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List of works by Johanna Ivaska

68Ga-DOTA-E[c(RGDfK)]2 PET Imaging of SHARPIN-Regulated Integrin Activity in Mice

scientific article published on 08 March 2019

A Negative Feedback Loop Regulates Integrin Inactivation and Promotes Neutrophil Recruitment to Inflammatory Sites

scientific article published on 19 August 2019

A Strong Contractile Actin Fence and Large Adhesions Direct Human Pluripotent Colony Morphology and Adhesion.

scientific article published on 13 June 2017

A ZO-1/α5β1-integrin complex regulates cytokinesis downstream of PKCε in NCI-H460 cells plated on fibronectin

scientific article (publication date: 2013)

A functional genetic screen reveals new regulators of β1-integrin activity

scientific article

A peptide inhibiting the collagen binding function of integrin alpha2I domain.

scientific article

A phase II trial of bevacizumab with dacarbazine and daily low-dose interferon-alpha2a as first line treatment in metastatic melanoma

scientific article published in August 2010

AMPK negatively regulates tensin-dependent integrin activity.

scientific article published on 13 March 2017

Adhesion receptors and cell invasion: mechanisms of integrin-guided degradation of extracellular matrix

scientific article

An RNAi screen identifies KIF15 as a novel regulator of the endocytic trafficking of integrin

scientific article published on 21 March 2014

Aneuploidy facilitates oncogenic transformation via specific genetic alterations, including Twist2 upregulation

scientific article published on 20 May 2013

Author Correction: Every step of the way: integrins in cancer progression and metastasis

scientific article published on 01 March 2019

Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes.

scientific article

Blocking integrin inactivation as an anti-angiogenic therapy

scientific article published on 31 March 2015

CIP2A inhibits PP2A in human malignancies

scientific article

CIP2A is associated with human breast cancer aggressivity

scientific article

Calpains promote α2β1 integrin turnover in nonrecycling integrin pathway

scientific article published on 7 December 2011

Cell-derived matrices for studying cell proliferation and directional migration in a complex 3D microenvironment

scientific article

Clustering induces a lateral redistribution of alpha 2 beta 1 integrin from membrane rafts to caveolae and subsequent protein kinase C-dependent internalization.

scientific article

Competitive binding of Rab21 and p120RasGAP to integrins regulates receptor traffic and migration

scientific article

Cooperation between integrins and growth factor receptors in signaling and endocytosis

scientific article published on 10 June 2011

Corrigendum: Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes.

scientific article published on 22 July 2016

Cross-talk between integrins alpha1beta1 and alpha2beta1 in renal epithelial cells

scientific article published on 3 September 2008

Cyt-Geist: Current and Future Challenges in Cytometry: Reports of the CYTO 2018 Conference Workshops

scientific article published on 01 June 2019

Cytokinesis failure due to derailed integrin traffic induces aneuploidy and oncogenic transformation in vitro and in vivo

scientific article

Differential expression of collagen- and laminin-binding integrins mediates ureteric bud and inner medullary collecting duct cell tubulogenesis

scientific article published on 8 June 2004

Distinct c-Met activation mechanisms induce cell rounding or invasion through pathways involving integrins, RhoA and HIP1.

scientific article

Distinct recognition of collagen subtypes by alpha(1)beta(1) and alpha(2)beta(1) integrins. Alpha(1)beta(1) mediates cell adhesion to type XIII collagen

scientific journal article

Distinct recycling of active and inactive β1 integrins

scientific article published on 31 January 2012

Distinct roles of AKT isoforms in regulating β1-integrin activity, migration, and invasion in prostate cancer

scientific article

Editorial overview: Cell architecture: Integrating physics and chemistry in emergent cellular properties

scientific article published on 21 December 2018

Endosomes: Emerging Platforms for Integrin-Mediated FAK Signalling

scientific article published on March 2016

Endothelial destabilization by angiopoietin-2 via integrin β1 activation.

scientific article

Epithelial vimentin plays a functional role in mammary gland development

scientific article

Erratum: Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2

scientific article published on 01 February 2017

Every step of the way: integrins in cancer progression and metastasis

scientific article published on 01 September 2018

Fetal liver endothelium regulates the seeding of tissue-resident macrophages

scientific article published on 12 October 2016

FiloQuant reveals increased filopodia density during breast cancer progression.

