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List of works by Heike L. Pahl

A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2.

scientific article published on 9 January 2012

A novel role for nuclear factor-erythroid 2 in erythroid maturation by modulation of mitochondrial autophagy

scientific article published on 16 June 2016

A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF-kappa B.

scientific article

A phase II trial of pegylated interferon alpha-2b therapy for polycythemia vera and essential thrombocythemia: feasibility, clinical and biologic effects, and impact on quality of life.

scientific article published in June 2006

AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617F-independent overexpression of NF-E2

scientific article

Activation of NF-kappa B by ER stress requires both Ca2+ and reactive oxygen intermediates as messengers

scientific article published on 01 August 1996

Activation of transcription factor NF-kappaB by the adenovirus E3/19K protein requires its ER retention

scientific article published on February 1996

Altered NFE2 activity predisposes to leukemic transformation and myelosarcoma with AML-specific aberrations

scientific article published on 12 February 2019

Associations between gender, disease features and symptom burden in patients with myeloproliferative neoplasms: an analysis by the MPN QOL International Working Group

scientific article

Carbon monoxide inhalation reduces pulmonary inflammatory response during cardiopulmonary bypass in pigs

scientific article published on 01 June 2008

Comparison of methods for polycythemia rubra vera-1 mRNA quantification in whole-blood leukocytes and purified granulocytes

scientific article published in March 2004

Concomitant constitutive LNK and NFE2 mutation with loss of sumoylation in a case of hereditary thrombocythemia

scientific article published on 18 June 2020

Control of gene expression by proteolysis

scientific article

Differential effects of volatile anesthetics on hepatic heme oxygenase-1 expression in the rat.

scientific article published in November 2002

Dobutamine inhibits phorbol-myristate-acetate-induced activation of nuclear factor-kappaB in human T lymphocytes in vitro

scientific article published in November 2004

Elevated nuclear factor erythroid-2 levels promote epo-independent erythroid maturation and recapitulate the hematopoietic stem cell and common myeloid progenitor expansion observed in polycythemia vera patients

scientific article published on 22 January 2013

Enhanced expression of the sphingosine-1-phosphate-receptor-3 causes acute myelogenous leukemia in mice

scientific article published on 21 October 2019

Epigenetic regulation of NFE2 overexpression in myeloproliferative neoplasms.

scientific article published on 8 March 2018

Expression of influenza virus hemagglutinin activates transcription factor NF-kappa B.

scientific article published on March 1995

Gab2 is Essential for Transformation by FLT3-ITD in Acute Myeloid Leukemia

scientific article published on 22 February 2019

Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors.

scientific article

Gene expression profiling in polycythaemia vera: overexpression of transcription factor NF-E2.

scientific article

Gene mutations and clonal architecture in myelodysplastic syndromes and changes upon progression to acute myeloid leukaemia and under treatment

article

Genetic defects in PRC2 components other than EZH2 are not common in myeloid malignancies

scientific article published on 01 February 2012

Immunohistochemical staining of transcription factor NFE2 for the discrimination of primary myelofibrosis from essential thrombocythemia

scientific article published on 30 March 2016

Increased leukocyte survival and accelerated onset of lymphoma in the absence of MCL-1 S159-phosphorylation

scientific article

Inhibition of activator protein 1 by barbiturates is mediated by differential effects on mitogen-activated protein kinases and the small G proteins ras and rac-1.

scientific article

Isoflurane pretreatment lowers portal venous resistance by increasing hepatic heme oxygenase activity in the rat liver in vivo.

scientific article

JAK2V617F-negative ET patients do not display constitutively active JAK/STAT signaling

scientific article published on 30 August 2007

LSD1 Inhibition Prolongs Survival in Mouse Models of MPN by Selectively Targeting the Disease Clone

scientific article published on 08 June 2018

Limited effects on JAK2 mutational status after pegylated interferon alpha-2b therapy in polycythemia vera and essential thrombocythemia

scientific article published on 01 September 2006

MPN patients harbor recurrent truncating mutations in transcription factor NF-E2

scientific article published on May 2013

Myeloproliferative neoplasm (MPN) symptom assessment form total symptom score: prospective international assessment of an abbreviated symptom burden scoring system among patients with MPNs

scientific article published on 15 October 2012

NFE2 regulates transcription of multiple enzymes in the heme biosynthesis pathway.

scientific article published on 20 June 2014

Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms.

