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List of works by Sharon Tooze

A Molecular Perspective of Mammalian Autophagosome Biogenesis

scientific article

A comprehensive glossary of autophagy-related molecules and processes

scientific article published on 16 May 2010

A comprehensive glossary of autophagy-related molecules and processes (2nd edition)

scientific article

A novel syntaxin 6-interacting protein, SHIP164, regulates syntaxin 6-dependent sorting from early endosomes

scientific article published in May 2010

A role for Rap2 in recycling the extended conformation of LFA-1 during T cell migration.

scientific article

A switch from canonical to noncanonical autophagy shapes B cell responses.

scientific article published on February 2017

AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1

scientific article

ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8.

scientific article published on 15 February 2017

ATG9A protects the plasma membrane from programmed and incidental permeabilization

scientific article published on 12 July 2021

ATG9A shapes the forming autophagosome through Arfaptin 2 and phosphatidylinositol 4-kinase IIIβ

scientific article published on 27 March 2019

ATG9A supplies PtdIns4P to the autophagosome initiation site

scientific article published on 23 June 2019

Activation of ULK Kinase and Autophagy by GABARAP Trafficking from the Centrosome Is Regulated by WAC and GM130.

scientific article

An siRNA screen for ATG protein depletion reveals the extent of the unconventional functions of the autophagy proteome in virus replication.

scientific article published on August 2016

Analysis of the sorting of secretory proteins to the regulated secretory pathway. A subcellular fractionation approach

scientific article published on January 1998

Antibodies to secretogranin II reveal potential processing sites

scientific article published on January 1994

Application of CRISPR/Cas9 to Autophagy Research

scientific article published on December 2016

Assessing mammalian autophagy.

scientific article published on January 2015

Atg9 trafficking in Mammalian cells.

scientific article published on 20 January 2007

Autophagosome formation--the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage.

scientific article published on 29 May 2013

Autophagosome formation: not necessarily an inside job.

scientific article

Autophagy Captures the Nobel Prize

scientific article

Autophagy pathway: Cellular and molecular mechanisms

scientific article

Autophagy proteins regulate the secretory component of osteoclastic bone resorption

scientific article published on 4 November 2011

Autophagy regulation through Atg9 traffic ⬇️

scientific article published on July 23, 2012

Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations

scientific article published on 01 January 2018

Axonal autophagosome maturation defect through failure of ATG9A sorting underpins pathology in AP-4 deficiency syndrome

scientific article published on 29 May 2019

Bicaudal D1 impairs autophagosome maturation in chronic obstructive pulmonary disease

scientific article published on 29 October 2019

Binding of the Atg1/ULK1 kinase to the ubiquitin-like protein Atg8 regulates autophagy

scientific article

Biogenesis of secretory granules in the trans-Golgi network of neuroendocrine and endocrine cells

scientific article published on 01 August 1998

Biosynthetic protein transport in the secretory pathway

scientific article

CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction

scientific article published on 19 October 2011

Cell biology. GGAs tie up the loose ends

scientific article

Cell-free protein sorting to the regulated and constitutive secretory pathways

scientific article published on March 1990

Centrosome to autophagosome signaling: Specific GABARAP regulation by centriolar satellites

scientific article

Changing directions: clathrin-mediated transport between the Golgi and endosomes

scientific article

Chapter 17 Correlative Light and Electron Microscopy

scientific article published on 01 January 2009

Characterization of the endopeptidase PC2 activity towards secretogranin II in stably transfected PC12 cells

scientific article

Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival

scientific article published on 18 March 2016

Coiling up with SCOC and WAC: two new regulators of starvation-induced autophagy

scientific article published on 21 June 2012

Compartmentalized regulation of autophagy regulators: fine-tuning AMBRA1 by Bcl-2.

