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List of works by Laura Machesky

"Wunder" F-BAR domains: going from pits to vesicles

scientific article published on May 2007

A RAC-GEF network critical for early intestinal tumourigenesis

scientific article published on 04 January 2021

A Rac1-independent role for P-Rex1 in melanoblasts

scientific article published on 30 July 2014

A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity

scientific article published on 20 May 2010

Actin dynamics at sites of extracellular matrix degradation.

scientific article published on 28 September 2006

Actin dynamics at the leading edge: from simple machinery to complex networks.

scientific article published on September 2009

Actin filament formation, reorganization and migration are impaired in hepatic stellate cells under influence of trichostatin A, a histone deacetylase inhibitor

scientific journal article

Actin on trafficking: could actin guide directed receptor transport?

scientific article published on 17 October 2012

Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis ⬇️

scientific article

Actin-based protrusions: promoters or inhibitors of cancer invasion?

scientific article

Actin-bundling proteins in cancer progression at a glance ⬇️

scientific article published on March 1, 2012

Activated mutant NRas(Q61K) drives aberrant melanocyte signaling, survival, and invasiveness via a Rac1-dependent mechanism

scientific article

Alan Hall 1952-2015.

scientific article published on 25 May 2015

Analysis of the mechanisms of Salmonella-induced actin assembly during invasion of host cells and intracellular replication

scientific article published in November 2004

Arabidopsis group Ie formins localize to specific cell membrane domains, interact with actin-binding proteins and cause defects in cell expansion upon aberrant expression

scientific article published in December 2005

Arp2/3 complex activity in filopodia of spreading cells.

scientific article

Bacterial and host determinants of MAL activation upon EPEC infection: the roles of Tir, ABRA, and FLRT3

scientific article

Bar domain proteins: a role in tubulation, scission and actin assembly in clathrin-mediated endocytosis

scientific article published on September 2006

Biophysical approaches for investigation of the cytoskeleton. A special issue stemming from research presented at the 2012 ECF meeting: a FEBS/EMBO workshop lecture course in Pécs, Hungary

scientific article published in October 2013

CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells.

scientific article

CYRI (FAM49) proteins are local inhibitors of Scar/WAVE induced lamellipodia that bind directly to active Rac1

CYRI/ Fam49 Proteins Represent a New Class of Rac1 Interactors

scientific article published on 23 July 2019

Cell structure and dynamics

scientific article published on 01 February 2003

Cell-substrate adhesion drives Scar/WAVE activation and phosphorylation by a Ste20-family kinase, which controls pseudopod lifetime

scientific article published on 03 August 2020

Cells Assemble Invadopodia-Like Structures and Invade into Matrigel in a Matrix Metalloprotease Dependent Manner in the Circular Invasion Assay ⬇️

scientific article published on February 8, 2012

Characterisation of IRTKS, a novel IRSp53/MIM family actin regulator with distinct filament bundling properties

scientific article

Collagen VI expression is negatively mechanosensitive in pancreatic cancer cells and supports the metastatic niche

scientific article published in 2022

Congenital myopathies: diseases of the actin cytoskeleton.

scientific article

Coordination by Cdc42 of Actin, Contractility, and Adhesion for Melanoblast Movement in Mouse Skin

scientific article published on 18 February 2017

Correction: Lineage Tracing of Pf4-Cre Marks Hematopoietic Stem Cells and Their Progeny.

scientific article published on 31 May 2013

CrkL directs ASAP1 to peripheral focal adhesions.

scientific article

Cyclical action of the WASH complex: FAM21 and capping protein drive WASH recycling, not initial recruitment

scientific article published on January 2013

Cytokinesis: IQGAPs find a function ⬇️

scientific article published on March 12, 1998

Deadly actin collapse by disulfidptosis

scientific article published in March 2023

Development of a cost effective automated platform to produce human liver spheroids for basic and applied research

scientific article published on 02 October 2020

Enhancement of ATRA-induced cell differentiation by inhibition of calcium accumulation into the endoplasmic reticulum: cross-talk between RAR alpha and calcium-dependent signaling

scientific article published on 19 December 2002

Expression of WASP and Scar1/WAVE1 actin-associated proteins is differentially modulated during differentiation of HL-60 cells

scientific article published on April 2003

Fam49/CYRI interacts with Rac1 and locally suppresses protrusions

scientific article published on 24 September 2018

Fascin 1 is dispensable for developmental and tumour angiogenesis

scientific article published on 19 September 2013

Fascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation

scientific article

Fascin expression is increased in metastatic lesions but does not correlate with progression nor outcome in melanoma

