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Authors whose works are in public domain in at least one jurisdiction

List of works by Silke Leimkühler

A novel MOCS2 mutation reveals coordinated expression of the small and large subunit of molybdopterin synthase

scientific article

A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis

scientific article

A single nucleotide polymorphism causes enhanced radical oxygen species production by human aldehyde oxidase

scientific article

Analysis of the Cellular Roles of MOCS3 Identifies a MOCS3-Independent Localization of NFS1 at the Tips of the Centrosome

scientific article published on 13 March 2019

Anion Binding and Oxidative Modification at the Molybdenum Cofactor of Formate Dehydrogenase from Rhodobacter capsulatus Studied by X-ray Absorption Spectroscopy

scientific article published on 09 December 2019

Assembly and catalysis of molybdenum or tungsten-containing formate dehydrogenases from bacteria

scientific article

Bacterial molybdoenzymes: old enzymes for new purposes

scientific article published on 13 October 2015

Biochemical, stabilization and crystallization studies on a molecular chaperone (PaoD) involved in the maturation of molybdoenzymes

scientific article (publication date: 2014)

Crystal structure of YnjE fromEscherichia coli, a sulfurtransferase with three rhodanese domains

scientific article

Crystal structures of the active and alloxanthine-inhibited forms of xanthine dehydrogenase from Rhodobacter capsulatus

scientific article

Dendritic polyglycerol-poly(ethylene glycol)-based polymer networks for biosensing application.

scientific article published on 5 June 2014

Direct Comparison of the Enzymatic Characteristics and Superoxide Production of the Four Aldehyde Oxidase Enzymes Present in Mouse

scientific article

Direct comparison of the four aldehyde oxidase enzymes present in mouse gives insight into their substrate specificities.

scientific article

Dual Role of the Molybdenum Cofactor Biosynthesis Protein MOCS3 in tRNA Thiolation and Molybdenum Cofactor Biosynthesis in Humans ⬇️

scientific article published on March 27, 2012

Effective Electrochemistry of Human Sulfite Oxidase Immobilized on Quantum-Dots-Modified Indium Tin Oxide Electrode

scientific article published on 10 September 2015

Electrical Wiring of the Aldehyde Oxidoreductase PaoABC with a Polymer Containing Osmium Redox Centers: Biosensors for Benzaldehyde and GABA.

scientific article published on 3 November 2014

Electrocatalytic sulfite biosensor with human sulfite oxidase co-immobilized with cytochrome c in a polyelectrolyte-containing multilayer

scientific article published on 21 October 2008

Elucidation of the dual role of Mycobacterial MoeZR in molybdenum cofactor biosynthesis and cysteine biosynthesis

scientific article

Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction

scientific article published in 2022

Evidence for the physiological role of a rhodanese-like protein for the biosynthesis of the molybdenum cofactor in humans

scientific article

Evolution, expression, and substrate specificities of aldehyde oxidase enzymes in eukaryotes

scientific article published on 06 March 2020

Functional Complementation Studies Reveal Different Interaction Partners of Escherichia coli IscS and Human NFS1.

scientific article published on 2 August 2017

Functional Studies on Oligotropha carboxidovorans Molybdenum-Copper CO Dehydrogenase Produced in Escherichia coli.

scientific article published on 20 April 2018

Heavy metal ions inhibit molybdoenzyme activity by binding to the dithiolene moiety of molybdopterin in Escherichia coli

scientific article

Human aldehyde oxidase (hAOX1): structure determination of the Moco-free form of the natural variant G1269R and biophysical studies of single nucleotide polymorphisms

scientific article published on 15 April 2019

Human sulfite oxidase electrochemistry on gold nanoparticles modified electrode

scientific article published on 08 December 2011

Identification of YdhV as the First Molybdoenzyme Binding a Bis-Mo-MPT Cofactor in Escherichia coli

scientific article published on 17 April 2019

Identification of a bis-molybdopterin intermediate in molybdenum cofactor biosynthesis in Escherichia coli

scientific article published on 3 September 2013

Identification of crucial amino acids in mouse aldehyde oxidase 3 that determine substrate specificity

scientific journal article

Iron Sulfur and Molybdenum Cofactor Enzymes Regulate the Drosophila Life Cycle by Controlling Cell Metabolism.