scientific article

Filopodia Quantification Using FiloQuant

scientific article published on 01 January 2019

Filopodia and adhesion in cancer cell motility

scientific article

Filopodia in cell adhesion, 3D migration and cancer cell invasion

scientific article

Filopodome Mapping Identifies p130Cas as a Mechanosensitive Regulator of Filopodia Stability

scientific article published on 10 January 2019

Filopodome mapping identifies p130Cas as a mechanosensitive regulator of filopodia stability

Fluctuation-Based Super-Resolution Traction Force Microscopy

scientific article published on 20 March 2020

Formin-like 2 Promotes β1-Integrin Trafficking and Invasive Motility Downstream of PKCα.

scientific article published on 5 August 2015

GGA2 and RAB13 promote activity-dependent β1-integrin recycling

scientific article published on 07 June 2019

GGA2 and RAB13 regulate activity-dependent β1-integrin recycling

High-throughput methods in identification of protein tyrosine phosphatase inhibitors and activators

scientific article published on January 2011

IGFBP2 secretion by mammary adipocytes limits breast cancer invasion

scientific article published in 2023

Identification of Protein Interactions Involved in Cellular Signaling ⬇️

scientific article published on March 12, 2013

Inhibition of receptor tyrosine kinase signalling by small molecule agonist of T-cell protein tyrosine phosphatase

scientific article

Integrin "endoadhesome" signaling suppresses anoikis

scientific article published on 22 February 2016

Integrin Binding Dynamics Modulate Ligand-Specific Mechanosensing in Mammary Gland Fibroblasts

scientific article published on 13 February 2020

Integrin Binding Dynamics Modulate Ligand-Specific Mechanosensing in Mammary Gland Fibroblasts

scientific article published on 04 September 2020

Integrin activity in neuronal connectivity

scientific article published on 15 June 2018

Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta.

scientific article

Integrin alpha2beta1 mediates isoform-specific activation of p38 and upregulation of collagen gene transcription by a mechanism involving the alpha2 cytoplasmic tail

scientific article

Integrin bondage: filamin takes control

scientific article published in May 2015

Integrin endosomal signalling suppresses anoikis

scientific article published on 05 October 2015

Integrin inactivators: balancing cellular functions in vitro and in vivo

scientific article published on 30 May 2013

Integrin signaling and mechanotransduction in regulation of somatic stem cells

scientific article published on 25 February 2019

Integrin traffic - the update

scientific article published on 06 February 2015

Integrin trafficking in cells and tissues

scientific article published on 02 January 2019

Integrin trafficking regulated by Rab21 is necessary for cytokinesis

scientific article published on September 2008

Integrin α2I Domain Recognizes Type I and Type IV Collagens by Different Mechanisms

scientific article published in Journal of Biological Chemistry

Integrin-mediated cell adhesion to type I collagen fibrils

scientific article

Integrin-protein kinase C relationships

scientific article

Integrin-specific control of focal adhesion kinase and RhoA regulates membrane protrusion and invasion

scientific article

Integrins and mutant p53 on the road to metastasis.

scientific article published in December 2009

Integrins as biomechanical sensors of the microenvironment

scientific article published on 01 August 2019

Internalization of echovirus 1 in caveolae.

scientific article published on February 2002

Interplay between cell adhesion and growth factor receptors: from the plasma membrane to the endosomes

scientific article published on September 2009

Johanna Ivaska: Finding opposing forces in integrins

scientific article published on March 2015

Kinase-Independent Functions of MASTL in Cancer: A New Perspective on MASTL Targeting

scientific article published on 06 July 2020

L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling

scientific article

Loss of ADAM9 expression impairs β1 integrin endocytosis, focal adhesion formation and cancer cell migration

scientific article published on 15 November 2017

Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation

scientific article published in May 2018

MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels

scientific article published on 25 May 2022

MASTL promotes cell contractility and motility through kinase-independent signaling

scientific article published on 01 June 2020

Mammary-derived growth inhibitor (MDGI) interacts with integrin α-subunits and suppresses integrin activity and invasion

scientific article

Mammary-derived growth inhibitor alters traffic of EGFR and induces a novel form of cetuximab resistance

scientific article published on 13 October 2009

Mechano-responsiveness of fibrillar adhesions on stiffness-gradient gels

scientific article published on 11 May 2020

Mitosis-Resistant Adhesions Provide Molecular Memory to Dividing Cells

scientific article published in April 2018

Molecular mechanism of T-cell protein tyrosine phosphatase (TCPTP) activation by mitoxantrone

scientific article

Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis.

