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List of works by Manuela Baccarini

"RAF" neighborhood: protein-protein interaction in the Raf/Mek/Erk pathway

scientific article

A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal

scientific article published on 15 February 2009

A balance between Raf-1 and Fas expression sets the pace of erythroid differentiation

scientific article published on 9 March 2006

A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis

scientific article (publication date: 21 December 2016)

A fast and objective assay for cell mediated intra- and extracellular killing of Leishmania promastigotes

scientific article published on 01 February 1986

A radiolabel release microassay for phagocytic killing of Candida albicans

scientific article published on 01 August 1982

Activating mutations in MEK1 enhance homodimerization and promote tumorigenesis

scientific article published on 30 October 2018

Activation of bcl-2 suppressible 40 and 44 kDa p38-like kinases during apoptosis of early and late B lymphocytic cell lines

scientific article published on May 1998

Alike but Different: RAF Paralogs and Their Signaling Outputs

scientific article published on May 2015

An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion.

scientific article

An old kinase on a new path: Raf and apoptosis

scientific article

Angiogenic sprouting requires the fine tuning of endothelial cell cohesion by the Raf-1/Rok-α complex

scientific article published on 29 December 2011

B-Raf and C-Raf are required for melanocyte stem cell self-maintenance

scientific journal article

B-Raf is required for ERK activation and tumor progression in a mouse model of pancreatic beta-cell carcinogenesis

scientific article published on 19 May 2008

BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling

scientific article

Bacterially expressed murine CSF-1 possesses agonistic activity in its monomeric form

scientific article published on April 1993

C-Raf is required for the initiation of lung cancer by K-Ras(G12D).

scientific article published on 11 May 2011

Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis

scientific article published on October 2004

Cellular mechanisms underlying the adjuvant activity of Candida albicans in a mouse lymphoma model.

scientific article

Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock

scientific article

Colony stimulating factor-1 (CSF-1) stimulates temperature dependent phosphorylation and activation of the RAF-1 proto-oncogene product

scientific article

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

scientific article published on 25 April 2019

Combined effects of cyclophosphamide and thymostimulin treatment on the in vitro natural killer and candidacidal activity of murine spleen cells

scientific article published on 01 January 1984

Comparison between natural reactivity (NR) against Candida albicans and natural killer (NK) activity against YAC-1 tumour cells

scientific article published on January 1, 1983

Conservation of Salmonella infection mechanisms in plants and animals

scientific article

Constitutive activation of the MAPK pathway mediates v-fes-induced mitogenesis in murine macrophages.

scientific article

Cooperative effects of colony-stimulating factor 1 and recombinant interleukin 2 on proliferation and induction of cytotoxicity of macrophage precursors generated from mouse bone marrow cell cultures

scientific article published on March 1989

Coordinate expression of the lineage-specific growth factor colony-stimulating factor (CSF)-1 and its receptor selectively promotes macrophage maturation during differentiation of multipotential progenitor cells.

scientific article published on October 1994

Correlation between in vivo and in vitro studies of modulation of resistance to experimental Candida albicans infection by cyclophosphamide in mice

scientific article published on April 1983

Deciphering signaling pathways in vivo: the Ras/Raf/MEK/ERK cascade.

scientific article

Deciphering the RAS/ERK pathway in vivo

scientific article published on February 2017

Dephosphorylation of Ser-259 regulates Raf-1 membrane association

scientific article

Distinct mechanisms target stress and extracellular signal-activated kinase 1 and Jun N-terminal kinase during infection of macrophages with Salmonella.

scientific article published on November 1999

EGFR-ras-raf signaling in epidermal stem cells: roles in hair follicle development, regeneration, tissue remodeling and epidermal cancers

scientific article published on 25 September 2013

ERK and beyond: insights from B-Raf and Raf-1 conditional knockouts

scientific article

ERK signaling, but not c-Raf, is required for gonadotropin-releasing hormone (GnRH)-induced regulation of Nur77 in pituitary gonadotropes

scientific article published on 20 December 2011

Editorial overview: Cell regulation

Effect of human recombinant IL-2 on murine macrophage precursors. Involvement of a receptor distinct from the p55 (Tac) protein

scientific article published on 01 January 1989

Efficient natural defense mechanisms against Listeria monocytogenes in T and B cell-deficient allogeneic bone marrow radiation chimeras. Preactivated macrophages are the main effector cells in an early phase after bone marrow transfer.

