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List of works by Wiltrud Richter

A Growth and Differentiation Factor-5 (GDF-5)-coated Suture Stimulates Tendon Healing in an Achilles Tendon Model in Rats ⬇️

scientific article published on January 1, 2001

A New Porcine In Vivo Animal Model of Disc Degeneration

scientific article published on 01 December 2009

A chondrogenic gene expression signature in mesenchymal stem cells is a classifier of conventional central chondrosarcoma.

scientific article

Accelerated intervertebral disc degeneration in scoliosis versus physiological ageing develops against a background of enhanced anabolic gene expression

article

Adenovirus-Mediated Gene Transfer of Growth and Differentiation Factor-5 into Tenocytes and the Healing Rat Achilles Tendon

article

Adipose-derived stromal cells for osteoarticular repair: trophic function versus stem cell activity

scientific article

An in vivo study of a growth-factor enhanced, cell free, two-layered collagen-tricalcium phosphate in deep osteochondral defects

scientific article

Antibodies to the M(r) 64,000 (64K) protein in islet cell antibody positive non-diabetic individuals indicate high risk for impaired beta-cell function

scientific article published on 01 June 1992

Application of VEGFA and FGF-9 enhances angiogenesis, osteogenesis and bone remodeling in type 2 diabetic long bone regeneration

scientific article

Autologous chondrocyte implantation using the original periosteum-cover technique versus matrix-associated autologous chondrocyte implantation: a randomized clinical trial

scientific article published on 4 December 2009

Autoreactive epitopes defined by diabetes-associated human monoclonal antibodies are localized in the middle and C-terminal domains of the smaller form of glutamate decarboxylase ⬇️

scientific article published on April 1, 1993

BMP activation and Wnt-signalling affect biochemistry and functional biomechanical properties of cartilage tissue engineering constructs

scientific article published on 23 November 2013

BMP and TGFbeta pathways in human central chondrosarcoma: enhanced endoglin and Smad 1 signaling in high grade tumors

scientific article

Biomechanics of cartilage tissue engineering constructs : Sensitive test procedure for assessment of biomechanical functionality and further development after in vivo transplantation

scientific article published in April 2013

Bone morphogenetic protein-2 and growth and differentiation factor-5 enhance the healing of necrotic bone in a sheep model

scientific article published in January 2001

Calcification or dedifferentiation: requirement to lock mesenchymal stem cells in a desired differentiation stage.

scientific article published in April 2009

Cartilage-like gene expression in differentiated human stem cell spheroids: a comparison of bone marrow-derived and adipose tissue-derived stromal cells.

scientific article

Cell-based cartilage repair: illusion or solution for osteoarthritis

scientific article published on September 2007

Changes in gene expression and protein distribution at different stages of mechanically induced disc degeneration--an in vivo study on the New Zealand white rabbit

scientific article published in March 2006

Chondral Differentiation of Induced Pluripotent Stem Cells Without Progression Into the Endochondral Pathway

scientific article published on 01 November 2019

Chondrocyte expressed protein-68 (CEP-68), a novel human marker gene for cultured chondrocytes

scientific article

Chondrocyte secreted CRTAC1: a glycosylated extracellular matrix molecule of human articular cartilage

scientific article published on 16 September 2006

Chondrogenesis of human mesenchymal stem cells by local transforming growth factor-beta delivery in a biphasic resorbable carrier

scientific article

Chondrogenesis of mesenchymal stem cells in gel-like biomaterials in vitro and in vivo

scientific article

Chondrogenesis of mesenchymal stem cells: role of tissue source and inducing factors

scientific article published on 13 October 2010

Chondrogenic pre-induction of human mesenchymal stem cells on β-TCP: Enhanced bone quality by endochondral heterotopic bone formation

scientific article published on 01 February 2010

Comparison of mesenchymal stem cells from bone marrow and adipose tissue for bone regeneration in a critical size defect of the sheep tibia and the influence of platelet-rich plasma

scientific article

Complete subchondral bone defect regeneration with a tricalcium phosphate collagen implant and osteoinductive growth factors: a randomized controlled study in Göttingen minipigs.

