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List of works by Norman Sharpless

A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response

scientific article

A phase II study of troglitazone, an activator of the PPARgamma receptor, in patients with chemotherapy-resistant metastatic colorectal cancer

scientific article published in September 2002

A quantitative model for age-dependent expression of the p16INK4a tumor suppressor

scientific article published on 14 September 2009

Alterations of LKB1 and KRAS and risk of brain metastasis: comprehensive characterization by mutation analysis, copy number, and gene expression in non-small-cell lung carcinoma.

scientific article

An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation.

scientific article published on 2 May 2016

Arp2/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxis

scientific article

Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo

scientific article

CD200 is induced by ERK and is a potential therapeutic target in melanoma

scientific article

CDK4/6 inhibition induces epithelial cell cycle arrest and ameliorates acute kidney injury.

scientific article published on 11 December 2013

CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control

scientific article published on 14 April 2008

Cancer: crime and punishment

scientific article

Cdkn2a is an atherosclerosis modifier locus that regulates monocyte/macrophage proliferation.

scientific article

Cells exhibiting strong promoter activation in vivo display features of senescence

article published in the Proceedings of the National Academy of Sciences of the United States of America

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.

scientific article

Circular RNAs are abundant, conserved, and associated with ALU repeats

scientific article

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

scientific article

Co-clinical trials demonstrate superiority of crizotinib to chemotherapy in ALK-rearranged non-small cell lung cancer and predict strategies to overcome resistance

scientific article published on 10 December 2013

Combined PI3K/mTOR and MEK inhibition provides broad antitumor activity in faithful murine cancer models

scientific article published on 07 August 2012

Combined Targeted DNA Sequencing in Non-Small Cell Lung Cancer (NSCLC) Using UNCseq and NGScopy, and RNA Sequencing Using UNCqeR for the Detection of Genetic Aberrations in NSCLC.

scientific article published on 15 June 2015

Coming of age: molecular drivers of aging and therapeutic opportunities

scientific article published in March 2013

Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model

scientific article

Constitutive telomerase expression promotes mammary carcinomas in aging mice

scientific article

Decreased IRF8 expression found in aging hematopoietic progenitor/stem cells

scientific article published on 3 July 2008

Defective cell cycle checkpoint functions in melanoma are associated with altered patterns of gene expression

scientific article

Defining the toxicology of aging

scientific article

Detecting and characterizing circular RNAs

scientific article

Docetaxel-Loaded PLGA Nanoparticles Improve Efficacy in Taxane-Resistant Triple-Negative Breast Cancer.

scientific article

Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer

scientific article published in April 2012

Effect of cytotoxic chemotherapy on markers of molecular age in patients with breast cancer

scientific article

Engineering and selection of shuffled AAV genomes: a new strategy for producing targeted biological nanoparticles

scientific article

Epidermal growth factor receptor and Ink4a/Arf

article

Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk.

scientific article

Expression of p16(INK4a) as a biomarker of T-cell aging in HIV-infected patients prior to and during antiretroviral therapy

scientific article published on October 2012

Expression of p16(INK4a) prevents cancer and promotes aging in lymphocytes

scientific article

Expression of p16INK 4a is a biomarker of chondrocyte aging but does not cause osteoarthritis

scientific article published on 09 May 2018

Expression of p16Ink4a compensates for p18Ink4c loss in cyclin-dependent kinase 4/6-dependent tumors and tissues.

scientific article published in May 2007

Forging a signature of in vivo senescence

scientific article published on July 2015

Genetic "lnc"-age of noncoding RNAs to human disease

scientific article

Genetically engineered cancer models, but not xenografts, faithfully predict anticancer drug exposure in melanoma tumors

scientific article

Gone but not forgotten

scientific article published in Nature

HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice

scientific article published on August 2009

HMGA2, microRNAs, and stem cell aging

scientific article

Hot topics in stem cells and self-renewal: 2010.

scientific article published on 24 June 2010

How stem cells age and why this makes us grow old.

scientific article

IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma

scientific article published on May 2015

INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis

scientific article

INK4a/ARF: a multifunctional tumor suppressor locus

scientific article

Identification of Human Papillomavirus Infection in Cancer Tissue by Targeted Next-generation Sequencing.