scientific article published on 14 February 2018

Iron-Dependent Regulation of Molybdenum Cofactor Biosynthesis Genes in Escherichia coli

scientific article published on 08 August 2019

Iron-sulfur cluster carrier proteins involved in the assembly of Escherichia coli NADH:ubiquinone oxidoreductase (complex I)

scientific article published on 23 October 2018

IscS functions as a primary sulfur-donating enzyme by interacting specifically with MoeB and MoaD in the biosynthesis of molybdopterin in Escherichia coli

scientific article

Ketoxime coupling of p-acetylphenylalanine at neutral pH for site-directed spin labeling of human sulfite oxidase.

scientific article published on 13 June 2014

Layer-by-layer arrangement by protein-protein interaction of sulfite oxidase and cytochrome c catalyzing oxidation of sulfite

scientific article

Mechanism of Substrate and Inhibitor Binding of Rhodobacter capsulatus Xanthine Dehydrogenase

scientific article

Mechanistic Studies of Human Molybdopterin Synthase Reaction and Characterization of Mutants Identified in Group B Patients of Molybdenum Cofactor Deficiency ⬇️

scientific article published on May 5, 2003

Miniature direct electron transfer based sulphite/oxygen enzymatic fuel cells

scientific article published on 06 November 2014

MocA is a specific cytidylyltransferase involved in molybdopterin cytosine dinucleotide biosynthesis in Escherichia coli

scientific article

Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry

scientific article

Molybdenum enzymes, their maturation and molybdenum cofactor biosynthesis in Escherichia coli

scientific article

Molybdopterin dinucleotide biosynthesis in Escherichia coli: identification of amino acid residues of molybdopterin dinucleotide transferases that determine specificity for binding of guanine or cytosine nucleotides

scientific article

Mutations in LYRM4, encoding iron-sulfur cluster biogenesis factor ISD11, cause deficiency of multiple respiratory chain complexes

scientific article published on 28 June 2013

Nickel electrodes as a cheap and versatile platform for studying structure and function of immobilized redox proteins.

scientific article published on 9 September 2016

Novel frataxin isoforms may contribute to the pathological mechanism of Friedreich ataxia

scientific article

Optimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide Polymorphisms

scientific article

Protein electrodes with direct electrochemical communication

scientific article published on January 2008

Protonation and Sulfido versus Oxo Ligation Changes at the Molybdenum Cofactor in Xanthine Dehydrogenase (XDH) Variants Studied by X-ray Absorption Spectroscopy

scientific article published on 7 February 2017

Pyranopterin dithiolene distortions relevant to electron transfer in xanthine oxidase/dehydrogenase.

scientific article

Ready to use bioinformatics analysis as a tool to predict immobilisation strategies for protein direct electron transfer (DET).

scientific article

Reconstitution of Molybdoenzymes with Bis-Molybdopterin Guanine Dinucleotide Cofactors

scientific article published on 01 January 2019

Same but different: Comparison of two system-specific molecular chaperones for the maturation of formate dehydrogenases

scientific article published in PLoS ONE

Second and Outer Coordination Sphere Effects in Nitrogenase, Hydrogenase, Formate Dehydrogenase, and CO Dehydrogenase

scientific article published in 2022

Shared Sulfur Mobilization Routes for tRNA Thiolation and Molybdenum Cofactor Biosynthesis in Prokaryotes and Eukaryotes

scientific article published on 14 January 2017

Shared function and moonlighting proteins in molybdenum cofactor biosynthesis

scientific article published on 11 March 2017

Shewanella decolorationis LDS1 Chromate Resistance

scientific article published on 29 August 2019

Site directed mutagenesis of amino acid residues at the active site of mouse aldehyde oxidase AOX1

scientific article

Site-directed mutagenesis of the active site loop of the rhodanese-like domain of the human molybdopterin synthase sulfurase MOCS3. Major differences in substrate specificity between eukaryotic and bacterial homologs

scientific article

Small membranous proteins of the TorE/NapE family, crutches for cognate respiratory systems in Proteobacteria

scientific article published in Scientific Reports

Structural basis for the role of mammalian aldehyde oxidases in the metabolism of drugs and xenobiotics

scientific article published on 23 January 2017

Structural data on the periplasmic aldehyde oxidoreductase PaoABC from Escherichia coli: SAXS and preliminary X-ray crystallography analysis ⬇️

scientific article

Structural insights into xenobiotic and inhibitor binding to human aldehyde oxidase

scientific article

Structure and function of mammalian aldehyde oxidases

scientific article published on 26 February 2016

Sulfido and cysteine ligation changes at the molybdenum cofactor during substrate conversion by formate dehydrogenase (FDH) from Rhodobacter capsulatus

scientific article

Ten novel mutations in the molybdenum cofactor genes MOCS1 and MOCS2 and in vitro characterization of a MOCS2 mutation that abolishes the binding ability of molybdopterin synthase

scientific article

The 1,6,7,12-Tetraazaperylene Bridging Ligand as an Electron Reservoir and Its Disulfonato Derivative as Redox Mediator in an Enzyme-Electrode Process.