article

Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes

scientific article

Fascin regulates the migration of subventricular zone-derived neuroblasts in the postnatal brain

scientific article published on July 2013

Fascin1 in carcinomas: Its regulation and prognostic value

scientific article

Fascin: Invasive filopodia promoting metastasis

scientific article published on May 2010

Fluorescence lifetime imaging with a megapixel SPAD camera and neural network lifetime estimation

scientific article published on 02 December 2020

Functional analysis of Dictyostelium IBARa reveals a conserved role of the I-BAR domain in endocytosis

scientific article

Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex

scientific article

Grab, stick, pull and digest: the functional diversity of actin-associated matrix-adhesion structures. Workshop on Invadopodia, Podosomes and Focal Adhesions in Tissue Invasion

scientific article published on 18 January 2008

Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling

scientific article published on 05 February 2019

Identification and characterisation of a novel human isoform of Arp2/3 complex subunit p16-ARC/ARPC5.

scientific article

Identification and characterisation of a novel human isoform of Arp2/3 complex subunit p16-ARC/ARPC5. T.H. Millard, B. Behrendt, S. Launay, K. Fütterer, L.M. Machesky, Cell Motil.Cytoskeleton (2003) 54(1):81-90

Identification of the insulin-responsive tyrosine phosphorylation sites on IRSp53.

scientific article

Identification of the p16-Arc subunit of the Arp 2/3 complex as a substrate of MAPK-activated protein kinase 2 by proteomic analysis

scientific article

In vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis

scientific article published on 31 January 2013

Inclusion of Scar/WAVE3 in a similar complex to Scar/WAVE1 and 2

scientific article

Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerization.

scientific article published on July 2006

Invasion by Force: The C. elegans Anchor Cell Leads the Way

scientific article published on 01 February 2019

Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-B.

scientific article

Involvement of the Arp2/3 complex and Scar2 in Golgi polarity in scratch wound models

scientific article

LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells

scientific article

Lamellipodia and filopodia in metastasis and invasion

scientific article published on 07 April 2008

Laura Machesky: actin opens the way.

scientific article published on September 2014

Ligand-Occupied Integrin Internalization Links Nutrient Signaling to Invasive Migration

scientific article published on 15 January 2015

Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny

scientific article

Linked regulation of motility and integrin function in activated migrating neutrophils revealed by interference in remodelling of the cytoskeleton

scientific article published in February 2003

Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis.

scientific article published on 19 April 2018

Loss of Scar/WAVE complex promotes N-WASP- and FAK-dependent invasion.

scientific article

Loss of reelin expression in breast cancer is epigenetically controlled and associated with poor prognosis

scientific article

Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour

scientific article published on 7 July 2016

MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta

scientific article

MIM: a multifunctional scaffold protein

scientific article

MRL proteins: leading Ena/VASP to Ras GTPases

scientific article published on 01 November 2004

Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane

scientific article published on 10 January 2013

Melanoblasts Populate the Mouse Choroid Earlier in Development Than Previously Described

scientific article published on 01 August 2020

Melanoblasts on the move: Rac1 sets the pace

scientific article published in April 2012

Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal

scientific article (publication date: October 2014)

Membrane binding properties of IRSp53-missing in metastasis domain (IMD) protein.

scientific article

Microtubule involvement in NIH 3T3 Golgi and MTOC polarity establishment

scientific article published on February 2003

Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency

scientific article published on 28 August 2017

Mtss1 promotes cell-cell junction assembly and stability through the small GTPase Rac1

scientific article

Myopathy mutations in alpha-skeletal-muscle actin cause a range of molecular defects.

scientific article published on July 2004

Myopathy-causing actin mutations promote defects in serum-response factor signalling

scientific article

N-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell Metastasis

scientific article published on 24 October 2019

N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods

scientific article

N-WASP involvement in dorsal ruffle formation in mouse embryonic fibroblasts

scientific article

N-WASP regulates extension of filopodia and processes by oligodendrocyte progenitors, oligodendrocytes, and Schwann cells-implications for axon ensheathment at myelination

scientific article published on June 2007

Overflow in science and its implications for trust.

scientific article

P-Rex1 is required for efficient melanoblast migration and melanoma metastasis

scientific article

Phenotypes induced by NM causing alpha-skeletal muscle actin mutants in fibroblasts, Sol 8 myoblasts and myotubes

scientific article

Phenotypes of myopathy-related actin mutants in differentiated C2C12 myotubes

scientific article

Phenotypic analysis of Myo10 knockout (Myo10) mice lacking full-length (motorized) but not brain-specific headless myosin X

scientific article published in Scientific Reports

Platelet lamellipodium formation is not required for thrombus formation and stability

scientific article published on 01 December 2019

Podosomes in adhesion, migration, mechanosensing and matrix remodeling.

