List of works - Laoise McNamara

* Mimicking the Biochemical and Mechanical Extracellular Environment of the Endochondral Ossification Process to Enhance the In Vitro Mineralization Potential of Human Mesenchymal Stem Cells.

scientific article published on 29 July 2017

A Developmental Engineering-Based Approach to Bone Repair: Endochondral Priming Enhances Vascularization and New Bone Formation in a Critical Size Defect

scientific article published on 31 March 2020

A Novel 3D Osteoblast and Osteocyte Model Revealing Changes in Mineralization and Pro-osteoclastogenic Paracrine Signaling During Estrogen Deficiency

scientific article published on 10 June 2020

A coupled diffusion-fluid pressure model to predict cell density distribution for cells encapsulated in a porous hydrogel scaffold under mechanical loading

scientific article published on 3 August 2017

A fluid-structure interaction model to characterize bone cell stimulation in parallel-plate flow chamber systems.

scientific article published on 30 January 2013

A model for the role of integrins in flow induced mechanotransduction in osteocytes

scholarly article

A three-scale finite element investigation into the effects of tissue mineralisation and lamellar organisation in human cortical and trabecular bone

scientific article published on 20 March 2012

Administration of Human Non-Diabetic Mesenchymal Stromal Cells to a Murine Model of Diabetic Fracture Repair: A Pilot Study

scientific article published on 03 June 2020

Alterations in osteocyte mediated osteoclastogenesis during estrogen deficiency and under ROCK-II inhibition: An in vitro study using a novel postmenopausal multicellular niche model

scientific article published on 21 April 2020

Altered architecture and cell populations affect bone marrow mechanobiology in the osteoporotic human femur

scientific article published on 22 November 2016

Altered mechanical environment of bone cells in an animal model of short- and long-term osteoporosis.

scientific article

An Experimental and Computational Investigation of Bone Formation in Mechanically Loaded Trabecular Bone Explants.

scientific article published on 25 July 2015

An in vitro bone tissue regeneration strategy combining chondrogenic and vascular priming enhances the mineralization potential of mesenchymal stem cells in vitro while also allowing for vessel formation

scientific article published on 3 March 2015

An in vitro evaluation of the impact of eccentric deployment on transcatheter aortic valve hemodynamics.

scientific article published on 10 April 2014

An in vitro model quantifying the effect of calcification on the tissue-stent interaction in a stenosed aortic root

scientific article published on 25 October 2018

Are all osteocytes equal? Multiscale modelling of cortical bone to characterise the mechanical stimulation of osteocytes.

scientific article

Attachment of osteocyte cell processes to the bone matrix

scientific article

Biomimetic approaches in bone tissue engineering: Integrating biological and physicomechanical strategies.

scientific article

Bone Mineral Is More Heterogeneously Distributed in the Femoral Heads of Osteoporotic and Diabetic Patients: A Pilot Study

scientific article published on 11 December 2019

Bone cell mechanosensation of fluid flow stimulation: a fluid-structure interaction model characterising the role integrin attachments and primary cilia

scientific article

Bone mechanical properties and changes with osteoporosis

scientific article published on June 2016

Bone remodelling algorithms incorporating both strain and microdamage stimuli

scientific article published on 22 August 2006

Bone tissue material properties are altered during osteoporosis.

scientific article published in October 2005

Cell morphology and focal adhesion location alters internal cell stress

scientific article

Comparison of Surgical Smoke Generated During Electrosurgery with Aerosolized Particulates from Ultrasonic and High-Speed Cutting

scientific article published on 07 August 2020

Comparison of in vitro human endothelial cell response to self-expanding stent deployment in a straight and curved peripheral artery simulator

scientific article published on 30 January 2013

Computational modelling of the mechanics of trabecular bone and marrow using fluid structure interaction techniques.

scientific article

Dielectric characterization of diseased human trabecular bones at microwave frequency

scientific article published on 07 February 2020

Differential β3 and β1 Integrin Expression in Bone Marrow and Cortical Bone of Estrogen Deficient Rats.

scientific article published on 3 June 2015

Effects of ageing, prolonged estrogen deficiency and zoledronate on bone tissue mineral distribution.

scientific article published on 14 September 2013

Effects of in vitro endochondral priming and pre-vascularisation of human MSC cellular aggregates in vivo.