scientific article published in February 2018

Pegylated interferon for the treatment of high risk essential thrombocythemia: results of a phase II study

scientific article published on 01 October 2005

Phase I dose escalation study of lestaurtinib in patients with myelofibrosis

scientific article published on 07 January 2015

Phase II trial of Lestaurtinib, a JAK2 inhibitor, in patients with myelofibrosis

scientific article published on 22 January 2019

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli

scientific article

Prevalence and characteristics of myeloproliferative neoplasms with concomitant monoclonal gammopathy

scientific article published on 15 September 2020

Ptch2 loss drives myeloproliferation and myeloproliferative neoplasm progression

scientific article

Quantification of PRV-1 mRNA distinguishes polycythemia vera from secondary erythrocytosis

scientific article published on 31 July 2003

Reactive oxygen intermediates as second messengers of a general pathogen response.

scientific article

Regulation of the adaptor molecule LAT2, an in vivo target gene of AML1/ETO (RUNX1/RUNX1T1), during myeloid differentiation

scientific article published on 13 April 2011

Regulation of the transcription factors NF-kappa B and AP-1 by redox changes

scientific article published on 01 June 1994

Repression of T-cell function by thionamides is mediated by inhibition of the activator protein-1/nuclear factor of activated T-cells pathway and is associated with a common structure

scientific article published on 18 September 2007

Sevoflurane inhibits phorbol-myristate-acetate-induced activator protein-1 activation in human T lymphocytes in vitro: potential role of the p38-stress kinase pathway

scientific article

Sevoflurane-mediated activation of p38-mitogen-activated stresskinase is independent of apoptosis in Jurkat T-cells

scientific article

Subcellular mislocalization of the transcription factor NF-E2 in erythroid cells discriminates prefibrotic primary myelofibrosis from essential thrombocythemia.

scientific article published on 13 May 2013

Symptom burden profile in myelofibrosis patients with thrombocytopenia: Lessons and unmet needs

scientific article published on 14 October 2017

Symptomatic Profiles of Patients With Polycythemia Vera: Implications of Inadequately Controlled Disease.

scientific article published on 23 November 2015

The AML1/ETO target gene LAT2 interferes with differentiation of normal hematopoietic precursor cells

scientific article

The ER-overload response: activation of NF-kappa B.

scientific article published on February 1997

The JAK2V617F mutation is acquired secondary to the predisposing alteration in familial polycythaemia vera

scientific article published on 01 September 2005

The Jak2V617F mutation, PRV-1 overexpression, and EEC formation define a similar cohort of MPD patients

scientific article published on 28 June 2005

The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB.

scientific article published in April 1996

The mitogen-activated protein kinase p38 regulates activator protein 1 by direct phosphorylation of c-Jun

scientific article published on July 2007

The oligodendrocyte lineage transcription factor 2 (OLIG2) is epigenetically regulated in acute myeloid leukemia

scientific article published on 28 July 2017

The transcription factor NFE2 enhances expression of the hematopoietic master regulators SCL/TAL1 and GATA2

scientific article published on 25 June 2020

Thionamides inhibit the transcription factor nuclear factor-kappaB by suppression of Rac1 and inhibitor of kappaB kinase alpha

scientific article published on 30 November 2007

Thiopental inhibits the activation of nuclear factor kappaB.

scientific article published in May 2002

Thiopental protects human T lymphocytes from apoptosis in vitro via the expression of heat shock protein 70.

scientific article published on 24 January 2008

Thrombotic and bleeding complications in four subpopulations of patients with essential thrombocythemia defined by c-Mpl protein expression and PRV-1 mRNA levels

scientific article published on 01 June 2005

Tissue microarray technique is applicable to bone marrow biopsies of myeloproliferative neoplasms

scientific article published on 20 August 2016

Transcription factor nuclear factor erythroid-2 mediates expression of the cytokine interleukin 8, a known predictor of inferior outcome in patients with myeloproliferative neoplasms

scientific article published on 26 February 2013

Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha

scientific article published on 01 September 1996

Volatile anesthetics induce caspase-dependent, mitochondria-mediated apoptosis in human T lymphocytes in vitro.

scientific article published in June 2005

Water pipe smoking as a cause of secondary erythrocytosis.

scientific article

[Differential diagnosis of myeloproliferative neoplasms. Quantitative NF-E2 immunohistochemistry for differentiating between essential thrombocythemia and primary myelofibrosis].

scientific article

p38β-regulated induction of the heat shock response by carbon monoxide releasing molecule CORM-2 mediates cytoprotection in lung cells in vitro

scientific article

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