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List of works by Frauke Melchior

"ChopNSpice," a mass spectrometric approach that allows identification of endogenous small ubiquitin-like modifier-conjugated peptides

scientific article

A fluorescence resonance energy transfer-based assay to study SUMO modification in solution

scientific article published in January 2005

A novel SUMO1-specific interacting motif in dipeptidyl peptidase 9 (DPP9) that is important for enzymatic regulation.

scientific article published on 14 November 2012

A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II.

scientific article published on 10 January 2014

A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2

scientific article

A stable chemical SUMO1-Ubc9 conjugate specifically binds as a thioester mimic to the RanBP2-E3 ligase complex

scientific article published on 27 April 2015

Activation of transforming growth factor-beta signaling by SUMO-1 modification of tumor suppressor Smad4/DPC4

scientific article (publication date: 23 May 2003)

An in vitro FRET-based assay for the analysis of SUMO conjugation and isopeptidase cleavage

scientific article published on January 2009

Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry

scientific article

CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis

scientific article

Calcium, viruses and nuclear pores: meeting report from the EMBO workshop 'Signal-Transduction-Mediated Regulation of Nuclear Transport', Strasbourg, France, 11--14 August 2001

scientific article published on 01 January 2002

Cell biology: SUMO.

scientific article

Concepts in sumoylation: a decade on

scientific article

Control of SUMO and Ubiquitin by ROS: Signaling and disease implications

scientific article published on 04 August 2018

Detecting endogenous SUMO targets in mammalian cells and tissues

scientific article

Dynamically regulated sumoylation of HDAC2 controls p53 deacetylation and restricts apoptosis following genotoxic stress

scientific article

Exploring the association between genetic variation in the SUMO isopeptidase gene USPL1 and breast cancer through integration of data from the population-based GENICA study and external genetic databases

scientific article

Frauke Melchior: How SUMO wrestles other proteins. Interview by Caitlin Sedwick.

scientific article published on November 2009

GTP hydrolysis by Ran occurs at the nuclear pore complex in an early step of protein import ⬇️

scientific article published on November 1, 1995

Grapevine stilbene synthase cDNA only slightly differing from chalcone synthase cDNA is expressed in Escherichia coli into a catalytically active enzyme

scientific article published on 01 July 1990

Hypoxia-induced Changes in SUMO Conjugation Affect Transcriptional Regulation Under Low Oxygen

scientific article published on 29 March 2019

IRAK2 directs stimulus-dependent nuclear export of inflammatory mRNAs.

scientific article published on 9 October 2017

Identification and analysis of endogenous SUMO1 and SUMO2/3 targets in mammalian cells and tissues using monoclonal antibodies

scientific article published on 20 March 2014

Importin α/β mediates nuclear import of individual SUMO E1 subunits and of the holo-enzyme

scientific article

In vivo localization and identification of SUMOylated proteins in the brain of His6-HA-SUMO1 knock-in mice

scientific article

Induction of stilbene synthase by Botrytis cinerea in cultured grapevine cells.

scientific article published in January 1991

Mdm2-SUMO1: is bigger better?

scientific article

Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25

scientific article

Modification of Ran GTPase-activating Protein by the Small Ubiquitin-related Modifier SUMO-1 Requires Ubc9, an E2-type Ubiquitin-conjugating Enzyme Homologue ⬇️

scientific article published on March 13, 1998

Molecular Characterization of the SUMO-1 Modification of RanGAP1 and Its Role in Nuclear Envelope Association ⬇️

scientific article published on January 26, 1998

Nuclear Pore Complex Structure and Dynamics Revealed by Cryoelectron Tomography

scientific article published in Science

Nuclear Protein Import in a Permeabilized Cell Assay

scientific article published on January 1, 1998

Nucleocytoplasmic transport: more than the usual suspects

scientific article

Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding.

scientific article published in May 2003

PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies

scientific article

Performing in vitro sumoylation reactions using recombinant enzymes.