scientific article published on 21 November 2013

Conformation-dependent GAD65 autoantibodies in diabetes

scientific article published on 8 September 2004

Cooperation of SV40 large T antigen and the cellular protein p53 in maintenance of cell transformation.

scientific article published in September 1989

Correlation of COL10A1 induction during chondrogenesis of mesenchymal stem cells with demethylation of two CpG sites in the COL10A1 promoter.

scientific article

Correlation of hypoxic signalling to histological grade and outcome in cartilage tumours

scientific article published on 01 April 2010

Cytoplasmic islet cell antibodies recognize distinct islet antigens in IDDM but not in stiff man syndrome

scientific article published on 01 November 1993

DNA vaccination with glutamic acid decarboxylase (GAD) generates a strong humoral immune response in BALB/c, C57BL/6, and in diabetes-prone NOD mice

scientific article published on 01 October 1998

Design and characterization of a new bioreactor for continuous ultra-slow uniaxial distraction of a three-dimensional scaffold-free stem cell culture

article

Detection of Apoptotic Cartilage Cells in Symptomatic Central Tears of the Triangular Fibrocartilage

scientific article published on 01 May 2007

Development of Novel Scaffolds for Tissue Engineering by Flock Technology

article

Different culture media affect growth characteristics, surface marker distribution and chondrogenic differentiation of human bone marrow-derived mesenchymal stromal cells

scientific article

Differential Regulation of SOX9 Protein During Chondrogenesis of Induced Pluripotent Stem Cells Versus Mesenchymal Stromal Cells: A Shortcoming for Cartilage Formation

scientific article published on 24 February 2016

Differential expression of GAD65 and GAD67 in human, rat, and mouse pancreatic islets.

scientific article published on December 1993

Differential expression of TGF-β superfamily members and role of Smad1/5/9-signalling in chondral versus endochondral chondrocyte differentiation

scientific article published on 16 November 2016

Differential gene expression analysis in fracture callus of patients with regular and failed bone healing

article

Disc distraction shows evidence of regenerative potential in degenerated intervertebral discs as evaluated by protein expression, magnetic resonance imaging, and messenger ribonucleic acid expression analysis

scientific article

Discrimination between cells of murine and human origin in xenotransplants by species specific genomic in situ hybridization

article

Early and stable upregulation of collagen type II, collagen type I and YKL40 expression levels in cartilage during early experimental osteoarthritis occurs independent of joint location and histological grading

scientific article

Ectopic bone formation associated with mesenchymal stem cells in a resorbable calcium deficient hydroxyapatite carrier

scientific article published in October 2005

Effect of cytokines on proliferation of Epstein Barr virus-transformed B lymphocytes

scientific article published on February 1990

Effects of local application of growth and differentiation factor-5 (GDF-5) in a full-thickness cartilage defect model

scientific article published in March 2004

Engineering hydrophobin DewA to generate surfaces that enhance adhesion of human but not bacterial cells

scholarly article by Stephane Boeuf published in March 2012

Enhanced Early Tissue Regeneration after Matrix-Assisted Autologous Mesenchymal Stem Cell Transplantation in Full Thickness Chondral Defects in a Minipig Model

scientific article published on 29 April 2009

Enhanced ITM2A expression inhibits chondrogenic differentiation of mesenchymal stem cells

scientific article

Enhanced biochemical and biomechanical properties of scaffolds generated by flock technology for cartilage tissue engineering

scientific article

Enhanced expression of the human chitinase 3-like 2 gene (YKL-39) but not chitinase 3-like 1 gene (YKL-40) in osteoarthritic cartilage

scientific article (publication date: 22 November 2002)

Enhanced reconstruction of long bone architecture by a growth factor mutant combining positive features of GDF-5 and BMP-2.