scientific article

Impaired Processing of DNA Photoproducts and Ultraviolet Hypermutability With Loss of p16INK4a or p19ARF

scientific article published on 01 December 2004

Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions

scientific journal article

Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

scientific article (publication date: 28 September 2006)

Ink4a/Arf links senescence and aging

scientific article

Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors

scientific article

LKB1 and lung cancer: more than the usual suspects

scientific article published on May 2008

LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues.

scientific article

LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma

scientific article published on June 2012

Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma

scientific article published on February 2007

Lamellipodia are crucial for haptotactic sensing and response

scientific article published on 12 May 2016

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

scientific article

Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

scientific article

Medical problems in patients with malignancy: case 2. Wernicke's encephalopathy: an unusual acute neurologic complication of lymphoma and its therapy

scientific article published in October 2004

Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer

scientific article published on 28 May 2013

Metastasis in an orthotopic murine model of melanoma is independent of RAS/RAF mutation

scientific article

Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition.

scientific article

Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model

scientific article

Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy

scientific article published in February 2012

Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma

scientific article published on 24 September 2014

Overexpression of the cell cycle inhibitor p16INK4a promotes a prothrombotic phenotype following vascular injury in mice

scientific article

PARP and cancer--if it's broke, don't fix it.

scientific article published on 5 January 2011

Pharmacokinetics and efficacy of PEGylated liposomal doxorubicin in an intracranial model of breast cancer.

scientific article

Predicting drug responsiveness in human cancers using genetically engineered mice.

scientific article published on 18 June 2013

RAS unplugged: Negative feedback and oncogene-induced senescence

scientific article published on 01 December 2006

RNA expression analysis of formalin-fixed paraffin-embedded tumors

article

ROS as a tumour suppressor?

scientific article

Regression of advanced melanoma upon withdrawal of immunosuppression: case series and literature review

scientific article

Review: a meta-analysis of GWAS and age-associated diseases

scientific article

Role of senescence marker p16 INK4a measured in peripheral blood T-lymphocytes in predicting length of hospital stay after coronary artery bypass surgery in older adults

scientific article

Senescence-escape in melanoma

scientific article published in July 2012

Somatic LKB1 mutations promote cervical cancer progression

scientific article

Somatic p16(INK4a) loss accelerates melanomagenesis

scientific article

Stem cell aging

scientific article published on 19 February 2009

Stem cells and the rate of living

scientific article published in June 2007

Stem cells: Down's syndrome link to ageing

scientific article published on 11 September 2013

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

scientific article published in Nature

Targeted next generation sequencing identifies clinically actionable mutations in patients with melanoma.

scientific article

Targeting of C-terminal binding protein (CtBP) by ARF results in p53-independent apoptosis

scientific article

Telomeres, p21 and the cancer-aging hypothesis

The INK4A/ARF locus and its two gene products

scientific article

The INK4a/ARF locus and melanoma

scientific article

The LKB1 tumor suppressor as a biomarker in mouse and human tissues

scientific article

The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis.

scientific article published in January 2004

The genetics of pancreatic adenocarcinoma: a roadmap for a mouse model

scientific article

The mighty mouse: genetically engineered mouse models in cancer drug development

scientific article published on 18 August 2006

The regulation of INK4/ARF in cancer and aging

scientific article

The restricted nature of HIV-1 tropism for cultured neural cells

scientific article published on December 1992

Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner

scientific article

Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion

scientific article published in April 2017

Tumor suppressor mechanisms in immune aging

scientific article published on 15 June 2009

VHL Inactivation: A New Road to Senescence

article

What's so special about RB?

scientific article published on April 2010

mTOR signaling in melanoma: oncogene-induced pseudo-senescence?

scientific article

p16(INK4a) protects against dysfunctional telomere-induced ATR-dependent DNA damage responses

scientific article published on 16 September 2013

p16(Ink4a) interferes with Abelson virus transformation by enhancing apoptosis

scientific article published on April 2004

p16INK4a induces an age-dependent decline in islet regenerative potential

scientific article

p16INK4a reporter mice reveal age-promoting effects of environmental toxicants

scientific article

p19ARF targets certain E2F species for degradation.

scholarly article

p38MAPK Controls Expression of Multiple Cell Cycle Inhibitors and Islet Proliferation with Advancing Age

scientific article published in July 2009

p53: good cop/bad cop.

scientific article

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