scientific article published on April 2011

Control of GABARAP-mediated autophagy by the Golgi complex, centrosome and centriolar satellites

scientific article

Control of cellular homeostasis: organelles take the pilot's seat

scientific article published in March 2015

Coordinated regulation of autophagy by p38alpha MAPK through mAtg9 and p38IP

scientific article

Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes

scientific article published on September 2009

Cross talk between tetanus neurotoxin-insensitive vesicle-associated membrane protein-mediated transport and L1-mediated adhesion

scientific article

Current views on the source of the autophagosome membrane

scientific article published on January 2013

Differential distribution of mannose-6-phosphate receptors and furin in immature secretory granules

scientific article published on November 1999

Digesting the Expanding Mechanisms of Autophagy

scientific article published on 2 April 2016

Direct and GTP-dependent Interaction of ADP-ribosylation Factor 1 with Clathrin Adaptor Protein AP-1 on Immature Secretory Granules

scientific article published in Journal of Biological Chemistry

Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy.

scientific article

Early endosomes and endosomal coatomer are required for autophagy

scientific article published on 13 April 2009

Emerging roles of ATG proteins and membrane lipids in autophagosome formation

scientific article published on 26 May 2020

Emerging roles of transcriptional programs in autophagy regulation

scientific article published on 5 October 2017

Endocytosis and autophagy: Shared machinery for degradation.

scientific article

Endocytosis and autophagy: exploitation or cooperation?

scientific article published on May 2014

Formation of secretory vesicles in the biosynthetic pathway

scientific article published on August 1997

Fundamental mechanisms deliver the Nobel Prize to Ohsumi

scientific article published on 17 January 2017

Fusion and confusion in the secretory pathway

scientific article published on 01 June 1996

GABARAP activates ULK1 and traffics from the centrosome dependent on Golgi partners WAC and GOLGA2/GM130

scientific article published on 17 March 2016

GGA function is required for maturation of neuroendocrine secretory granules

scientific article published on 6 April 2006

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HRES-1/Rab4 promotes the formation of LC3(+) autophagosomes and the accumulation of mitochondria during autophagy

scientific article published on 3 January 2014

High-throughput screening approaches to identify regulators of mammalian autophagy.

scientific article published on 14 February 2015

Homotypic fusion of immature secretory granules during maturation in a cell-free assay

scientific article

Homotypic fusion of immature secretory granules during maturation requires syntaxin 6

scientific article published on June 2001

Imaging endosomes and autophagosomes in whole mammalian cells using correlative cryo-fluorescence and cryo-soft X-ray microscopy (cryo-CLXM)

scientific article

Inhibition of LRRK2 kinase activity stimulates macroautophagy

scientific journal article

Inhibition of the vacuolar H+-ATPase perturbs the transport, sorting, processing and release of regulated secretory proteins

scientific article published on 01 September 2000

Interaction of furin in immature secretory granules from neuroendocrine cells with the AP-1 adaptor complex is modulated by casein kinase II phosphorylation

scientific article published on August 1997

Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism

scientific article

Liaisons dangereuses: autophagy, neuronal survival and neurodegeneration

scientific article published on 23 October 2008

Listeria phospholipases subvert host autophagic defenses by stalling pre-autophagosomal structures.

scientific article published on 25 October 2013

MDH1 and MPP7 Regulate Autophagy in Pancreatic Ductal Adenocarcinoma

scientific article published on 14 February 2019

Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation

scientific article

Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs

scientific article published on 04 March 2019

Metabolic labeling with sulfate

scientific article published in May 2001

Microtubules facilitate autophagosome formation and fusion of autophagosomes with endosomes

scientific journal article

Molecular Mechanisms of Autophagy-Part B.

scientific article published on 10 January 2017

Molecular Pathways Controlling Autophagy in Pancreatic Cancer

scientific article

Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins

scientific article published on 03 May 2019

New insights into the function of Atg9.

scientific article

Newly synthesized synaptophysin is transported to synaptic-like microvesicles via constitutive secretory vesicles and the plasma membrane.

scientific article published on December 1991

PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic.

