List of works - Irmgard Sinning

60S ribosome biogenesis requires rotation of the 5S ribonucleoprotein particle

scientific article

Arabidopsis Stromal-derived Factor2 (SDF2) Is a Crucial Target of the Unfolded Protein Response in the Endoplasmic Reticulum

scientific article

Assembly of the eukaryotic PLP-synthase complex from Plasmodium and activation of the Pdx1 enzyme

scientific article

Chromodomains read the arginine code of post-translational targeting

scientific article

Co-translational capturing of nascent ribosomal proteins by their dedicated chaperones

scientific article

Conserved Properties of Polypeptide Transport-associated (POTRA) Domains Derived from Cyanobacterial Omp85

scientific article

Consistent mutational paths predict eukaryotic thermostability

scientific article

Crystal structure of the complete core of archaeal signal recognition particle and implications for interdomain communication

scientific article

Crystal structure of the human Fe65-PTB1 domain

scientific article

Crystal structures of Rea1-MIDAS bound to its ribosome assembly factor ligands resembling integrin-ligand-type complexes

scientific article published on 11 July 2019

Drosophila photoreceptor cells exploited for the production of eukaryotic membrane proteins: receptors, transporters and channels

scientific article

FlhA provides the adaptor for coordinated delivery of late flagella building blocks to the type III secretion system

scientific article published on 22 June 2010

Following the signal sequence from ribosomal tunnel exit to signal recognition particle

scientific article

Functional implications of MIR domains in protein <i>O</i>-mannosylation

scientific article published on 24 December 2020

Head-to-tail interactions of the coiled-coil domains regulate ClpB activity and cooperation with Hsp70 in protein disaggregation

scientific article

High-resolution X-ray and NMR structures of the SMN Tudor domain: conformational variation in the binding site for symmetrically dimethylated arginine residues

scientific article (publication date: 21 March 2003)

High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation

scientific article published on 25 January 2022

Lipids Trigger a Conformational Switch That Regulates Signal Recognition Particle (SRP)-mediated Protein Targeting

scientific article

Mdm38 is a 14‐3‐3‐Like Receptor and Associates with the Protein Synthesis Machinery at the Inner Mitochondrial Membrane ⬇️

scientific article published on July 22, 2011

MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments

scientific article published on 07 February 2020

Molecular Basis for the Unique Role of the AAA+ Chaperone ClpV in Type VI Protein Secretion

scientific article

On the significance of Toc-GTPase homodimers

scientific article

Phosphorylation of LRP1 regulates the interaction with Fe65

scientific article

SRP RNA remodeling by SRP68 explains its role in protein translocation

scientific article

Structural Basis for Conserved Regulation and Adaptation of the Signal Recognition Particle Targeting Complex

scientific article

Structural Basis for Tail-Anchored Membrane Protein Biogenesis by the Get3-Receptor Complex

scientific article

Structural Basis for a Distinct Catalytic Mechanism in Trypanosoma brucei Tryparedoxin Peroxidase

scientific article

Structural analysis of the SRP Alu domain from Plasmodium falciparum reveals a non-canonical open conformation

scientific article published in 2021

Structural analysis of the human Golgi-associated plant pathogenesis related protein GAPR-1 implicates dimerization as a regulatory mechanism

scientific article

Structural basis for 5'-ETS recognition by Utp4 at the early stages of ribosome biogenesis.

scientific article

Structural basis for specific substrate recognition by the chloroplast signal recognition particle protein cpSRP43

scientific article

Structural basis for the complex DNA binding behavior of the plant stem cell regulator WUSCHEL

scientific article published on 06 May 2020

Structural basis for the molecular evolution of SRP-GTPase activation by protein

scientific article

Structural characterization of a eukaryotic chaperone--the ribosome-associated complex

scientific article

Structural insights into tail-anchored protein binding and membrane insertion by Get3

scientific article

Structural insights into the assembly of the human and archaeal signal recognition particles

scientific article

Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones ⬇️

scientific article published on December 28, 2012

Structure and Switch Cycle of SRβ as Ancestral Eukaryotic GTPase Associated with Secretory Membranes

scientific article

Structure of a bacterial pyridoxal 5'-phosphate synthase complex

scientific article

Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2

scientific article

Synchronizing nuclear import of ribosomal proteins with ribosome assembly

scientific article

Targeting of Drosophila rhodopsin requires helix 8 but not the distal C-terminus

scientific article

The GTPase cycle of the chloroplast import receptors Toc33/Toc34: implications from monomeric and dimeric structures

scientific article

The crystal structure of Ebp1 reveals a methionine aminopeptidase fold as binding platform for multiple interactions

scientific article

The crystal structure of the periplasmic domain of the Escherichia coli membrane protein insertase YidC contains a substrate binding cleft

scientific article

The crystal structure of the third signal-recognition particle GTPase FlhF reveals a homodimer with bound GTP

scientific article

The ribosome-associated complex RAC serves in a relay that directs nascent chains to Ssb

scientific article published on 20 March 2020

The structure of Get4 reveals an alpha-solenoid fold adapted for multiple interactions in tail-anchored protein biogenesis

scientific article

The structure of the chloroplast signal recognition particle (SRP) receptor reveals mechanistic details of SRP GTPase activation and a conserved membrane targeting site

scientific article

The structure of the regulatory domain of the adenylyl cyclase Rv1264 from Mycobacterium tuberculosis with bound oleic acid

scientific article

The zinc-finger protein Red1 orchestrates MTREC submodules and binds the Mtl1 helicase arch domain

scientific article published on 08 June 2021

Towards the structure of the mammalian signal recognition particle

scientific article (publication date: February 2002)

