List of works - Marta Miączyńska

APPL endosomes are not obligatory endocytic intermediates but act as stable cargo-sorting compartments

scientific article

APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment

scientific article

APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain

scientific article published on 18 November 2015

APPL1 endocytic adaptor as a fine tuner of Dvl2-induced transcription

scientific article published on 23 January 2015

APPL1 regulates basal NF-κB activity by stabilizing NIK.

scientific article published on 8 June 2012

Abstract 3845: Endocytic protein APPL2 as a regulator of glioblastoma cell growth

Amino- and carboxy-terminal domains of the yeast Rab escort protein are both required for binding of Ypt small G proteins.

scientific article published on October 1996

Biochemical characterization of APPL endosomes: the role of annexin A2 in APPL membrane recruitment

scientific article published on 3 July 2011

Cholesterol restricts lymphotoxin β receptor-triggered NF-κB signaling

scientific article published on 26 December 2019

Clathrin- and dynamin-dependent endocytosis limits canonical NF-κB signaling triggered by lymphotoxin β receptor

scientific article published on 04 November 2020

Concurrent depletion of Vps37 proteins evokes ESCRT-I destabilization and profound cellular stress responses

scientific article published on 08 January 2021

Dynamin inhibitors impair endocytosis and mitogenic signaling of PDGF.

scientific article published on 12 March 2013

ESCRT proteins restrict constitutive NF-κB signaling by trafficking cytokine receptors.

scientific article published on 19 January 2016

ESCRT-I controls lysosomal membrane protein homeostasis and restricts MCOLN1-dependent TFEB/TFE3 signaling

scientific article published on 28 July 2021

ESCRT-I fuels lysosomal degradation to restrict TFEB/TFE3 signaling via the Rag-mTORC1 pathway

scientific article published on 30 March 2022

Effects of membrane trafficking on signaling by receptor tyrosine kinases

scientific article

Efficient Enhancement of Signaling Capacity: Signaling Endosomes

scientific article published in 2013

Endocytic Adaptor Protein Tollip Inhibits Canonical Wnt Signaling

scientific article published on 25 June 2015

Endocytic proteins in the regulation of nuclear signaling, transcription and tumorigenesis

scientific article published on 11 June 2009

Endocytic regulation of cytokine receptor signaling

scientific article

Endocytic trafficking of GAS6-AXL complexes is associated with sustained AKT activation

scientific article published on 27 May 2022

Endosomal "sort" of signaling control: The role of ESCRT machinery in regulation of receptor-mediated signaling pathways.

scientific article published on 7 August 2017

Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription

scientific article published on 11 May 2009

FGFR1 clustering with engineered tetravalent antibody improves the efficiency and modifies the mechanism of receptor internalization

scientific article published on 08 June 2020

Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex.

scientific article

Functional synergy between Rab5 effector Rabaptin-5 and exchange factor Rabex-5 when physically associated in a complex

scientific article

GAS6-AXL signaling triggers actin remodeling and macropinocytosis that drive cancer cell invasion

scientific article published on 18 March 2020

Genome-wide co-localization of active EGFR and downstream ERK pathway kinases mirrors mitogen-inducible RNA polymerase 2 genomic occupancy.

scientific article published on September 2016

Impaired dynamin 2 function leads to increased AP-1 transcriptional activity through the JNK/c-Jun pathway

scientific article

Integration of the Endocytic System into the Network of Cellular Functions

scientific article published on 01 January 2018

Labeling of platelet-derived growth factor by reversible biotinylation to visualize its endocytosis by microscopy

scientific article published on January 2014

Mechanisms and functions of endocytosis

scientific article

Membrane trafficking: vesicle formation, cargo sorting and fusion

scientific article published on 01 March 2020

Missense variant in CCDC22 causes X-linked recessive intellectual disability with features of Ritscher-Schinzel/3C syndrome

scientific article

Missense variant in CCDC22 causes X-linked recessive intellectual disability with features of Ritscher-Schinzel/3C syndrome

article published in 2015

Mosaic organization of the endocytic pathway

scientific article

Mrs6p, the yeast homologue of the mammalian choroideraemia protein: immunological evidence for its function as the Ypt1p Rab escort protein.