scientific article

Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling

scientific article published on 23 November 2015

Myosin-X and talin modulate integrin activity at filopodia tips

scientific article published on 01 September 2021

Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP

scientific article

Negative regulators of integrin activity

scientific article published on 20 July 2012

Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription

scientific article published on 04 August 2016

Novel functions of vimentin in cell adhesion, migration, and signaling

scientific article published on 14 April 2007

OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity.

scientific article

PKC epsilon controls the traffic of beta1 integrins in motile cells

scientific article published on July 2002

PKCepsilon is a permissive link in integrin-dependent IFN-gamma signalling that facilitates JAK phosphorylation of STAT1.

scientific article published in April 2003

PKCepsilon regulation of an alpha5 integrin-ZO-1 complex controls lamellae formation in migrating cancer cells.

scientific article published on 30 June 2009

PKCepsilon-mediated phosphorylation of vimentin controls integrin recycling and motility

scientific article

Pressure Drives Rapid Burst-Like Coordinated Cellular Motion from 3D Cancer Aggregates

scientific article published on 07 January 2022

ProLIF – quantitative integrin protein–protein interactions and synergistic membrane effects on proteoliposomes

scientific article published on 20 August 2018

PtdIns(3,4,5)P₃ is a regulator of myosin-X localization and filopodia formation

scientific article published in October 2010

Regulation of Cell Migration and β1 Integrin Trafficking by the Endosomal Adaptor GGA3.

scientific article

SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin

scientific article

SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras ⬇️

scientific article published on 6 March 2017

SHARPIN is an endogenous inhibitor of β1-integrin activation

scientific article

SHARPIN regulates collagen architecture and ductal outgrowth in the developing mouse mammary gland.

scientific article published on 14 December 2016

SHARPIN regulates uropod detachment in migrating lymphocytes

scientific article

SORLA regulates endosomal trafficking and oncogenic fitness of HER2

scientific article published on 28 May 2019

SORLA-driven endosomal trafficking regulates the oncogenic fitness of HER2

Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2.

scientific article

Serum angiogenin levels predict treatment response in patients with stage IV melanoma

scientific article published on 29 August 2007

Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins

scientific article

Sortilin-related receptor is a druggable therapeutic target in breast cancer

scientific article published in January 2022

Superresolution architecture of cornerstone focal adhesions in human pluripotent stem cells

scientific article published on 18 October 2019

Syndecan-1 and -4 differentially regulate oncogenic K-ras dependent cell invasion into collagen through α2β1 integrin and MT1-MMP.

scientific article published on 23 March 2011

Syndecan-1 supports integrin alpha2beta1-mediated adhesion to collagen

scientific article

Targeting β1-integrin inhibits vascular leakage in endotoxemia

article published in the Proceedings of the National Academy of Sciences of the United States of America

Tensin-4-Dependent MET Stabilization Is Essential for Survival and Proliferation in Carcinoma Cells.

scientific article published on 9 June 2014

Tensin-4-dependent MET stabilization is essential for survival and proliferation in carcinoma cells

scientific article

Tensins: Bridging AMP-Activated Protein Kinase with Integrin Activation

scientific article published on 8 July 2017

The R-Ras interaction partner ORP3 regulates cell adhesion

scientific article published on 12 February 2008

The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling

scientific article

The complexity of integrins in cancer and new scopes for therapeutic targeting

scientific article

The protein tyrosine phosphatase TCPTP controls VEGFR2 signalling

scientific article published on 7 October 2008

Transcytosis route mediates rapid delivery of intact antibodies to draining lymph nodes

scientific article published on 24 June 2019

Unanchoring integrins in focal adhesions ⬇️

scientific article published on 01 October 2012

Using xCELLigence RTCA Instrument to Measure Cell Adhesion

scientific article published in December 2017

Vascular Morphogenesis: An Integrin and Fibronectin Highway

scientific article published on 01 February 2017

Vimentin coordinates fibroblast proliferation and keratinocyte differentiation in wound healing via TGF-β-Slug signaling

scientific article published on 08 July 2016

Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer

scientific article published on 8 November 2010

Vimentin-ERK Signaling Uncouples Slug Gene Regulatory Function

scientific article

Vimentin: Central hub in EMT induction?

scientific article published on January 2011

Whom to blame for metastasis, the epithelial-mesenchymal transition or the tumor microenvironment?

scientific article

Zebrafish Embryo Xenograft and Metastasis Assay

publication published on 20 September 2018

“RKKH” Peptides from the Snake Venom Metalloproteinase ofBothrops jararacaBind Near the Metal Ion-dependent Adhesion Site of the Human Integrin α2I-domain

scientific article published in Journal of Biological Chemistry

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