scientific article published on 13 May 2013

Evidence for somatic mutation and affinity maturation of diabetes associated human autoantibodies to glutamate decarboxylase

scientific article published on June 1996

Extracellular matrix content and WNT/β-catenin levels of cartilage determine the chondrocyte response to compressive load

scientific article published on 19 December 2017

FGF-2 addition during expansion of human bone marrow-derived stromal cells alters MSC surface marker distribution and chondrogenic differentiation potential

scientific article published in August 2013

Fibrinogen scaffolds with immunomodulatory properties promote in vivo bone regeneration

scientific article

Fusion proteins for combined analysis of autoantibodies to the 65-kDa isoform of glutamic acid decarboxylase and islet antigen-2 in insulin-dependent diabetes mellitus

scientific article published on May 2001

Global chondrocyte gene expression after a single anabolic loading period: Time evolution and re-inducibility of mechano-responses

scientific article published on 28 March 2017

High-resolution autoreactive epitope mapping and structural modeling of the 65 kDa form of human glutamic acid decarboxylase

scientific article published on 01 April 1999

Human articular chondrocytes secrete parathyroid hormone-related protein and inhibit hypertrophy of mesenchymal stem cells in coculture during chondrogenesis

scientific article published on 01 September 2010

Human immunoglobulin G autoantibodies to the thyrotropin receptor from Epstein-Barr virus-transformed B lymphocytes: characterization by immunoprecipitation with recombinant antigen and biological activity

scientific article published on September 1996

Human monoclonal islet cell antibodies from a patient with insulin-dependent diabetes mellitus reveal glutamate decarboxylase as the target antigen ⬇️

scientific article published on September 15, 1992

Human monoclonal islet specific autoantibodies share features of islet cell and 64 kDa antibodies

scientific article published in August 1993

Identification of novel SHOX target genes in the developing limb using a transgenic mouse model

scientific article (publication date: 2014)

Immune reactivity of diabetes-associated human monoclonal autoantibodies defines multiple epitopes and detects two domain boundaries in glutamate decarboxylase

scientific article published on December 1996

Immune-mediated retinopathy in a patient with stiff-man syndrome

scientific article published on 01 March 1999

Immunoglobulin gene usage in diabetes-associated human monoclonal antibodies recognizing glutamate decarboxylase.

scientific article

Immunoglobulin variable gene analysis of human autoantibodies reveals antigen-driven immune response to glutamate decarboxylase in type 1 diabetes mellitus

scientific article

Impact of c-MYC expression on proliferation, differentiation, and risk of neoplastic transformation of human mesenchymal stromal cells

Impact of growth factors and PTHrP on early and late chondrogenic differentiation of human mesenchymal stem cells

scientific article published in April 2010

Increased bone formation in a rabbit long-bone defect model after single local and single systemic application of erythropoietin

scientific article published on 27 June 2016

Increased urinary concentration of collagen type II C-telopeptide fragments in patients with osteoarthritis

scientific article published on 01 January 2004

Induction of intervertebral disc-like cells from adult mesenchymal stem cells

scientific article

Inferior ectopic bone formation of mesenchymal stromal cells from adipose tissue compared to bone marrow: rescue by chondrogenic pre-induction

scientific article

Influence of depression symptoms on serum tumor necrosis factor-α of patients with chronic low back pain

scientific article

Influence of platelet-rich plasma on osteogenic differentiation of mesenchymal stem cells and ectopic bone formation in calcium phosphate ceramics

scientific article published in January 2006

Inhibition of gamma-aminobutyric acid synthesis by glutamic acid decarboxylase autoantibodies in stiff-man syndrome

scientific article

Initial WNT/β-Catenin Activation Enhanced Mesoderm Commitment, Extracellular Matrix Expression, Cell Aggregation and Cartilage Tissue Yield From Induced Pluripotent Stem Cells

scientific article published on 30 October 2020

Injection of a polymerized hyaluronic acid/collagen hydrogel matrix in an in vivo porcine disc degeneration model.