scientific article

Multifunctional protein APPL2 contributes to survival of human glioma cells.

scientific article published on 5 September 2012

Multiple routes of endocytic internalization of PDGFRβ contribute to PDGF-induced STAT3 signaling

scientific article published on 15 December 2016

Not just a sink: endosomes in control of signal transduction

scientific article published in August 2004

Nuclear functions of endocytic proteins.

scientific article published on 20 June 2007

Observing the growth of individual actin filaments in cell extracts by time-lapse atomic force microscopy

scientific article published on 01 September 2003

Opportunities in Poland

scientific article published in Nature

Phosphatidylinositol-3-OH kinases are Rab5 effectors.

scientific article

Phosphorylation of EEA1 by p38 MAP kinase regulates mu opioid receptor endocytosis

scientific article

Prenyltransferases regulate CD20 protein levels and influence anti-CD20 monoclonal antibody-mediated activation of complement-dependent cytotoxicity

scientific article

Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain

scientific article

Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes.

scientific article

Recruitment of APPL1 to ubiquitin-rich aggresomes in response to proteasomal impairment

scientific article published on 19 February 2011

Role of Rab5 in the Recruitment of hVps34/p150 to the Early Endosome

scientific article published on 01 June 2002

Selective membrane recruitment of EEA1 suggests a role in directional transport of clathrin-coated vesicles to early endosomes

scientific article published on 01 February 2000

Signaling endosomes: seeing is believing

scientific article

Signaling from endosomes: location makes a difference.

scientific article published on 07 October 2008

Splicing variants of an endocytic regulator, BMP2K, differentially control autophagic degradation in erythroid cells

scientific article published on 13 October 2020

Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells

scientific article published on 14 August 2020

Splicing variation of BMP2K balances endocytosis, COPII trafficking and autophagy in erythroid cells

scientific article published on 7 May 2020

Synthetic lethality between VPS4A and VPS4B triggers an inflammatory response in colorectal cancer

scientific article published on 13 January 2020

The GAS6-AXL signaling pathway triggers actin remodeling that drives membrane ruffling, macropinocytosis, and cancer-cell invasion

scientific article published on 13 July 2021

The new faces of endocytosis in signaling

scientific article published on 16 August 2011

The topology of lymphotoxin β receptor accumulated upon endolysosomal dysfunction dictates the NF-κB signaling outcome

scientific article published on 21 November 2018

The yeast Rab escort protein binds intracellular membranes in vivo and in vitro

scientific article

Tollip‐deficient zebrafish display no abnormalities in development, organ morphology or gene expression in response to lipopolysaccharide

scientific article published on 3 May 2022

Ypt protein prenylation depends on the interplay among levels of Rab escort protein and geranylgeranyl diphosphate in yeast cells.

scientific article published in June 2001

[Effectors of GTPase Rab5 in endocytosis and signal transduction]

scientific article published on 01 January 2009

List of works by Marta Miączyńska

APPL endosomes are not obligatory endocytic intermediates but act as stable cargo-sorting compartments

APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment

APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain

APPL1 endocytic adaptor as a fine tuner of Dvl2-induced transcription

APPL1 regulates basal NF-κB activity by stabilizing NIK.

Abstract 3845: Endocytic protein APPL2 as a regulator of glioblastoma cell growth

Amino- and carboxy-terminal domains of the yeast Rab escort protein are both required for binding of Ypt small G proteins.

Biochemical characterization of APPL endosomes: the role of annexin A2 in APPL membrane recruitment

Cholesterol restricts lymphotoxin β receptor-triggered NF-κB signaling

Clathrin- and dynamin-dependent endocytosis limits canonical NF-κB signaling triggered by lymphotoxin β receptor

Concurrent depletion of Vps37 proteins evokes ESCRT-I destabilization and profound cellular stress responses

Dynamin inhibitors impair endocytosis and mitogenic signaling of PDGF.

ESCRT proteins restrict constitutive NF-κB signaling by trafficking cytokine receptors.