scientific article

Polarised cell migration: intrinsic and extrinsic drivers

scientific article

Predicting cell shapes in melanomas.

scientific article published on 23 October 2013

Pseudopod growth and evolution during cell movement is controlled through SCAR/WAVE dephosphorylation

scientific article

Rab11FIP proteins link endocytic recycling vesicles for cytoskeletal transport and tethering

scientific article published in 2019

Rab5 and rac team up in cell motility

scientific article published on 01 July 2008

Rac1 cycling fast in melanoma with P29S.

scientific article published on 8 February 2013

Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression

scientific article

Rac1 in the driver’s seat for melanoma

Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow.

scientific article

Regulation of WASP: PIP2 Pipped by Toca-1?

scientific article published in July 2004

Rho-kinase and myosin-II control phagocytic cup formation during CR, but not FcgammaR, phagocytosis

scientific article published on August 2002

SCAR knockouts in Dictyostelium: WASP assumes SCAR's position and upstream regulators in pseudopods

scientific article

Scar/WAVE3 contributes to motility and plasticity of lamellipodial dynamics but not invasion in three dimensions.

scientific article

Seeing around corners: Cells solve mazes and respond at a distance using attractant breakdown

scientific article

Sharks' teeth and dunes

scientific article published in Nature

Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex

scientific article published on May 2004

Simulation of melanoblast displacements reveals new features of developmental migration.

scientific article published on 11 June 2018

Single-sample image-fusion upsampling of fluorescence lifetime images

scientific article published on 24 May 2024

So far, yet so close: α-Catenin dimers help migrating cells get together.

scientific article

Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells

scientific article published on March 2005

Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling

scientific article

Src-dependent phosphorylation of Scar1 promotes its association with the Arp2/3 complex

scientific article published in January 2006

Structural Basis of CYRI-B Direct Competition with Scar/WAVE Complex for Rac1

scientific article published on 17 November 2020

Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53

scientific article

Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents

scholarly article by Stuart Francis et al published 15 April 2019 in Bioorganic & Medicinal Chemistry Letters

Studies on the actin-binding protein HS1 in platelets

scientific article

The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration

scientific article

The Arp2/3 complex is critical for colonisation of the mouse skin by melanoblasts

scientific article published on 07 October 2020

The Nance-Horan syndrome protein encodes a functional WAVE homology domain (WHD) and is important for co-ordinating actin remodelling and maintaining cell morphology.

scientific article

The RAC1 target NCKAP1 plays a crucial role in progression of BRAF/PTEN -driven melanoma in mice

scientific article published on 07 August 2020

The WASP-Arp2/3 pathway: genetic insights

scientific article published on April 2004

The WAVE Regulatory Complex Is Required to Balance Protrusion and Adhesion in Migration

scientific article published on 07 July 2020

The actin binding proteins cortactin and HS1 are dispensable for platelet actin nodule and megakaryocyte podosome formation

scientific article published on 25 October 2016

The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion

scientific article

The cell pushes back: The Arp2/3 complex is a key orchestrator of cellular responses to environmental forces

scientific article published on 22 September 2020

The creatine-phosphagen system is mechanoresponsive in pancreatic adenocarcinoma and fuels invasion and metastasis

scientific article published on 20 January 2020

The liver metastatic niche: modelling the extracellular matrix in metastasis

scientific article published on 24 April 2021

The role of Arabidopsis SCAR genes in ARP2-ARP3-dependent cell morphogenesis

scientific article published on 31 January 2007

The stressful tumour environment drives plasticity of cell migration programmes, contributing to metastasis

scientific article published on 14 February 2020

Tissue engineering the cancer microenvironment-challenges and opportunities

scientific article published on 08 November 2018

Tissue inducible Lifeact expression allows visualization of actin dynamics in vivo and ex vivo

scientific article

Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium.

scientific article

Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages

scientific article

WASP Restricts Active Rac to Maintain Cells' Front-Rear Polarization

scientific article published on 27 November 2019

WAVE/Scars in platelets

scientific article

WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasion

scientific article

WIP is necessary for matrix invasion by breast cancer cells.

scientific article published on 7 August 2014

WIP: WASP-interacting proteins at invadopodia and podosomes.

scientific article published on 21 July 2012

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