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List of works by Ingrid Grummt

A kinetic framework for a mammalian RNA polymerase in vivo

scientific article

A metabolic throttle regulates the epigenetic state of rDNA.

scientific article published on May 2008

A model for the topology of active ribosomal RNA genes

scientific article published on 18 February 2011

A novel RNA binding surface of the TAM domain of TIP5/BAZ2A mediates epigenetic regulation of rRNA genes

scientific article published on 27 April 2015

AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply

scientific article published on 06 October 2009

Acetylation of UBF changes during the cell cycle and regulates the interaction of UBF with RNA polymerase I.

scientific article

Actin and myosin as transcription factors

scientific article

Activation of RNA polymerase I transcription by cockayne syndrome group B protein and histone methyltransferase G9a

scientific journal article

Alu element-containing RNAs maintain nucleolar structure and function

scientific article

Autoantibodies to NOR 90/hUBF: longterm clinical and serological followup in a patient with limited systemic sclerosis suggests an antigen driven immune response

scientific article

CSB is a component of RNA pol I transcription

scientific journal article

Cell Differentiation and Carcinogenesis

Cellular stress and nucleolar function

scientific article

Chromatin-specific regulation of mammalian rDNA transcription by clustered TTF-I binding sites

scientific article

Cooperative Action of Cdk1/cyclin B and SIRT1 Is Required for Mitotic Repression of rRNA Synthesis

scientific article published on 29 May 2015

DNA sequence encoded repression of rRNA gene transcription in chromatin

scientific article published on 25 April 2010

Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1.

scholarly article

Development of a species-specific RNA polymerase I-based shRNA expression vector

scientific article published on 7 December 2006

Different epigenetic layers engage in complex crosstalk to define the epigenetic state of mammalian rRNA genes

scientific article published on April 2007

Dynamic regulation of nucleolar architecture

scientific article published on 9 March 2018

Dynamic subcellular partitioning of the nucleolar transcription factor TIF-IA under ribotoxic stress

scientific article published on 18 May 2009

Epigenetic control of RNA polymerase I transcription in mammalian cells

scientific article

Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells

scientific article published on 13 March 2007

Epigenetic mechanism of rRNA gene silencing: temporal order of NoRC-mediated histone modification, chromatin remodeling, and DNA methylation

scientific article

Epigenetic silencing of RNA polymerase I transcription

scientific article

GADD45A binds R-loops and recruits TET1 to CpG island promoters

scientific article published on 07 January 2019

Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis

scientific journal article

Heat shock represses rRNA synthesis by inactivation of TIF-IA and lncRNA-dependent changes in nucleosome positioning

scientific article published on June 2016

Human Cdc14B promotes progression through mitosis by dephosphorylating Cdc25 and regulating Cdk1/cyclin B activity

scientific article

Identification of protein phosphorylation sites by combination of elastase digestion, immobilized metal affinity chromatography, and quadrupole-time of flight tandem mass spectrometry

scientific article published on 01 July 2002

Interaction of noncoding RNA with the rDNA promoter mediates recruitment of DNMT3b and silencing of rRNA genes

scientific article published on October 2010

Intergenic transcripts originating from a subclass of ribosomal DNA repeats silence ribosomal RNA genes in trans

scientific article

Intergenic transcripts regulate the epigenetic state of rRNA genes

scientific journal article

Krebsentstehung und Differenzierung

Life on a planet of its own: regulation of RNA polymerase I transcription in the nucleolus

scientific article

Linking rDNA transcription to the cellular energy supply

scientific article published on 12 January 2010

LncRNA Khps1 Regulates Expression of the Proto-oncogene SPHK1 via Triplex-Mediated Changes in Chromatin Structure.

scientific article

Long noncoding RNA TARID directs demethylation and activation of the tumor suppressor TCF21 via GADD45A.

scientific article

Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription

scientific article

Modulation of RNA polymerase assembly dynamics in transcriptional regulation

scientific article published on May 2008

Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter

scientific article

NoRC silences rRNA genes, telomeres, and centromeres.

scientific article published on 13 January 2014

NoRC-dependent nucleosome positioning silences rRNA genes

scientific article published on 30 November 2006

Noisy silence: non-coding RNA and heterochromatin formation at repetitive elements

scientific article published on 11 October 2013

NuRD blocks reprogramming of mouse somatic cells into pluripotent stem cells

scientific article

Nuclear myosin I acts in concert with polymeric actin to drive RNA polymerase I transcription

scientific article published on 29 January 2008

PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation

scientific article

Phosphorylation by casein kinase 2 facilitates rRNA gene transcription by promoting dissociation of TIF-IA from elongating RNA polymerase I.

scientific article published on 16 June 2008

Proteasomal ATPases are associated with rDNA: the ubiquitin proteasome system plays a direct role in RNA polymerase I transcription

scientific article published on 6 September 2008

Purine- and pyrimidine-triple helix forming oligonucleotides recognize qualitatively different target sites at the ribosomal DNA locus

scientific article

Quiescence-induced LncRNAs trigger H4K20 trimethylation and transcriptional silencing

scientific article published on 24 April 2014

Recruitment of the nucleolar remodeling complex NoRC establishes ribosomal DNA silencing in chromatin

scientific article published on February 2004

Regulation of Mammalian Ribosomal Gene Transcription by RNA Polymerase I

article

Repression of RNA polymerase I upon stress is caused by inhibition of RNA-dependent deacetylation of PAF53 by SIRT7.

scientific article

Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing

scientific journal article

Ribosomal RNA transcription in vitro is species specific

scientific article published in Nature

Ribosomes Dance to a Daily Rhythm

scientific article published on 17 June 2017

Role of pescadillo and upstream binding factor in the proliferation and differentiation of murine myeloid cells

scientific article

SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability

scientific article published on 8 August 2017

SIRT7-dependent deacetylation of CDK9 activates RNA polymerase II transcription

scientific article

SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing

scientific article published on 12 February 2016

TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation

scientific article

TFIIH plays an essential role in RNA polymerase I transcription

scientific article

The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats

scientific journal article

The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing

scientific journal article

The RNA polymerase I transcription machinery: an emerging target for the treatment of cancer

scientific article

The chromatin remodeling complex NoRC and TTF-I cooperate in the regulation of the mammalian rRNA genes in vivo

scientific article

The chromatin remodeling complex NoRC controls replication timing of rRNA genes

scientific article

The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription

scientific article

The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions ⬇️

scientific article published on May 8, 2012

The chromatin remodelling complex NoRC safeguards genome stability by heterochromatin formation at telomeres and centromeres

scientific article

The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription

scientific article

The epigenetics of rRNA genes: from molecular to chromosome biology

scientific article published on January 2008

The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription

scientific journal article

The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis

scientific article published on April 2005

The nucleolus—guardian of cellular homeostasis and genome integrity

scientific article

The seven faces of SIRT7.

scientific article published on 9 January 2017

The structure of NoRC-associated RNA is crucial for targeting the chromatin remodelling complex NoRC to the nucleolus

scientific journal article

Wisely chosen paths--regulation of rRNA synthesis: delivered on 30 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden

scientific article

c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription.

scientific article published on 20 February 2005

lncRNA-Induced Nucleosome Repositioning Reinforces Transcriptional Repression of rRNA Genes upon Hypotonic Stress

scientific article published on 16 February 2016

mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability

scientific article

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