ESCRT-I controls lysosomal membrane protein homeostasis and restricts MCOLN1-dependent TFEB/TFE3 signaling

ESCRT-I fuels lysosomal degradation to restrict TFEB/TFE3 signaling via the Rag-mTORC1 pathway

Effects of membrane trafficking on signaling by receptor tyrosine kinases

Efficient Enhancement of Signaling Capacity: Signaling Endosomes

Endocytic Adaptor Protein Tollip Inhibits Canonical Wnt Signaling

Endocytic proteins in the regulation of nuclear signaling, transcription and tumorigenesis

Endocytic regulation of cytokine receptor signaling

Endocytic trafficking of GAS6-AXL complexes is associated with sustained AKT activation

Endosomal "sort" of signaling control: The role of ESCRT machinery in regulation of receptor-mediated signaling pathways.

Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription

FGFR1 clustering with engineered tetravalent antibody improves the efficiency and modifies the mechanism of receptor internalization

Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex.

Functional synergy between Rab5 effector Rabaptin-5 and exchange factor Rabex-5 when physically associated in a complex

GAS6-AXL signaling triggers actin remodeling and macropinocytosis that drive cancer cell invasion

Genome-wide co-localization of active EGFR and downstream ERK pathway kinases mirrors mitogen-inducible RNA polymerase 2 genomic occupancy.

Impaired dynamin 2 function leads to increased AP-1 transcriptional activity through the JNK/c-Jun pathway

Integration of the Endocytic System into the Network of Cellular Functions

Labeling of platelet-derived growth factor by reversible biotinylation to visualize its endocytosis by microscopy

Mechanisms and functions of endocytosis

Membrane trafficking: vesicle formation, cargo sorting and fusion

Missense variant in CCDC22 causes X-linked recessive intellectual disability with features of Ritscher-Schinzel/3C syndrome

Missense variant in CCDC22 causes X-linked recessive intellectual disability with features of Ritscher-Schinzel/3C syndrome

Mosaic organization of the endocytic pathway

Mrs6p, the yeast homologue of the mammalian choroideraemia protein: immunological evidence for its function as the Ypt1p Rab escort protein.

Multifunctional protein APPL2 contributes to survival of human glioma cells.

Multiple routes of endocytic internalization of PDGFRβ contribute to PDGF-induced STAT3 signaling

Not just a sink: endosomes in control of signal transduction

Nuclear functions of endocytic proteins.

Observing the growth of individual actin filaments in cell extracts by time-lapse atomic force microscopy

Opportunities in Poland

Phosphatidylinositol-3-OH kinases are Rab5 effectors.

Phosphorylation of EEA1 by p38 MAP kinase regulates mu opioid receptor endocytosis

Prenyltransferases regulate CD20 protein levels and influence anti-CD20 monoclonal antibody-mediated activation of complement-dependent cytotoxicity

Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain

Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes.

Recruitment of APPL1 to ubiquitin-rich aggresomes in response to proteasomal impairment

Role of Rab5 in the Recruitment of hVps34/p150 to the Early Endosome

Selective membrane recruitment of EEA1 suggests a role in directional transport of clathrin-coated vesicles to early endosomes

Signaling endosomes: seeing is believing

Signaling from endosomes: location makes a difference.

Splicing variants of an endocytic regulator, BMP2K, differentially control autophagic degradation in erythroid cells

Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells

Splicing variation of BMP2K balances endocytosis, COPII trafficking and autophagy in erythroid cells

Synthetic lethality between VPS4A and VPS4B triggers an inflammatory response in colorectal cancer

The GAS6-AXL signaling pathway triggers actin remodeling that drives membrane ruffling, macropinocytosis, and cancer-cell invasion

The new faces of endocytosis in signaling

The topology of lymphotoxin β receptor accumulated upon endolysosomal dysfunction dictates the NF-κB signaling outcome

The yeast Rab escort protein binds intracellular membranes in vivo and in vitro

Tollip‐deficient zebrafish display no abnormalities in development, organ morphology or gene expression in response to lipopolysaccharide

Ypt protein prenylation depends on the interplay among levels of Rab escort protein and geranylgeranyl diphosphate in yeast cells.

[Effectors of GTPase Rab5 in endocytosis and signal transduction]