scientific article

Endochondral Priming: A Developmental Engineering Strategy for Bone Tissue Regeneration

scientific article published on 19 October 2016

Estrogen Plus Estrogen Receptor Antagonists Alter Mineral Production by Osteoblasts In Vitro

article

Estrogen deficiency attenuates fluid flow-induced [Ca2+]i oscillations and mechanoresponsiveness of MLO-Y4 osteocytes

scientific article published on 31 March 2017

Estrogen deficiency impairs integrin αβ-mediated mechanosensation by osteocytes and alters osteoclastogenic paracrine signalling

scientific article published on 15 March 2019

Estrogen plus estrogen receptor antagonists alter mineral production by osteoblasts in vitro

scientific article

Estrogen withdrawal from osteoblasts and osteocytes causes increased mineralization and apoptosis

scientific article

Fluid flow in the osteocyte mechanical environment: a fluid-structure interaction approach

scientific article published on 09 April 2013

Heat-shock-induced cellular responses to temperature elevations occurring during orthopaedic cutting.

scientific article

How bone tissue and cells experience elevated temperatures during orthopaedic cutting: an experimental and computational investigation

scientific article published in February 2014

In silico study of bone tissue regeneration in an idealised porous hydrogel scaffold using a mechano-regulation algorithm

scientific article published on 4 August 2017

Integrins in Osteocyte Biology and Mechanotransduction

scientific article published on 01 August 2019

Investigating the interplay between substrate stiffness and ligand chemistry in directing mesenchymal stem cell differentiation within 3D macro-porous substrates.

scientific article

Investigation of the optimal timing for chondrogenic priming of MSCs to enhance osteogenic differentiation in vitro as a bone tissue engineering strategy.

scientific article

Loss of trabeculae by mechano-biological means may explain rapid bone loss in osteoporosis

scientific article published on October 2008

Mechanical stimulation of bone marrow in situ induces bone formation in trabecular explants.

scientific article published on 4 October 2014

Mechanical stimuli and matrix properties modulate cancer spheroid growth in three-dimensional gelatin culture

scientific article published on 16 December 2020

Mechanisms of osteocyte stimulation in osteoporosis

scientific article published on 10 May 2016

Multiscale fluid-structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold

scientific article published on 06 June 2014

Multiscale modeling of trabecular bone marrow: understanding the micromechanical environment of mesenchymal stem cells during osteoporosis

scientific article published on 01 January 2015

Osteocyte differentiation and the formation of an interconnected cellular network in vitro.

scientific article published on 24 May 2016

Osteocyte differentiation is regulated by extracellular matrix stiffness and intercellular separation

scientific article published on 18 July 2013

Osteogenic Differentiation of Mesenchymal Stem Cells by Mimicking the Cellular Niche of the Endochondral Template

scientific article published on 7 September 2016

Osteogenic differentiation of mesenchymal stem cells is regulated by osteocyte and osteoblast cells in a simplified bone niche

scientific article published on 12 January 2012

Perforation of cancellous bone trabeculae by damage-stimulated remodelling at resorption pits: a computational analysis

scientific article published in February 2005

Perspective on post-menopausal osteoporosis: establishing an interdisciplinary understanding of the sequence of events from the molecular level to whole bone fractures

scientific article

Primary Human Osteoblasts Cultured in a 3D Microenvironment Create a Unique Representative Model of Their Differentiation Into Osteocytes

scientific article published on 24 April 2020

Primary cilia exist in a small fraction of cells in trabecular bone and marrow

scientific article published on 15 November 2014

Primary cilia expression in bone marrow in response to mechanical stimulation in explant bioreactor culture

scientific article published on 19 July 2016

Quantification of fluid shear stress in bone tissue engineering scaffolds with spherical and cubical pore architectures.

scientific article published on 30 July 2015

ROCK-II inhibition suppresses impaired mechanobiological responses in early estrogen deficient osteoblasts

scientific article published on 05 September 2020

Shear Stress Within Trabecular Bone Marrow due to Low Magnitude High Frequency Vibration

scientific article

Simulation of self expanding transcatheter aortic valve in a realistic aortic root: implications of deployment geometry on leaflet deformation.

scientific article published on 10 June 2014

Site specific increase in heterogeneity of trabecular bone tissue mineral during oestrogen deficiency

scientific article published on 15 May 2011

Strain amplification and integrin based signaling in osteocytes

scientific article published on October 2008

Strain amplification in bone mechanobiology: a computational investigation of the in vivo mechanics of osteocytes

scientific article

Strength of cancellous bone trabecular tissue from normal, ovariectomized and drug-treated rats over the course of ageing

scientific article published on 27 April 2006

Stress-concentrating effect of resorption lacunae in trabecular bone

scientific article published in January 2006

Temporal changes in bone composition, architecture, and strength following estrogen deficiency in osteoporosis

scientific article published on 18 October 2012

The effect of equiaxial stretching on the osteogenic differentiation and mechanical properties of human adipose stem cells

scientific article published on 13 April 2017

The effect of substrate stiffness, thickness, and cross-linking density on osteogenic cell behavior

scientific article

The effects of estrogen deficiency and bisphosphonate treatment on tissue mineralisation and stiffness in an ovine model of osteoporosis

article

The impact of implantation depth of the Lotus™ valve on mechanical stress in close proximity to the bundle of His

scientific article published on 20 August 2018

The in situ mechanics of trabecular bone marrow: the potential for mechanobiological response

scientific article published on 01 January 2015

The role of adhesion junctions in the biomechanical behaviour and osteogenic differentiation of 3D mesenchymal stem cell spheroids.