scientific article published on 25 April 2012

Intermittent PTHrP(1-34) exposure augments chondrogenesis and reduces hypertrophy of mesenchymal stromal cells

scientific article

Interplay Between Local Versus Soluble Transforming Growth Factor-Beta and Fibrin Scaffolds: Role of Cells and Impact on Human Mesenchymal Stem Cell Chondrogenesis

scientific article published on 14 May 2012

Is Total Disk Replacement a Cost-effective Treatment for Cervical Degenerative Disk Disease?

scientific article published on June 2017

Isolation of IgG islet cell autoantibody-producing B lymphocytes from the peripheral blood of type 1 diabetic patients and an ICA-positive non-diabetic individual

scientific article published in December 1989

Local application of a collagen type I/hyaluronate matrix and growth and differentiation factor 5 influences the closure of osteochondral defects in a minipig model by enchondral ossification

scientific article published on 01 December 2006

Long-term mechanical loading of chondrocyte-chitosan biocomposites in vitro enhanced their proteoglycan and collagen content.

scientific article published in January 2006

Matrix metalloprotease inhibitors suppress initiation and progression of chondrogenic differentiation of mesenchymal stromal cells in vitro

scientific article

Matrix-assisted cell transfer for intervertebral disc cell therapy.

scientific article published in June 2005

Mesenchymal stem cell differentiation in an experimental cartilage defect: restriction of hypertrophy to bone-close neocartilage

scientific article published in September 2009

Mesenchymal stroma cells trigger early attraction of M1 macrophages and endothelial cells into fibrin hydrogels, stimulating long bone healing without long-term engraftment

scientific article published on 22 July 2014

Mesenchymal stromal cell implantation for stimulation of long bone healing aggravates Staphylococcus aureus induced osteomyelitis

scientific article published on 22 March 2015

Methods to monitor distribution and metabolic activity of mesenchymal stem cells following in vivo injection into nucleotomized porcine intervertebral discs

scientific article published on 29 December 2009

Molecular analysis of expansion, differentiation, and growth factor treatment of human chondrocytes identifies differentiation markers and growth-related genes

article

Molecular characterization of spontaneous and growth-factor-augmented chondrogenesis in periosteum–bone tissue transferred into a joint

scientific article published on 01 June 2005

Neue Ansätze für die in situ Regeneration und das Tissue Engineering von Knochen

scholarly article by P Janicki & Wiltrud Richter published 1 February 2012 in Deutsche Zeitschrift fur Sportmedizin

New In Vivo Animal Model to Create Intervertebral Disc Degeneration and to Investigate the Effects of Therapeutic Strategies to Stimulate Disc Regeneration

scientific article published on 01 December 2002

No effect of subperiosteal growth factor application on periosteal neo-chondrogenesis in osteoperiosteal bone grafts for osteochondral defect repair

scientific article published on 17 March 2013

OA in 2011: Age-related OA--a concept emerging from infancy?

scientific article published on 10 January 2012

Occurrence and regional distribution of apoptosis in scoliotic discs.

scientific article published in March 2005

Osteoarthritis in the Knee Joints of Göttingen Minipigs after Resection of the Anterior Cruciate Ligament? Missing Correlation of MRI, Gene and Protein Expression with Histological Scoring

scientific article

Osteoarthritis: cellular and molecular changes in degenerating cartilage

scientific article

Peptide-functionalized starPEG/heparin hydrogels direct mitogenicity, cell morphology and cartilage matrix distribution in vitro and in vivo

scientific article published on 13 January 2017

Platelet-rich plasma improves expansion of human mesenchymal stem cells and retains differentiation capacity and in vivo bone formation in calcium phosphate ceramics

scientific article published in November 2006

Porosity and pore size of beta-tricalcium phosphate scaffold can influence protein production and osteogenic differentiation of human mesenchymal stem cells: an in vitro and in vivo study

scientific article published on 11 June 2008

Prediction of in vivo bone forming potency of bone marrow-derived human mesenchymal stem cells.

scientific article

Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice

article

Prevalence and correlates of inflammatory arthritis in Germany: data from the First National Health Survey.