scientific article

Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene

scientific article published on April 2001

Enhancement of natural killer cell activity in mice by treatment with a thymic factor

scientific article published on 01 January 1984

Epidermal RAF prevents allergic skin disease

scientific article

Epidermal growth factor stimulates phosphorylation of RAF-1 independently of receptor autophosphorylation and internalization.

scientific article published on June 1991

Erratum: Ras and Raf pathways in epidermis development and carcinogenesis

article

Essential role of B-Raf in ERK activation during extraembryonic development

scholarly article

Essential role of B-Raf in oligodendrocyte maturation and myelination during postnatal central nervous system development

scientific article

Essential, non-redundant roles of B-Raf and Raf-1 in Ras-driven skin tumorigenesis

scientific article

Fibronectin-tissue transglutaminase matrix rescues RGD-impaired cell adhesion through syndecan-4 and beta1 integrin co-signaling

scientific article

From autoinhibition to inhibition in trans: the Raf-1 regulatory domain inhibits Rok-alpha kinase activity

scientific article published on November 2009

Functional heterogeneity of macrophage precursor cells from spleen of Leishmania donovani-infected and untreated mice

scientific article published in April 1989

Functional heterogeneity of murine macrophage precursor cells from spleen and bone marrow

scientific article published on 01 September 1986

Growth phase-regulated induction of Salmonella-induced macrophage apoptosis correlates with transient expression of SPI-1 genes

scientific article

Heterogeneous activity of immature and mature cells of the murine monocyte-macrophage lineage derived from different anatomical districts against yeast-phase Candida albicans

scientific article

Host factor I, Hfq, binds to Escherichia coli ompA mRNA in a growth rate-dependent fashion and regulates its stability.

scientific article published on November 1998

IFN-gamma/lipopolysaccharide activation of macrophages is associated with protein kinase C-dependent down-modulation of the colony-stimulating factor-1 receptor

scientific article published on October 1992

In vitro natural cell-mediated cytotoxicity against Candida albicans: macrophage precursors as effector cells

scientific article published on 01 April 1985

Involvement of the protein tyrosine phosphatase SHP-1 in Ras-mediated activation of the mitogen-activated protein kinase pathway.

scientific article published on November 1996

Keratinocyte-specific stat3 heterozygosity impairs development of skin tumors in human papillomavirus 8 transgenic mice

scientific article published on 28 September 2010

Killing of yeast, germ-tube and mycelial forms of Candida albicans by murine effectors as measured by a radiolabel release microassay

scientific article published on 01 March 1985

Knock-in(g) RAF for a loop

scientific article published on 15 December 2015

Lipopolysaccharide induces activation of the Raf-1/MAP kinase pathway. A putative role for Raf-1 in the induction of the IL-1 beta and the TNF-alpha genes

scientific article published on December 1994

Lipopolysaccharide induces jun N-terminal kinase activation in macrophages by a novel Cdc42/Rac-independent pathway involving sequential activation of protein kinase C zeta and phosphatidylcholine-dependent phospholipase C.

scientific article published on October 2000

Listeria monocytogenes infection rewires host metabolism with regulatory input from type I interferons

scientific article published on 08 July 2021

Liver-associated macrophage precursor cells proliferate under impairment of regular hemopoiesis

scientific article published on May 1988

Liver-associated macrophage precursors as natural cytotoxic effectors againstCandida albicans and Yac-1 cells

scholarly article by Thomas Decker et al published 1986 in European Journal of Immunology

MEK1 is required for PTEN membrane recruitment, AKT regulation, and the maintenance of peripheral tolerance

scientific article published on 28 February 2013

MEK1 is required for the development of NRAS-driven leukemia

scientific article published on 10 October 2016

Macrophage function in murine allogeneic bone marrow radiation chimeras in the early phase after transplantation

scientific article

Modulation of polymorphonucleate-mediated cytotoxicity against Candida albicans by thymosin alpha 1.

scientific article

Natural cell-mediated cytotoxicity against Candida albicans induced by cyclophosphamide: nature of the in vitro cytotoxic effector.

scientific article published on October 1983

Opposite effects of different doses of MCSF on ERK phosphorylation and cell proliferation in macrophages

scientific article

Organ-associated macrophage precursor activity: isolation of candidacidal and tumoricidal effectors from the spleens of cyclophosphamide-treated mice

scientific article published in February 1986

Pancreatic β-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcription

scientific journal article

Partner exchange: protein-protein interactions in the Raf pathway

scientific article published on December 2010

Phagocytic killing of Candida albicans by different murine effector cells

scientific article published on 01 December 1983

Protective role of Raf-1 in Salmonella-induced macrophage apoptosis

scientific article published on February 2001

RAF dimers control vascular permeability and cytoskeletal rearrangements at endothelial cell-cell junctions

scientific article published on 18 March 2019

RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma.