scientific article

The role of integrin α(V)β(3) in osteocyte mechanotransduction.

scientific article published on 10 November 2014

Thermally induced osteocyte damage initiates a remodelling signaling cascade.

scientific article

Thermally induced osteocyte damage initiates pro-osteoclastogenic gene expression in vivo

scientific article published on June 2016

Total ellipse of the heart valve: the impact of eccentric stent distortion on the regional dynamic deformation of pericardial tissue leaflets of a transcatheter aortic valve replacement

scientific article

List of works by Laoise McNamara

* Mimicking the Biochemical and Mechanical Extracellular Environment of the Endochondral Ossification Process to Enhance the In Vitro Mineralization Potential of Human Mesenchymal Stem Cells.

A Developmental Engineering-Based Approach to Bone Repair: Endochondral Priming Enhances Vascularization and New Bone Formation in a Critical Size Defect

A Novel 3D Osteoblast and Osteocyte Model Revealing Changes in Mineralization and Pro-osteoclastogenic Paracrine Signaling During Estrogen Deficiency

A coupled diffusion-fluid pressure model to predict cell density distribution for cells encapsulated in a porous hydrogel scaffold under mechanical loading

A fluid-structure interaction model to characterize bone cell stimulation in parallel-plate flow chamber systems.

A model for the role of integrins in flow induced mechanotransduction in osteocytes

A three-scale finite element investigation into the effects of tissue mineralisation and lamellar organisation in human cortical and trabecular bone

Administration of Human Non-Diabetic Mesenchymal Stromal Cells to a Murine Model of Diabetic Fracture Repair: A Pilot Study

Alterations in osteocyte mediated osteoclastogenesis during estrogen deficiency and under ROCK-II inhibition: An in vitro study using a novel postmenopausal multicellular niche model

Altered architecture and cell populations affect bone marrow mechanobiology in the osteoporotic human femur

Altered mechanical environment of bone cells in an animal model of short- and long-term osteoporosis.

An Experimental and Computational Investigation of Bone Formation in Mechanically Loaded Trabecular Bone Explants.

An in vitro bone tissue regeneration strategy combining chondrogenic and vascular priming enhances the mineralization potential of mesenchymal stem cells in vitro while also allowing for vessel formation

An in vitro evaluation of the impact of eccentric deployment on transcatheter aortic valve hemodynamics.

An in vitro model quantifying the effect of calcification on the tissue-stent interaction in a stenosed aortic root

Are all osteocytes equal? Multiscale modelling of cortical bone to characterise the mechanical stimulation of osteocytes.

Attachment of osteocyte cell processes to the bone matrix

Biomimetic approaches in bone tissue engineering: Integrating biological and physicomechanical strategies.

Bone Mineral Is More Heterogeneously Distributed in the Femoral Heads of Osteoporotic and Diabetic Patients: A Pilot Study

Bone cell mechanosensation of fluid flow stimulation: a fluid-structure interaction model characterising the role integrin attachments and primary cilia

Bone mechanical properties and changes with osteoporosis

Bone remodelling algorithms incorporating both strain and microdamage stimuli

Bone tissue material properties are altered during osteoporosis.

Cell morphology and focal adhesion location alters internal cell stress

Comparison of Surgical Smoke Generated During Electrosurgery with Aerosolized Particulates from Ultrasonic and High-Speed Cutting

Comparison of in vitro human endothelial cell response to self-expanding stent deployment in a straight and curved peripheral artery simulator

Computational modelling of the mechanics of trabecular bone and marrow using fluid structure interaction techniques.

Dielectric characterization of diseased human trabecular bones at microwave frequency

Differential β3 and β1 Integrin Expression in Bone Marrow and Cortical Bone of Estrogen Deficient Rats.

Effects of ageing, prolonged estrogen deficiency and zoledronate on bone tissue mineral distribution.

Effects of in vitro endochondral priming and pre-vascularisation of human MSC cellular aggregates in vivo.