scientific article

PIKfyve regulation of endosome-linked pathways

scientific article published on July 2009

Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation

scientific journal article

Phosphoproteomic identification of ULK substrates reveals VPS15-dependent ULK/VPS34 interplay in the regulation of autophagy

scientific article published on 14 June 2021

Prognostic impact of p62 expression in cutaneous malignant melanoma

scientific article

Protein Trafficking into Autophagosomes

scientific article published on 01 January 2008

Proteolytic processing of chromogranin B and secretogranin II by prohormone convertases

scientific article published in January 1998

Quantifying Autophagic Structures in Mammalian Cells Using Confocal Microscopy

scientific article published on 12 November 2016

Rab11, a small GTPase associated with both constitutive and regulated secretory pathways in PC12 cells

scientific article published on November 1993

Rab3D is critical for secretory granule maturation in PC12 cells

scientific article

Rabs and GAPs in starvation-induced autophagy

scientific article published on 26 September 2016

Recycling endosomes contribute to autophagosome formation

scientific article published on 9 August 2012

Reduction of the disulfide bond of chromogranin B (secretogranin I) in the trans-Golgi network causes its missorting to the constitutive secretory pathways.

scientific article

Regulation and recruitment of phosphatidylinositol 4-kinase on immature secretory granules is independent of ADP-ribosylation factor 1.

scientific article published on April 2002

Regulation of autophagosome formation by Rho kinase

scientific article published on 10 September 2012

Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2.

scientific article published on 4 January 2013

SNAREing an ARP requires a LIR.

scientific article published on 15 February 2018

SNX18 regulates ATG9A trafficking from recycling endosomes by recruiting Dynamin-2.

scientific article published on 7 February 2018

So Long Tom!

scientific article published on 01 January 2017

Suppression of autophagy during mitosis via CUL4-RING ubiquitin ligases-mediated WIPI2 polyubiquitination and proteasomal degradation

scientific article published on 30 March 2019

Synaptotagmin IV is necessary for the maturation of secretory granules in PC12 cells

scientific journal article

Syntaxin 6: the promiscuous behaviour of a SNARE protein.

scientific article

TBC1D14 and TRAPP - Regulating autophagy through ATG9

scientific article published on 22 April 2016

TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes

scientific article

TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic

scientific article

TBC1D14 sets the TRAPP for ATG9

scientific article published on 12 May 2016

Tales of the autophagy crusaders

scientific article published on March 2012

The AP-1 adaptor complex binds to immature secretory granules from PC12 cells, and is regulated by ADP-ribosylation factor

scientific article published on February 1996

The Art of Protein Sorting: Meeting Report from the Annaberg Meeting, Goldegg, Austria, 9-13 January 2001

scientific article published on 01 May 2001

The EmERgence of Autophagosomes

scientific article published on 01 December 2009

The Role of Autophagy in Pancreatic Cancer-Recent Advances

scientific article published on 28 December 2019

The autophagosome: origins unknown, biogenesis complex

scientific article

The essential role of early endosomes in autophagy is revealed by loss of COPI function

scientific article

The majority of clathrin coated vesicles from lactating rabbit mammary gland arises from the secretory pathway

scientific article published on 01 November 1999

The origin of the autophagosomal membrane ⬇️

scientific article published on September 1, 2010

The phosphatidylinositol 3-phosphate-binding protein SNX4 controls ATG9A recycling and autophagy

scientific article published on 10 February 2021

The puzzling origin of the autophagosomal membrane

scientific article published on December 2011

The role of membrane proteins in mammalian autophagy

scientific article published on 27 March 2010

The slippery slopes of secretion

scientific article

Trafficking and signaling in mammalian autophagy

scientific article published on July 2010

Trimeric G-proteins of the trans -Golgi network are involved in the formation of constitutive secretory vesicles and immature secretory granules

scientific article published on 01 December 1991

ULK1 regulates melanin levels in MNT-1 cells independently of mTORC1.

scientific article

Vesicular trafficking and autophagosome formation

scientific article published on 17 April 2009

WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1.

scientific article published on 19 June 2014

WIPI2B links PtdIns3P to LC3 lipidation through binding ATG16L1.

scientific article published on January 2015

WIPI2b and Atg16L1: setting the stage for autophagosome formation

scientific article

[10] Cell-free formation of immature secretory granules and constitutive secretory vesicles from trans-golgi network

scientific article published on 01 January 1992

mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1

scientific article (publication date: 12 October 2016)

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8⁺ T cells

scientific article

pH-dependent processing of secretogranin II by the endopeptidase PC2 in isolated immature secretory granules.

scientific article published on January 1997

siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy

scientific article

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