 2014

Hungary's 'reforms' are threatening basic science

scientific article published in Nature

Hybrid adeno-associated viral vectors utilizing transposase-mediated somatic integration for stable transgene expression in human cells

scientific article

Hybrid lentivirus-transposon vectors with a random integration profile in human cells.

scientific article

Identification and re-addressing of a transcriptionally permissive locus in the porcine genome

scientific article published on 29 October 2015

Improved molecular platform for the gene therapy of rare diseases by liver protein secretion.

scientific article published on 25 April 2018

In vivo hematopoietic stem cell gene therapy ameliorates murine thalassemia intermedia.

scientific article published on 18 December 2018

In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors

scientific article published on 23 August 2016

Induction and Analysis of Oxidative Stress in Sleeping Beauty Transposon-Transfected Human Retinal Pigment Epithelial Cells

scientific article published on 11 December 2020

Insertional engineering of chromosomes with Sleeping Beauty transposition: an overview

scientific article published on January 2011

Insertional mutagenesis of the mouse germline with Sleeping Beauty transposition

scientific article published in January 2008

Integrating HDAd5/35++ Vectors as a New Platform for HSC Gene Therapy of Hemoglobinopathies.

scientific article

Integration profile and safety of an adenovirus hybrid-vector utilizing hyperactive sleeping beauty transposase for somatic integration

scientific article published on 04 October 2013

Involvement of a bifunctional, paired-like DNA-binding domain and a transpositional enhancer in Sleeping Beauty transposition

scientific article

Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression

scientific article published on 21 January 2016

Long-Term PEDF Release in Rat Iris and Retinal Epithelial Cells after Sleeping Beauty Transposon-Mediated Gene Delivery.

scientific article published on 12 August 2017

Long-Term Prevention of Congenital Thrombotic Thrombocytopenic Purpura in ADAMTS13 Knockout Mice by Sleeping Beauty Transposon-Mediated Gene Therapy

scientific article published on 2 March 2017

Loss of Piccolo Function in Rats Induces Cerebellar Network Dysfunction and Pontocerebellar Hypoplasia Type 3-like Phenotypes

scientific article published on 02 March 2020

Molecular domestication of transposable elements: from detrimental parasites to useful host genes.

scientific article

Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates

scientific article (publication date: June 2009)

Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction

scientific article published in 2022

Nonviral gene delivery with the sleeping beauty transposon system.

scientific article published on September 2011

Novel hyperactive transposons for genetic modification of induced pluripotent and adult stem cells: a nonviral paradigm for coaxed differentiation.

scientific article published on October 2010

Nuclear inclusions of pathogenic ataxin-1 induce oxidative stress and perturb the protein synthesis machinery

scientific article published on 11 February 2020

Pluripotency and the endogenous retrovirus HERVH: Conflict or serendipity?

scientific article

Preclinical Evaluation of a Cell-Based Gene Therapy Using the Sleeping Beauty Transposon System in Choroidal Neovascularization

scientific article published on 09 November 2019

Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells

scientific article

Proceedings of the Frontiers of Retrovirology Conference 2016.

scientific article published on 26 September 2016

Progress and prospects in rat genetics: a community view.

scientific article

Purification and characterization of CeqI restriction endonuclease

scientific article published on November 1, 1992

Regulated complex assembly safeguards the fidelity of Sleeping Beauty transposition.

scientific article published on December 2016

Regulation of DNA transposition by CpG methylation and chromatin structure in human cells

scientific article published on 15 May 2013

Reliable transgene-independent method for determining Sleeping Beauty transposon copy numbers ⬇️

scientific article published on March 3, 2011

Repetitive elements and genome instability

scientific article published on 01 August 2010

Repetitive elements and their genetic applications in zebrafish

scientific article published on January 1, 1997

Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells

scientific article published on 8 January 2016

Retargeting sleeping beauty transposon insertions by engineered zinc finger DNA-binding domains

scientific article

Retargeting transposon insertions by the adeno-associated virus Rep protein.

scientific article

Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites

scientific article published on 20 May 2015

Safe and efficient in vivo hematopoietic stem cell transduction in nonhuman primates using HDAd5/35++ vectors