scientific article

Proliferation as a requirement for in vitro chondrogenesis of human mesenchymal stem cells

scientific article published on 15 February 2012

Rapid regulation of collagen but not metalloproteinase 1, 3, 13, 14 and tissue inhibitor of metalloproteinase 1, 2, 3 expression in response to mechanical loading of cartilage explants in vitro

scientific article published on 01 February 2003

Reduced chondrogenic potential of adipose tissue derived stromal cells correlates with an altered TGFbeta receptor and BMP profile and is overcome by BMP-6.

scientific article published in June 2007

Reduced reactivation from dormancy but maintained lineage choice of human mesenchymal stem cells with donor age.

scientific article

Regulating chondrogenesis of human mesenchymal stromal cells with a retinoic Acid receptor-Beta inhibitor: differential sensitivity of chondral versus osteochondral development.

scientific article

Regulation of H19 and its encoded microRNA-675 in osteoarthritis and under anabolic and catabolic in vitro conditions

scientific article

Regulation of WNT5A and WNT11 during MSC in vitro chondrogenesis: WNT inhibition lowers BMP and hedgehog activity, and reduces hypertrophy

scientific article published on 12 April 2019

Regulation of aggrecanases from the ADAMTS family and aggrecan neoepitope formation during in vitro chondrogenesis of human mesenchymal stem cells

scientific article published on 4 May 2012

Release of active and depot GDF-5 after adenovirus-mediated overexpression stimulates rabbit and human intervertebral disc cells

scientific article published on 11 December 2003

Replicative aging of human articular chondrocytes during ex vivo expansion

scientific article published on 01 November 2002

Report on a large animal study with Göttingen Minipigs where regenerates and controls for articular cartilage were created in a large number. Focus on the conditions of the operated stifle joints and suggestions for standardized procedures

scientific article published on 26 December 2019

Role of PTHrP(1-34) Pulse Frequency Versus Pulse Duration to Enhance Mesenchymal Stromal Cell Chondrogenesis

scientific article

Secretion of matrix metalloproteinase 3 by expanded articular chondrocytes as a predictor of ectopic cartilage formation capacity in vivo

scientific article published on 01 February 2008

Sensitivity of notochordal disc cells to mechanical loading: an experimental animal study

scientific article

Sequence homology of the diabetes-associated autoantigen glutamate decarboxylase with coxsackie B4-2C protein and heat shock protein 60 mediates no molecular mimicry of autoantibodies

scientific article published on August 1994

Short-term follow-up of disc cell therapy in a porcine nucleotomy model with an albumin-hyaluronan hydrogel: in vivo and in vitro results of metabolic disc cell activity and implant distribution

scientific article published on 7 May 2014

Significance of MEF2C and RUNX3 Regulation for Endochondral Differentiation of Human Mesenchymal Progenitor Cells

scientific article published on 04 March 2020

Stage-Specific miRs in Chondrocyte Maturation: Differentiation-Dependent and Hypertrophy-Related miR Clusters and the miR-181 Family

scientific article published on 2 October 2015

StarPEG/heparin-hydrogel based in vivo engineering of stable bizonal cartilage with a calcified bottom layer

Stellenwert der autologen Chondrozytentransplantation (ACT) in der Behandlung von Knorpelschäden des Kniegelenks - Empfehlungen der AG Klinische Geweberegeneration der DGOU

scientific article published on 19 February 2013

Stiff-man syndrome: identification of 17 beta-hydroxysteroid dehydrogenase type 4 as a novel 80-kDa antineuronal antigen

scientific journal article

Stiff-person syndromes: motor cortex hyperexcitability correlates with anti-GAD autoimmunity

scientific article published in April 2004

Stimulation of a calcified cartilage connecting zone by GDF-5-augmented fibrin hydrogel in a novel layered ectopic in vivo model

scientific article published on 25 October 2017

Stimulation of calvarial bone healing with human bone marrow stromal cells versus inhibition with adipose-tissue stromal cells on nanostructured β-TCP-collagen

scientific article published on 20 June 2018

Stimulation of gene expression and loss of anular architecture caused by experimental disc degeneration--an in vivo animal study