scientific article

Plant polyketide synthases leading to stilbenoids have a domain catalyzing malonyl-CoA:CO2 exchange, malonyl-CoA decarboxylation, and covalent enzyme modification and a site for chain lengthening

scientific article published on 01 July 1997

Pyrophosphate modulates plant stress responses via SUMOylation

article

Quantitative SUMO-1 modification of a vaccinia virus protein is required for its specific localization and prevents its self-association

scientific article

RanGAP1*SUMO1 is phosphorylated at the onset of mitosis and remains associated with RanBP2 upon NPC disassembly

scientific article

RanGTP Targets p97 to RanBP2, a Filamentous Protein Localized at the Cytoplasmic Periphery of the Nuclear Pore Complex ⬇️

scientific article published on December 1, 1997

Recombinant reconstitution of sumoylation reactions in vitro

scientific article published on 01 January 2012

Reconstitution of the Recombinant RanBP2 SUMO E3 Ligase Complex.

scientific article published on January 2016

Redox regulation of SUMO enzymes is required for ATM activity and survival in oxidative stress

scientific article published on 12 May 2016

Regulation of SUMOylation by reversible oxidation of SUMO conjugating enzymes.

scientific article

Regulation of Smad4 sumoylation and transforming growth factor-beta signaling by protein inhibitor of activated STAT1.

scientific article published on 17 March 2004

Retraction: Pyrophosphate modulates plant stress responses via SUMOylation

article

SCF<sup>Fbxw5</sup> targets kinesin-13 proteins to facilitate ciliogenesis

scientific article published on 09 August 2021

SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression

scientific article

SUMO modification of the ubiquitin-conjugating enzyme E2-25K

SUMO unloads the Kap114 cab.

scientific article published on 4 May 2012

SUMO-1 and p53.

scientific article

SUMO: ligases, isopeptidases and nuclear pores

scientific article published on November 2003

SUMO: regulating the regulator.

scientific article published on 29 June 2006

SUMOylation of the corepressor N-CoR modulates its capacity to repress transcription.

scientific article

SUMOylation-dependent LRH-1/PROX1 interaction promotes atherosclerosis by decreasing hepatic reverse cholesterol transport

scientific article

Structure determination of the small ubiquitin-related modifier SUMO-1 ⬇️

scientific article published on July 10, 1998

Sumoylation inhibits alpha-synuclein aggregation and toxicity.

scientific article

Sumoylation of the GTPase Ran by the RanBP2 SUMO E3 Ligase Complex.

scientific article published on 6 August 2015

Sumoylation: a regulatory protein modification in health and disease

scientific article

The Nup358-RanGAP complex is required for efficient importin alpha/beta-dependent nuclear import

scientific article published on 27 February 2008

The Ran GTPase-activating protein (RanGAP1) is critically involved in smooth muscle cell differentiation, proliferation and migration following vascular injury: implications for neointima formation and restenosis

scientific article

The RanBP2 SUMO E3 ligase is neither HECT- nor RING-type

scientific journal article

The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes

scientific article

The RanBP2/RanGAP1*SUMO1/Ubc9 complex is a multisubunit SUMO E3 ligase.

scientific article published on 29 March 2012

The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase

scientific article

The cytoplasmic peptidase DPP9 is rate-limiting for degradation of proline-containing peptides.

scientific article

The nucleoporin RanBP2 has SUMO1 E3 ligase activity

scientific journal article

The ubiquitin-like modifier FAT10 interferes with SUMO activation

scientific article published on 01 October 2019

Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases

scientific article

Transcription factor Sp3 is silenced through SUMO modification by PIAS1

scientific article

Transient deSUMOylation of IRF2BP proteins controls early transcription in EGFR signaling

scientific article published on 22 January 2021

Two-way trafficking with Ran ⬇️

scientific article published on May 1, 1998

Ubiquitin-related modifier SUMO1 and nucleocytoplasmic transport.

scientific article

Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions

scientific article

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