Safe and efficient in vivo hematopoietic stem cell transduction in nonhuman primates using HDAd5/35++ vectors

scientific article published in 2022

Sleeping Beauty Transposition.

scientific article published on April 2015

Sleeping Beauty Transposon Vectors in Liver-directed Gene Delivery of LDLR and VLDLR for Gene Therapy of Familial Hypercholesterolemia

scientific article published on 16 December 2015

Sleeping Beauty hits them all: transposon-mediated saturation mutagenesis in the mouse germline

scientific article published on 01 October 2005

Sleeping Beauty transposase modulates cell-cycle progression through interaction with Miz-1.

scholarly article

Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering.

scientific article published on 30 March 2016

Sleeping Beauty transposition: from biology to applications.

scientific article

Sleeping Beauty transposon mutagenesis in rat spermatogonial stem cells ⬇️

scientific article published on September 8, 2011

Sleeping Beauty transposon mutagenesis of the rat genome in spermatogonial stem cells

scientific article

Sleeping Beauty transposon-based system for cellular reprogramming and targeted gene insertion in induced pluripotent stem cells.

scientific article published on 28 December 2012

Sleeping Beauty transposon-mediated transfection of retinal and iris pigment epithelial cells.

scientific article

Sleeping beauty transposition: biology and applications for molecular therapy

scientific article

Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system

scientific article

Structural Determinants of Sleeping Beauty Transposase Activity

scientific article published on 12 July 2016

Suicidal autointegration of sleeping beauty and piggyBac transposons in eukaryotic cells

scientific article

Targeted Sleeping Beauty transposition in human cells

scientific article published on 10 April 2007

Targeted gene insertion for molecular medicine

scientific article published on 08 July 2008

Targeting CD33 in Chemoresistant AML Patient-Derived Xenografts by CAR-CIK Cells Modified with an Improved SB Transposon System

scientific article published on 30 May 2020

Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats

scientific article

Technology transfer from worms and flies to vertebrates: transposition-based genome manipulations and their future perspectives

scientific article

Ten things you should know about transposable elements

scientific article published on 19 November 2018

The Antibiotic-free pFAR4 Vector Paired with the Sleeping Beauty Transposon System Mediates Efficient Transgene Delivery in Human Cells.

scientific article

The DNA-bending protein HMGB1 is a cellular cofactor of Sleeping Beauty transposition

scientific article

The Frog Prince: a reconstructed transposon from Rana pipiens with high transpositional activity in vertebrate cells

scientific article published on December 2003

The Sleeping Beauty transposable element: evolution, regulation and genetic applications

scientific article published on January 2004

The Sleeping Beauty transposon system for clinical applications

scientific article published on 19 December 2011

The Sleeping Beauty transposon toolbox.

scientific article published on January 2012

The ancient mariner sails again: transposition of the human Hsmar1 element by a reconstructed transposase and activities of the SETMAR protein on transposon ends

scientific article

The expanding universe of transposon technologies for gene and cell engineering.

scientific article published on 07 December 2010

The hyperactive Sleeping Beauty transposase SB100X improves the genetic modification of T cells to express a chimeric antigen receptor

scientific article

Transcriptional activities of the Sleeping Beauty transposon and shielding its genetic cargo with insulators.

scientific article published on 11 December 2007

Translating Sleeping Beauty transposition into cellular therapies: victories and challenges

scientific article

Transposable elements as plasmid-based vectors for long-term gene transfer into tumors.

scientific article

Transposable elements for transgenesis and insertional mutagenesis in vertebrates: a contemporary review of experimental strategies

scientific article

Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes

scientific article

Transposition of the bamboo Mariner-like element Ppmar1 in yeast.

scientific article published on 8 February 2017

Transposon-mediated genome manipulation in vertebrates

scientific article

Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits.

scientific article published on 29 November 2012

Transposons for gene therapy!

scientific article

Two-stage ligation-mediated PCR enhances the detection of integrated transgenic DNA

scientific article published on 01 November 1993

Wide Awake and Ready to Move: 20 Years of Non-Viral Therapeutic Genome Engineering with the Sleeping Beauty Transposon System

scientific article published on 4 September 2017

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