scientific article

Subtractive gene expression profiling of articular cartilage and mesenchymal stem cells: serpins as cartilage-relevant differentiation markers

scientific article

Superior angiogenic potential of GDF-5 and GDF-5(V453/V456) compared with BMP-2 in a rabbit long-bone defect model

scientific article

TGF-beta1 as a marker of delayed fracture healing

scientific article published on 02 April 2005

Telomere length and telomerase activity during expansion and differentiation of human mesenchymal stem cells and chondrocytes

scientific article published on 28 November 2003

The Radiation Resistance of Human Multipotent Mesenchymal Stromal Cells Is Independent of Their Tissue of Origin

scientific article published on 9 January 2018

The Role of Extracellular Matrix Expression, ERK1/2 Signaling and Cell Cohesiveness for Cartilage Yield from iPSCs ⬇️

scientific article published on 02 September 2019

The collagen component of biological bone graft substitutes promotes ectopic bone formation by human mesenchymal stem cells

scientific article published on 28 March 2013

The course of high-sensitive C-reactive protein in correlation with pain and clinical function in patients with acute lumbosciatic pain and chronic low back pain-A 6 months prospective longitudinal study

The effect of two point mutations in GDF-5 on ectopic bone formation in a beta-tricalciumphosphate scaffold

scientific article published on 18 February 2010

The glutamate decarboxylase and 38KD autoantigens in type 1 diabetes: aspects of structure and epitope recognition.

scientific article

The short stature homeodomain protein SHOX induces cellular growth arrest and apoptosis and is expressed in human growth plate chondrocytes

scientific article published on 15 May 2004

The use of mesenchymal stem cells for chondrogenesis.

scientific article published on April 2008

Three-dimensional chitin-based scaffolds from Verongida sponges (Demospongiae: Porifera). Part I. Isolation and identification of chitin

scientific article

Three-dimensional chitin-based scaffolds from Verongida sponges (Demospongiae: Porifera). Part II: Biomimetic potential and applications

scientific article

Time-dependent contribution of BMP, FGF, IGF, and HH signaling to the proliferation of mesenchymal stroma cells during chondrogenesis

scientific article published on 01 June 2018

Tissue distribution of a human Ca v 1.2 alpha1 subunit splice variant with a 75 bp insertion

scientific article published in July 2005

Treatment of Focal Cartilage Defects in Minipigs with Zonal Chondrocyte/Mesenchymal Progenitor Cell Constructs ⬇️

scientific article published on 02 February 2019

Two or three-dimensional cleaned chitin skeleton of dictyoceratid sponges, method for the production and use thereof

patent

VEGF producing bone marrow stromal cells (BMSC) enhance vascularization and resorption of a natural coral bone substitute

scientific article published on 6 July 2007

Vascular endothelial growth factor gene-activated matrix (VEGF165-GAM) enhances osteogenesis and angiogenesis in large segmental bone defects

scientific article published on 5 July 2005

Xenogeneic transplantation of articular chondrocytes into full-thickness articular cartilage defects in minipigs: fate of cells and the role of macrophages

scientific article published on 17 August 2014

[Indications and implementation of recommendations of the working group "Tissue Regeneration and Tissue Substitutes" for autologous chondrocyte transplantation (ACT)]

scientific article published on 01 September 2004

[Post-treatment rehabilitation after autologous chondrocyte implantation: State of the art and recommendations of the Clinical Tissue Regeneration Study Group of the German Society for Accident Surgery and the German Society for Orthopedics and Orth

scientific article published on 01 March 2014

[Regenerative medicine in orthopaedics. Cell therapy - tissue engineering - in situ regeneration]

scientific article published on 07 August 2009

[Stimulation of degenerative changes in the intervertebral disc through axial compression. Radiologic, histologic and biomechanical research in an animal model]

scientific article published on 01 July 2003

[Tribological assessment of articular cartilage. A system for the analysis of the friction coefficient of cartilage, regenerates and tissue engineering constructs; initial results]

scientific article published on 01 October 2012

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