Endochondral Priming: A Developmental Engineering Strategy for Bone Tissue Regeneration

Estrogen Plus Estrogen Receptor Antagonists Alter Mineral Production by Osteoblasts In Vitro

Estrogen deficiency attenuates fluid flow-induced [Ca2+]i oscillations and mechanoresponsiveness of MLO-Y4 osteocytes

Estrogen deficiency impairs integrin αβ-mediated mechanosensation by osteocytes and alters osteoclastogenic paracrine signalling

Estrogen plus estrogen receptor antagonists alter mineral production by osteoblasts in vitro

Estrogen withdrawal from osteoblasts and osteocytes causes increased mineralization and apoptosis

Fluid flow in the osteocyte mechanical environment: a fluid-structure interaction approach

Heat-shock-induced cellular responses to temperature elevations occurring during orthopaedic cutting.

How bone tissue and cells experience elevated temperatures during orthopaedic cutting: an experimental and computational investigation

In silico study of bone tissue regeneration in an idealised porous hydrogel scaffold using a mechano-regulation algorithm

Integrins in Osteocyte Biology and Mechanotransduction

Investigating the interplay between substrate stiffness and ligand chemistry in directing mesenchymal stem cell differentiation within 3D macro-porous substrates.

Investigation of the optimal timing for chondrogenic priming of MSCs to enhance osteogenic differentiation in vitro as a bone tissue engineering strategy.

Loss of trabeculae by mechano-biological means may explain rapid bone loss in osteoporosis

Mechanical stimulation of bone marrow in situ induces bone formation in trabecular explants.

Mechanical stimuli and matrix properties modulate cancer spheroid growth in three-dimensional gelatin culture

Mechanisms of osteocyte stimulation in osteoporosis

Multiscale fluid-structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold

Multiscale modeling of trabecular bone marrow: understanding the micromechanical environment of mesenchymal stem cells during osteoporosis

Osteocyte differentiation and the formation of an interconnected cellular network in vitro.

Osteocyte differentiation is regulated by extracellular matrix stiffness and intercellular separation

Osteogenic Differentiation of Mesenchymal Stem Cells by Mimicking the Cellular Niche of the Endochondral Template

Osteogenic differentiation of mesenchymal stem cells is regulated by osteocyte and osteoblast cells in a simplified bone niche

Perforation of cancellous bone trabeculae by damage-stimulated remodelling at resorption pits: a computational analysis

Perspective on post-menopausal osteoporosis: establishing an interdisciplinary understanding of the sequence of events from the molecular level to whole bone fractures

Primary Human Osteoblasts Cultured in a 3D Microenvironment Create a Unique Representative Model of Their Differentiation Into Osteocytes

Primary cilia exist in a small fraction of cells in trabecular bone and marrow

Primary cilia expression in bone marrow in response to mechanical stimulation in explant bioreactor culture

Quantification of fluid shear stress in bone tissue engineering scaffolds with spherical and cubical pore architectures.

ROCK-II inhibition suppresses impaired mechanobiological responses in early estrogen deficient osteoblasts

Shear Stress Within Trabecular Bone Marrow due to Low Magnitude High Frequency Vibration

Simulation of self expanding transcatheter aortic valve in a realistic aortic root: implications of deployment geometry on leaflet deformation.

Site specific increase in heterogeneity of trabecular bone tissue mineral during oestrogen deficiency

Strain amplification and integrin based signaling in osteocytes

Strain amplification in bone mechanobiology: a computational investigation of the in vivo mechanics of osteocytes

Strength of cancellous bone trabecular tissue from normal, ovariectomized and drug-treated rats over the course of ageing

Stress-concentrating effect of resorption lacunae in trabecular bone

Temporal changes in bone composition, architecture, and strength following estrogen deficiency in osteoporosis

The effect of equiaxial stretching on the osteogenic differentiation and mechanical properties of human adipose stem cells

The effect of substrate stiffness, thickness, and cross-linking density on osteogenic cell behavior

The effects of estrogen deficiency and bisphosphonate treatment on tissue mineralisation and stiffness in an ovine model of osteoporosis

The impact of implantation depth of the Lotus™ valve on mechanical stress in close proximity to the bundle of His

The in situ mechanics of trabecular bone marrow: the potential for mechanobiological response

The role of adhesion junctions in the biomechanical behaviour and osteogenic differentiation of 3D mesenchymal stem cell spheroids.

The role of integrin α(V)β(3) in osteocyte mechanotransduction.

Thermally induced osteocyte damage initiates a remodelling signaling cascade.

Thermally induced osteocyte damage initiates pro-osteoclastogenic gene expression in vivo

Total ellipse of the heart valve: the impact of eccentric stent distortion on the regional dynamic deformation of pericardial tissue leaflets of a transcatheter aortic valve replacement