scientific article

RAF1/BRAF dimerization integrates the signal from RAS to ERK and ROKα.

scientific article published on 7 March 2017

RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein

scientific article

RKIP regulates MAP kinase signaling in cells with defective B-Raf activity

scientific article published on 14 February 2013

Raf Kinases Are Essential for Phosphate Induction of ERK1/2 Phosphorylation in Hypertrophic Chondrocytes and Normal Endochondral Bone Development.

scientific article published on 10 January 2017

Raf kinase signaling functions in sensory neuron differentiation and axon growth in vivo

scientific article published on 29 March 2007

Raf kinases in cancer-roles and therapeutic opportunities

scientific article (publication date: 11 August 2011)

Raf protects against colitis by promoting mouse colon epithelial cell survival through NF-kappaB

scientific article published on 30 April 2008

Raf-1 addiction in Ras-induced skin carcinogenesis

scientific article published in August 2009

Raf-1 and B-Raf proteins have similar regional distributions but differential subcellular localization in adult rat brain

scientific journal article

Raf-1 antagonizes erythroid differentiation by restraining caspase activation

scientific article published on November 2002

Raf-1 regulates Rho signaling and cell migration

scientific article published on 7 March 2005

Raf-1 sets the threshold of Fas sensitivity by modulating Rok-alpha signaling

scientific journal article

Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation

scientific article published in Journal of Biological Chemistry

Ras and Raf pathways in epidermis development and carcinogenesis

scientific article

Ras-dependent and -independent pathways target the mitogen-activated protein kinase network in macrophages.

scientific article published on January 1995

Ras/MAP kinase-dependent and -independent signaling pathways target distinct ternary complex factors

scientific article published on August 1994

Regulation of cytosolic phospholipase A2 in arachidonic acid release of rat-liver macrophages

scientific article published on 01 January 1997

Relationships among tumor load, route of tumor inoculation, and response to immunochemotherapy in a murine lymphoma model

article

Role of cytosolic phospholipase A2 in arachidonic acid release of rat-liver macrophages: regulation by Ca2+ and phosphorylation

scientific article published on October 1995

Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1.

scientific article

Salmonella typhimurium and lipopolysaccharide stimulate extracellularly regulated kinase activation in macrophages by a mechanism involving phosphatidylinositol 3-kinase and phospholipase D as novel intermediates.

scientific article published on March 1999

Salmonella-induced caspase-2 activation in macrophages: a novel mechanism in pathogen-mediated apoptosis

scientific article published on October 2000

Second nature: biological functions of the Raf-1 "kinase"

scientific article

Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer

scientific article

Skin tumorigenesis stimulated by Raf inhibitors relies upon Raf functions that are dependent and independent of ERK.

scientific article

Sorafenib suppresses JNK-dependent apoptosis through inhibition of ZAK.

scientific article published on 29 October 2013

Suppression of growth factor-mediated MAP kinase activation by v-raf in macrophages: a putative role for the MKP-1 phosphatase

scientific article published on March 1995

Targets of Raf in tumorigenesis

scientific article published on 04 January 2010

The Raf-1 kinase associates with vimentin kinases and regulates the structure of vimentin filaments

scientific article published on October 2000

The dimer-dependent catalytic activity of RAF family kinases is revealed through characterizing their oncogenic mutants

scholarly article by Jimin Yuan published in June 2018

The response of gamma interferon activation factor is under developmental control in cells of the macrophage lineage

scientific article published on June 1993

The role of the peritoneal cavity in successful treatment of a murine lymphoma with chemotherapy and non-specific immunostimulation

scientific article published on 01 January 1982

Transient activation of RAF-1, MEK, and ERK2 coincides kinetically with ternary complex factor phosphorylation and immediate-early gene promoter activity in vivo

scientific article published on September 1994

Upregulation of lineage specific receptors and ligands in multipotential progenitor cells is part of an endogenous program of differentiation

scientific article published on 01 January 1993

c-Raf promotes angiogenesis during normal growth plate maturation

scientific article

c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma

scientific article published on 21 April 2011

p38 links RAS to GATA2.

scientific article published on 3 August 2014

v-raf confers CSF-1 independent growth to a macrophage cell line and leads to immediate early gene expression without MAP-kinase activation

scientific article published on December 1993

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