Translational arrest by a prokaryotic signal recognition particle is mediated by RNA interactions

scientific article

X-ray crystal structure of Saccharomyces cerevisiae Pdx1 provides insights into the oligomeric nature of PLP synthases

scientific article

List of works by Irmgard Sinning

60S ribosome biogenesis requires rotation of the 5S ribonucleoprotein particle

Arabidopsis Stromal-derived Factor2 (SDF2) Is a Crucial Target of the Unfolded Protein Response in the Endoplasmic Reticulum

Assembly of the eukaryotic PLP-synthase complex from Plasmodium and activation of the Pdx1 enzyme

Chromodomains read the arginine code of post-translational targeting

Co-translational capturing of nascent ribosomal proteins by their dedicated chaperones

Conserved Properties of Polypeptide Transport-associated (POTRA) Domains Derived from Cyanobacterial Omp85

Consistent mutational paths predict eukaryotic thermostability

Crystal structure of the complete core of archaeal signal recognition particle and implications for interdomain communication

Crystal structure of the human Fe65-PTB1 domain

Crystal structures of Rea1-MIDAS bound to its ribosome assembly factor ligands resembling integrin-ligand-type complexes

Drosophila photoreceptor cells exploited for the production of eukaryotic membrane proteins: receptors, transporters and channels

FlhA provides the adaptor for coordinated delivery of late flagella building blocks to the type III secretion system

Following the signal sequence from ribosomal tunnel exit to signal recognition particle

Functional implications of MIR domains in protein <i>O</i>-mannosylation

Head-to-tail interactions of the coiled-coil domains regulate ClpB activity and cooperation with Hsp70 in protein disaggregation

High-resolution X-ray and NMR structures of the SMN Tudor domain: conformational variation in the binding site for symmetrically dimethylated arginine residues

High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation

Lipids Trigger a Conformational Switch That Regulates Signal Recognition Particle (SRP)-mediated Protein Targeting

Mdm38 is a 14‐3‐3‐Like Receptor and Associates with the Protein Synthesis Machinery at the Inner Mitochondrial Membrane ⬇️

MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments

Molecular Basis for the Unique Role of the AAA+ Chaperone ClpV in Type VI Protein Secretion

On the significance of Toc-GTPase homodimers

Phosphorylation of LRP1 regulates the interaction with Fe65

SRP RNA remodeling by SRP68 explains its role in protein translocation

Structural Basis for Conserved Regulation and Adaptation of the Signal Recognition Particle Targeting Complex

Structural Basis for Tail-Anchored Membrane Protein Biogenesis by the Get3-Receptor Complex

Structural Basis for a Distinct Catalytic Mechanism in Trypanosoma brucei Tryparedoxin Peroxidase

Structural analysis of the SRP Alu domain from Plasmodium falciparum reveals a non-canonical open conformation

Structural analysis of the human Golgi-associated plant pathogenesis related protein GAPR-1 implicates dimerization as a regulatory mechanism

Structural basis for 5'-ETS recognition by Utp4 at the early stages of ribosome biogenesis.

Structural basis for specific substrate recognition by the chloroplast signal recognition particle protein cpSRP43

Structural basis for the complex DNA binding behavior of the plant stem cell regulator WUSCHEL

Structural basis for the molecular evolution of SRP-GTPase activation by protein

Structural characterization of a eukaryotic chaperone--the ribosome-associated complex

Structural insights into tail-anchored protein binding and membrane insertion by Get3

Structural insights into the assembly of the human and archaeal signal recognition particles

Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones ⬇️

Structure and Switch Cycle of SRβ as Ancestral Eukaryotic GTPase Associated with Secretory Membranes

Structure of a bacterial pyridoxal 5'-phosphate synthase complex

Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2

Synchronizing nuclear import of ribosomal proteins with ribosome assembly

Targeting of Drosophila rhodopsin requires helix 8 but not the distal C-terminus

The GTPase cycle of the chloroplast import receptors Toc33/Toc34: implications from monomeric and dimeric structures

The crystal structure of Ebp1 reveals a methionine aminopeptidase fold as binding platform for multiple interactions

The crystal structure of the periplasmic domain of the Escherichia coli membrane protein insertase YidC contains a substrate binding cleft

The crystal structure of the third signal-recognition particle GTPase FlhF reveals a homodimer with bound GTP

The ribosome-associated complex RAC serves in a relay that directs nascent chains to Ssb

The structure of Get4 reveals an alpha-solenoid fold adapted for multiple interactions in tail-anchored protein biogenesis

The structure of the chloroplast signal recognition particle (SRP) receptor reveals mechanistic details of SRP GTPase activation and a conserved membrane targeting site

The structure of the regulatory domain of the adenylyl cyclase Rv1264 from Mycobacterium tuberculosis with bound oleic acid

The zinc-finger protein Red1 orchestrates MTREC submodules and binds the Mtl1 helicase arch domain

Towards the structure of the mammalian signal recognition particle

Translational arrest by a prokaryotic signal recognition particle is mediated by RNA interactions

X-ray crystal structure of Saccharomyces cerevisiae Pdx1 provides insights into the oligomeric nature of PLP synthases