scientific article published on 4 September 2017

The ABCB7-Like Transporter PexA in Is Involved in the Translocation of Reactive Sulfur Species

scientific article published on 13 March 2019

The Escherichia coli Periplasmic Aldehyde Oxidoreductase Is an Exceptional Member of the Xanthine Oxidase Family of Molybdoenzymes

scientific article

The Eukaryotic-Specific ISD11 Is a Complex-Orphan Protein with Ability to Bind the Prokaryotic IscS

scientific article

The First Mammalian Aldehyde Oxidase Crystal Structure: INSIGHTS INTO SUBSTRATE SPECIFICITY

scientific article

The L-cysteine desulfurase NFS1 is localized in the cytosol where it provides the sulfur for molybdenum cofactor biosynthesis in humans

scientific article

The Molybdenum Active Site of Formate Dehydrogenase Is Capable of Catalyzing C-H Bond Cleavage and Oxygen Atom Transfer Reactions

scientific article published on 7 April 2016

The N-Terminus of Iron-Sulfur Cluster Assembly Factor ISD11 Is Crucial for Subcellular Targeting and Interaction with l-Cysteine Desulfurase NFS1.

scientific article

The Respiratory Arsenite Oxidase: Structure and the Role of Residues Surrounding the Rieske Cluster

scientific article

The Role of SufS Is Restricted to Fe-S Cluster Biosynthesis in Escherichia coli

scientific article

The biosynthesis of the molybdenum cofactors

scientific article published on July 2014

The biosynthesis of the molybdenum cofactors in Escherichia coli

scientific article published on 01 April 2020

The cysteine-desulfurase IscS promotes the production of the rhodanese RhdA in the persulfurated form

scientific article published on 21 November 2005

The four aldehyde oxidases of Drosophila melanogaster have different gene expression patterns and enzyme substrate specificities

scientific article

The functional diversity of the prokaryotic sulfur carrier protein TusA

scientific article published on 23 August 2019

The history of the discovery of the molybdenum cofactor and novel aspects of its biosynthesis in bacteria ⬇️

scientific article published on May 1, 2011

The identification of a novel protein involved in molybdenum cofactor biosynthesis in Escherichia coli

scientific article

The impact of single nucleotide polymorphisms on human aldehyde oxidase

scientific article

The regulation of Moco biosynthesis and molybdoenzyme gene expression by molybdenum and iron in bacteria

scientific article published on 01 October 2019

The role of FeS clusters for molybdenum cofactor biosynthesis and molybdoenzymes in bacteria

scientific article published on 28 September 2014

The role of system-specific molecular chaperones in the maturation of molybdoenzymes in bacteria

scientific article published on 30 November 2010

The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia

scientific article published in Nature Communications

The sulfur carrier protein TusA has a pleiotropic role in Escherichia coli that also affects molybdenum cofactor biosynthesis

scientific article

The sulfurtransferase activity of Uba4 presents a link between ubiquitin-like protein conjugation and activation of sulfur carrier proteins

scientific article

Transient Catalytic Voltammetry of Sulfite Oxidase Reveals Rate Limiting Conformational Changes

scientific article published on 20 July 2017

TusA Is a Versatile Protein That Links Translation Efficiency to Cell Division in Escherichia coli

scientific article published in 2021

Vibrational Probes of Molybdenum Cofactor-Protein Interactions in Xanthine Dehydrogenase.

scientific article published on 7 June 2017

Wiring of the aldehyde oxidoreductase PaoABC to electrode surfaces via entrapment in low potential phenothiazine-modified redox polymers.

scientific article

YcdY protein of Escherichia coli, an atypical member of the TorD chaperone family

scientific article published on 30 September 2011

ecoAO: A Simple System for the Study of Human Aldehyde Oxidases Role in Drug Metabolism

scientific article published on 22 August 2017

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