List of works by Helen Walden

A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease

scientific article

Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening.

scientific article published on 24 April 2017

Allosteric mechanism for site-specific ubiquitination of FANCD2

scientific article published on 23 December 2019

Autoregulation of Parkin activity through its ubiquitin-like domain

scientific article

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.

scientific article

Characterisation of FANCL variants observed in patient cancer cells

scientific article published on 18 May 2020

Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA

scientific article published on 08 June 2020

Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.

scientific article published on 7 August 2015

Enzymatic preparation of monoubiquitinated FANCD2 and FANCI proteins

scientific article published on 11 February 2019

Hydrophobic, Aromatic, and Electrostatic Interactions Play a Central Role in Amyloid Fibril Formation and Stability

scientific article published on 22 February 2011

Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8

scientific article (publication date: 20 March 2003)

Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations

scientific article published on 27 February 2005

Mechanism and disease association of E2-conjugating enzymes: lessons from UBE2T and UBE2L3

scientific article

Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements

scientific article published on 21 September 2017

Modes of allosteric regulation of the ubiquitination machinery

scientific article published on 15 April 2020

Molecular replacements

scientific article published on 18 October 2013

Parkin function in Parkinson's disease

scientific article published on 01 April 2018

Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity

scientific article published on 17 April 2017

RBR E3 ubiquitin ligases: new structures, new insights, new questions

scientific article

RBR ligase–mediated ubiquitin transfer: a tale with many twists and turns

RNF12 X-Linked Intellectual Disability Mutations Disrupt E3 Ligase Activity and Neural Differentiation.

scientific article

Regulation of Parkin E3 ubiquitin ligase activity.

scientific article published on 19 April 2012

Selenium incorporation using recombinant techniques

scientific article published on 24 March 2010

Small, N-terminal tags activate Parkin E3 ubiquitin ligase activity by disrupting its autoinhibited conformation.

scientific article

Specificity and disease in the ubiquitin system

scientific article published on February 2016

Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1 ⬇️

scientific article published on 12 October 2018

Structural Analysis of Human FANCL, the E3 Ligase in the Fanconi Anemia Pathway

scientific article

Structural analysis of Escherichia coli ThiF.

scientific article

Structural basis of generic versus specific E2-RING E3 interactions in protein ubiquitination

scientific article published on 23 August 2019

Structure and function of a regulated archaeal triosephosphate isomerase adapted to high temperature

scientific article published in September 2004

Structure of the Human FANCL RING-Ube2T Complex Reveals Determinants of Cognate E3-E2 Selection

scientific article

Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

scientific article

Synergistic Recruitment of UbcH7~Ub and Phosphorylated Ubl Domain Triggers Parkin Activation

Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation

scientific article published on 16 November 2018

The <i>CCP</i>4 suite: integrative software for macromolecular crystallography

scientific article published in 2023

The Fanconi Anemia DNA Repair Pathway Is Regulated by an Interaction between Ubiquitin and the E2-like Fold Domain of FANCL

scientific article

The Fanconi anemia DNA repair pathway: structural and functional insights into a complex disorder

scientific article

The deubiquitinase USP7 uses a distinct ubiquitin-like domain to deubiquitinate NF-κB subunits

scientific article published on 25 June 2020

The structural basis for substrate promiscuity in 2-keto-3-deoxygluconate aldolase from the Entner-Doudoroff pathway in Sulfolobus solfataricus

scientific article

The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1

scientific article

The structure of the catalytic subunit FANCL of the Fanconi anemia core complex

scientific article

Towards a molecular understanding of the fanconi anemia core complex

scientific article

Types of Ubiquitin Ligases

scientific article published on 01 March 2016

Ubiquitin and Parkinson's disease through the looking glass of genetics

scientific article published on 13 April 2017

Ubiquitin signalling in DNA replication and repair

Ubiquitin-like protein activation.

scientific article published on March 2004

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